| Jones, Daniel |
NCT04951128: The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery |
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| Not yet recruiting | 4 | 50 | US | Tranexamic acid injection, Local anesthetic control | Consultants in Ophthalmic and Facial Plastics Surgery | Edema, Ecchymosis; Eyelid | 12/21 | 07/22 | | |
| Recruiting | 3 | 500 | US | Anticoagulant Therapy, Catheter-Directed Therapy | NYU Langone Health, National Heart, Lung, and Blood Institute (NHLBI) | Pulmonary Embolism | 01/27 | 01/28 | | |
TETON-PPF, NCT05943535: Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis |
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| Recruiting | 3 | 698 | Canada, US, RoW | Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer | United Therapeutics | Progressive Pulmonary Fibrosis, Interstitial Lung Disease | 11/27 | 11/27 | | |
ASPIRE, NCT06588686: A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis. |
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| Recruiting | 2 | 270 | Europe, Canada, US, RoW | Buloxibutid, C21, Placebo | Vicore Pharma AB, Population Services International | Idiopathic Pulmonary Fibrosis (IPF) | 02/27 | 03/27 | | |
BYPASS-CTCA, NCT03736018: Randomised Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients |
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| Active, not recruiting | N/A | 688 | Europe | CTCA, Computed Tomography Cardiac angiography | Queen Mary University of London | Ischaemic Heart Disease, Contrast-induced Nephropathy | 08/22 | 09/23 | | |
| Completed | N/A | 300 | Europe | Beetroot Juice | Queen Mary University of London | Cardiovascular Diseases | 12/22 | 12/22 | | |
| Recruiting | N/A | 3000 | Europe | Observation only | Queen Mary University of London | Myocardial Infarction, Gender, Coronary Microvascular Disease | 09/26 | 09/26 | | |
| Recruiting | N/A | 20000 | Europe | | Queen Mary University of London | Myocardial Infarction, ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction | 12/25 | 12/26 | | |
| Carlo, Waldemar A |
NCT06518603: Caffeine Citrate in Preterm Infants At Risk of Apnea in Zambia |
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| Not yet recruiting | 4 | 340 | RoW | Caffeine citrate 20mg/kg/day, Placebo-Sterile water 1ml/kg/day | University of Alabama at Birmingham, University Teaching Hospital, Lusaka, Zambia, Centre for Infectious Disease Research in Zambia | Premature Infant Disease, Apnea of Prematurity, Development, Infant | 12/25 | 11/26 | | |
| Active, not recruiting | 3 | 1824 | US | Liberal Cell Transfusion, Restricted red cell transfusion | NICHD Neonatal Research Network, National Heart, Lung, and Blood Institute (NHLBI), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Bronchopulmonary Dysplasia (BPD), Anemia | 01/20 | 08/25 | | |
| Active, not recruiting | 3 | 800 | US | Hydrocortisone, Placebo | NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute (NHLBI), National Center for Advancing Translational Sciences (NCATS) | Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia | 09/20 | 01/25 | | |
| Terminated | 3 | 827 | US | Caffeine Citrate, Placebo | NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Apnea of Prematurity | 01/23 | 03/23 | | |
NCT04214834: Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS) |
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| Active, not recruiting | 3 | 190 | US | Morphine, Methadone | Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Neonatal Opioid Withdrawal Syndrome | 01/24 | 06/26 | | |
| Not yet recruiting | 3 | 316 | US | Milrinone infusion, Placebo infusion | NICHD Neonatal Research Network, National Heart, Lung, and Blood Institute (NHLBI) | Post-ligation Cardiac Syndrome | 06/27 | 08/29 | | |
| Active, not recruiting | 3 | 1160 | US | budesonide (Pulmicort nebulizing suspension)., Pulmicort nebulizing suspension., surfactant (poractant alfa;Curosurf), poractant alfa;Curosurf | NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal | 09/24 | 12/26 | | |
| Active, not recruiting | 3 | 836 | US | Active Treatment, Expectant Management | NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth | 04/25 | 05/27 | | |
MIDAS, NCT03231735: Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome |
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| Completed | 2/3 | 60 | US | Mid frequency ventilation, Standard frequency ventilation | University of Alabama at Birmingham, University of South Alabama | Ventilator-Induced Lung Injury, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Infant | 11/21 | 10/24 | | |
NCT03779711: Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome |
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| Active, not recruiting | 2b | 95 | US | Autologous (self) mononuclear cells derived from umbilical cord blood, Stage II Surgical repair | Timothy J Nelson, MD, PhD, University of Oklahoma, Children's Hospital of Philadelphia, Children's Hospital Los Angeles, Children's Hospital Colorado, Children's Hospitals and Clinics of Minnesota, Ochsner Health System, Children's of Alabama, Children's Hospital Medical Center, Cincinnati | Hypoplastic Left Heart Syndrome | 05/22 | 02/26 | | |
| Active, not recruiting | 2 | 66 | US | Milrinone, Milrinone Lactate Injection, Primacor, Placebo (5% Dextrose), D5W | NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia | 09/24 | 03/25 | | |
| Not yet recruiting | 2 | 1000 | RoW | Sildenafil 50 mg Oral Tablet, Revatio, Sildenafil, Placebo Oral Tablet | University of Alabama at Birmingham, University Teaching Hospital, Lusaka, Zambia, Egerton University, Cameroon Baptist Convention Health | Neonatal Asphyxia, Intrapartum Fetal Distress, Development, Infant, Intrapartum Asphyxia | 08/26 | 09/28 | | |
NCT06522854: Oral Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings |
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| Not yet recruiting | 2 | 2000 | RoW | Sildenafil 50 mg Oral Tablet, Revatio, Placebo Oral Tablet | University of Alabama at Birmingham, University of Lagos, Nigeria, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Lagos State University, National Health and Medical Research Council, Australia, Mater Medical Research Institute, The University of Queensland | Intrapartum Fetal Distress, Neonatal Asphyxia, Intrapartum Asphyxia, Instrumental Delivery; Affecting Fetus | 05/26 | 11/26 | | |
NCT04907526: Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD |
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| Active, not recruiting | 1 | 30 | US | Autologous mononuclear cells | Timothy J Nelson, MD, PhD, Mayo Clinic, University of Oklahoma, Children's Hospital of Philadelphia, Children's Hospital Los Angeles, Children's Hospitals and Clinics of Minnesota, Children's Hospital Colorado, Ochsner Health System, Children's of Alabama, Children's Hospital Medical Center, Cincinnati, The Hospital for Sick Children | Congenital Heart Disease, SRV Dependent | 05/23 | 06/25 | | |
NCT05403684: Impact of Hindmilk on Weight Gain Among Moderate to Very Preterm Infants in Zambia |
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| Completed | N/A | 214 | RoW | High-volume breastmilk | University of Alabama at Birmingham, Centre for Infectious Disease Research in Zambia, Chiesi Foundation | Postnatal Growth Restriction | 12/22 | 02/23 | | |
COCO, NCT04792099: CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial |
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| Completed | N/A | 38 | US | Continuous positive airway pressure, CPAP, Nasal Cannula, NC | University of Alabama at Birmingham | Infant, Newborn, Disease, Hypoxia, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia | 03/23 | 03/23 | | |
| Recruiting | N/A | 950000 | US, RoW | There is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery. | NICHD Global Network for Women's and Children's Health | Pregnancy Outcome Trends in Low-resource Geographic Areas | 01/25 | 01/25 | | |
NCT01604317: Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I |
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| Active, not recruiting | N/A | 182 | RoW | Resuscitation-torso plastic bag, Resuscitation-partial-head plastic bag | University of Alabama at Birmingham, Children's Health System, Alabama | Hypothermia, Immature Newborn | 08/25 | 08/25 | | |
| Recruiting | N/A | 188 | US | Finger puppet, Bookworm reading intervention training and routine EDI care. | University of Alabama at Birmingham | Child Development, Infant Development, Infant, Premature, Diseases | 08/26 | 08/28 | | |
| Recruiting | N/A | 1700 | US | Phototherapy lights | NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Hyper Bilirubinemia, Premature Infant | 07/25 | 07/25 | | |
NPC-QIC, NCT02852031: National Collaborative to Improve Care of Children With Complex Congenital Heart Disease |
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| Recruiting | N/A | 1000 | Europe, Canada, US | Collaborative Learning Network | Children's Hospital Medical Center, Cincinnati | Hypoplastic Left Heart Syndrome (HLHS) | 05/26 | 05/28 | | |
NCT00063063: Generic Database of Very Low Birth Weight Infants |
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| Recruiting | N/A | 80000 | US | | NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature | 03/30 | 03/30 | | |
| Recruiting | N/A | 68000 | US | | NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature | 03/30 | 03/30 | | |
| Jansen, Jan |
| Recruiting | 3 | 1100 | US | LTOWB, Components | University of Alabama at Birmingham, National Heart, Lung, and Blood Institute (NHLBI), The University of Texas Health Science Center, Houston | Wounds and Injuries, Shock, Hemorrhagic | 12/26 | 06/27 | | |
| Withdrawn | N/A | 40 | NA | Resuscitative Endovascular balloon occlusion of the aorta using a REBOA catheter device, REBOA procedure | University of Alabama at Birmingham | Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation, Ventricular Tachycardia | 10/22 | 10/22 | | |
CAPP, NCT04755179: Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population |
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| Completed | N/A | 1308 | Europe | Laparoscopic appendectomy, Open appendectomy, Non-operative treatment, Direct appendectomy | Ramon Gorter, ZonMw: The Netherlands Organisation for Health Research and Development, Amsterdam UMC, location VUmc | Appendicitis, Appendix Mass, Appendicitis Perforated | 07/24 | 07/24 | | |
| Terminated | N/A | 1 | US | XSTAT, XSTAT 12, Standard of Care | University of Alabama at Birmingham | Shock, Hemorrhagic, Injury Penetrating, Hemorrhage | 06/23 | 08/23 | | |
MOBI-1, NCT04893837: Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner |
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| Recruiting | N/A | 440 | US | Standard care plus infrascans | University of Alabama at Birmingham, United States Department of Defense, InfraScan, Inc. | Brain Injuries, Traumatic | 06/25 | 06/25 | | |
| Brown, Cynthia J |
ELEVAATE, NCT05856331: Study of SAR447537 (INBRX-101) Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema |
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| Active, not recruiting | 2 | 99 | Europe, US, RoW | SAR447537, Zemaira, Respreeza | Sanofi | Alpha 1-Antitrypsin Deficiency, Emphysema | 08/25 | 10/25 | | |
NCT04798014: HERO-2: Home-Reported Outcomes With CFTR Modulator Therapy |
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| Completed | N/A | 860 | US | | Indiana University, Folia Health, Cystic Fibrosis Foundation | Cystic Fibrosis | 08/23 | 08/23 | | |
| Recruiting | N/A | 146 | US | Parenthood | University of Pittsburgh, Cystic Fibrosis Foundation, National Heart, Lung, and Blood Institute (NHLBI) | Cystic Fibrosis, Parenthood Status | 02/30 | 02/31 | | |
| R |
PRP, NCT06249503: Ultrasound Guided Activated and Non Activated Platelet Rich Plasma Injection Versus Hydro Dissection by Steroids. |
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| Recruiting | 4 | 90 | RoW | platelet rich plasma, PRP, steroids | Ain Shams University | Carpal Tunnel Syndrome, Compare Steroids Versus PRP in Dissection of Median Nerve by Ultrasound | 09/24 | 09/24 | | |
| Active, not recruiting | 3 | 41 | Europe, Canada, Japan, US, RoW | Emapalumab, NI-0501, emapalumab-lzsg, ATC code: L04AA39 (WHO) | Swedish Orphan Biovitrum | Macrophage Activation Syndrome, Secondary Hemophagocytic Lymphohistiocytosis, Still Disease, Systemic Lupus Erythematosus, SJIA, AOSD, MAS | 06/24 | 09/25 | | |
| Recruiting | N/A | 140 | US | UC-A, UC-N | Think Now Incorporated, University of California, Los Angeles, University of California, Berkeley | Attention Deficit Hyperactivity Disorder | 08/24 | 10/24 | | |
NCT06243757: A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers |
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| Recruiting | N/A | 10 | US | MDASI-GI, MD Anderson Symptom Inventory for gastrointestinal cancer | Memorial Sloan Kettering Cancer Center | Gastric Cancer, GastroEsophageal Cancer, Gastroesophageal Junction Adenocarcinoma | 01/36 | 01/36 | | |
NCT03839784: Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient |
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| Recruiting | N/A | 250 | US | Neurocognition Interventions | Stanford University | Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium, Anesthesia; Reaction, Anesthesia; Adverse Effect | 08/30 | 08/30 | | |
NCT04296903: Post-approval Registry Study to Evaluate the Continued Safety and Probable Benefit of the MID-C System for 5 Years Post-Implantation in Adolescent Idiopathic Scoliosis (AIS) |
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| Active, not recruiting | N/A | 200 | US | MID-C System | Apifix | Adolescent Idiopathic Scoliosis | 06/29 | 06/30 | | |
| Driver, Brian E |
PLATINUM, NCT04443608: Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management |
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| Terminated | 4 | 115 | US | Patiromer Powder for Oral Suspension [Veltassa], Active drug, Placebo, Inactive substance | Comprehensive Research Associates | Hyperkalemia | 03/23 | 06/23 | | |
| Recruiting | 4 | 2364 | US | Ketamine, Etomidate | Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), Patient-Centered Outcomes Research Institute | Acute Respiratory Failure | 01/27 | 02/27 | | |
| Recruiting | N/A | 1400 | US, RoW | End-tidal oxygen monitor | Sydney Local Health District | Critical Illness, Hypoxia, Respiratory Failure | 12/25 | 12/25 | | |
| Recruiting | N/A | 1800 | US | Therapeutic Hypothermia | University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) | Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain | 07/28 | 08/28 | | |
| Recruiting | N/A | 3090 | US | Standard neuromuscular blocker practices, Education | Washington University School of Medicine, National Heart, Lung, and Blood Institute (NHLBI) | Awareness, Mechanical Ventilation, Intubation Complication, PTSD | 03/27 | 09/27 | | |
| Contact, Central |
NCT03641560: A Safety and Efficacy Study of Enzalutamide in Indian Patients With Progressive Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated With Docetaxel-Based Chemotherapy |
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| Completed | 4 | 52 | RoW | Enzalutamide, MDV3100, Xtandi, Androgen deprivation therapy (ADT) | Astellas Pharma Inc | Metastatic Castration Resistant Prostate Cancer | 02/24 | 02/24 | | |
| Recruiting | 4 | 30 | US | IgPro10, Privigen | CSL Behring | Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) | 12/29 | 12/29 | | |
NCT02294461: An Asian Study to Evaluate Efficacy and Safety of Oral Enzalutamide in Progressive Metastatic Prostate Cancer Participants |
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| Completed | 3 | 395 | RoW | Enzalutamide, Xtandi, MDV3100, Placebo | Astellas Pharma Inc | Progressive Metastatic Prostate Cancer | 09/15 | 07/24 | | |
NCT06524739: Double-blind, Randomized, Placebo-controlled Study Evaluating Efficacy and Safety of IgPro20 in Post-COVID-19 POTS |
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| Recruiting | 3 | 177 | Canada, US | IgPro20, HIZENTRA®, Placebo | CSL Behring | Post-COVID Postural Orthostatic Tachycardia Syndrome | 09/27 | 09/27 | | |
NCT06617897: Phase 3 Study of Fibrinogen Concentrate (CSL511) in Subjects With Pseudomyxoma Peritonei Undergoing Cytoreductive Surgery |
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| Recruiting | 3 | 90 | Europe | CSL511 Fibrinogen concentrate (human), Cryoprecipitate | CSL Behring | Acquired Fibrinogen Deficiency | 09/26 | 10/26 | | |
TAP, NCT05568888: Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( Study ) |
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| Terminated | 3 | 1370 | Europe, US, RoW | BE1116, 4-Factor Prothrombin Complex, Kcentra®, Beriplex®, Placebo | CSL Behring | Traumatic Injury | 10/24 | 10/24 | | |
NCT02439268: The Safety and Efficacy Study of Vemurafenib (CT) Compared With Vemurafenib (Zelbolaf®) in Advanced Patients Harboring the V600 BRAF Mutation |
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| Active, not recruiting | 2 | 100 | RoW | Vemurafenib, Zelboraf, Vemurafenib (CT), RO5185426, PLX4032 | Cancer Centre of Monoclonal Therapy, LLC, The European Association for Cancer Research, Melanoma Research Foundation, Alliance for Clinical Trials in Oncology in EU | Colorectal Cancer, Recurrent/Refractory BRAFV600E-mutant Gliomas, Advanced Cancers, Melanoma, Advanced BRAF-mutant Cancers | 07/15 | 05/18 | | |
NCT02430220: The Safety and Efficacy Study of Regorafenib (CT) Compared With Regorafenib (STIVARGA) in Patients With Solid Tumors |
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| Active, not recruiting | 2 | 152 | RoW | Regorafenib (CT), BAY 73-4506, Regorafenib (STIVARGA) | Cancer Centre of Monoclonal Therapy, LLC, Clinical Cancer Hospital, Bayer | Solid Tumors, Colorectal Cancer | 04/18 | 09/18 | | |
| Active, not recruiting | 2 | 100 | US | ALG-055009, Placebo | Aligos Therapeutics | NASH, MASH, Metabolic Dysfunction-Associated Steatohepatitis, Nonalcoholic Steatohepatitis | 11/24 | 12/24 | | |
NCT06545916: Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder |
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| Recruiting | 2 | 200 | US | Sunobinop, V117957, Placebo to match sunobinop | Imbrium Therapeutics, Purdue Pharma LP | Alcohol Use Disorder | 07/25 | 07/25 | | |
NCT06285214: Study of V117957 in Interstitial Cystitis/Bladder Pain Syndrome |
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| Completed | 1 | 47 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Interstitial Cystitis/Bladder Pain Syndrome | 01/25 | 01/25 | | |
NCT04285827: Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease |
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| Completed | 1 | 28 | Europe, US | CSL889 | CSL Behring | Sickle Cell Disease | 07/23 | 07/23 | | |
NCT03426254: Comparison of Safety and Clinical Benefit of Injections Subcutaneously Talazoparib Versus Oral Talazoparib in Patients With Solid Tumors |
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| Withdrawn | 1 | 10 | RoW | Injections Subcutaneously Talazoparib, MDV3800, BMN673, Oral capsules Talazoparib | Center Trials & Treatment, BioGene Pharmaceutical | Advanced or Recurrent Solid Tumors, Breast Neoplasm | 12/23 | 01/24 | | |
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| Recruiting | 1 | 174 | US | PRL-02 injection, prednisone, dexamethasone, enzalutamide | Astellas Pharma Global Development, Inc. | Prostate Cancer, Metastatic Castration Resistant Prostate Cancer, Metastatic Castration-sensitive Prostate Cancer | 08/25 | 05/29 | | |
NCT06364696: A Study to Find a Suitable Dose of ASP4396 in Adults With Solid Tumors |
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| Recruiting | 1 | 175 | US | ASP4396 | Astellas Pharma Inc | Solid Tumor | 04/27 | 04/27 | | |
| Recruiting | 1 | 229 | US | ASP1012, Pembrolizumab | Astellas Pharma Global Development, Inc. | Solid Tumor | 06/29 | 06/29 | | |
NCT06248086: A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell Lymphomas |
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| Terminated | 1 | 1 | RoW | ASP2802, MACT, MA-20, ASP101G, MicAbody | Astellas Pharma Global Development, Inc. | B-cell Lymphoma | 12/24 | 12/24 | | |
NCT06024642: Study of V117957 in Overactive Bladder Syndrome |
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| Completed | 1 | 51 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Overactive Bladder Syndrome | 05/24 | 05/24 | | |
| Completed | N/A | 1443 | US | | Shire | Hunter Syndrome | 02/23 | 02/23 | | |
NCT05104840: A Randomized Study to Determine the Expression of the Furin Protein in Patients With SARS-CoV-2 and Vaccinated Against Coronavirus |
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| Terminated | N/A | 2432 | US, RoW | | Center Trials & Treatment, Oleg Martynenko | COVID-19, SARS-CoV-2, Furin, RGMc Processing, Paired Basic Amino Acid Cleaving Enzyme (PACE) | 03/23 | 03/23 | | |
| Recruiting | N/A | 1257 | US | | Shire | Gaucher Disease | 09/25 | 09/25 | | |
NCT06734585: Using Gilteritinib to Keep People With Acute Myeloid Leukemia Cancer-free After a Stem Cell Transplant |
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| Recruiting | N/A | 200 | RoW | Gilteritinib, ASP2215, XOSPATA® | Astellas Pharma Singapore Pte. Ltd. | Acute Myeloid Leukemia | 06/25 | 06/25 | | |
OPTION-VMS, NCT06049797: A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats |
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| Recruiting | N/A | 1000 | US | Fezolinetant, ESN364, VEOZAH, Paroxetine, Citalopram, Escitalopram, Desvenlafaxine, Venlafaxine, Gabapentin, Clonidine, Pregabalin, Oxybutynin, Any other SSRI/SNRI not already specified, Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above | Astellas Pharma Global Development, Inc. | Hot Flashes | 02/26 | 11/26 | | |
NCT03971253: Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis |
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| Recruiting | N/A | 3000 | Japan | Peficitinib, ASP015K, Smyraf | Astellas Pharma Inc | Rheumatoid Arthritis (RA) | 12/25 | 12/25 | | |
NCT05886348: The Evaluation of Safety and Myopia Progression Control Using Novel Spectacle Lens |
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| Active, not recruiting | N/A | 249 | RoW | Model-A Novel spectacle lens, Model-B Novel spectacle lens, Single vision spectacle lens | HOYA Lens Thailand LTD. | Myopia | 05/26 | 05/27 | | |
NCT06011954: A Study to Survey Adults in South Korea With Cancer Who Receive PADCEV Injection |
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| Recruiting | N/A | 202 | RoW | Enfortumab Vedotin, PADCEV, ASG-22CE | Astellas Pharma Korea, Inc., Seagen Inc. | Urothelial Cancer | 07/27 | 07/27 | | |
| Recruiting | N/A | 350 | US | Veye Lung nodules | Aidence | Lung; Node | 07/21 | 07/21 | | |
| Semler, Matthew W |
| Recruiting | 4 | 2364 | US | Ketamine, Etomidate | Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), Patient-Centered Outcomes Research Institute | Acute Respiratory Failure | 01/27 | 02/27 | | |
| Completed | N/A | 1301 | US | Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen | Vanderbilt University Medical Center, University of Colorado, Denver | Acute Respiratory Failure | 10/23 | 11/23 | | |
NCT06069206: Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes |
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| Active, not recruiting | N/A | 500 | US | T2Bacteria® Panel (direct-from-blood testing), Usual Care | Vanderbilt University Medical Center | Bloodstream Infection, Sepsis Bacterial, MRSA Bacteremia, Vancomycin | 12/24 | 02/25 | | |
| Travers, Colm P |
NCT05403684: Impact of Hindmilk on Weight Gain Among Moderate to Very Preterm Infants in Zambia |
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| Completed | N/A | 214 | RoW | High-volume breastmilk | University of Alabama at Birmingham, Centre for Infectious Disease Research in Zambia, Chiesi Foundation | Postnatal Growth Restriction | 12/22 | 02/23 | | |
NCT02742454: VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants |
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| Active, not recruiting | N/A | 570 | Canada, US | Standard 30-60 Seconds Cord Clamping, VentFirst 120 Seconds Cord Clamping | University of Virginia, Brigham and Women's Hospital, Mayo Clinic, St. Louis University, University of Colorado, Denver, Oregon Health and Science University, University of Calgary, Columbia University, Indiana University, University of California, Davis, University of Alberta, University of Alabama at Birmingham | Intraventricular Hemorrhage | 03/23 | 12/23 | | |
| Completed | N/A | 70 | US | Owlet OSS 3.0 | University of Alabama at Birmingham, Owlet Baby Care, Inc. | Neonatal Bradycardia, Hypoxemia of Newborn | 07/23 | 07/23 | | |
| Recruiting | N/A | 1098 | US | Non-invasive forced airway oscillometry | University of Alabama at Birmingham | Infant, Premature, Diseases, Infant, Newborn, Diseases, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn, Meconium Aspiration Syndrome, Transient Tachypnea of the Newborn | 05/25 | 05/27 | | |
| Recruiting | N/A | 188 | US | Finger puppet, Bookworm reading intervention training and routine EDI care. | University of Alabama at Birmingham | Child Development, Infant Development, Infant, Premature, Diseases | 08/26 | 08/28 | | |
ROMPER, NCT06565390: Remote Oximeter Monitoring Post-discharge to Reduce Emergency Room Visits and Rehospitalization |
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| Not yet recruiting | N/A | 700 | NA | Babies in the Owlet monitor group | University of Alabama at Birmingham, Owlet Baby Care, Inc. | Emergencies | 10/27 | 12/30 | | |
| Not yet recruiting | N/A | 24 | NA | Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP | University of Alabama at Birmingham | Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn, Ventilation Perfusion Mismatch | 07/25 | 12/25 | | |
| Not yet recruiting | N/A | 188 | US | Coach-led caregiver-implemented early literacy and developmental programming, Reach Out and Read Training | University of Alabama at Birmingham | Term Infant, Late Preterm Infant | 06/28 | 06/31 | | |
NCT05685745: Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset |
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| Recruiting | N/A | 5000 | Europe, Canada, Japan, US | | The University of Texas Health Science Center, Houston, Nationwide Children's Hospital, University of Iowa, University of Alabama at Birmingham, Jichi Medical University, Saitama Medical University | Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal | 01/28 | 01/28 | | |
| Russell, Derek W |
| Recruiting | 4 | 2364 | US | Ketamine, Etomidate | Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), Patient-Centered Outcomes Research Institute | Acute Respiratory Failure | 01/27 | 02/27 | | |
| Recruiting | 2 | 1500 | US | Remdesivir, GS-5734, Imatinib Mesylate, Dexamethasone, Cenicriviroc, Icatibant, Firazyr, Apremilast, Otezla, dornase alfa, Pulmozyme, Celecoxib, celebrex, Famotidine, Pepcid, IC14, Aviptadil, Zyesami, narsoplimab, OMS721, Cyproheptadine, periactin, Cyclosporine, CsA | QuantumLeap Healthcare Collaborative, University of California, San Francisco, University of Pennsylvania, Emory University, University of Alabama at Birmingham, University of Colorado, Denver, University of Southern California, Yale University, Wake Forest University Health Sciences, Sanford Health, Long Beach Memorial Medical Center, Georgetown University, University of California, Davis, Hoag Memorial Hospital Presbyterian, Main Line Health, DHR Health Institute for Research and Development, University of California, Irvine, Corewell Health, Kaiser Permanente, University of Michigan, West Virginia University, University of Miami, University Hospitals Cleveland Medical Center, Virtua Health, M.D. Anderson Cancer Center | COVID-19 | 07/28 | 07/30 | | |
| Completed | N/A | 1301 | US | Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen | Vanderbilt University Medical Center, University of Colorado, Denver | Acute Respiratory Failure | 10/23 | 11/23 | | |
| Gibbs, Kevin |
| Recruiting | 4 | 2364 | US | Ketamine, Etomidate | Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), Patient-Centered Outcomes Research Institute | Acute Respiratory Failure | 01/27 | 02/27 | | |
NCT05354141: Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS) |
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| Recruiting | 3 | 970 | US | ExoFlo, Intravenous normal saline | Direct Biologics, LLC | Acute Respiratory Distress Syndrome, ARDS | 03/25 | 08/25 | | |
| Completed | N/A | 139 | US | mode of mechanical ventilation | Wake Forest University Health Sciences | Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Ventilator Lung | 11/19 | 02/20 | | |
| Completed | N/A | 1301 | US | Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen | Vanderbilt University Medical Center, University of Colorado, Denver | Acute Respiratory Failure | 10/23 | 11/23 | | |
| Rubio |
| Active, not recruiting | 3 | 41 | Europe, Canada, Japan, US, RoW | Emapalumab, NI-0501, emapalumab-lzsg, ATC code: L04AA39 (WHO) | Swedish Orphan Biovitrum | Macrophage Activation Syndrome, Secondary Hemophagocytic Lymphohistiocytosis, Still Disease, Systemic Lupus Erythematosus, SJIA, AOSD, MAS | 06/24 | 09/25 | | |
| Yarar-Fisher, Ceren |
| Recruiting | N/A | 60 | US | Ketogenic Diet, Standard Diet | Ohio State University | Spinal Cord Injuries | 01/26 | 01/26 | | |
| Zelada, Henry |
NCT05352230: Continuous Glucose Monitoring (CGM) in Kidney-Transplanted Adults |
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| Terminated | N/A | 5 | US | Free style libre-2 | University of Alabama at Birmingham | Diabetes Mellitus, Kidney Transplant; Complications | 05/24 | 05/24 | | |
| Sandberg, Sarah |
ASPIRE, NCT06588686: A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis. |
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| Recruiting | 2 | 270 | Europe, Canada, US, RoW | Buloxibutid, C21, Placebo | Vicore Pharma AB, Population Services International | Idiopathic Pulmonary Fibrosis (IPF) | 02/27 | 03/27 | | |
