University of Colorado Anschutz Medical Campus
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 407 Trials 
974 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Schwartz, David
NRG-LU008, NCT05624996: Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer

Recruiting
3
474
US
Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Durvalumab, Imfinzi, Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer, MEDI-4736, MEDI4736, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP-16, VP-16-213, VP16, Image Guided Radiation Therapy, IGRT, image-guided radiation therapy, Image-Guided Radiotherapy, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pemetrexed, MTA, Multitargeted Antifolate, Pemfexy, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stereotactic Body Radiation Therapy, SABR, SBRT, Stereotactic Ablative Body Radiation Therapy
NRG Oncology, National Cancer Institute (NCI)
Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
10/31
10/36
RTOG 1216, NCT01810913: Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Recruiting
2/3
613
Canada, US, RoW
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cetuximab, C 225, C-225, C225, Cetuximab Biosimilar CDP-1, Cetuximab Biosimilar CMAB009, Cetuximab Biosimilar KL 140, Chimeric Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225, Chimeric Monoclonal Antibody C225, Erbitux, IMC-C225, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Docetaxel, Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate, Intensity-Modulated Radiation Therapy, IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Quality-of-Life Assessment, Quality of Life Assessment
National Cancer Institute (NCI), NRG Oncology
Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7
01/27
01/27
NCT03478553: The Genetics of Pulmonary Fibrosis

Recruiting
N/A
1000
US
Blood draw, Questionnaire
University of Colorado, Denver, United States Department of Defense, University of Alabama at Birmingham, National Jewish Health, University of California, San Francisco, University of Pittsburgh, Baylor University
Idiopathic Pulmonary Fibrosis (IPF)
12/26
12/26
APPLe, NCT04564183: Advancing Prevention of Pulmonary Fibrosis

Active, not recruiting
N/A
800
US
Sample collection, Questionnaires, High resolution CT scan of the chest, Pulmonary Function Test
University of Colorado, Denver, Mayo Clinic, University of California, Los Angeles, University of Texas, University of Pennsylvania
IPF, Pulmonary Fibrosis, ILD
10/24
08/26
GWAS, NCT01088217: Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)

Recruiting
N/A
8000
US, RoW
National Jewish Health, University of Colorado, Denver, Vanderbilt University, Landspitali University Hospital
Idiopathic Pulmonary Fibrosis, Familial Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, Familial Interstitial Pneumonia
06/25
06/25
Lillehei, Kevin O
SONOBIRD, NCT05902169: Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Recruiting
3
560
Europe, US
SonoCloud-9 (SC9), Carboplatin, CycloButane DiCarboxylic Acid (CBDCA), Lomustine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), Temozolomide, Temodal
CarThera
Glioblastoma, Recurrent Glioblastoma, GBM
01/28
06/28
DCVax-L EAP, NCT02146066: Expanded Access Protocol for GBM Patients With Already Manufactured DCVax®-L Who Have Screen-Failed Protocol 020221

Available
N/A
US
DCVax-L
Northwest Biotherapeutics
GBM, Glioblastoma Multiforme
 
 
Thompson, John
NCT05307341: Improving Pain Management and Decreasing LOS After Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA)

Recruiting
4
100
US
sufentanil, sufentanil (DSUVIA)
More Foundation
Pain
06/23
06/23
RECOVER-AUTO, NCT06305780: NOMIC Platform Protocol

Recruiting
2
380
US
IVIG + Coordinated Care, IVIG Placebo + Coordinated Care, Ivabradine + Coordinated Care, Ivabradine Placebo + Coordinated Care, IVIG + Usual Care, IVIG Placebo + Usual Care, Ivabradine + Usual Care, Ivabradine Placebo + Usual Care
Kanecia Obie Zimmerman
Long COVID, Long Covid19, Long Covid-19
12/25
03/26
MAGNIFY, NCT05893537: Study to Evaluate the Efficacy and Safety of Oral CT1812 in Participants with Geographic Atrophy (GA) Secondary to Dry Age-Related Macular Degeneration (AMD).

Active, not recruiting
2
100
US
Active Comparator CT1812, Placebo Comparator
Cognition Therapeutics
Age-Related Macular Degeneration
07/27
08/27
PYNNACLE, NCT04585750: The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Recruiting
1/2
230
Europe, US, RoW
PC14586, rezatapopt, pembrolizumab, KEYTRUDA®, MK-3475, KEYNOTE-D79, MK-3475-D79
PMV Pharmaceuticals, Inc, Merck Sharp & Dohme LLC
Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor, Lung Cancer, Ovarian Cancer, Endometrial Cancer, Prostate Cancer, Colorectal Cancer, Breast Cancer, Other Cancer, Locally Advanced, Head and Neck Cancer
03/26
07/26
NCT03377569: Subcortical Oscillations in Human Sleep Dysregulation

Active, not recruiting
N/A
15
US
Sleep, PD and DBS
University of Colorado, Denver
Parkinson Disease, REM Behavior Disorder
08/20
12/24
NCT04620551: Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease

Active, not recruiting
N/A
20
US
Sub-clinical stimulation
University of Nebraska, Stanford University, University of Colorado, Denver, University of Pennsylvania
Parkinson Disease, Sleep Fragmentation
06/25
06/25
Smith, Clayton
CULMINATE, NCT04023526 / 2019-000473-23: A Study of Cusatuzumab Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia Who Are Not Candidates for Intensive Chemotherapy

Checkmark Data from CULMINATE trial in combination with azacitidine for newly diagnosed AML
Jan 2021 - Jan 2021: Data from CULMINATE trial in combination with azacitidine for newly diagnosed AML
Active, not recruiting
2
103
Europe, RoW
Azacitidine, Cusatuzumab, OV-1001, JNJ-74494550, ARGX-110
OncoVerity, Inc., argenx, Janssen Research & Development, LLC
Leukemia, Myeloid, Acute
08/23
08/24
ELEVATE, NCT04150887: Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia

Hourglass Sep 2021 - Dec 2021 : P1b data from ELEVATE trial in combination with azacitidine and venetoclax for AML
Active, not recruiting
1
61
Europe, Canada, US
Cusatuzumab, JNJ-74494550, ARGX-110, Azacitidine, Vidaza, Venetoclax, Venclexta
OncoVerity, Inc., argenx, Janssen Research & Development, LLC
Leukemia, Myeloid, Acute
05/25
05/25
ARRR, NCT05259618: ALT Routinely Recorded Remotely: A Comparator Study of Liver Function Tests Using the Tasso+ to Venipuncture.

Recruiting
N/A
80
US
Tasso+ SST, Tasso+
Tasso Inc.
Elevated Alanine Transaminase (ALT)
11/22
11/22
Norris, Jill
RISEMS, NCT03586986: Risk Factors in Early Multiple Sclerosis

Recruiting
N/A
300
US
Brain MRI, Blood analysis, Bioscreen, Symbol Digit Modality Test (SDMT)
University of Colorado, Denver, Colorado School of Public Health
Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome, Radiologically Isolated Syndrome
05/24
05/24
Newman, Lee
NCT05250284: The Intersection of Oncology Care and Worker Well-Being

Recruiting
N/A
400
US
WellBQ, PROMIS
University of Colorado, Denver, National Institute for Occupational Safety and Health (NIOSH/CDC)
Solid Tumor
05/26
08/27
Messersmith, Wells
NCT03781154: Predictors of Physical Activity Maintenance in Colorectal Cancer Survivors

Completed
3
31
US
Group Exercise
University of Colorado, Denver, American Cancer Society, Inc., Colorado State University
Colorectal Cancer
06/23
06/23
AGICC, NCT02723331: Perioperative Therapy for Resectable and Borderline-Resectable Pancreatic Adenocarcinoma With Molecular Correlates

Active, not recruiting
2
48
US
Nab paclitaxel, Abraxane, Gemcitabine, Gemzar
Academic Thoracic Oncology Medical Investigators Consortium, Celgene Corporation, Criterium, Inc., University of Colorado, Denver
Pancreatic Cancer, Pancreatic Adenocarcinoma, Pancreas Ductal Adenocarcinoma
12/22
05/25
C-800-25, NCT05608044: A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer

Active, not recruiting
2
234
Europe, US, RoW
Botensilimab, AGEN1181, Balstilimab, AGEN2034, Standard of Care
Agenus Inc.
Metastatic Colorectal Cancer
02/25
07/25
NCT05167409: A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer

Active, not recruiting
2
48
US
Evorpacept (ALX148), evorpacept, Cetuximab, Erbitux, Pembrolizumab, Keytruda
University of Colorado, Denver, ALX Oncology Inc., Merck Sharp & Dohme LLC, Eli Lilly and Company, Criterium, Inc., Academic GI Cancer Consortium (AGICC)
Microsatellite Stable Metastatic Colorectal Cancer
12/25
03/26
NCT02521844: A Study to Evaluate the Safety and Tolerability of ETC-1922159 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumours

Active, not recruiting
1
89
US, RoW
ETC-1922159, Pembrolizumab
EDDC (Experimental Drug Development Centre), A*STAR Research Entities, PPD DEVELOPMENT, LP
Solid Tumors
10/24
10/24
NX-1607-101, NCT05107674: A Study of NX-1607 in Adults With Advanced Malignancies

Recruiting
1
345
Europe, US
NX-1607, Cbl-b Inhibitor, Paclitaxel
Nurix Therapeutics, Inc.
Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma, Metastatic or Unresectable Melanoma, Non-small Cell Lung Cancer (NSCLC), Metastatic Castration-resistant Prostate Cancer (mCRPC), Malignant Pleural Mesothelioma (MPM), Triple Negative Breast Cancer (TNBC), Metastatic Urothelial Carcinoma, Cervical Cancer, Diffuse Large B Cell Lymphoma (DLBCL), Richter Transformation, Microsatellite Stable Colorectal Carcinoma
08/26
02/28
NCT02955446: Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies

No Longer Available
N/A
US
PF-03084014, Gamma Secretase Inhibitor
University of Colorado, Denver, SpringWorks Therapeutics, Inc.
Neoplasm, Desmoid Tumor
 
 
Hill, James
IWCR, NCT04907396: International Weight Control Registry

Recruiting
N/A
100000
US
Tufts University, University of Alabama at Birmingham, University of Colorado, Denver, University of Kansas Medical Center, Pennington Biomedical Research Center, University of New Hampshire, United States Military Academy, West Point
Weight Loss, Overweight, Obesity
12/25
12/25
NPC-QIC, NCT02852031: National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

Recruiting
N/A
1000
Europe, Canada, US
Collaborative Learning Network
Children's Hospital Medical Center, Cincinnati
Hypoplastic Left Heart Syndrome (HLHS)
05/26
05/28
NCT05701657: Nutrition for Precision Health, Powered by the All of Us

Recruiting
N/A
8000
US
Diet A, Diet B, Diet C, Liquid Mixed Meal Tolerance Test, LMMTT, Diet-Specific Mixed Meal Tolerance Test, Diet-Specific MMTT
RTI International, National Institutes of Health (NIH), University of North Carolina, Chapel Hill, Northwestern University, Illinois Institute of Technology, University of Chicago, Pennington Biomedical Research Center, Louisiana State University Health Sciences Center in New Orleans, University of California, Davis, University of California, Los Angeles, Cedars-Sinai Medical Center, University of Alabama at Birmingham, Tufts University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Center for Advancing Translational Sciences (NCATS), National Cancer Institute (NCI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), City University of New York, School of Public Health, Mayo Clinic, University of California, San Diego, University of Hawaii, Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), National Center for Complementary and Integrative Health (NCCIH), National Institute of Drug Abuse, Public Health Informatics Computational and Operations Research, University of Southern California, Cornell University, University of Alabama, Tuscaloosa, North Carolina State University, University of North Carolina, Charlotte, Duke University, Stevens Institute of Technology, Purdue University, United States Military Academy at West Point, USDA, Western Human Nutrition Research Center, North Carolina Central University, Wake Forest University Health Sciences, Boston University, Children's Hospital of Richmond, Virginia Commonwealth University, Verily Life Sciences LLC, Indiana University, Fred Hutchinson Cancer Center, Columbia University, University of Pennsylvania
Nutrition, Health, Dietary Habits
12/26
01/27
NCT06082453: Modernizing Perinatal Syphilis Testing

Recruiting
N/A
924
US
Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
The University of Texas Health Science Center, Houston, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Syphilis
11/27
11/27
NCT05685745: Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

Recruiting
N/A
5000
Europe, Canada, Japan, US
The University of Texas Health Science Center, Houston, Nationwide Children's Hospital, University of Iowa, University of Alabama at Birmingham, Jichi Medical University, Saitama Medical University
Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal
01/28
01/28
Keith, Robert
NCT03347838: Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

Active, not recruiting
2
36
US
Nivolumab, Opdivo, BMS-936558, MDX1106, ONO-4538
University of Colorado, Denver, Bristol-Myers Squibb
Bronchial Dysplasia, Tobacco Smoking, History of Non-Small Cell Lung Cancer, History of Head and Neck Cancer
12/25
12/26
NCT04931017: Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer

Recruiting
2
50
Canada, US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bronchoscopy, Extended Release Metformin Hydrochloride, ER Metformin Hydrochloride, Extended-release Metformin Hydrochloride, Glucophage XR, Glumetza, Metformin Hydrochloride Extended Release, Questionnaire Administration
National Cancer Institute (NCI)
Lung Carcinoma
04/26
11/26
NCT03881098: The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

Recruiting
N/A
240
US
Bronchoscopies, Sputum Sample, Venipuncture
University of Colorado, Denver, Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Lung Cancer
12/25
01/26
DECAMP-2, NCT02504697: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

Active, not recruiting
N/A
665
US
Biosamples from airway and blood
Boston University, American College of Radiology Imaging Network
Pulmonary Disease
12/27
12/27
Schwartz, Robert S
NCT04219540: Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults

Recruiting
4
796
US
XR-B (SUBLOCADETM), SUBLOCADE TM, XR-NTX, Vivitrol®
NYU Langone Health, National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
06/24
12/24
NCT04496518: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)

Active, not recruiting
N/A
2200
Europe, US
Intrinsic Antitachycardia Pacing (iATP) Therapy
Medtronic
Ventricular Tachycardia
01/25
01/27
NCT04489225: Personalized Therapy Study - HFRS (TriageHF) Post Approval Study

Active, not recruiting
N/A
2200
Europe, US
Observational
Medtronic
Heart Failure
01/25
01/27
ASQ, NCT04024943: Personalized Therapy Study - Attain Stability Quad Post-Approval Study

Active, not recruiting
N/A
1092
Europe, US
Quadripolar LV Lead, Medtronic CRT-P, Medtronic CRT-D
Medtronic
Heart Failure
01/27
04/27
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Benatar, Michael
ATLAS, NCT04856982 / 2020-004590-51: A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

Recruiting
3
150
Europe, Canada, Japan, US, RoW
Tofersen, BIIB067, QALSODY, Placebo
Biogen
Amyotrophic Lateral Sclerosis Associated With a SOD1 Gene Mutation
08/27
08/27
NCT02093624: A Phase II Trial of Rituximab In Myasthenia Gravis

Not yet recruiting
2
50
US
Rituximab, Placebo
Yale University
Myasthenia Gravis
05/17
12/17
CAPTURE, NCT03489278: Clinical Procedures to Support Research in ALS

Recruiting
N/A
1200
US
University of Miami, Muscular Dystrophy Association, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH)
Amyotrophic Lateral Sclerosis, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
06/25
06/25
NCT03912987: TRIAL READY (Clinical Trial Readiness)

Active, not recruiting
N/A
610
US
University of Miami, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
06/25
06/25
PGB2, NCT04875416: Phenotype, Genotype and Biomarkers 2

Recruiting
N/A
300
US, RoW
University of Miami, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy, Frontotemporal Dementia
08/25
08/26
NCT02327845: Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Enrolling by invitation
N/A
700
Europe, US, RoW
University of Miami, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS), St. Jude Children's Research Hospital, ALS Association
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Progressive Muscular Atrophy, Multisystem Proteinopathy
07/25
07/25
CRiALS, NCT00136500: Clinical Research in ALS Study

Recruiting
N/A
10000
US
University of Miami, ALS Association, ALS Recovery Fund
Amyotrophic Lateral Sclerosis
12/27
12/27
Pre-fALS, NCT00317616: The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis () Study

Recruiting
N/A
500
US
University of Miami, ALS Association
Amyotrophic Lateral Sclerosis
12/27
12/27
Jimeno, Antonio
COMMANDER-001, NCT05357898: Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

Terminated
1/2
20
US
SQZ-eAPC-HPV, Pembrolizumab
SQZ Biotechnologies
Adult Solid Tumor
11/23
11/23
NCT04440735: A Study of DSP107 Alone and in Combination with Atezolizumab for Patients with Advanced Solid Tumors

Active, not recruiting
1/2
125
US
DSP107, Atezolizumab
Kahr Medical
Advanced Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer
09/25
09/25
NCT06384352: A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

Recruiting
1
155
Canada, US, RoW
YL211
MediLink Therapeutics (Suzhou) Co., Ltd., Hoffmann-La Roche
Advanced Solid Tumors
04/27
04/29
NCT05053737: Radiotherapy in Combination With Atezolizumab Prior to Surgical Resection for HPV Unrelated HNSCC

Completed
1
11
US
Atezolizumab, MPDL3280A, RG7446, Tecentriq, Stereotactic Body Radiation Therapy, SBRT
University of Colorado, Denver, Genentech, Inc.
Squamous Cell Carcinoma of Head and Neck
11/23
06/24
NCT02331134: Tissue and Hematopoietic/Mesenchymal Stem Cell for Humanized Xenograft Studies in Melanoma and Squamous Head and Neck Cancer

Active, not recruiting
N/A
9
US
Filgrastim, Neupogen
University of Colorado, Denver, Karsh Family Research Fund
Malignant Melanoma, Head and Neck Cancer
07/18
03/25
Tuttle, Katherine R
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons with Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
RECOVER-AUTO, NCT06305780: NOMIC Platform Protocol

Recruiting
2
380
US
IVIG + Coordinated Care, IVIG Placebo + Coordinated Care, Ivabradine + Coordinated Care, Ivabradine Placebo + Coordinated Care, IVIG + Usual Care, IVIG Placebo + Usual Care, Ivabradine + Usual Care, Ivabradine Placebo + Usual Care
Kanecia Obie Zimmerman
Long COVID, Long Covid19, Long Covid-19
12/25
03/26
REBOOT, NCT03949855: Belimumab With Rituximab for Primary Membranous Nephropathy

Recruiting
2
58
Canada, US
Belimumab, Benlysta®, Placebo for Belimumab, Belimumab placebo, Rituximab, Rituxan®
National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN), GlaxoSmithKline, PPD DEVELOPMENT, LP, Rho Federal Systems Division, Inc.
Membranous Nephropathy, Nephrotic Syndrome
03/29
03/30
TREASURE-CKD, NCT05536804 / 2021-005273-47: A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Recruiting
2
140
Europe, Canada, US, RoW
Tirzepatide, Placebo
Eli Lilly and Company, Eli Lilly and Company
Overweight, Obesity, Chronic Kidney Disease, Type 2 Diabetes, T2D
01/26
02/26
RT1D, NCT05822609: Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

Recruiting
2
60
Canada, US
Semaglutide, Placebo
University of Washington, Juvenile Diabetes Research Foundation, University of Colorado, Denver, Providence Healthcare, University of Toronto
Diabetic Kidney Disease, Type 1 Diabetes
06/26
06/26
NEPTUNE, NCT01209000: Nephrotic Syndrome Study Network

Recruiting
N/A
1200
Canada, US
Kidney Biopsy
University of Michigan, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), The NephCure Foundation
Minimal Change Disease (MCD), Membranous Nephropathy, Glomerulosclerosis, Focal Segmental
06/26
06/26
NCT05172024: Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)

Active, not recruiting
N/A
15178
US
NYU Langone Health, National Heart, Lung, and Blood Institute (NHLBI)
SARS-CoV2 Infection
04/25
05/25
Chow, Christopher
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor

Recruiting
3
1250
Canada, US, RoW
Retatrutide, LY3437943, Semaglutide
Eli Lilly and Company
Diabetes Mellitus, Type 2
12/26
03/27
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
02/29
02/29
ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting
3
2749
Europe, US, RoW
Orforglipron, LY3502970, Insulin Glargine
Eli Lilly and Company
Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
09/25
01/26
ACHIEVE-3, NCT06045221: A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Active, not recruiting
3
1576
Japan, US, RoW
Orforglipron, LY3502970, Semaglutide
Eli Lilly and Company
Type 2 Diabetes
09/25
09/25
TRIUMPH-3, NCT05882045: A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Active, not recruiting
3
1800
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Obesity, Cardiovascular Diseases
01/26
02/26
TRIUMPH-2, NCT05929079: A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Active, not recruiting
3
1000
Europe, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
05/26
05/26
REGEN-006, NCT05099770: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

Recruiting
3
685
Europe, Canada, US, RoW
Renal Autologous Cell Therapy (REACT), Sham Comparator
Prokidney, Iqvia Pty Ltd, PPD
Type 2 Diabetes Mellitus, Chronic Kidney Diseases
02/27
02/27
TREASURE-CKD, NCT05536804 / 2021-005273-47: A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Recruiting
2
140
Europe, Canada, US, RoW
Tirzepatide, Placebo
Eli Lilly and Company, Eli Lilly and Company
Overweight, Obesity, Chronic Kidney Disease, Type 2 Diabetes, T2D
01/26
02/26
Edmundowicz, Steven
SWAT-BE, NCT05530343: Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

Recruiting
N/A
2298
US
Seattle protocol, WATS3D brushings
University of Colorado, Denver
Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma
03/26
03/26
Aquilante, Christina L
NCT01686191: Genetic Predictors of Renal Dysfunction Following Heart Transplantation

Active, not recruiting
N/A
300
US
University of Colorado, Denver, National Jewish Health
Heart Transplantation, Chronic Renal Insufficiency
12/25
12/25
Stern, John
MTLE, NCT05135091: FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy

Recruiting
1/2
40
US
NRTX-1001, GABA-secreting interneurons, Sham Comparator
Neurona Therapeutics, California Institute for Regenerative Medicine (CIRM)
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
05/25
05/26
NCT04526418: Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Epilepsy Involving the Temporal Lobe Region.

Recruiting
N/A
110
Europe, US
24/7 EEG™ SubQ system
UNEEG Medical A/S
Epilepsy
09/25
04/26
Corboy, John
BEAT-MS, NCT04047628: Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis

Recruiting
3
156
US
Autologous Hematopoietic Stem Cell Transplantation, AHSCT, Best Available Therapy (BAT), natalizumab (Tysabri®), alemtuzumab (Campath®, Lemtrada®), ocrelizumab (Ocrevus®), rituximab (Rituxan®), cladribine (Mavenclad®), ofatumumab (Kesimpta®), ublituximab (BRIUMVI™)
National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN), Blood and Marrow Transplant Clinical Trials Network, PPD DEVELOPMENT, LP, Rho Federal Systems Division, Inc.
Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
10/26
10/29
RISEMS, NCT03586986: Risk Factors in Early Multiple Sclerosis

Recruiting
N/A
300
US
Brain MRI, Blood analysis, Bioscreen, Symbol Digit Modality Test (SDMT)
University of Colorado, Denver, Colorado School of Public Health
Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome, Radiologically Isolated Syndrome
05/24
05/24
Rasouli, Neda
SIB, NCT04979130: Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus

Recruiting
4
42
US
Semaglutide, Ozempic, PDS290 pen-injector, Placebo
University of Colorado, Denver, Novo Nordisk A/S
Type 2 Diabetes, Chronic Inflammation, Intestinal Permeability
12/23
12/23
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor

Recruiting
3
1250
Canada, US, RoW
Retatrutide, LY3437943, Semaglutide
Eli Lilly and Company
Diabetes Mellitus, Type 2
12/26
03/27
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Recruiting
3
12500
Europe, Canada, Japan, US, RoW
Lepodisiran Sodium, LY3819469, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
03/29
03/29
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
02/29
02/29
QWINT-1, NCT05662332: A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time

Completed
3
795
US, RoW
Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Glargine
Eli Lilly and Company
Type 2 Diabetes, T2D
07/24
07/24
ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting
3
2749
Europe, US, RoW
Orforglipron, LY3502970, Insulin Glargine
Eli Lilly and Company
Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
09/25
01/26
ATTAIN-1, NCT05869903: A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Active, not recruiting
3
3000
Europe, Japan, US, RoW
Orforglipron, LY3502970, Placebo
Eli Lilly and Company
Obesity, Overweight, Overweight or Obesity
07/25
07/27
SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting
3
15374
Europe, Canada, Japan, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Overweight
10/27
10/27
NCT05166382: Impact of SomaSignal Tests on the Choice of Glucose-lowering Medications

Active, not recruiting
N/A
350
US
Informed of results from SomaSignal Cardiovascular Risk Test in Type 2 Diabetes (CVD-T2D), Informed, Not informed of results from SomaSignal Cardiovascular Risk Test in Type 2 Diabetes (CVD-T2D), Uninformed
University of Colorado, Denver, SomaLogic, Inc.
Type 2 Diabetes, Cardiovascular Diseases
01/24
01/24
RADIANT, NCT05544266: Rare and Atypical Diabetes Network

Recruiting
N/A
2000
US
University of South Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
09/30
09/30
Garg, Satish K
QWINT-5, NCT05463744: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Completed
3
692
Europe, Japan, US, RoW
Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Degludec
Eli Lilly and Company
Type 1 Diabetes, Diabetes
05/24
05/24
OPTI-2, NCT06238778: Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec

Recruiting
2
230
US
HDV-Lispro, HDV-L, Lispro, LIS
Diasome Pharmaceuticlas, Inc.
Diabetes Mellitus, Type 1
06/25
12/25
NCT05714059: Safety and Effectiveness of the MiniMed™ 780G System With DS5 CGM

Completed
N/A
250
US
Insulin Pump with Continuous Glucose Monitoring
Medtronic Diabetes
Type 1 Diabetes
12/23
12/23
NCT06719531: SYNERGY PLUS: Evaluation of Next Generation Sensors (NGS) and Algorithm in Patients with Type 1 and Type 2 Diabetes

Not yet recruiting
N/A
1500
US
Continuous Glucose Monitoring
Medtronic Diabetes
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
12/25
12/25
Leehey, Maureen
PPMI, NCT04477785: Clinical - Establishing a Deeply Phenotyped PD Cohort

Recruiting
N/A
4500
Europe, Canada, US, RoW
Michael J. Fox Foundation for Parkinson's Research, Institute for Neurodegenerative Disorders
Parkinson Disease
12/33
12/33
Shah, Raj C
PREVENTABLE, NCT04262206: Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Recruiting
4
20000
US
Atorvastatin 40 Mg Oral Tablet, Lipitor, Placebo oral tablet
Duke University, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI), Wake Forest University Health Sciences
Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
12/26
12/26
MINT, NCT02981407: Myocardial Ischemia and Transfusion

Completed
3
3506
Europe, Canada, US, RoW
Red Blood Cell Transfusion
Rutgers, The State University of New Jersey, University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction, Anemia
05/23
10/23
LIFT-AD, NCT04488419: ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease

Completed
2/3
554
US
ATH-1017, Placebo
Athira Pharma
Alzheimer Disease, Dementia of Alzheimer Type
07/24
07/24
NCT05153161: Memesto Wearable Device for Persons With Dementia

Completed
1
9
US
Memesto
Edgewater Safety Systems, Inc., Rush University Medical Center
Alzheimer Disease
11/23
11/23
AWARD, NCT06596278: Memesto Wearable Repetitive Message and Music Therapy Device Music Therapy Device That Senses and Reduces Agitation in People With AD,

Completed
N/A
9
US
Memesto
Edgewater Safety Systems, Inc., Rush University Medical Center
Alzheimer's Disease
11/23
12/23
NCT05458791: Intra-arterial Perfusion in Interventional Radiology

Recruiting
N/A
20
US
Intra-arterial Perfusion
Palo Alto Veterans Institute for Research, Canon Medical Systems, USA
Hepatocellular Carcinoma
07/23
01/24
NCT03421340: Non-Complex Biliary Stones DSC vs ERC

Completed
N/A
250
Europe, US, RoW
DSC, Direct Solitary Cholangioscopy, ERC, Endoscopic Retrograde Cholangiography
Boston Scientific Corporation
Biliary Stones
09/23
10/23
ADNI3, NCT02854033: Alzheimer's Disease Neuroimaging Initiative 3

Recruiting
N/A
2000
Canada, US
University of Southern California, Northern California Institute of Research and Education, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
12/24
12/24
NCT04115826: ESWL vs. Pancreatoscopy-guided Lithotripsy for Painful Chronic Calcific Pancreatitis

Enrolling by invitation
N/A
150
US
Per-oral Pancreatoscopy-guided Lithotripsy, Extracorporeal Shock-Wave Lithotripsy
University of Colorado, Denver
Pancreatitis, Chronic
03/25
06/26
QOLAPI, NCT03632616: Quality of Life Assessment of Chronic Pancreatitis Endoscopic Interventions

Enrolling by invitation
N/A
500
US
PANQOLI (quality of life instrument), Visual Analog Scale for pain
University of Colorado, Denver, Johns Hopkins University
Chronic Pancreatitis
08/25
08/26
Santoro, Nanette
KEEPS, NCT00623311: Cognitive and Affective Study

Active, not recruiting
4
720
US
oral conjugated equine estrogens, transdermal estradiol, micronized progesterone, Placebo
University of Wisconsin, Madison, Kronos Longevity Research Institute, University of Utah, University of California, Albert Einstein College of Medicine of Yeshiva University, Brigham and Women's Hospital, Columbia University, Mayo Clinic, University of Washington, Yale University
Perimenopause, Coronary Disease, Estrogen Replacement Therapy, Hormone Replacement Therapy
04/12
04/12
PREGnant, NCT06375811: Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp

Recruiting
3
288
US
Elagolix 200 MG, Orlissa, Placebo or SOC IVF
Yale University, University of Colorado, Denver, Northwestern University, University of North Carolina, Duke University, Johns Hopkins University
Infertility, Endometriosis
06/26
06/26
 

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