| Sinha, Rajita |
NCT03980184: Guanfacine to Improve Substance Use Outcomes in Women |
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| Completed | 2 | 74 | US | Guanfacine, Tenex,, Behavioral Counseling, Manualized Drug Counseling | Yale University, National Institute on Drug Abuse (NIDA) | Substance Use Disorders | 11/22 | 11/22 | | |
SICA 2, NCT05322941: Effect of AEF0117 on Treatment-seeking Patients With Cannabis Use Disorder (CUD) |
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| Completed | 2 | 333 | US | AEF0117, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one, Placebo oral capsule, Placebo | Aelis Farma, National Institute on Drug Abuse (NIDA) | Marijuana Abuse | 04/24 | 07/24 | | |
NCT05781009: Pregnenolone for the Treatment of Alcohol Use Disorder |
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| Recruiting | 2 | 150 | US | Pregnenolone, Placebo | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 07/28 | 07/28 | | |
NCT04793685: Prazosin for Alcohol Use Disorder With Withdrawal Symptoms |
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| Recruiting | 1/2 | 150 | US | Prazosin, Minipress, 12-Step Facilitation with Relapse Prevention and Contingency Management | Yale University | Alcohol Withdrawal | 06/26 | 06/27 | | |
NCT04226690: Safety and Effects on Responses to Stress and Pain of Natural Medical Marijuana Products |
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| Completed | 1 | 24 | US | Active CBD/THC Dose 1, Medical marijuana medicine, Active CBD/THC Dose 2, matched placebo comparator, Placebo | Yale University, Connecticut Pharmaceutical Solutions | Pain | 12/23 | 12/23 | | |
NCT05447286: Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study |
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| Active, not recruiting | 1 | 9 | US | NYX-783, ((2S, 3R)-3-hydroxy-2-((S)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide), Placebo, Oxycodone | Yale University, National Institute on Drug Abuse (NIDA), Aptinyx | Opioid Use Disorder | 12/24 | 12/24 | | |
NCT04779697: GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight |
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| Active, not recruiting | 1 | 96 | US | GLP-1 analogue - semaglutide, Semaglutide, Placebo | Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Obesity | 01/25 | 06/25 | | |
NCT02616094: Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse |
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| Completed | N/A | 224 | US | Multi-method Neuroendocrine and Neuroimaging Procedure Scan 1, Multi-method Neuroendocrine and Neuroimaging Procedure Scan 2 | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Dependence | 06/22 | 06/22 | | |
NCT04419831: Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function |
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| Completed | N/A | 81 | US | Yale Stress Pain Test (YSPT) | Yale University | Pain Response, Stress, Trauma | 12/23 | 12/23 | | |
NCT03950453: Preventing Childhood Obesity Through a Mindfulness-Based Parent Stress Intervention |
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| Active, not recruiting | N/A | 246 | US | Parenting Mindfully for Health Nutrition (PMH), Contact Control Nutrition (C+N), Non-randomized historical control (WLC) assessment only, assessment only group | Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Child Obesity | 06/23 | 10/24 | | |
| Hart, Rachel |
NCT05781009: Pregnenolone for the Treatment of Alcohol Use Disorder |
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| Recruiting | 2 | 150 | US | Pregnenolone, Placebo | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 07/28 | 07/28 | | |
NCT04793685: Prazosin for Alcohol Use Disorder With Withdrawal Symptoms |
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| Recruiting | 1/2 | 150 | US | Prazosin, Minipress, 12-Step Facilitation with Relapse Prevention and Contingency Management | Yale University | Alcohol Withdrawal | 06/26 | 06/27 | | |
NCT04226690: Safety and Effects on Responses to Stress and Pain of Natural Medical Marijuana Products |
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| Completed | 1 | 24 | US | Active CBD/THC Dose 1, Medical marijuana medicine, Active CBD/THC Dose 2, matched placebo comparator, Placebo | Yale University, Connecticut Pharmaceutical Solutions | Pain | 12/23 | 12/23 | | |
NCT03953612: The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders |
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| Completed | 1 | 58 | US | Pregnenolone (PREG), Placebos | Yale University, National Institute on Drug Abuse (NIDA) | Cocaine-Related Disorders | 05/23 | 05/23 | | |
NCT05447286: Safety, Tolerability and Pharmacokinetics of NYX-783 and Oxycodone DDI Study |
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| Active, not recruiting | 1 | 9 | US | NYX-783, ((2S, 3R)-3-hydroxy-2-((S)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide), Placebo, Oxycodone | Yale University, National Institute on Drug Abuse (NIDA), Aptinyx | Opioid Use Disorder | 12/24 | 12/24 | | |
| Completed | N/A | 54 | US | Intensive Day Monitoring | Yale University, Peter McManus Charitable Trust | Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder | 12/23 | 12/23 | | |
NCT04419831: Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function |
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| Completed | N/A | 81 | US | Yale Stress Pain Test (YSPT) | Yale University | Pain Response, Stress, Trauma | 12/23 | 12/23 | | |
CLR2, NCT05833230: Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users |
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| Recruiting | N/A | 60 | US | Intensive Day Monitoring | Yale University, Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award | Cannabis Use, Cannabis, Cannabis Abuse | 01/25 | 01/25 | | |
| Milivojevic, Verica |
NCT05781009: Pregnenolone for the Treatment of Alcohol Use Disorder |
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| Recruiting | 2 | 150 | US | Pregnenolone, Placebo | Yale University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 07/28 | 07/28 | | |
NCT03953612: The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders |
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| Completed | 1 | 58 | US | Pregnenolone (PREG), Placebos | Yale University, National Institute on Drug Abuse (NIDA) | Cocaine-Related Disorders | 05/23 | 05/23 | | |
| Wemm, Stephanie |
NCT04116619: Investigating Stress-related Mechanisms in the Laboratory and Real World in Individuals With Cannabis Use Disorder |
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| Completed | N/A | 39 | US | Guided Imagery Laboratory Session | Yale University, National Institutes of Health (NIH), National Center for Advancing Translational Sciences (NCATS) | Cannabis Use Disorder | 09/21 | 02/22 | | |
| Completed | N/A | 54 | US | Intensive Day Monitoring | Yale University, Peter McManus Charitable Trust | Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder | 12/23 | 12/23 | | |
CLR2, NCT05833230: Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users |
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| Recruiting | N/A | 60 | US | Intensive Day Monitoring | Yale University, Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award | Cannabis Use, Cannabis, Cannabis Abuse | 01/25 | 01/25 | | |
