Active, not recruiting

3

1150

Europe

ABVD (Adriamycin, Bleomycin, Vincristine, Dacarbazine), 20 Gy IFRT (Involved Field Radiotherapy)

University of Cologne

Hodgkin Lymphoma

09/18

12/21

Active, not recruiting

2

26

Europe

Nivolumab plus radiotherapy

University of Cologne, Bristol-Myers Squibb, GHSG

Classical Hodgkin Lymphoma

05/24

12/24

Recruiting

2

29

Europe

Pembrolizumab plus Chemotherapy (ICE or DHAP)

University of Cologne

Classical Hodgkin Lymphoma

05/26

05/28

Completed

2

323

Europe

Comirnaty(BTN162b2), BioNTech/ Pfizer, Spikevax (mRNA-1273), Moderna

Oliver Cornely, MD, European Commission, VACCELERATE

Vaccination Reaction, COVID-19, Vaccination; Infection

10/22

09/23

Recruiting

N/A

2000

Europe

University of Cologne

Invasive Candidiases

12/25

12/26

Completed

N/A

1587

Europe

Nasopharyngeal swab for SARS-CoV-2

University of Cologne, City Council of Cologne, Department of Public Health, NRW, Germany, City Council of Cologne, Department of Social Affairs, Health and Environment, NRW, Germany

COVID-19 Respiratory Infection, SARS-CoV-2 Infection

12/20

06/21

Active, not recruiting

3

250

Europe, Canada, Japan, US, RoW

LOXO-305, Pirtobrutinib, Idelalisib, Zydelig, Bendamustine, Treanda, Treakisym, Ribomustin, Levact, Rituximab, Rituxan, MabThera, Truxima

Loxo Oncology, Inc., Eli Lilly and Company

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

08/23

05/27

Active, not recruiting

3

897

Europe, RoW

Ibrutinib, Imbruvica, Venetoclax, ABT-199, Venclyxto, Obinutuzumab, GA101, Gazyvaro

German CLL Study Group, Stichting Hemato-Oncologie voor Volwassenen Nederland (HOVON), Nordic CLL Study Group (NCLLSG), Swiss Group for Clinical Cancer Research (SAKK), Cancer Trials Ireland, Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA), Grupo Español de Leucemia Linfocítica Crónica (GELLC), The Israeli CLL Study Group (ICLLSG), Janssen Pharmaceutica N.V., Belgium, AbbVie, Hoffmann-La Roche

Chronic Lymphoid Leukemia

09/27

09/27

Recruiting

1/2

359

Europe, Canada, Japan, US, RoW

NVL-520

Nuvalent Inc., Nuvalent, Inc.

Locally Advanced Solid Tumor, Metastatic Solid Tumor

10/25

10/26

Recruiting

N/A

30000

Europe

observational, non-interventional

Prof. Dr. Juergen Wolf, Charite University, Berlin, Germany, Helios Klinikum Emil von Behring, Vivantes Hospital Berlin Neukölln, University Hospital Carl Gustav Carus, Heinrich-Heine University, Duesseldorf, University Hospital Erlangen, University Hospital, Essen, Goethe University, University Hospital Freiburg, University Hospital Giessen and Marburg, University Hospital Halle (Saale), Universitätsklinikum Hamburg-Eppendorf, University Hospital Heidelberg, Klinikum Hanover-Siloah Hospital, University Hospital, Bonn, University Hospital Schleswig-Holstein, Johannes Gutenberg University Mainz, University Hospital Munich (LMU), University Hospital rechts der Isar Munich (TUM), Pius-Hospital Oldenburg, University Hospital Regensburg, University Hospital Tuebingen, Robert Bosch Hospital Stuttgart, University Hospital Ulm, Wuerzburg University Hospital, University Hospital of Cologne

Carcinoma, Non-Small-Cell Lung

12/30

12/30

Terminated

2a

61

Europe, US, RoW

DRP-104, atezolizumab

Dracen Pharmaceuticals, Inc., Dracen Pharmaceuticals, Inc.

Advanced Solid Tumor, Non Small Cell Lung Cancer Metastatic

03/23

03/23

Completed

2

90

Europe

Nivolumab, Ipilimumab

Lung Cancer Group Cologne, Bristol-Myers Squibb

Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell Lung

08/22

11/23

Active, not recruiting

2

67

Europe

Atezolizumab

Technische Universität Dresden, Roche Pharma AG

Large Cell Neuroendocrine Carcinoma of the Lung

01/28

01/29

Completed

1

18

Europe

EGF816, Nazartinib, Trametinib, Mekinist

University of Cologne

Bronchial Neoplasms

09/22

11/23

Active, not recruiting

N/A

850

Europe

DigiNet intervention

University of Cologne, Gemeinsamer Bundesausschuss (G-BA), AOK Rheinland/Hamburg, AOK Nordwest, BARMER, University Hospital, Essen, Charite University, Berlin, Germany, Berlin Institute of Health, Helios Klinikum Emil von Behring, University Hospital Carl Gustav Carus, Deutsche Krebsgesellschaft e.V., Berufsverband der Niedergelassenen Hämatologen und Onkologen in Deutschland e.V., AOK Bundesverband, FOM Hochschule für Oekonomie und Management, University Medicine Greifswald, Technische Universität Dresden

Non-small Cell Lung Cancer Stage IV

03/25

03/25

Active, not recruiting

N/A

21

Europe

TheraSorb sFlt-1 adsorber

Miltenyi Biomedicine GmbH, Cromsource

Preeclampsia

07/25

12/25

Recruiting

N/A

500

Europe

Biosampling

Prof. Dr. Paul Brinkkoetter, German Research Foundation, Medical Faculty and the Faculty of Natural Sciences of the University of Cologne, Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases, Cologne Center for Genomics

Glomerulosclerosis, Focal Segmental, Minimal Change Disease, Idiopathic Nephrotic Syndrome

03/28

03/33

Completed

3

100

Europe

Fondazione Italiana Linfomi - ETS

Hodgkin Lymphoma

11/21

11/24

Terminated

2

22

Europe

ERDAFITINIB, JNJ -42756493, WHO NUMBER 10147

Lung Cancer Group Cologne

Lung Cancer, NSCLC, Pulmonary Neoplasm, Squamous Cell Lung Cancer, NSCLC Stage IV

09/22

10/22

Recruiting

2

49

Europe

Consolidation with ADCT-402 (loncastuximab tesirine) after salvage immunochemotherapy at standard dose (R-BAC, Rituximab - Bendamustine, Ara-C)), Consolidation with ADCT-402 (loncastuximab tesirine) after salvage immunochemotherapy at reduced dose (R-BAC, Rituximab - Bendamustine, Ara-C)

Fondazione Italiana Linfomi - ETS

Relapsed Mantle Cell Lymphoma, Refractory Mantle Cell Lymphoma

04/26

04/29

Recruiting

2

28

Europe

Tislelizumab

Fondazione Italiana Linfomi - ETS

Hodgkin Lymphoma

11/27

11/29

Completed

1

106

Europe, US

Tinostamustine, EDO-S101

Mundipharma Research Limited

Hematological Malignancies, Multiple Myeloma, Hodgkin's Lymphoma, Cutaneous T Cell Lymphoma

05/23

11/23

Recruiting

N/A

200

Europe

Incyte Biosciences Italy S.r.l, Advice Pharma Group srl

DLBCL - Diffuse Large B Cell Lymphoma

06/25

06/27

Recruiting

3

870

Europe

R-CHOP/R-DHAP, rituximab, CHOP, DHAP, Ibrutinib (Induction), Imbruvica, ASCT conditioning, THAM or BEAM, Ibrutinib (Maintenance)

Prof. Dr. M. Dreyling (co-chairman), LMU Klinikum

Mantle Cell Lymphoma

05/21

05/26

Completed

2

70

Europe

B-CAP, Brentuximab Vedotin, Cyclophosphamide, Doxorubicine, Predniso(lo)ne

University of Cologne

Hodgkin Lymphoma

03/22

03/22

Recruiting

2

29

Europe

Pembrolizumab plus Chemotherapy (ICE or DHAP)

University of Cologne

Classical Hodgkin Lymphoma

05/26

05/28

2

20

Europe

Tafasitamab, Lenalidomide, Rituximab, Methotrexate

University of Cologne, Incyte Corporation

Non-Hodgkin Lymphoma

02/27

04/27

Completed

1/2

10

Europe

MB-CART20.1, CD20-targeting CAR T Cells, Anti-CD20 CAR T cells

Miltenyi Biomedicine GmbH

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, B-cell Lymphoma Refractory, B-cell Lymphoma Recurrent

09/24

09/24

Active, not recruiting

N/A

200

Europe

University of Cologne

Hypercalcemia

03/21

12/25

Recruiting

N/A

60

Europe

Water administration, NaCl-Administration

University of Cologne

Hyponatremia

06/25

06/25

Recruiting

N/A

1000

Europe

University of Cologne

Hyponatremia

12/25

12/25

Recruiting

N/A

200

Europe

Retrospective data collection of demographics, Retrospective data collection of underlying diseases, Retrospective data collection of duration of hospitalization

University of Cologne

Leptospirosis

02/30

12/30

Recruiting

N/A

2000

Europe

University of Cologne

ADPKD (Autosomal Dominant Polycystic Kidney Disease)

11/25

12/27

Terminated

3

120

Europe

Current standard of care and COVID-19 convalescent and vaccinated plasma, Current standard of care

Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen, NHS Blood and Transplant, Erasmus Medical Center

COVID-19

01/24

06/24

Recruiting

N/A

170

Europe

Rectal swabs - microbiological analysis, Examination of patient room

University Hospital of Cologne, University of Freiburg, Universitätsklinikum Hamburg-Eppendorf, University Hospital Lübeck

VRE Infection, Antibiotic Resistant Infection

12/20

12/20

Recruiting

2

142

Europe

ARTICE

Artcline GmbH, Zentrum für Klinische Studien Jena, CRO Kottmann

Sepsis, Severe

12/24

05/25

Active, not recruiting

3

292

Europe

nitrofurantoin, Furadantin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination, amoxicilline/clavulanic acid, augmentin, clavulin, Trimethoprim/sulfamethoxazole, bactrim, Cefixime, cefixoral

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Ministero della Salute, Italy, IL Sogno di Stefano

Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, Chronic Kidney Disease

01/20

01/25

Recruiting

3

102

Europe

Dapagliflozin, Placebo

University Hospital Goettingen, German Research Foundation

Chronic Kidney Failure in Children and Young Adults

09/26

12/26

Completed

N/A

69

Europe

Structured exercise training plus mediterranean diet

Technical University of Munich

Hereditary Breast and Ovarian Cancer

11/14

04/24

Recruiting

N/A

37853

Europe, RoW

Rigshospitalet, Denmark, Gilead Sciences, ViiV Healthcare

HIV

12/25

12/25

Recruiting

N/A

100000

Europe

Antiinfectives, Antifungals, Antibacterials, Antivirals

University Hospital of Cologne

Hematological Malignancies, Cancer, Chemotherapy, Neutropenia, Immunosuppression

12/50

12/50

Recruiting

N/A

6550

Europe

Observational of different courses of SARS-CoV-2 infection in different phases (acute vs. post-acute) and settings

Goethe University, Nationwide Network of University Medicine (NUM) on Covid-19

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

03/21

09/23

Recruiting

2

50

Europe

Osimertinib, Tagrisso, Pemetrexed, Cisplatin, Carboplatin

Goethe University

NSCLC Stage IIIB, NSCLC Stage IV

11/23

11/26

Recruiting

N/A

500

Europe, US, RoW

biopsy sampling

Heidelberg University

Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy

10/28

12/28

Recruiting

N/A

53

Europe

Corheart 6 Left Ventricular Assist System

Shenzhen Core Medical Technology CO.,LTD.

Refractory Heart Failure

06/25

06/30

Recruiting

N/A

100

Europe

EORTC QLQ C30, EORTC QLQ CR29

Ludwig-Maximilians - University of Munich

Rectal Cancer, Quality of Life, Radiation Therapy, Chemoradiation

12/21

12/26

Recruiting

N/A

100

Europe

observational

Ludwig-Maximilians - University of Munich

Hepatocellular Cancer, Quality of Life, Stereotactic Body Radiation Therapy, Observational

07/22

07/27

Recruiting

N/A

52

US

Nicotinamide Riboside, Placebo

Roskamp Institute Inc., United States Department of Defense, Nova Southeastern University

Gulf War Illness

02/25

02/25

Recruiting

N/A

30

US

Central Venous Access

Merit Medical Systems, Inc.

Venous Disease

02/25

02/25

Recruiting

N/A

110

Europe

Xeltis Hemodialysis Access (aXess) graft

Xeltis

End-stage Renal Disease

01/25

06/29