The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center
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 10 Trials 
8 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Desjardins, Annick
DERIVe, NCT03688178: DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Active, not recruiting
2
43
US
Human CMV pp65-LAMP mRNA-pulsed autologous DCs, Temozolomide, Temodar, TMZ, Temodal, Varlilumab, anti-CD27, Td, Tetanus-diphtheria (Td) toxoid, Td pre-conditioning, Unpulsed DCs, Unpulsed DCs pre-conditioning
Annick Desjardins, MD, Celldex Therapeutics
Glioblastoma
03/25
03/25
NCT05879367: Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma

Recruiting
1
66
US
Eflornithine (Dose Level 1), DFMO, Eflornithine (Dose Level 2), Eflornithine (Dose Level -1), Temozolomide, Temodar, TMZ
Orbus Therapeutics, Inc.
Glioblastoma, IDH-wildtype, Glioblastoma, Glioblastoma Multiforme, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype, GBM
12/24
12/24
Peters, Katherine B
GBM AGILE, NCT03970447 / 2020-002250-24: A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Calendar Jan 2030 - Dec 2030: Market entry for glioblastoma
Oct 2023 - Dec 2023: Top-line data from GBM AGILE trial for glioblastoma
Recruiting
2/3
1030
Europe, Canada, US, RoW
Temozolomide, Temodar, Temodal, Temcad, Lomustine, CCNU, CeeNU, Gleostine, Regorafenib, Stivarga, BAY 73-4506, Radiation, Paxalisib, GDC-0084, VAL-083, Dianhydrogalactitol, VT1021, Troriluzole, BHV-4157, ADI-PEG 20, Pegargiminase
Global Coalition for Adaptive Research, Bayer, Kazia Therapeutics Limited, Kintara Therapeutics, Inc., Biohaven Pharmaceuticals, Inc., Vigeo Therapeutics, Inc., Polaris Group
Glioblastoma
06/26
06/28
BMX-HGG, NCT02655601: Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001

Active, not recruiting
2
160
US
BMX-001, manganese butoxyethyl pyridyl porphyrin, Radiation Therapy, Temozolomide, TMZ
BioMimetix JV, LLC, Duke Cancer Institute, National Cancer Institute (NCI)
High Grade Glioma, Astrocytoma, Grade III, Glioblastoma
08/23
12/24
PROSPECT, NCT04947319: Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma ( Study)

Recruiting
2
112
US
Tirabrutinib, ONO-4059
Ono Pharmaceutical Co. Ltd
Refractory Primary Central Nervous System Lymphoma, Primary CNS Lymphoma
03/27
03/27
NCT05023551: Study of DSP-0390 in Patients with Recurrent High-Grade Glioma

Active, not recruiting
1
39
Japan, US
DSP-0390
Sumitomo Pharma America, Inc.
High Grade Glioma, Glioblastoma Multiforme
09/26
10/26
ViCToRy, NCT05609994: Vorasidenib in Combination with Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

Not yet recruiting
1
48
US
PEPIDH1M vaccine + vorasidenib
Katy Peters, MD, PhD, Servier
Low Grade Glioma of Brain
08/27
08/29
SPiRiT, NCT04567251: Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy

Terminated
N/A
5
US
Namzaric®, Placebo
Duke University, Varian Medical Systems
Brain Metastases, Adult, Primary Brain Tumor, Lung Cancer
05/24
05/24

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