| Ripley, David L |
PROTEUS, NCT05028179: Evaluating the Use of Artificial Intelligence to Support Stress Echocardiography Testing for Heart Disease |
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| Active, not recruiting | N/A | 2338 | Europe | EchoGo | Ultromics Ltd, University of Oxford, Academic Health Science Centres, National Institute for Health Research, United Kingdom | Coronary Heart Disease | 06/23 | 12/23 | | |
BRITISH, NCT05568069: RCT of Implantable Defibrillators in Patients with Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure |
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| Recruiting | N/A | 2504 | Europe | Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) | University Hospital Southampton NHS Foundation Trust, British Heart Foundation, University of Southampton | Heart Failure | 04/26 | 04/36 | | |
| Recruiting | N/A | 2844 | Europe, RoW | Aortic valve replacement | University of Leicester, University of Auckland, New Zealand, University Hospitals, Leicester, The University of Western Australia | Aortic Stenosis | 04/31 | 04/31 | | |
| McCann, Gerry P |
AMEND, NCT05887271: A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction |
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| Recruiting | 2/3 | 102 | Europe | Low calorie meal replacement plan, Diet, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, CMR, Transthoracic echocardiography, Blood test, Electrocardiogram, ECG, Accelerometery, 6 minute walk test (6MWT), Skeletal muscle strength using handgrip strength and quadriceps (Cybex dynamometer), Assessment of quality of life and heart failure symptoms, Assessment of sarcopenia, Assessment of frailty, Qualitative interview, Skeletal muscle magnetic resonance spectroscopy | University of Leicester, University of Oxford, University of Manchester | Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Obesity Adult Onset | 06/25 | 01/26 | | |
Diastolic, NCT02590822: Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction |
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| Recruiting | N/A | 120 | Europe | Cambridge Weight Plan, Supervised Exercise Sessions, Physical Activity | University of Leicester, University Hospitals, Leicester, National Institute for Health Research, United Kingdom | Diabetes | 08/28 | 08/28 | | |
NCT03948555: Magnetic Resonance Imaging (MRI) for Aortic Dissection to Visualise Inflammation |
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| Recruiting | N/A | 20 | Europe | Magnetic Resonance Imaging (MRI) using ultrasmall super paramagnetic iron oxides (USPIOs) | University of Leicester | Aortic Dissection, Aortic Diseases | 03/22 | 03/22 | | |
| Recruiting | N/A | 420 | Europe | | University of Leicester, University Hospitals, Leicester, National Institute for Health Research, United Kingdom, The George Davies Charitable Trust | Peripheral Arterial Disease, Critical Limb Ischemia, Frailty, Cognitive Impairment, Coronary Artery Disease | 05/22 | 05/31 | | |
| Recruiting | N/A | 64 | Europe | Cardiac and brain magnetic resonance imaging. | University of Leicester | Atrial Fibrillation, Stroke | 09/24 | 09/24 | | |
| Recruiting | N/A | 60 | Europe | Minnesota Living with Heart Failure Questionnaire, Echocardiogram, Six-minute walk test, Manganese-enhanced MRI and 31-P magnetic resonance spectroscopy, Cardiovascular magnetic resonance scan, Blood tests | University of Leicester | Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes | 02/26 | 02/36 | | |
NCT01918215: Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction. |
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| Active, not recruiting | N/A | 449 | Europe, RoW | ICD, ILR | Flinders University, South Australian Health and Medical Research Institute | Heart Failure, Left Ventricular Systolic Dysfunction | 08/25 | 08/25 | | |
BRITISH, NCT05568069: RCT of Implantable Defibrillators in Patients with Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure |
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| Recruiting | N/A | 2504 | Europe | Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) | University Hospital Southampton NHS Foundation Trust, British Heart Foundation, University of Southampton | Heart Failure | 04/26 | 04/36 | | |
| Recruiting | N/A | 80 | Europe | | University of Leicester | Heart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Frailty | 09/26 | 09/26 | | |
PREDICT, NCT03132129: Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus |
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| Recruiting | N/A | 593 | Europe | Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring, Cardiopulmonary exercise testing, Manganese-enhanced magnetic resonance imaging (MEMRI), Ambulatory blood pressure monitoring, Accelerometer watch, Blood tests | University of Leicester | Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies | 10/29 | 10/29 | | |
| Recruiting | N/A | 2000 | Europe | Part 1: DCM Cohort, Whole genome sequencing and biomarker analysis, Part 2: Heritable CV Diseases and Family Members, Biomarker analysis | Imperial College London, British Heart Foundation, Royal Brompton & Harefield NHS Foundation Trust | Dilated Cardiomyopathy, Cardiovascular Diseases | 07/27 | 07/27 | | |
| Recruiting | N/A | 2844 | Europe, RoW | Aortic valve replacement | University of Leicester, University of Auckland, New Zealand, University Hospitals, Leicester, The University of Western Australia | Aortic Stenosis | 04/31 | 04/31 | | |
| Flett, Andrew |
ENVI, NCT05348226: The Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI |
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| Completed | N/A | 50 | Europe | Additional Cardiac Magnetic Resonance Scan | University Hospital Southampton NHS Foundation Trust | Heart Failure With Reduced Ejection Fraction | 03/23 | 03/23 | | |
| Recruiting | N/A | 16 | Europe | Ferric derisomaltose | University Hospital Southampton NHS Foundation Trust, Portsmouth Hospitals NHS Trust | Heart Failure, Iron Deficiencies | 02/26 | 02/27 | | |
| Active, not recruiting | N/A | 1686 | Europe, Canada, Japan, US, RoW | SyncAV programmed ON, Fixed AV delay | Abbott Medical Devices | Congestive Heart Failure | 06/25 | 12/25 | | |
NCT06345989: Time and Cost-implications of Intraoral Scans vs Alginate Impressions: A Randomised Controlled Trial |
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| Not yet recruiting | N/A | 68 | Europe | Alginate impression, Intraoral scan | University of Sheffield, Nottingham University Hospitals NHS Trust | Chairside Time and Costs Associated With Intraoral Scanning Versus Alginate Impressions | 06/25 | 12/25 | | |
BRITISH, NCT05568069: RCT of Implantable Defibrillators in Patients with Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure |
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| Recruiting | N/A | 2504 | Europe | Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) | University Hospital Southampton NHS Foundation Trust, British Heart Foundation, University of Southampton | Heart Failure | 04/26 | 04/36 | | |
| Bomken, Charlotte |
| Recruiting | 3 | 740 | Europe | R1: Ixazomib, Lenalidomide, Dexamethasone (IRD) induction therapy - reactive arm, Ninlaro, Revlimid, R1: Ixazomib, Lenalidomide, Dexamethasone (IRD) induction therapy - adaptive arm, R2: Lenalidomide plus placebo maintenance, R2: Lenalidomide + ixazomib maintenance | University of Leeds, Cancer Research UK, Takeda, Celgene | Multiple Myeloma | 12/24 | 12/24 | | |
| Rao, Archie |
BRITISH, NCT05568069: RCT of Implantable Defibrillators in Patients with Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure |
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| Recruiting | N/A | 2504 | Europe | Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) | University Hospital Southampton NHS Foundation Trust, British Heart Foundation, University of Southampton | Heart Failure | 04/26 | 04/36 | | |
| Todd, Anne |
| Recruiting | 3 | 2032 | Europe | Abemaciclib, Verzenios, Endocrine therapy (letrozole, anastrozole, exemestane or tamoxifen), Arimidex, Aromasin, Femara, or Tamoxifen | Institute of Cancer Research, United Kingdom | Breast Cancer Female | 09/30 | 03/32 | | |
| Loke, Ian |
BRITISH, NCT05568069: RCT of Implantable Defibrillators in Patients with Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure |
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| Recruiting | N/A | 2504 | Europe | Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD) | University Hospital Southampton NHS Foundation Trust, British Heart Foundation, University of Southampton | Heart Failure | 04/26 | 04/36 | | |
