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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Singhal, Tarun
NCT04510220: 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis	Recruiting	3	10	US	Ofatumumab, OMB157, [F-18]PBR06, [18F]PBR06	Brigham and Women's Hospital, Novartis	Relapsing Multiple Sclerosis	12/21	12/21
NCT04144257: Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue	Recruiting	1/2	12	US	[F-18]PBR06, [18F]PBR06, [C-11]Methylreboxetine, [C-11]MRB	Brigham and Women's Hospital, U.S. Army Medical Research Acquisition Activity	Multiple Sclerosis	09/21	09/21
MAPET, NCT02649985: Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease	Recruiting	1/2	105	US	[F-18]PBR06, [F-18] PBR06, [C-11]PBR28, [C-11] PBR28	Brigham and Women's Hospital	Multiple Sclerosis, Alzheimer's Disease	12/21	12/21
NCT03207464: Molecular Imaging of Norepinephrine Transporter (NET) Using [C-11]Methylreboxetine PET in Multiple Sclerosis	Recruiting	1/2	19	US	[C-11]Methylreboxetine, [C-11]MRB	Brigham and Women's Hospital	Multiple Sclerosis	12/21	12/21
NCT03983252: Effect of Alemtuzumab on Microglial Activation Positron Emission Tomography (PET) in Multiple Sclerosis	Not yet recruiting	1/2	10	US	[F-18]PBR06, [18F]PBR06	Brigham and Women's Hospital, Genzyme, a Sanofi Company	Multiple Sclerosis	05/24	05/24
NCT04634994: Novel Assessment of Synaptic Density in Progressive MS	Recruiting	1	30	US	[F-18]SDM-8	Brigham and Women's Hospital, Massachusetts General Hospital	Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Relapsing Multiple Sclerosis, Multiple Sclerosis	08/22	08/22
Khurana, Vikram
NCT05486806: Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders	Recruiting	N/A	50	US	18F-PBR06	Brigham and Women's Hospital	Neurodegenerative Diseases, sca3, MSA - Multiple System Atrophy, Ataxia, Synucleinopathies	09/24	11/24