| Woods, Scott |
| Recruiting | N/A | 424 | US | Standard health coaching, Habit-focused health coaching | Habit Design, University of Washington, TriHealth Inc. | Metabolic Syndrome | 04/24 | 12/24 | | |
NCT04338152: Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial |
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| Active, not recruiting | N/A | 220 | Canada, US | Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC) | University of California, Los Angeles, National Institute of Mental Health (NIMH) | Psychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, Psychosis, Family | 06/26 | 12/26 | | |
| Recruiting | N/A | 2617 | Europe, Canada, US, RoW | | Brigham and Women's Hospital, Orygen, Yale University, National Institute of Mental Health (NIMH) | Clinical High Risk, Psychosis, Remission, Conversion | 12/24 | 05/25 | | |
| Lewis, Ian J |
| Not yet recruiting | N/A | 10000 | Canada | | University of Calgary, Alberta Health Services | Bacterial Urinary Tract Infection | 08/23 | 10/23 | | |
| Miller, Robert C |
| Recruiting | 3 | 820 | Europe, US, RoW | Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG), Placebo | University of Minnesota, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) | COVID, SARS-CoV2 Infection, Covid19 | 08/26 | 08/26 | | |
NCT06089486: MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation |
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| Recruiting | N/A | 576 | Canada | ICA, PET | Ottawa Heart Institute Research Corporation, Canadian Institutes of Health Research (CIHR) | Cardiac Allograft Vasculopathy | 10/28 | 03/29 | | |
NCT05427370: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C) |
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| Recruiting | N/A | 754 | Europe, Canada, US, RoW | Revascularization by PCI, Revascularization by CABG | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR), Weill Medical College of Cornell University | Coronary Artery Disease, Heart Failure Systolic | 04/29 | 12/29 | | |
| Ho, Chester H |
NCT05255679: Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery |
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| Completed | N/A | 35 | Canada | Early FES, Delayed FES | University of Alberta, Royal Alexandra Hospital, Glenrose Foundation | Acute Spinal Cord Injury | 08/23 | 10/23 | | |
| Hart, Robert |
| Recruiting | N/A | 130 | Canada | | University of Calgary, Qualisure Diagnostics Inc., Alberta Health services | Papillary Thyroid Cancer | 05/28 | 05/28 | | |
| Gerstein, Hertzel |
| Completed | 3 | 159 | Canada | IDegLira, insulin degludec / liraglutide, insulin degludec, Metformin, Lifestyle Therapy, diet and exercise | Population Health Research Institute, Novo Nordisk A/S | Type 2 Diabetes Mellitus | 06/22 | 07/23 | | |
| Gillis, Anne M |
| Recruiting | N/A | 670 | Canada | Aggressive Risk Factor Control, Standard of Care | Nova Scotia Health Authority, Canadian Institutes of Health Research (CIHR), Abbott, Phillips, Cardiac Arrhythmia Network of Canada | Atrial Fibrillation | 06/25 | 06/27 | | |
NCT01608893: Carvedilol for Prevention of Paroxysmal Atrial Fibrillation |
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| Active, not recruiting | N/A | 300 | Canada | Carvedilol, Coreg, Metoprolol, Lopressor | University of Calgary, Heart and Stroke Foundation of Canada, Libin Cardiovascular Institute of Alberta | Atrial Fibrillation | 06/25 | 06/25 | | |
| Exner, Derek V |
| Active, not recruiting | 3 | 700 | Europe, Canada, US, RoW | Implantable Cardioverter Defibrillator + Usual Care, Implantable Cardioverter Defibrillator, ICD, Usual care, Standard medical therapy alone | University of Calgary, Canadian Institutes of Health Research (CIHR), Alberta Innovation and Science, Medtronic, GE Healthcare, Cardiac Arrhythmia Network of Canada, Accelerating Clinical Trials Consortium | Myocardial Infarction, Sudden Death | 12/24 | 12/24 | | |
| Completed | N/A | 144 | Canada | HeartWatch | HelpWear Inc. | Arrhythmias, Cardiac, Palpitation, Syncope, Light Headedness | 07/24 | 07/24 | | |
| Sheldon, Robert S |
NCT02123056: Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects |
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| Active, not recruiting | 4 | 52 | Canada | Metoprolol, Lopressor, Toprol-XL, Mteprolol Succinate ER, Matching Placebo | University of Calgary, Vanderbilt University | Vasovagal Syncope | 03/21 | 12/25 | | |
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study |
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| Recruiting | 4 | 42 | Canada | Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill | University of Calgary | Atrial Fibrillation | 12/27 | 12/27 | | |
| Recruiting | 3 | 180 | Canada | Atomoxetine Hydrochloride, Placebo | University of Calgary | Vasovagal Syncope | 09/26 | 09/27 | | |
POST 9, NCT05657925: Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9) |
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| Not yet recruiting | 3 | 24 | Canada | ondansetron 8 mg, Matching placebo | University of Calgary | Sleep Syncope | 12/26 | 12/27 | | |
POST 11, NCT05755737: A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11) |
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| Recruiting | 2 | 70 | Canada | Ondansetron, Placebo | University of Calgary | Vasovagal Syncope (VVS), Syncope | 12/25 | 12/26 | | |
| Recruiting | N/A | 125 | Canada | Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel | University of Calgary | Postural Tachycardia Syndrome | 12/24 | 12/25 | | |
| Recruiting | N/A | 25 | Canada | Pacing | University of Calgary | Vasovagal Syncope | 01/27 | 01/28 | | |
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults |
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| Recruiting | N/A | 100 | Canada | handgrip test | University of Calgary | Heart Failure | 12/25 | 12/26 | | |
| Recruiting | N/A | 80 | Canada | Sequential Gas Delivery | University of Calgary | Orthostatic Hypotension, Neurogenic Orthostatic Hypotension | 12/26 | 05/27 | | |
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome |
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| Recruiting | N/A | 26 | Canada | RespirAct™ system (Thornhill Research Inc., Toronto, Canada) | University of Calgary | Postural Tachycardia Syndrome, Orthostatic Intolerance | 12/26 | 12/26 | | |
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study |
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| Recruiting | N/A | 28 | Canada | CO2 ReHaler | University of Calgary | Neurogenic Orthostatic Hypotension, Autonomic Failure | 12/27 | 12/28 | | |
POST10, NCT05776810: Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope Trial |
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| Recruiting | N/A | 144 | Canada | Diagnostic Test: Head Up Tilt Table (HUT), Device: Implantable Loop Recorder | University of Calgary | Syncope | 12/26 | 12/26 | | |
| Recruiting | N/A | 100 | Canada | IV normal saline (999 mL infusion), IV normal saline (50 mL infusion) | University of Calgary | Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection | 12/28 | 12/29 | | |
| Burgess, John |
SBU+ClassV, NCT05361746: Scotchbond Universal Plus Compared to Scotchbond Universal With Filtek Universal Restorative to Restore Class V NCCLs |
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| Active, not recruiting | N/A | 38 | US | Scotchbond Universal Plus Adhesive, Scotchbond Universal Adhesive | Solventum US LLC | Class V Non-carious Cervical Dental Lesions | 07/25 | 07/25 | | |
| Cowie, Robert |
| Active, not recruiting | N/A | 1500 | Canada | | McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR), GlaxoSmithKline, AstraZeneca, Pfizer, Boehringer Ingelheim, Novartis, Takeda, Merck Sharp & Dohme LLC, Almirall, SAS | COPD, Chronic Obstructive Pulmonary Disease | 12/22 | 12/22 | | |
| Sigal, Ronald J |
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor |
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| Recruiting | 3 | 1250 | Canada, US, RoW | Retatrutide, LY3437943, Semaglutide | Eli Lilly and Company | Diabetes Mellitus, Type 2 | 12/26 | 03/27 | | |
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons with Type 1 Diabetes and Diabetic Kidney Disease |
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| Recruiting | 3 | 150 | Canada, US | Sotagliflozin, INPEFA, Placebo | Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D | Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure | 12/28 | 05/29 | | |
NCT04348630: Establishing Evidence-based Indoor Temperature Thresholds to Protect Health |
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| Completed | N/A | 16 | Canada | Simulated heatwave exposure | University of Ottawa | Aging, Heat Stress, Physiological Stress | 11/21 | 11/21 | | |
NCT05695079: Efficacy of Electric Fans for Mitigating Thermal Strain in Older Adults During Heat Waves |
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| Completed | N/A | 19 | Canada | No cooling (control), Electric fan (low airflow), Electric fan (high airflow) | University of Ottawa | Hyperthermia, Weather; Heat, Heat Stress, Aging | 04/23 | 04/23 | | |
NCT05601713: Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling |
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| Completed | N/A | 18 | Canada | No cooling (control), Lower limb immersion, Lower limb immersion + neck cooling | University of Ottawa | Hyperthermia, Weather; Heat, Heat Stress, Heat Syncope, Aging | 05/23 | 05/23 | | |
NCT05274009: Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat |
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| Not yet recruiting | N/A | 60 | Canada | No cooling (control), Recommended cooling, Hybrid cooling | University of Ottawa | Hyperthermia, Heat; Weather, Aging, Type2 Diabetes, Hypertension, Heat Stress | 05/24 | 05/24 | | |
| Kennedy, Sidney H |
| Recruiting | 4 | 400 | Canada | Escitalopram, Cipralex, Brexpiprazole, Rexulti | Nova Scotia Health Authority, Unity Health Toronto, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University | Major Depressive Disorder | 12/28 | 04/29 | | |
NCT04162522: Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study |
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| Completed | 3 | 1 | Canada | Escitalopram, Cipralex, Brexpiprazole, Rexulti | University Health Network, Toronto, Unity Health Toronto, Baycrest, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University | Major Depressive Disorder | 12/22 | 12/22 | | |
NCT05711940: Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD |
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| Recruiting | 3 | 568 | Europe, Canada, US, RoW | Psilocybin, COMP360 | COMPASS Pathways | Treatment Resistant Depression | 03/25 | 05/25 | | |
NCT03674671: Ketamine Versus Electroconvulsive Therapy in Depression |
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| Suspended | 3 | 240 | Canada | Intravenous Ketamine, Ketalar, Electroconvulsive Therapy, ECT | University of Ottawa, McGill University, Queen's University, University Health Network, Toronto, Ontario Shores Centre for Mental Health Sciences | Depressive Disorder, Major, Bipolar Depression | 12/25 | 12/25 | | |
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression |
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| Completed | 2 | 197 | Canada, US | Liafensine, Placebo | Denovo Biopharma LLC | Treatment Resistant Depression | 02/24 | 03/24 | | |
NCT04495543: Mitigating Suicide Risk With Single Session 'Brief Skills for Safer Living' |
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| Completed | N/A | 77 | Canada | Brief Skills for Safer Living, Brief-SfSL | Unity Health Toronto | Suicidal Ideation, Suicide, Mental Health Issue, Depression | 03/23 | 03/23 | | |
| Recruiting | N/A | 900 | Canada | | St. Joseph's Healthcare Hamilton, Unity Health Toronto, Centre for Addiction and Mental Health, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Nova Scotia Health Authority, University of Michigan, Simon Fraser University, University Health Network, Toronto | Mood Disorders, Depressive Disorder, Bipolar and Related Disorders | 03/26 | 03/26 | | |
| Hilsden, Robert J |
| Not yet recruiting | 2 | 100 | Canada | acetylsalicylic acid delayed release tablets, 81mg, ASPIRIN 81mg, Drug Identification Number 02237726 | University of Calgary, Canadian Institutes of Health Research (CIHR), Canadian Cancer Society (CCS) | Colorectal Cancer, Colorectal Adenoma, Colorectal Adenomatous Polyp | 03/23 | 07/23 | | |
FIT2RUN, NCT05396560: Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy |
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| Recruiting | N/A | 3000 | Canada | | University of Calgary | Colorectal Neoplasms | 04/26 | 04/27 | | |
| Hodgins, David C |
NCT03614884: Effectiveness of an Online Integrated Treatment for Problem Gambling and Tobacco Smoking |
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| Recruiting | N/A | 300 | Canada | Gambling and Smoking Treatment, Online CBT and MI, Gambling only treatment | University of Manitoba | Gambling Disorder | 08/21 | 12/21 | | |
| Completed | N/A | 88 | Canada | Contingency management | University of Calgary, Alberta Health services | Methamphetamine, Methamphetamine Abuse, Methamphetamine-dependence, Contingency Management, Substance Use, Substance Abuse, Substance Use Disorders, Drug Use, Drug Abuse, Adults, Humans | 12/22 | 12/23 | | |
| Raj, Satish |
NCT05603741: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers |
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| Active, not recruiting | 4 | 155 | Canada | 0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, Lignocaine | University of Calgary, Vanderbilt University Medical Center | Ehlers-Danlos Syndrome, Anesthesia, Local | 01/27 | 06/27 | | |
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study |
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| Recruiting | 4 | 42 | Canada | Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill | University of Calgary | Atrial Fibrillation | 12/27 | 12/27 | | |
| Not yet recruiting | 4 | 80 | NA | Low Dose Naltrexone, LDN, Microcrystalline cellulose, Placebo | University of Calgary | Postural Orthostatic Tachycardia Syndrome | 06/28 | 12/28 | | |
NCT04186286: Crossover Study of Propranolol vs Ivabradine in POTS |
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| Recruiting | 2 | 20 | Canada | Ivabradine 4-week course, Lancora, Propranolol 4-week course, Inderal, Placebo 4-week course | University of Calgary, Dysautonomia International | Postural Tachycardia Syndrome | 12/25 | 12/26 | | |
| Active, not recruiting | 1/2 | 150 | US | Acetazolamide, Diamox, Atomoxetine, Strattera, NO Drug, Clonidine, Catapres, Entacapone, Comtan, Entacapone & Propranolol, Inderal, Atomoxetine & Propranolol, Indomethacin, Indocin, Mecamylamine, inversine, Isosorbide Dinitrate, Isordil, Melatonin, Midodrine, pro-amatine, Modafinil, provigil, Octreotide, sandostatin, Placebo, Propranolol, Modafinil & Propranolol, Provigil, Sertraline, Zoloft, IV Saline, NaCl solution (0.9%), Drinking Water, Breathing Device, memantine, Namenda, Abdominal binder | Satish R. Raj, National Center for Advancing Translational Sciences (NCATS) | Tachycardia, Chronic Orthostatic Intolerance | 12/27 | 12/27 | | |
| Recruiting | N/A | 30 | Canada | Waist-High Compression Tights, Abdominal Compression Garments, Abdominal shapewear, compression shorts, Medications that modulate heart rate and blood pressure | University of Calgary | Postural Orthostatic Tachycardia Syndrome | 12/24 | 12/24 | | |
NCT00962728: Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS) |
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| Active, not recruiting | N/A | 30 | US | Inspiratory Threshold Device (Res-Q-Gard ITD), Res-Q-Gard ITD device 7.0 (Ref:12-0463-000), Sham Inspiratory Threshold Device, Model 002850P, Sims Portex Inc, Keene NH | Alfredo Gamboa, Vanderbilt University Medical Center | Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome | 11/25 | 12/25 | | |
IOH, NCT03970551: Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension |
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| Active, not recruiting | N/A | 64 | Canada | Physical Counter-maneuver, Stress Test, Cold Pressor Test, Serial 7's Stress Test, Functional Electrical Stimulation | University of Calgary | Orthostatic Intolerance, Syncope, Fainting, Presyncope | 12/23 | 12/23 | | |
| Recruiting | N/A | 125 | Canada | Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel | University of Calgary | Postural Tachycardia Syndrome | 12/24 | 12/25 | | |
NCT01000350: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS) |
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| Active, not recruiting | N/A | 40 | US | Saline, Normal Saline, 0.9% saline, Placebo | Vanderbilt University Medical Center | Postural Tachycardia Syndrome | 06/28 | 06/28 | | |
| Recruiting | N/A | 2554 | Canada | Remote Patient Management, Standard of Care | Ratika Parkash, Cardiac Arrhythmia Network of Canada | Cardiac Arrhythmia | 12/24 | 06/25 | | |
| Recruiting | N/A | 25 | Canada | Pacing | University of Calgary | Vasovagal Syncope | 01/27 | 01/28 | | |
| Not yet recruiting | N/A | 28 | Canada | Controlled CO2 delivery, Controlled CO2 delivery (Sham) | University of Calgary | Neurogenic Orthostatic Hypotension | 12/28 | 12/28 | | |
NCT04391465: Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate |
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| Recruiting | N/A | 20 | Canada | Electrophysiological Pacing | University of Calgary | Cerebrovascular Circulation, Physiology | 06/26 | 06/27 | | |
NCT02196376: Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome |
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| Active, not recruiting | N/A | 212 | US | History, Physical, blood draw, Questionnaires | Vanderbilt University | Postural Orthostatic Tachycardia Syndrome | 07/27 | 07/27 | | |
| Active, not recruiting | N/A | 260 | US | DAXOR, Volumex, QSweat, QSART, Quantitative Axonal Sudomotor Reflex Testing, Intrinsic Heart Rate, Inderal, IHR | Satish R. Raj, National Institutes of Health (NIH) | Tachycardia, Postural Orthostatic Tachycardia Syndrome | 12/27 | 12/27 | | |
NCT00581321: Oral Water Ingestion in Heart Transplant Patients |
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| Active, not recruiting | N/A | 40 | US | water | Satish R. Raj, National Center for Research Resources (NCRR) | Blood Pressure, Cardiac Transplantation | 12/27 | 12/27 | | |
NCT00580996: Water and the Gastropressor Response - Tachyphylaxis |
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| Active, not recruiting | N/A | 20 | US | water high dose, water tiny dose | Satish R. Raj | Orthostatic Hypotension | 12/27 | 12/27 | | |
| Active, not recruiting | N/A | 30 | US | normal saline (0.9%) | Vanderbilt University, National Center for Research Resources (NCRR), National Heart, Lung, and Blood Institute (NHLBI) | Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance | 12/27 | 12/27 | | |
NCT00581373: Water and the Gastropressor Response - Diurnal Variability |
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| Active, not recruiting | N/A | 20 | US | water 16 fl oz | Satish R. Raj | Orthostatic Hypotension | 12/27 | 12/27 | | |
NCT00692471: Sleep Actigraphy in Postural Tachycardia Syndrome (POTS) |
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| Active, not recruiting | N/A | 100 | US | Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter, ActiWatch from Minimitter | Satish R. Raj, National Center for Research Resources (NCRR) | Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders | 12/27 | 12/27 | | |
NCT03218761: POTS NET mRNA Functional Correlation With NET Activity |
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| Active, not recruiting | N/A | 200 | US | NET mRNA level, Plasma catechols, Urine Catechols | Vanderbilt University Medical Center, National Institute of Neurological Disorders and Stroke (NINDS), University of Calgary, Dysautonomia International | Postural Tachycardia Syndrome | 12/27 | 12/27 | | |
NCT04036305: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers |
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| Enrolling by invitation | N/A | 230 | US | 0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, lignocaine, Bupivacaine Injection 0.5%, marcaine | Vanderbilt University Medical Center, University of Calgary | Ehlers-Danlos Syndrome, Anesthesia, Local | 12/27 | 12/27 | | |
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults |
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| Recruiting | N/A | 100 | Canada | handgrip test | University of Calgary | Heart Failure | 12/25 | 12/26 | | |
| Recruiting | N/A | 80 | Canada | Sequential Gas Delivery | University of Calgary | Orthostatic Hypotension, Neurogenic Orthostatic Hypotension | 12/26 | 05/27 | | |
| Recruiting | N/A | 50 | Canada | Sodium Chloride Capsules, Microcystalline Cellulose Capsules | University of Calgary | Postural Orthostatic Tachycardia Syndrome | 06/28 | 12/28 | | |
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome |
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| Recruiting | N/A | 26 | Canada | RespirAct™ system (Thornhill Research Inc., Toronto, Canada) | University of Calgary | Postural Tachycardia Syndrome, Orthostatic Intolerance | 12/26 | 12/26 | | |
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study |
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| Recruiting | N/A | 28 | Canada | CO2 ReHaler | University of Calgary | Neurogenic Orthostatic Hypotension, Autonomic Failure | 12/27 | 12/28 | | |
| Recruiting | N/A | 100 | Canada | IV normal saline (999 mL infusion), IV normal saline (50 mL infusion) | University of Calgary | Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection | 12/28 | 12/29 | | |
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry |
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| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Defibrillation using EV-ICD | Medtronic | Ventricular Arrhythmia, Tachycardia | 05/30 | 10/37 | | |
| Anderson, Craig |
ASPIRING, NCT04522102: Antiplatelet Secondary Prevention International Randomised Trial After INtracerebral haemorrhaGe ()-Pilot Phase |
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| Active, not recruiting | 3 | 80 | RoW | Start antiplatelet monotherapy | The George Institute for Global Health, China, University of Edinburgh, Huashan Hospital, The University of Western Australia | Intracerebral Hemorrhage | 10/23 | 10/23 | | |
| Completed | 3 | 2425 | RoW | urapidil, Intensive BP lowing | The George Institute for Global Health, China, Shanghai East Hospital, China, First Affiliated Hospital of Chengdu Medical College, China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, China | Stroke, Acute, Cerebrovascular Disorders | 11/23 | 11/23 | | |
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 |
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| Recruiting | 3 | 4000 | Canada, RoW | Tenecteplase, TNKase, Metalyse | University of Calgary, The George Institute for Global Health, Australia | Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic | 09/30 | 12/30 | | |
| Recruiting | 3 | 20000 | Canada, RoW | Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine | The George Institute, University of Calgary, Berry Consultants | Stroke | 09/34 | 09/34 | | |
| Recruiting | 3 | 1600 | Europe, RoW | telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg, Triple Pill, Placebo | The George Institute, The University of New South Wales | Intracerebral Haemorrhage (ICH), Hypertension | 06/25 | 06/25 | | |
NCT05066620: Chinese Herbal Medicine in Acute INtracerebral Haemorrhage (CHAIN) Trial |
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| Not yet recruiting | 3 | 1504 | RoW | Chinese herbal medicine FYTF-919, Chinese herbal medicine | Guangzhou University of Traditional Chinese Medicine, The George Institute | Intracerebral Hemorrhage | 12/24 | 01/25 | | |
| Recruiting | 3 | 400 | RoW | Atorvastatin, Standard Care | The George Institute, University of Sydney, Monash University, The Alfred, Universidad del Desarrollo, Chinese University of Hong Kong, Clinica Alemana de Santiago | Neurocognitive Impairment, Mild | 12/24 | 12/24 | | |
EAST, NCT06773364: Early Initiated Ambulance-delivered Levetiracetam and Headposition in Hyper-acute Stroke Trial |
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| Not yet recruiting | 3 | 2423 | NA | Levetiracetam, Guide-recommended management, The lying flat (0°) head position, The sitting-up (≥30°) head position | Shanghai East Hospital | Suspected Stroke | 12/28 | 12/29 | | |
| Suspended | 2 | 80 | RoW | TBO-309 | The George Institute, Heart Research Institute | Acute Ischemic Stroke | 02/26 | 05/26 | | |
NCT05483595: An Examination of Blinding for Chinese Herbal Oral Liquid and Matched Placebo |
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| Completed | N/A | 48 | RoW | Chinese herbal medicine FYTF-919, Zhong Feng Xing Nao (ZFXN) prescription | Guangzhou University of Traditional Chinese Medicine | Placebo Evaluate | 06/23 | 06/23 | | |
NCT06427096: Effect of Healthy Family Program on Population Blood Pressure |
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| Recruiting | N/A | 8000 | RoW | Multifaceted intervention | Heart Health Research Center | Blood Pressure | 02/25 | 08/25 | | |
ENCHANTED3/MT, NCT06352619: Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial |
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| Recruiting | N/A | 2000 | Canada, RoW | Conservative SBP Control, Moderate SBP Control, Intensive SBP Control | The George Institute, University of Calgary, Changhai Hospital | Ischemic Stroke, Acute | 05/26 | 05/26 | | |
| Recruiting | N/A | 382 | RoW | Mechanical thrombectomy | The George Institute for Global Health, China, Changhai Hospital | Acute Ischemic Stroke | 10/24 | 01/25 | | |
| Recruiting | N/A | 7200 | Europe, US, RoW | Low-intensity monitoring strategy, Guideline recommended standard monitoring | Craig Anderson, Genentech, Inc., Johns Hopkins University, The George Institute for Global Health, Australia | Acute Ischemic Stroke Patients Receiving Reperfusion Therapy | 11/24 | 03/25 | | |
| Recruiting | N/A | 1675 | RoW | Intensive BP Control, Control of home SBP to a target of 120mmHg, Standard BP Control, Control of home SBP to a target of 135mmHg | Beijing Anzhen Hospital, Heart Health Research Center, The George Institute for Global Health, China, The George Institute for Global Health, Australia, Fukuoka University | Atrial Fibrillation, Hypertension | 06/24 | 12/25 | | |
NCT04157231: Essential Acute Stroke Care in Low Resource Settings: a Pilot studY |
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| Not yet recruiting | N/A | 300 | RoW | Acute stroke care Intervention arm | The George Institute, World Heart Federation | Acute Stroke | 10/25 | 11/25 | | |
| Hill, Michael D |
PLATINUM, NCT04443608: Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management |
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| Terminated | 4 | 115 | US | Patiromer Powder for Oral Suspension [Veltassa], Active drug, Placebo, Inactive substance | Comprehensive Research Associates | Hyperkalemia | 03/23 | 06/23 | | |
| Completed | 3 | 850 | Europe, Canada, US, RoW | Placebo, Nerinetide, NA-1 | NoNO Inc., University of Calgary | Stroke, Acute | 08/23 | 08/23 | | |
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 |
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| Recruiting | 3 | 4000 | Canada, RoW | Tenecteplase, TNKase, Metalyse | University of Calgary, The George Institute for Global Health, Australia | Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic | 09/30 | 12/30 | | |
| Recruiting | 3 | 20000 | Canada, RoW | Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine | The George Institute, University of Calgary, Berry Consultants | Stroke | 09/34 | 09/34 | | |
TEMPO-2, NCT02398656: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion |
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| Completed | 3 | 1274 | Europe, Canada, RoW | Tenecteplase, TNK-tPA, Antiplatelet treatment, ASA, Clopidogrel | University of Calgary | Stroke, Acute | 01/24 | 04/24 | | |
| Recruiting | 2/3 | 200 | Europe, Canada, US | Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM) | Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati | Cerebral Ischemia | 12/24 | 12/24 | | |
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia. |
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| Recruiting | 2a | 120 | US | AV-001 Injection, AV-001 Placebo Injection | Vasomune Therapeutics, Inc. | Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome | 12/24 | 03/25 | | |
| Recruiting | 2 | 150 | US | Auxora, Placebo | CalciMedica, Inc. | Acute Kidney Injury | 08/25 | 08/25 | | |
