University Hospital Mannheim
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 32 Trials 
39 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Rudic, Boris
RAVENTA, NCT03867747: Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias

Completed
N/A
20
Europe
Cardiac Radiosurgery
University Hospital Schleswig-Holstein, Universitätsmedizin Mannheim
Ventricular Tachycardia
11/23
10/24
NCT04755569: Optimizer System With ODOCOR II CCM™ Leads

Recruiting
N/A
200
Europe
ODOCOR II CCM LEADS
Impulse Dynamics
Evaluate the Safety and Useability of the ODOCOR II Intra-cardiac Lead
12/24
12/25
Kasper, Bernd
DeFi, NCT03785964 / 2018-001991-39: Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

Checkmark Data from DeFi trial for Desmoid Tumors
May 2022 - May 2022: Data from DeFi trial for Desmoid Tumors
Completed
3
142
Europe, Canada, US
Nirogacestat oral tablet, PF-03084014, Placebo Oral Tablet
SpringWorks Therapeutics, Inc.
Desmoid Tumor, Aggressive Fibromatosis
04/22
10/24
STRASS 2, NCT04031677: Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Recruiting
3
250
Europe, Canada, Japan, US, RoW
Surgery, Preoperative chemotherapy, neoadjuvant chemotherapy
European Organisation for Research and Treatment of Cancer - EORTC, Canadian Cancer Trials Group, ECOG-ACRIN Cancer Research Group, Anticancer Fund, Belgium, Australia and New Zealand Sarcoma Association, Japan Clinical Oncology Group
Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
04/27
04/28
SUNRISELMS, NCT05269355 / 2022-000073-12: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Active, not recruiting
2/3
360
Europe, Canada, US, RoW
Unesbulin, PTC596, Dacarbazine, DTIC, Placebo
PTC Therapeutics, PTC Therapeutics, Inc.
Leiomyosarcoma
06/24
06/24
RINGSIDE, NCT04871282 / 2020-005833-34: A Study of AL102 in Patients With Progressing Desmoid Tumors

Active, not recruiting
2/3
192
Europe, US, RoW
AL102, Placebo
Immunome, Inc.
Desmoid, Desmoid Tumor
10/25
10/26
TRacKING, NCT04921553: Real Word European Registry of NTRK Fusions and Other Rare Actionable Fusions

Recruiting
N/A
500
Europe, RoW
Data collection and quality of life questionnaire
Centre Leon Berard
Cancer, Cancer Metastatic, NTRK Gene Fusion Overexpression, NTRK Family Gene Mutation, ATIC-ALK Fusion Protein Expression, ALK Fusion Protein Expression, BCR-FGFR1 Fusion Protein Expression, ROS1 Gene Translocation, COL1A1-PDGFB Fusion Protein Expression, RET Gene Translocation, Gene Fusion, ROS Gene Translocation, BRAF Gene Rearrangement, FGFR2 Gene Translocation, FGFR3 Gene Translocation, NTRK1 Gene Translocation
06/25
06/25
GISAR, NCT04122872: German Interdisciplinary Sarcoma Registry

Recruiting
N/A
9000
Europe
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Sarcoma, Sarcoma,Soft Tissue, Sarcoma of Bone, Carcinosarcoma
01/38
01/38
Reinwald, Mark
PRESTO, NCT05713838: Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery

Recruiting
2
32
Europe
Durvalumab, IMFINZI, FLOT, mFOLFOX-6, Radiotherapy
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Esophagus Adenocarcinoma
12/25
12/28
Giordano, Frank A
INTRAGO-II, NCT02685605: Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruiting
3
314
Europe, Canada, US, RoW
Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide
Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles
Glioblastoma
06/24
06/26
INDIRA-MISO, NCT03865277: Individualized Radiation Dose Prescription in HNSCC Based on F-MISO-PET Hypoxia-Imaging

Not yet recruiting
2
276
Europe
dose-escalated radiochemotherapy, dose-escalated radiochemotherapy with carbon ion boost, standard radiochemotherapy
Technische Universität Dresden
Head and Neck Squamous Cell Carcinoma
09/25
09/27
Gamma-GBM, NCT03055208: Early Stereotactic Gamma Knife Radiosurgery to Residual Tumor After Surgery of Newly Diagnosed Glioblastoma

Suspended
N/A
50
Europe
gamma knife radiosurgery (15 Gy to 50% isodose)
Universitätsmedizin Mannheim
Glioblastoma
03/20
05/23
RAVENTA, NCT03867747: Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias

Completed
N/A
20
Europe
Cardiac Radiosurgery
University Hospital Schleswig-Holstein, Universitätsmedizin Mannheim
Ventricular Tachycardia
11/23
10/24
OMX-EFS-01, NCT06533163: Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial

Not yet recruiting
N/A
40
NA
Oncomagnetic device
BioTex, Inc.
Glioblastoma Multiforme
11/27
11/27
Platten, Michael
AMPLIFY-NEOVAC, NCT03893903: AMPLIFYing NEOepitope-specific VACcine Responses in Progressive Diffuse Glioma

Active, not recruiting
1
60
Europe
IDH1R132H peptide vaccine, Avelumab
German Cancer Research Center
Malignant Glioma
09/24
12/24
INTERCEPT-H3, NCT04808245: A MultIceNTER Phase I Peptide VaCcine Trial for the Treatment of H3-Mutated Gliomas

Recruiting
1
15
Europe
Tecentriq 1200 MG in 20 ML Injection, Atezolizumab, H3K27M peptide vaccine, Imiquimod (5%), Aldara
German Cancer Research Center, Johannes Gutenberg University Mainz, Charite University, Berlin, Germany, Roche Pharma AG, German Cancer Aid
Newly Diagnosed H3-mutated Glioma
03/25
03/25
NCT05112549: Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)

Recruiting
1
46
Europe
Nivolumab [Opdivo]
University Hospital Tuebingen
Leptomeningeal Disease
09/25
09/26
Teufel, Andreas
ABC-HCC, NCT04803994 / 2020-004210-35: The Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma

Recruiting
3
434
Europe, Japan
Atezolizumab, Tecentriq, Bevacizumab, Avastin, TACE, transarterial chemoembolization
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, F. Hoffmann-La Roche Ltd
Hepatocellular Carcinoma
07/27
07/27
SPRING, NCT04595825 / 2019-002945-39: CM-101 in PSC Patients -The Study

Active, not recruiting
2
68
Europe, US, RoW
Anti-human CCL24 monoclonal antibody (CM-101), Placebo
ChemomAb Ltd., ChemomAb Ltd
Primary Sclerosing Cholangitis
09/24
09/25
NCT03645980 / 2017-002468-41: DKN-01 Inhibition in Advanced Liver Cancer

Recruiting
1/2
70
Europe
DKN-01 300 mg, DKN-01 600 mg, Sorafenib
Johannes Gutenberg University Mainz, Leap Therapeutics, Inc.
Hepatocellular Carcinoma
08/21
08/22
PBC-Cohort, NCT04076527 / 2016-004141-90: Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis

Recruiting
N/A
1200
Europe
UDCA, ursodeoxycholic acid, Ocaliva, obeticholic acid
University of Leipzig, RWTH Aachen University, Zentrum für Klinische Studien Leipzig, Intercept Pharma Europe Limited (IPEL), Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Hospital Erlangen, Medical care center for Gastroenterology, Berlin, Institute for Interdisciplinary Medicine, Hamburg, Leberhilfe Projekt gUG, Cologne, Hannover Medical School
PBC, Primary Biliary Cholangitis
03/24
03/24
Etminan, Nima
PROTECT-U, NCT03063541 / 2017-000514-35: Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms

Recruiting
3
776
Europe
Acetylsalicylic acid, aspirin, intensive blood pressure control
Universitätsmedizin Mannheim, UMC Utrecht, Schwiete Stiftung, Mannheim, Germany, KKS Netzwerk, University of Hamburg-Eppendorf
Unruptured Intracranial Aneurysms
10/22
10/22
INTRAGO-II, NCT02685605: Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruiting
3
314
Europe, Canada, US, RoW
Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide
Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles
Glioblastoma
06/24
06/26
HeMoVal, NCT04998370: Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury

Active, not recruiting
N/A
409
Europe
University of Zurich
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Delayed Cerebral Ischemia, Delayed Ischemic Neurological Deficit
06/24
10/24
Cifarelli, Christopher P
INTRAGO-II, NCT02685605: Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruiting
3
314
Europe, Canada, US, RoW
Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide
Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles
Glioblastoma
06/24
06/26
LIBERATE, NCT05383872: Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects with GlioBlastoma Brain Tumors

Recruiting
N/A
57
Canada, US
Focused Ultrasound (Exablate Model 4000)
InSightec
Glioblastoma, Glioma, Liquid Biopsy
12/24
03/25
Haenggi, Daniel
PROTECT-U, NCT03063541 / 2017-000514-35: Acetylsalicylic Acid Plus Intensive Blood Pressure Treatment in Patients With Unruptured Intracranial Aneurysms

Recruiting
3
776
Europe
Acetylsalicylic acid, aspirin, intensive blood pressure control
Universitätsmedizin Mannheim, UMC Utrecht, Schwiete Stiftung, Mannheim, Germany, KKS Netzwerk, University of Hamburg-Eppendorf
Unruptured Intracranial Aneurysms
10/22
10/22
Reiter, Andreas
ROP-ET, NCT06514807: A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients

Active, not recruiting
3
117
Europe, RoW
Ropeginterferon alfa-2b (BESREMi®)
AOP Orphan Pharmaceuticals AG
Essential Thrombocythaemia
03/28
03/28
NCT03125707: German MPN-Registry for BCR-ABL 1-Negative Myeloid Neoplasms (Study Group Ulm)

Recruiting
N/A
2172
Europe
Registry study
University of Ulm
BCR-ABL1-Negative Myeloid Neoplasms
09/45
09/45
Kirschning, Thomas
NCT05759377: V-A ECMO AUTO Mode Registry

Recruiting
N/A
30
Europe
V-A ECMO AUTO Mode algorithm
Abiomed Inc.
Heart Failure
03/25
06/25
COSMOS, NCT05146336: CytOSorb TreatMent Of Critically Ill PatientS Registry

Recruiting
N/A
3000
Europe
CytoSorb
CytoSorbents, Inc
Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis, Cardiogenic Shock, Pancreatitis, Acute on Chronic Liver Failure, Acute Liver Failure, Burns, Chimeric Antigen Receptor T-Cell Therapy (CAR-T) Cytokine Release Syndrome (CRS), Extracorporeal Life Support, Postoperative Endocarditis, Hemophagocytic Lymphohistiocytoses, Liver Transplant; Complications, Infectious Disease, Postoperative Vasoplegic Syndrome, Drug Overdose, Sepsis
06/32
09/32
Ehmann, Michael
INTRAGO-II, NCT02685605: Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruiting
3
314
Europe, Canada, US, RoW
Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide
Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles
Glioblastoma
06/24
06/26
Strahlentherapie, Studienzentrale
INTRAGO-II, NCT02685605: Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Active, not recruiting
3
314
Europe, Canada, US, RoW
Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide
Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles
Glioblastoma
06/24
06/26
Affolter, Annette
ProcemISA, NCT04398524 / 2020-003652-32: A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC

Hourglass May 2024 - Jul 2024 : Mid'24 - Data from ISA101b-OPC-03-19 study in recurrent metastatic HPV16 induced HNC
Active, not recruiting
2
65
Europe, US, RoW
ISA101b, Cemiplimab
ISA Pharmaceuticals, Regeneron Pharmaceuticals
Squamous Cell Carcinoma of the Oropharynx
06/24
12/24
ELOS, NCT06137378: European Larynx Organ Preservation Study () [MK-3475-C44]

Recruiting
2
140
Europe
KEYTRUDA®, Pembrolizumab, MK-3475
University of Leipzig, University of Göttingen, University of Jena, University of Cologne, University of Ulm, University of Regensburg, Wuerzburg University Hospital, Technical University of Munich, Ernst von Bergmann Hospital, Universitätsmedizin Mannheim, University of Kiel
Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma Stage III, Laryngeal Squamous Cell Carcinoma Stage IV, Squamous Cell Carcinoma of Larynx, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of the Larynx Stage III, Squamous Cell Carcinoma of the Larynx Stage IV, Laryngeal Squamous Cell Carcinoma, Laryngectomy; Status, Laryngeal Cancer, Laryngeal Neoplasms
12/28
12/30
NPC-Nivo, NCT06019130: Nivolumab in Children and Adults With Nasopharyngeal Carcinoma

Recruiting
2
57
Europe
Nivolumab, Opdivo, Cisplatin, Cisplatin Teva, 5-Fluorouracil, Fluorouracil-GRY, Gemcitabine, Gemcitabin-GRY, Radiotherapy, Interferon beta-1a, Rebif, MRI, PET, Patient-Reported Outcomes
German Society for Pediatric Oncology and Hematology GPOH gGmbH, Deutsche Krebshilfe e.V., Bonn (Germany)
Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Nasopharyngeal Neoplasms, Nasopharynx Cancer
01/26
01/28
Fenske, Wiebke K
DACH, NCT06268990: FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT

Recruiting
N/A
30
Europe
Fecal microbiota transplantation, FMT
Wiebke Kristin Fenske, Medical University of Graz
Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes, Insulin Resistance
12/24
12/24
AI-POD, NCT06595134: Clinical Validation Study for Obese Patients

Recruiting
N/A
1200
Europe, RoW
Non Interventional
University Hospital, Bonn, European Union
Acute Cardiovascular Disease
07/28
07/28
Bludau, Frederic
NCT06270173: Post-Market Study of The Tripod-Fix Vertebral Body Augmentation System in Osteoporotic Vertebral Compression Fractures

Recruiting
N/A
50
Europe
Tripod-Fix Vertebral Body Augmentation System (Tripod-Fix)
Wiltrom Co., Ltd., Maxis Medical GmbH
Osteoporotic Vertebral Compression Fractures
07/25
12/25

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