| Bunin, Nancy |
ALLELE, NCT03394365 / 2017-002949-30: Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants with Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy |
|
|
| Recruiting | 3 | 66 | Europe, Canada, US, RoW | tabelecleucel, tab-cel®, ATA129, EBV-CTL | Atara Biotherapeutics | Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications | 08/25 | 06/27 | | |
|
NCT02990819: Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies |
|
|
| Active, not recruiting | 2 | 60 | US | Apha/beta T and CD19+ cell depletion using CliniMACS device | Children's Hospital of Philadelphia, University of California, San Francisco | Immunodeficiencies, Immune Dysregulation Syndromes | 10/25 | 12/26 | | |
NCT03266627: Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection |
|
|
| Recruiting | 2 | 20 | US | cytotoxic t-lymphocytes, viral specific CTLs | New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Johns Hopkins University, University of California, San Francisco, University of Colorado, Denver, Indiana University, Washington University School of Medicine, University of California, Los Angeles | Adenovirus, Primary Immune Deficiency Disorder | 12/25 | 12/26 | | |
NCT03266640: Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV) |
|
|
| Recruiting | 2 | 20 | US | viral specific cytotoxic t-lymphocytes, CMV CTLs | New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Johns Hopkins University, University of California, San Francisco, Washington University School of Medicine, Indiana University, Children's Hospital Los Angeles | Cytomegalovirus Infections, Primary Immune Deficiency Disorder | 12/25 | 12/26 | | |
NCT03266653: EBV-specific Cytotoxic T-lymphocytes (CTLs) for Refractory EBV Infection |
|
|
| Recruiting | 2 | 20 | US | cytotoxic t-lymphocytes, CTLs | New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Indiana University, Washington University School of Medicine, University of California, Los Angeles, University of California, San Francisco | Epstein-Barr Virus Infections, Primary Immune Deficiency Disorder | 12/25 | 12/26 | | |
| Active, not recruiting | 2 | 140 | US | Alpha Beta T cell depletion | Children's Hospital of Philadelphia | Leukemia, Lymphoma, Myelodysplasia | 10/25 | 10/26 | | |
NCT01050855: Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders |
|
|
| Active, not recruiting | 2 | 75 | US | RIC: Distal Campath, Reduced Intensity Conditioning Regimen, RIC:Intermediate Campath, RIC: Mini Busulfan | Children's Hospital of Philadelphia | Non Malignant Diseases, Immunodeficiencies, Hemoglobinopathies | 12/25 | 12/26 | | |
NCT01656603: Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation |
|
|
| Recruiting | 2 | 9999 | US | unlicensed CBU | New York Blood Center | Infusion Reactions | 12/25 | 12/25 | | |
| Recruiting | 2 | 64 | Canada, US | Busulfan, Cell processing for TCRαβ+/CD19+ depletion, CliniMACS | Michael Pulsipher, MD | SCID | 08/26 | 08/26 | | |
| Recruiting | 2 | 23 | US | CMV Cytotoxic T-Lymphocytes, CTLs, Anti-viral Therapy, valganciclovir, ganciclovir | New York Medical College | Congenital Cytomegaloviral (CMV) Disease | 10/27 | 10/28 | | |
NCT04197596: Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs) |
|
|
| Recruiting | 1/2 | 40 | US | BK CTL | New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Johns Hopkins University, University of California, San Francisco | Viral Infection, Primary Immune Deficiency Disorder | 12/24 | 06/25 | | |
NCT04896606: SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease |
|
|
| Recruiting | 1/2 | 50 | US | Standard of Care, SARS-CoV2-CTLS | New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital | Covid19 | 12/24 | 12/25 | | |
BK-CTLs, NCT04293042: Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients |
|
|
| Recruiting | 1 | 20 | US | BK-virus specific CTLs | Children's Hospital of Philadelphia | BK Polyomavirus | 01/25 | 12/25 | | |
| Recruiting | 1 | 100 | US | Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs), CliniMACs | Children's Hospital of Philadelphia | Leukemia, Inborn Errors of Metabolism, Bone Marrow Failure Syndromes, Immunodeficiencies, Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome | 01/25 | 01/27 | | |
NCT03810196: CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT |
|
|
| Recruiting | N/A | 50 | US | CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Depleted Peripheral Stem Cell Addback | Children's Hospital of Philadelphia | Acute Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndromes, Acute Lymphoblastic Leukemia, Mixed Lineage Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma, Juvenile Myelomonocytic Leukemia | 02/25 | 01/26 | | |
NCT03047746: Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF |
|
|
| Recruiting | N/A | 50 | US | CliniMACs | Children's Hospital of Philadelphia | Acquired Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Inherited Bone Marrow Failure Syndromes | 03/25 | 03/26 | | |
NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) |
|
|
| Recruiting | N/A | 99999 | US | A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) | Center for International Blood and Marrow Transplant Research, National Marrow Donor Program | Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia | 10/41 | 10/41 | | |
| Adams, Denise |
EPIK-L1, NCT05948943: Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. |
|
|
| Recruiting | 2/3 | 230 | Europe, US, RoW | Alpelisib, BYL719, Placebo | Novartis Pharmaceuticals | Lymphatic Malformations | 10/27 | 05/30 | | |
| Recruiting | 2 | 205 | Europe, Canada, US, RoW | Alpelisib, Placebo | Novartis Pharmaceuticals | PIK3CA-related Overgrowth Spectrum (PROS) | 03/24 | 04/31 | | |
| Raffini, Leslie |
FiXET, NCT02486666: Pilot Feasibility and Safety of Administering Weight Adjusted Fixed LMWH Dose |
|
|
| Recruiting | 3 | 20 | Canada, US | Enoxaparin, Enoxaparin sodium | Hamilton Health Sciences Corporation, IWK Health Centre, Children's Hospital of Philadelphia, Children's Hospital of Eastern Ontario | Venous Thromboembolism | 12/22 | 12/22 | | |
NCT04583878: FUVID Study: Functional Characterization of Children With Chronic Venous Thromboembolic Disease |
|
|
| Recruiting | N/A | 125 | US | Blood draw (Visit 1), Blood draw (Visits 2 and 3) | University of Texas Southwestern Medical Center | Deep Venous Thrombosis, Pulmonary Embolism | 06/25 | 12/25 | | |
| Recruiting | N/A | 3000 | US | | American Thrombosis and Hemostasis Network, Pfizer, Hemophilia of Georgia, Inc., Genentech, Inc., Hemab Therapeutics, CSL Behring, Sanofi, Novo Nordisk A/S | Hematologic Disorder, Bleeding Disorder, Connective Tissue Disorder, Hemophilia, Thrombosis, Von Willebrand Diseases, Thrombophilia, Rare Bleeding Disorder, Platelet Disorder, Factor IX Deficiency, Factor VIII Deficiency, Thalassemia, Sickle Cell Disease | 06/35 | 12/35 | | |
| Fogel, Mark |
| Recruiting | 1/2 | 120 | US | Spironolactone | Children's Hospital of Philadelphia, National Heart, Lung, and Blood Institute (NHLBI) | Single-ventricle | 03/25 | 06/25 | | |
| Completed | N/A | 121 | US | Magnetic Resonance Imaging, MRI, Neurodevelopmental Testing, ND Testing | Children's Hospital of Philadelphia, National Heart, Lung, and Blood Institute (NHLBI) | Hypoplastic Left Heart Syndrome | 12/22 | 12/22 | | |
