| Link, Michael P |
NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17 |
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| Recruiting | 2 | 250 | US | bendamustine, TREANDA (R), Etoposide, VP-16, Vepeside, Doxorubicin, Adriamycin (R), Bleomycin, Blenoxane (R), Vincristine, Oncovin (R), Vinblastine, Velban (R), Prednisone, Prednisolone, Filgrastim, Neupogen (R), Brentuximab Vedotin, Adcetris, Cyclophosphamide, Cytoxan (R), DTIC, DACARBAZINE (R), Dimethyl Triazeno Imidazole Carboximide, Quality of Life Measurements, Quality of Life Measurements (QOL), Radiotherapy, radiation therapy, irradiation | St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc. | Hodgkin Lymphoma | 01/27 | 07/28 | | |
EFFORTS, NCT05116878: Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma |
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| Terminated | N/A | 15 | US | Omega-3, Placebo | Mayo Clinic | Vestibular Schwannoma | 08/23 | 08/23 | | |
| Waksman, Ron |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
V-PLAQUE, NCT05360446: Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events |
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| Active, not recruiting | 3 | 608 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Coronary Artery Disease | 01/27 | 01/27 | | |
VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease |
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| Active, not recruiting | 3 | 17004 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Atherosclerotic Cardiovascular Disease | 10/27 | 10/27 | | |
| Recruiting | N/A | 1150 | US, RoW | Portico transcatheter aortic valve, Commercially available transcatheter aortic valve | Abbott Medical Devices | Aortic Valve Stenosis | 10/19 | 07/25 | | |
NCT02799823: Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial |
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| Terminated | N/A | 11 | US | HLT Transcatheter Aortic Valve System | HLT Inc. | Aortic Valve Stenosis | 01/23 | 01/23 | | |
NCT03557242: Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 124 | US | TAVR, Warfarin plus Aspirin, Aspirin Only | Medstar Health Research Institute | Aortic Stenosis | 07/23 | 07/23 | | |
CAMEO, NCT04076813: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry |
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| Recruiting | N/A | 4000 | US | | Chiesi USA, Inc., Duke University | Myocardial Infarction | 10/24 | 10/24 | | |
| Active, not recruiting | N/A | 418 | Europe, Canada, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation | Coronary Restenosis | 07/25 | 08/29 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT03002272: Transcatheter Aortic Prosthesis Function: A Long-term Follow-up Study |
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| Recruiting | N/A | 100 | US | TAVR, SAVR | Medstar Health Research Institute | Aortic Valve Replacement | 01/24 | 01/28 | | |
| Active, not recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 07/24 | 08/29 | | |
| Not yet recruiting | N/A | 264 | NA | TAVR-explant, Redo-TAVR, Valve-in-Valve, TAV-in-TAV | Medstar Health Research Institute | Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure | 05/34 | 05/36 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Recruiting | N/A | 960 | US | PCI with SELUTION SLR DCB, PCI with FDA approved "-limus" DES | M.A. Med Alliance S.A., NAMSA, Cordis Corporation | Coronary Artery Disease | 08/25 | 08/29 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 1000 | Canada, US | | Medstar Health Research Institute | Mitral Valve Disease | 02/27 | 02/27 | | |
| Recruiting | N/A | 1000 | US | Outcomes for Patients with CMD | Medstar Health Research Institute | Coronary Microvascular Dysfunction | 01/33 | 01/33 | | |
| Shlofmitz, Richard |
AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort |
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| Active, not recruiting | 3 | 20 | US | AGENT DCB 40 mm | Boston Scientific Corporation | In-Stent Restenosis | 12/25 | 12/27 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Active, not recruiting | N/A | 399 | Europe, US | Shockwave Medical Coronary IVL System | Shockwave Medical, Inc. | Coronary Artery Disease | 12/24 | 04/28 | | |
| Patel, Chinmay |
| Active, not recruiting | N/A | 949 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 07/24 | 08/25 | | |
| Recruiting | N/A | 220 | Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 10/28 | 10/29 | | |
| Enrolling by invitation | N/A | 583 | US | | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 07/25 | 10/25 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Santiago, Lyn |
DETECT-HF, NCT06378632: AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM |
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| Recruiting | N/A | 500 | Europe, US, RoW | Hearo App | Cordio Medical | Heart Failure | 01/25 | 03/25 | | |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
| Completed | N/A | 89 | US | MRI/ CardioMEMS comparison | Abbott Medical Devices | Heart Failure, Cardiac Output, High | 01/24 | 01/24 | | |
NCT05046730: SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression |
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| Terminated | N/A | 128 | US | Ileostomy Reversal using Self Forming Magnets (SFM) | GI Windows, Inc. | Retraction of Ileostomy | 10/23 | 12/23 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 380 | Canada, US | Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry | Neovasc Inc., Shockwave Medical, Inc. | Refractory Angina | 06/25 | 12/28 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
NCT05666713: NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial |
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| Recruiting | N/A | 180 | US | TELLTALE BASILICA procedure | National Heart, Lung, and Blood Institute (NHLBI) | Valvular Heart Disease, Aortic Valve Failure | 03/25 | 03/25 | | |
| Active, not recruiting | N/A | 399 | Europe, US | Shockwave Medical Coronary IVL System | Shockwave Medical, Inc. | Coronary Artery Disease | 12/24 | 04/28 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
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| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
| Meise, Gretchen |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Active, not recruiting | N/A | 1720 | Europe, Canada, US | Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent) | Shanghai MicroPort Medical (Group) Co., Ltd. | Coronary Artery Disease | 12/23 | 06/27 | | |
| Recruiting | N/A | 220 | Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 10/28 | 10/29 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Enrolling by invitation | N/A | 583 | US | | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 07/25 | 10/25 | | |
| Recruiting | N/A | 1500 | US | Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF) | Impulse Dynamics | Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure | 02/25 | 02/26 | | |
ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients with Significant Carotid Artery Disease |
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| Active, not recruiting | N/A | 344 | US | Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting | Silk Road Medical | Carotid Artery Diseases | 09/25 | 09/25 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
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| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Ginete, Wilson |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Active, not recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 11/25 | 10/26 | | |
| Priore, Jean Del |
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation |
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| Completed | 4 | 339 | US | Dronedarone, Multaq | American Heart Association, Duke Clinical Research Institute, Sanofi | Atrial Fibrillation | 01/24 | 06/24 | | |
RESCUE, NCT04248868: tPA by Endovascular Administration for the Treatment of Submassive PE Using CDT for the Reduction of Thrombus Burden |
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| Completed | 3 | 109 | US | The Bashir™ Endovascular Catheter, r-tPA | Thrombolex, Inc., National Heart, Lung, and Blood Institute (NHLBI) | Pulmonary Embolism | 06/22 | 06/22 | | |
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation |
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| Recruiting | 3 | 5350 | US | AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI) | Atrial Fibrillation | 07/29 | 07/29 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Klein, Wendy |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Hodara, Roberto |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| McCotter, Craig |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Poulin, Marie-France |
| Recruiting | N/A | 410 | US | Transcatheter aortic valve replacement | Beth Israel Deaconess Medical Center | Aortic Stenosis, Transcatheter Aortic Valve Replacement, Heart Block | 12/24 | 12/24 | | |
| Active, not recruiting | N/A | 418 | Europe, Canada, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation | Coronary Restenosis | 07/25 | 08/29 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Frizzell, Jarrod |
| Active, not recruiting | N/A | 418 | Europe, Canada, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation | Coronary Restenosis | 07/25 | 08/29 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Recruiting | N/A | 150 | US | HF-OCT Imaging, FFR Pressure Wire, Angiography | Gentuity, LLC | Coronary Stenosis | 12/24 | 12/24 | | |
| Gilliam, Taylor |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
NCT05934487: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III |
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| Recruiting | N/A | 1650 | US | Cordella™ Pulmonary Artery Sensor System | Endotronix, Inc. | Heart Failure NYHA Class II, Heart Failure NYHA Class III | 09/27 | 09/29 | | |
| Miller, Joanna |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
| Kohtala, Erica |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Active, not recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 11/25 | 10/26 | | |
| Oseni, Abdul |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Klein, Wency |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
| Doukas, Demetrios |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Active, not recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 01/25 | 12/25 | | |
