| Ciardiello, Fortunato |
COLSTAR, NCT05223673 / 2021-003151-41: Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer |
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| Terminated | 3 | 7 | Europe, Japan, US | Futuximab/modotuximab, Trifluridine/Tipiracil | Institut de Recherches Internationales Servier, ADIR, a Servier Group company | Metastatic Colorectal Cancer | 06/23 | 06/23 | | |
| Active, not recruiting | 2 | 352 | Europe, Canada, US | tisotumab vedotin, TIVDAK, pembrolizumab, KEYTRUDA®, carboplatin, cisplatin | Seagen Inc., Genmab, Merck Sharp & Dohme LLC | Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck | 02/26 | 11/26 | | |
CAVE 2, NCT05291156: CAVE-2 GOIM Study: a Clinical Study of the Combination of Avelumab Plus Cetuximab as Rechallenge Strategy |
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| Recruiting | 2 | 173 | Europe | Cetuximab, Erbitux, Avelumab, Bavencio | University of Campania "Luigi Vanvitelli" | Metastatic Colorectal Cancer | 07/25 | 07/25 | | |
| Active, not recruiting | 2 | 219 | Europe | Cetuximab, Erbitux, FOLFIRI, FOLFOX regimen, FOLFOX, Irinotecan | University of Campania "Luigi Vanvitelli" | Metastatic Colorectal Adenocarcinoma | 08/25 | 06/26 | | |
METex14, NCT04868877 / 2021-000203-20: Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination |
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| Recruiting | 1/2 | 576 | Europe, US, RoW | MCLA-129, bispecific, Osimertinib, Tagrisso, Chemotherapy | Merus N.V. | Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Colorectal Cancer | 03/26 | 03/27 | | |
Argonaut, NCT05480865: SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation |
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| Terminated | 1 | 28 | Europe, RoW | BBP-398, sotorasib | Navire Pharma Inc., a BridgeBio company, Amgen | Solid Tumor, Adult, Metastatic Solid Tumor, Metastatic NSCLC, Non Small Cell Lung Cancer | 08/24 | 08/24 | | |
| Recruiting | N/A | 15000 | Europe | Data collection (retrospective), Data collection (prospective) | National Cancer Institute, Naples | Oncology | 01/25 | 07/26 | | |
| Recruiting | N/A | 3000 | Europe | | Federation of Italian Cooperative Oncology Groups, Roche Pharma AG, AstraZeneca, Bayer, Bristol-Myers Squibb, Janssen, LP, Takeda, Amgen, Daiichi Sankyo, Inc., Eli Lilly and Company, Novartis, Clinical Research Technology S.r.l. | Solid Tumours in Advanced Stages | 10/26 | 10/26 | | |
| Federico, Alessandro |
NCT05804955: Alpha-Glutathione-S-Transferase (AlphaGST) and MARINA Index in Metabolic-Dysfunction-Associated-Steatotic-Liver-Disease (MASLD) |
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| Completed | N/A | 260 | Europe | | University of Campania "Luigi Vanvitelli" | Fatty Liver | 06/17 | 07/22 | | |
| Completed | N/A | 515 | Europe | | University of Turin, Italy, Gilead Sciences | Chronic Hepatitis D | 06/24 | 12/24 | | |
NCT05618145: National Database on Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | N/A | 6000 | Europe | Clinical information | University of Milano Bicocca | Primary Sclerosing Cholangitis | 10/32 | 10/32 | | |
| Morisco, Filomena |
| Active, not recruiting | 3 | 238 | Europe, Canada, Japan, US, RoW | Linerixibat, Placebo | GlaxoSmithKline | Pruritus | 10/24 | 01/25 | | |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
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| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
| Recruiting | 3 | 251 | Europe, Canada, Japan, US, RoW | Linerixibat | GlaxoSmithKline, GlaxoSmithKline LLC, GlaxoSmithKline Research & Development Limited | Cholestasis | 02/27 | 02/27 | | |
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | 2 | 200 | Europe, Canada, US, RoW | Volixibat, SHP626, Placebo | Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc. | Primary Sclerosing Cholangitis | 09/25 | 12/25 | | |
| Completed | N/A | 515 | Europe | | University of Turin, Italy, Gilead Sciences | Chronic Hepatitis D | 06/24 | 12/24 | | |
NCT05618145: National Database on Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | N/A | 6000 | Europe | Clinical information | University of Milano Bicocca | Primary Sclerosing Cholangitis | 10/32 | 10/32 | | |
| Pellino, Gianluca |
ORALEV2, NCT04161599: Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial. |
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| Recruiting | 4 | 968 | Europe, RoW | Cefuroxime (750mg) I.V, Colonic Surgery, Cefuroxime 750mg oral, Metronidazole 250 MG Oral Tablet [Flagyl], Metronidazole 1 g Intravenous, Cefuroxime 1,5 g Intravenous, Sodium picosulfate, light magnesium oxide, anhydrous citric acid 10 mg/3.5 g/10.97 g Oral | Hospital Universitari Vall d'Hebron Research Institute | Wounds and Injuries, Surgery--Complications | 06/24 | 07/24 | | |
| Recruiting | N/A | 15000 | Europe | Surgical procedure for confirmed or suspected colorectal cancer | University of Bologna | Colorectal Neoplasms Malignant | 02/22 | 04/22 | | |
| Recruiting | N/A | 500 | Europe | Any surgery, Any medical treatment | University of Campania "Luigi Vanvitelli", University of Bologna, University of Rome Tor Vergata, Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) | Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Fertility Disorders, Pregnancy Complications, Delivery Problem | 10/24 | 10/24 | | |
DivAbsc2023, NCT06109506: Towards a Tailored Approach for Patients With Acute Diverticulitis and Abscess Formation. A Multicenter Cohort Analysis |
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| Recruiting | N/A | 400 | Europe | Conservative treatment with antibiotics and eventual percutaneous image-guided drainage of the abscess | University of Cagliari, Azienda Ospedaliero Universitaria di Cagliari | Acute Diverticulitis, Diverticular Diseases, Diverticulitis of Sigmoid, Acute Diverticular Perforation, Diverticulitis, Colonic, Sepsis | 11/23 | 11/23 | | |
| Not yet recruiting | N/A | 430 | Europe | MINERVA Machine Learning model | University of Cagliari, Università di Napoli Federico II, Università della Campania Luigi Vanvitelli | Acute Pancreatitis, Pancreatitis Due to Gallstones, Pancreatitis Biliary, Pancreatitis Relapsing | 12/24 | 12/25 | | |
