| Keymeulen, Bart |
| Active, not recruiting | 2 | 138 | Europe | Verapamil SR 120 mg, VeraHEXAL KHK 120 mg, Isoptin retard 120 mg, Placebo, Matching Placebo for Verapamil SR 120 mg | Medical University of Graz, Juvenile Diabetes Research Foundation | Diabetes Mellitus, Type 1 | 05/25 | 05/26 | | |
INRANGE, NCT04414280: The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs |
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| Recruiting | N/A | 1150 | Europe | Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/24 | 12/24 | | |
NCT05777330: Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes |
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| Recruiting | N/A | 75 | Europe | Oral glucose tolerance test (OGTT), OGTT, Hyperglycemic clamp test, clamp, Continuous glucose monitoring, Dexcom G6, CGM | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Juvenile Diabetes Research Foundation | Type1 Diabetes Mellitus | 04/26 | 04/27 | | |
| Ridder, Mark De |
PEGASUS, NCT02799706: Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer |
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| Active, not recruiting | 3 | 885 | Europe | Degarelix, approved GnRH agonist, Radiotherapy | European Organisation for Research and Treatment of Cancer - EORTC | Prostate Cancer | 08/23 | 06/26 | | |
| Recruiting | N/A | 120 | Europe | MR-guided RT | Universitair Ziekenhuis Brussel | Prostate Cancer | 07/24 | 07/29 | | |
| Recruiting | N/A | 35 | Europe | Radiotherapy with MRIdian with simultaneous integrated boost, Radiotherapy with MRIdian (ViewRay Inc.), Questionnaires before, during and after radiotherapy | Universitair Ziekenhuis Brussel | Rectal Cancer | 06/25 | 06/30 | | |
| SCHOTS, Rik |
| Active, not recruiting | 3 | 430 | Europe, Canada, US, RoW | Pelabresib, Ruxolitinib, Placebo | Constellation Pharmaceuticals | Myelofibrosis, Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis | 08/23 | 12/27 | | |
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NCT03083574: Extracorporeal Photopheresis Using Theraflex ECP™ for Patients With Refractory Chronic Graft Versus Host Disease (cGVHD) |
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| Recruiting | 2 | 100 | Europe | Photopheresis Theraflex ECP™ | Jules Bordet Institute, Macopharma, Belgian Hematological Society | Refractory Chronic Graft Versus Host Disease (cGVHD) | 09/22 | 09/23 | | |
NCT00603330: Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function |
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| Recruiting | 2 | 100 | Europe | Mesenchymal stem cells | University of Liege, KU Leuven, Maastricht University Medical Center, Ziekenhuis Netwerk Antwerpen (ZNA), University Hospital, Antwerp, University Hospital, Ghent, AZ-VUB, AZ Sint-Jan AV, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, University Hospital of Mont-Godinne, Jolimont Hospital Haine Saint Paul, Queen Fabiola Children's University Hospital | Graft-versus-host Disease, Poor Graft Function, Low Donor T-cell Chimerism | 08/24 | 08/24 | | |
| Recruiting | 2 | 180 | Europe, Japan, US, RoW | Epcoritamab, GEN3013, DuoBody®-CD3×CD20, EPKINLY™, Lenalidomide, Revlimid® | Genmab, AbbVie | Diffuse Large B-Cell Lymphoma | 01/26 | 03/27 | | |
NCT03852407: Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning |
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| Recruiting | 2 | 114 | Europe | Thymoglobulin, ATG, Melphalan, alkeran, Fludarabine, Cyclophosphamid, PTCy | University of Liege, Belgian Hematological Society | Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma | 11/33 | 11/38 | | |
NCT04220970: Breast Implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Registry |
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| Recruiting | N/A | 150 | Europe | BIA-ALCL | The Lymphoma Academic Research Organisation | Anaplastic Large Cell Lymphoma Associated With Breast Implants (BIA-ALCL) | 06/32 | 06/32 | | |
| Verma, Atul |
OCEAN, NCT02168829: Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial |
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| Active, not recruiting | 4 | 1284 | Europe, Canada, RoW | Rivaroxaban, Xarelto, Acetylsalicylic acid, Aspirin, ASA | Ottawa Heart Institute Research Corporation, Canadian Institutes of Health Research (CIHR), Bayer, Biotronik Canada Inc | Atrial Fibrillation, Stroke | 07/25 | 08/25 | | |
| Not yet recruiting | N/A | 30 | Canada | AcQMap Imaging and Mapping, AcQMap | Acutus Medical | Recurrent Atrial Fibrillation | 03/19 | 05/20 | | |
| Recruiting | N/A | 502 | Canada | Catheter ablation, Atrial Fibrillation Ablation | Ottawa Heart Institute Research Corporation, Heart and Stroke Foundation of Canada | Atrial Fibrillation | 12/24 | 12/24 | | |
NCT04893317: Cryoablation for Monomorphic Ventricular Tachycardia (CryoCure-VT) |
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| Active, not recruiting | N/A | 64 | Europe, Canada, RoW | Ablation in the ventricles with the Adagio Medical VT Cryoablation System | Adagio Medical | Monomorphic Ventricular Tachycardia | 06/24 | 09/24 | | |
| Active, not recruiting | N/A | 200 | Europe, Canada, US | Adagio AF Cryoablation System (iCLAS™) | Adagio Medical | Persistent Atrial Fibrillation | 08/23 | 08/24 | | |
| Recruiting | N/A | 78 | Europe, Canada, RoW | Atrial ablation for subject scheduled for a de novo endocardial ablation of symptomatic, drug-refractory PsAF. | Adagio Medical | Atrial Fibrillation | 10/24 | 05/25 | | |
| Active, not recruiting | N/A | 435 | Europe, Canada, US, RoW | Pulsed Field Ablation | Abbott Medical Devices | Atrial Arrhythmia, Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 01/26 | 01/26 | | |
NCT05015660: Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing |
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| Recruiting | N/A | 1300 | Canada | Left bundle branch pacing lead (Select Secure 3830 lead), Right ventricular active fixation lead | McGill University Health Centre/Research Institute of the McGill University Health Centre, Heart and Stroke Foundation of Canada, Canadian Institutes of Health Research (CIHR) | Pacemaker DDD, Heart Block | 07/26 | 07/27 | | |
| Recruiting | N/A | 615 | Europe, Canada, Japan, US, RoW | Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI), Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers), Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box) | McGill University Health Centre/Research Institute of the McGill University Health Centre, Montreal Heart Institute | Atrial Fibrillation | 08/26 | 01/27 | | |
NCT05337241: Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT |
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| Not yet recruiting | N/A | 130 | Canada, US | Saline Enhanced Radiofrequency (SERF) Ablation, Intramural Needle Ablation | Thermedical, Inc. | Refractory Ventricular Tachycardia | 06/27 | 06/27 | | |
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation |
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| Completed | N/A | 376 | Europe, Canada, US, RoW | Radiofrequency Ablation | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation, Atrial Fibrillation | 10/24 | 10/24 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Neyns, Bart |
COMBI-R2, NCT03754179: Dabrafenib/Trametinib/Hydroxychloroquine for Advanced Pretreated BRAF V600 Mutant Melanoma |
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| Recruiting | 2 | 63 | Europe | Dabrafenib, Tafinlar, DAB, Trametinib, Mekinist, TRA, Hydroxychloroquine, Plaquenil, HCQ | Universitair Ziekenhuis Brussel, University Hospital, Ghent | Melanoma | 12/21 | 07/22 | | |
| Completed | 2 | 45 | Europe | Trametinib, TRA, Mekinist, Dabrafenib, DAB, Tafinlar | Universitair Ziekenhuis Brussel | Stage IV Melanoma, Stage III Melanoma | 06/23 | 06/23 | | |
NCT05529316: A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma |
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| Suspended | 2 | 220 | Europe, US, RoW | Botensilimab, AGEN1181, Balstilimab, AGEN2034 | Agenus Inc. | Advanced Melanoma | 05/28 | 05/28 | | |
Luscid, NCT04571632: Clinical Trial of SBRT and Systemic Pembrolizumab With or Without Avelumab/Ipilimumab+ Dendritic Cells in Solid Tumors |
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| Recruiting | 2 | 36 | Europe | Avelumab, Bavencio, Ipilimumab 5 MG/ML, Yervoy, Pembrolizumab 100 MG in 4 ML Injection, Keytruda, CD1c (BDCA-1)+ / CD141 (BDCA-3)+ myDC | Universitair Ziekenhuis Brussel | Non Small Cell Lung Cancer, Solid Tumor | 12/23 | 12/23 | | |
1-2018 BSMO, NCT03967938: Efficacy of Olaparib in Advanced Cancers Occurring in Patients With Germline Mutations or Somatic Tumor Mutations in Homologous Recombination Genes |
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| Active, not recruiting | 2 | 540 | Europe | Olaparib Oral Capsule | AZ-VUB, AstraZeneca, Kom Op Tegen Kanker | Advanced Cancers Harbouring Mutations in HRG | 12/24 | 12/25 | | |
| Recruiting | 2 | 48 | Europe | Regorafenib 40 MG Oral Tablet, Triplet therapy | Universitair Ziekenhuis Brussel | Melanoma Stage III, Melanoma Stage IV | 12/24 | 03/25 | | |
myDCTV, NCT03747744: Intratumoral Injection of Autologous CD1c (BDCA-1)+ Myeloid Dendritic Cells Plus Talimogene Laherparepvec (T-VEC) |
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| Active, not recruiting | 1 | 18 | Europe | CD1c (BDCA-1)+ myDC, intratumoral injection of talimogene laherparepvec (T-VEC) | Universitair Ziekenhuis Brussel | Melanoma | 10/23 | 10/23 | | |
GlitIpNi, NCT03233152: Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma |
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| Active, not recruiting | 1 | 110 | Europe | Ipilimumab (YervoyTM, 50 mg/10 mL solution), Nivolumab (OpdivoTM, 40 mg/4 mL solution), Nivolumab (OpdivoTM, 40 mg/4mL solution) | Universitair Ziekenhuis Brussel | Glioblastoma | 11/23 | 11/23 | | |
CognIT, NCT05667857: Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Survivors Treated With Immunotherapy and the Efficacy of Integrative Neurocognitive Remediation Therapy |
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| Recruiting | N/A | 100 | Europe | Integrative neurocognitive remediation therapy | Universitair Ziekenhuis Brussel, Brugmann University Hospital | Cognitive Remediation, Neuropsychology, Quality of Life, Psycho-Oncology, Cognitive Behavioral Therapy, Cancer Survivors, Immunotherapy, Cognitive Dysfunction, Psychological Distress | 11/24 | 12/33 | | |
ICIT, NCT02673970: Biomarkers for the Activity of Immune Checkpoint Inhibitor Therapy in Patients With Advanced Melanoma |
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| Recruiting | N/A | 200 | Europe | | Universitair Ziekenhuis Brussel | Malignant Melanoma | 09/25 | 12/25 | | |
DW-MRi, NCT02907827: Whole-body DW-MRI and cfDNA Analysis for the Surveillance of Melanoma Patients at High Risk for Recurrence. |
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| Recruiting | N/A | 100 | Europe | follow up DW MRI, cfDNA | Universitair Ziekenhuis Brussel | Melanoma | 11/25 | 11/25 | | |
| Recruiting | N/A | 4975 | Europe, RoW | RP-1828 IMMUcan, RP-1759 AYA/TYA, RP-1843 Arcagen, RP-1920 BioRadon | European Organisation for Research and Treatment of Cancer - EORTC | All Tumor Types | 03/26 | 03/26 | | |
| Gluz, Oleg |
EMBER-3, NCT04975308 / 2021-000079-35: A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer |
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| Active, not recruiting | 3 | 866 | Europe, Japan, US, RoW | Imlunestrant, LY3484356, Exemestane, Fulvestrant, Abemaciclib, LY2835219 | Eli Lilly and Company, Eli Lilly and Company | Breast Neoplasms, Neoplasm Metastasis | 06/24 | 08/27 | | |
| Recruiting | 3 | 1260 | Europe | Abemaciclib 50 MG; 150mg 1-0-1 per os, Verzenios | West German Study Group, Eli Lilly and Company, Genomic Health®, Inc. | Breast Cancer Female | 08/26 | 03/28 | | |
ADAPTcycle, NCT04055493: Adj. Marker-adjusted Personalized Therapy Comparing ET+Ribociclib vs Chemotherapy in Intermediate Risk, HR+/HER2- EBC |
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| Active, not recruiting | 3 | 1684 | Europe | Ribociclib 200Mg Oral Tablet, Kisqali | West German Study Group, Novartis, Genomic Health®, Inc. | Breast Cancer Female | 07/27 | 07/27 | | |
| Active, not recruiting | 2 | 393 | Europe | Trastuzumab and Pertuzumab (FDC SC) and T-DM1, Trastuzumab emtansine, Phesgo, Kadcyla | MedSIR, Hoffmann-La Roche | Early Breast Cancer | 09/25 | 03/28 | | |
ADAPTHER2-IV, NCT05704829: NeoAdjuvant Therapy With Trastuzumab-deruxtecan Versus Chemotherapy+Trastuzumab+Pertuzumab in HER2+ Early Breast Cancer |
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| Recruiting | 2 | 402 | Europe | Trastuzumab deruxtecan, ENHERTU, Standard-of-Care, Chemotherapy+T+P | West German Study Group, AstraZeneca | HER2-positive Early Breast Cancer | 06/26 | 06/28 | | |
| Recruiting | 2 | 348 | Europe | Sacituzumab govitecan, Trodelvy, Pembrolizumab, Keytruda | West German Study Group, Gilead Sciences, Merck Sharp & Dohme LLC | Triple Negative Breast Cancer | 09/29 | 09/29 | | |
INFINITY, NCT04389541: Clinical Research Platform on Decision Making and Clinical Impact of Biomarker-Driven Precision Oncology |
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| Completed | N/A | 499 | Europe | | iOMEDICO AG, Bristol-Myers Squibb, Roche Pharma AG | Advanced Solid Tumors or Hematologic Malignancies | 06/23 | 06/23 | | |
| Recruiting | N/A | 1470 | Europe | | West German Study Group, Agendia | Female Breast Cancer | 03/35 | 06/35 | | |
| Moens, Maarten |
| Recruiting | N/A | 200 | Europe | Heart Rate Variability, Pain intensity | Moens Maarten | Chronic Pain | 10/21 | 10/21 | | |
| Completed | N/A | 8 | Europe | Virtual Reality application | Universitair Ziekenhuis Brussel | Diabetic Polyneuropathy | 06/23 | 07/23 | | |
| Recruiting | N/A | 100 | Europe | Indicators of central sensitisation | Universitair Ziekenhuis Brussel | Covid19 | 01/22 | 01/22 | | |
| Recruiting | N/A | 200 | Europe | Indicators of central sensitisation | Universitair Ziekenhuis Brussel | Covid19 | 01/23 | 01/23 | | |
| Recruiting | N/A | 200 | Europe | Dysautonomia | Moens Maarten | Covid19 | 01/23 | 01/23 | | |
NCT06030973: Opinions of Healthcare Providers About a European Neuromodulation Register |
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| Recruiting | N/A | 100 | Europe | Filling in an online survey | Moens Maarten, Vrije Universiteit Brussel | Registry, Neuromodulation, Survey | 09/23 | 09/23 | | |
| Recruiting | N/A | 114 | Europe | Best Medical Treatment, Subthreshold Spinal Cord Stimulation | Moens Maarten | Failed Back Surgery Syndrome | 01/24 | 08/24 | | |
| Recruiting | N/A | 250 | Europe | Spinal Cord Stimulation | Moens Maarten | Failed Back Surgery Syndrome, Persistent Spinal Pain Syndrome Type 2 | 08/26 | 08/26 | | |
| Recruiting | N/A | 112 | Europe | Usual Care trajectory, A biopsychosocial rehabilitation program | Moens Maarten, Vrije Universiteit Brussel, University Ghent, KU Leuven | Failed Back Surgery Syndrome, Spinal Cord Stimulation | 08/25 | 08/25 | | |
PIANISSIMO, NCT05861609: Pain Medication Tapering for Patients With Persistent Spinal Pain Syndrome Type 2, Treated With Spinal Cord Stimulation. |
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| Recruiting | N/A | 195 | Europe | Usual care, Standardized pain medication tapering, Personalized pain medication tapering | Moens Maarten, Vrije Universiteit Brussel | Persistent Spinal Pain Syndrome Type 2, Spinal Cord Stimulation | 09/26 | 09/26 | | |
| Asmundis, Carlo de |
| Recruiting | N/A | 2000 | Europe | Pulmonary vein isolation with the multielectrode radiofrequency balloon catheter | Universitair Ziekenhuis Brussel | Atrial Fibrillation | 01/30 | 12/30 | | |
| Recruiting | N/A | 200 | Europe, US | ILR, PMK, ICD | Texas Cardiac Arrhythmia Research Foundation | COVID-19, Atrial Fibrillation New Onset | 12/21 | 12/23 | | |
NCT06602635: Hybrid Score to Predict OTVA-SOO in Patients with Wide Basal QRS |
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| Recruiting | N/A | 100 | Europe | ECG and clinical score | Centro Medico Teknon, Hospital Universitario Puerta del Mar, Vrije Universiteit Brussel, Cisanello University Hospital (Pisa, Italy), Maria Cecilia Hospital | ECG, Ventricular Arrhythmias, Catheter Ablation | 09/24 | 10/24 | | |
LBBAP, NCT05401851: Bi-ventricular Epicardial Activation in Left Bundle Area Pacing: a Comparison Study |
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| Recruiting | N/A | 30 | Europe | Left Bundel Area Pacing | Universitair Ziekenhuis Brussel | Bradyarrhythmia, Pacemaker Syndrome, Biventricular Cardiac Pacemaker Malfunction | 02/24 | 10/24 | | |
| Recruiting | N/A | 400 | Europe, Canada, US, RoW | Pacing | Population Health Research Institute, Canadian Institutes of Health Research (CIHR) | Calcium Release Deficiency Syndrome (CRDS) | 12/25 | 03/26 | | |
| Recruiting | N/A | 3000 | Europe, Japan, RoW | Cardiac Resynchronization Therapy (CRT) | Biotronik SE & Co. KG | Heart Failure | 12/24 | 06/25 | | |
| Not yet recruiting | N/A | 500 | Europe, Canada, US, RoW | | Population Health Research Institute, Canadian Institutes of Health Research (CIHR) | Calcium Release Deficiency Syndrome | 12/50 | 12/50 | | |
| Recruiting | N/A | 2000 | Europe | Leadless Pacemaker (Micra) | Luigi Sacco University Hospital, Università degli Studi di Brescia, Centro Cardiologico Monzino, University Hospital, Zürich, Azienda Ospedaliera Cardinale G. Panico, Azienda Ospedaliera San Gerardo di Monza, IRCCS Azienda Ospedaliero-Universitaria di Bologna, San Raffaele University Hospital, Italy, Ospedale V. Fazzi, Ospedali Riuniti Ancona, Universitair Ziekenhuis Brussel, Università degli Studi di Ferrara, University of Padova | Block Complete Heart, Atrial Fibrillation | 12/24 | 12/24 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Active, not recruiting | N/A | 881 | Europe, US | ICD replacement or upgrade | MicroPort CRM | Inappropriate Shocks From Implanted Defibrillator, ICD Replacement or Upgrade | 05/25 | 05/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Enrolling by invitation | N/A | 500 | Europe, US | AtriCure Commercially Available Devices | AtriCure, Inc. | Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome | 01/27 | 01/27 | | |
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry |
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| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Defibrillation using EV-ICD | Medtronic | Ventricular Arrhythmia, Tachycardia | 05/30 | 10/37 | | |
| Recruiting | N/A | 12500 | Europe, Canada, RoW | Implant, Electrophysiologic procedure | Boston Scientific Corporation | Cardiac Disease | 12/30 | 12/30 | | |
| Recruiting | N/A | 1000 | Europe, RoW | DiamondTemp™ Ablation System | Medtronic Cardiac Rhythm and Heart Failure | Arrhythmia | 03/31 | 03/31 | | |
| Recruiting | N/A | 99999 | Europe | Post- Market Clinical Follow-up | Carlo de Asmundis | Post- Market Clinical Follow-up | 03/21 | 03/41 | | |
| Recruiting | N/A | 2000 | Europe | No intervention because it is a patient registry | Universitair Ziekenhuis Brussel | Brugada Syndrome | 01/32 | 01/32 | | |
| Nijs, Jo |
EPISIP, NCT06475859: The Role of Epigenetic Mechanisms in Stress Intolerance in Patients With Chronic Widespread Pain |
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| Recruiting | N/A | 88 | Europe | Montreal Imaging Stress Test, Relaxation breathing | Vrije Universiteit Brussel, Research Foundation Flanders, KU Leuven | Chronic Widespread Pain | 12/24 | 12/24 | | |
| Completed | N/A | 105 | Europe | Exercise, Aerobic Power Index, Mental Stress Test, Montreal Imaging Stress Task | Vrije Universiteit Brussel | Fatigue Syndrome, Chronic | 04/23 | 04/23 | | |
NCT04219072: Clinical Classification of Pain in Breast Cancer Survivors |
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| Completed | N/A | 96 | RoW | | Kutahya Health Sciences University, Vrije Universiteit Brussel | Chronic Pain, Cancer Pain, Breast Cancer | 08/23 | 10/23 | | |
| Recruiting | N/A | 156 | Europe | Pain Neuroscience Education (PNE), Motivational Interviewing (MI), Biomedically-focused education | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Kom Op Tegen Kanker, Hasselt University | Breast Neoplasms, Survivorship, Pain, Chronic | 07/24 | 12/25 | | |
BCS-PAIN, NCT04531917: The Effect of Pain Neuroscience Education and Behavioural Graded Activity on Chronic Pain in Breast Cancer Survivors |
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| Active, not recruiting | N/A | 122 | Europe | Pain Neuroscience Education, Behavioural Graded Activity, Usual care | Universitair Ziekenhuis Brussel, Fund for Scientific Research, Flanders, Belgium, Vrije Universiteit Brussel | Breast Neoplasms, Survivors, Chronic Pain | 07/24 | 07/24 | | |
PREMEO, NCT05387473: Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis |
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| Recruiting | N/A | 128 | Europe | Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions | Vrije Universiteit Brussel, KU Leuven, Universitaire Ziekenhuizen KU Leuven | Osteoarthritis, Knee, Insomnia | 05/25 | 11/25 | | |
B²EARS, NCT05047679: The Effectiveness of Pain Neuroscience Education in At-risk Patients Following Surgery for Lumbar Radiculopathy |
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| Terminated | N/A | 6 | Europe | Perioperative Pain Neuroscience Education, Pain Education, Perioperative Biomedical Education | Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, Research Foundation Flanders | Lumbar Radiculopathy | 10/23 | 10/23 | | |
| Recruiting | N/A | 50 | Europe | Patient-centered teleprehabilitation | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Ziekenhuis Oost-Limburg, Hasselt University, Kom Op Tegen Kanker | Breast Cancer, Breast Neoplasms, Surgery | 06/24 | 08/24 | | |
BO2WL, NCT05811624: Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT |
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| Recruiting | N/A | 252 | Europe | Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., EXP (Experimental intervention), Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone., CON (Control intervention) | Vrije Universiteit Brussel, Bern University of Applied Sciences, University of Applied Sciences and Arts of Southern Switzerland | Overweight or Obesity, Chronic Low-back Pain | 04/25 | 11/25 | | |
| Brucker, Michael De |
ELENA, NCT05560646: A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared with Placebo in Participants Aged 18 to 49 with Moderate to Severe Endometriosis-related Pain |
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| Recruiting | 2 | 380 | Europe, US, RoW | OG-6219, Placebo | Organon and Co, Iqvia Pty Ltd | Endometriosis | 12/24 | 12/24 | | |
| Becker, Ann De |
| Active, not recruiting | 3 | 66 | Europe | MaaT013 | MaaT Pharma, MaaT Pharma | Acute Graft Versus Host Disease in Intestine, Steroid Refractory GVHD | 11/24 | 11/25 | | |
| Recruiting | 3 | 149 | Europe | Multivirus (CMV, EBV, AdV)-specific T cells | Prof. Tobias Feuchtinger, European Commission, Simbec-Orion Group Ltd, Merthyr Tydfil, UK, Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany, Leiden University Medical Center, LUMC, Leiden, The Netherlands, Centre Hospitalier Universitaire de Nancy, CHU, Vandoeuvre-Lès-Nancy, France, Ghent University Hospital, UZG, Ghent, Belgium, Ospedale Pediatrico Bambino Gesù, OPBG, Rome, Italy, Newcastle University, UNEW, Newcastle, UK, Vall d'Hebron Institute of Oncology (VHIO) and Banc de Sang I Teixits (BST), Barcelona, Spain | AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications | 06/24 | 12/24 | | |
NCT03083574: Extracorporeal Photopheresis Using Theraflex ECP™ for Patients With Refractory Chronic Graft Versus Host Disease (cGVHD) |
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| Recruiting | 2 | 100 | Europe | Photopheresis Theraflex ECP™ | Jules Bordet Institute, Macopharma, Belgian Hematological Society | Refractory Chronic Graft Versus Host Disease (cGVHD) | 09/22 | 09/23 | | |
EXPAND, NCT05714345: Evaluation of Lymphodepletion With ALLO-647 in Adults With R/R Large B Cell Lymphoma Receiving ALLO-501A Allogeneic CAR T Cell Therapy |
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| Active, not recruiting | 2 | 70 | Europe, US | ALLO-647, Fludarabine, Cyclophosphamide, ALLO-501A | Allogene Therapeutics | Relapsed/Refractory Large B Cell Lymphoma | 02/24 | 10/29 | | |
NCT03852407: Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning |
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| Recruiting | 2 | 114 | Europe | Thymoglobulin, ATG, Melphalan, alkeran, Fludarabine, Cyclophosphamid, PTCy | University of Liege, Belgian Hematological Society | Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma | 11/33 | 11/38 | | |
REAL-V, NCT05033158: The Immune Reaction Upon COVID-19 Vaccination in the Belgian Cancer Population. |
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| Completed | N/A | 402 | Europe | Blood sampling | University Hospital, Antwerp, KomOpTegenKanker (non-profit organization) | Cancer | 12/22 | 06/23 | | |
| Fontaine, Christel |
EMBER-3, NCT04975308 / 2021-000079-35: A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer |
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| Active, not recruiting | 3 | 866 | Europe, Japan, US, RoW | Imlunestrant, LY3484356, Exemestane, Fulvestrant, Abemaciclib, LY2835219 | Eli Lilly and Company, Eli Lilly and Company | Breast Neoplasms, Neoplasm Metastasis | 06/24 | 08/27 | | |
| Active, not recruiting | 3 | 654 | Europe, Canada, Japan, US, RoW | Tucatinib, TUKYSA, ONT-380, ARRY-380, Trastuzumab, Herceptin, Herceptin Hylecta, Pertuzumab, Perjeta, Combination product: Trastuzumab + Pertuzumab, Phesgo, Placebo | Seagen Inc., Merck Sharp & Dohme LLC | HER2 Positive Breast Cancer | 05/25 | 10/27 | | |
1-2018 BSMO, NCT03967938: Efficacy of Olaparib in Advanced Cancers Occurring in Patients With Germline Mutations or Somatic Tumor Mutations in Homologous Recombination Genes |
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| Active, not recruiting | 2 | 540 | Europe | Olaparib Oral Capsule | AZ-VUB, AstraZeneca, Kom Op Tegen Kanker | Advanced Cancers Harbouring Mutations in HRG | 12/24 | 12/25 | | |
| Active, not recruiting | 2 | 65 | Europe | Entrectinib, Letrozole, Goserelin | Jules Bordet Institute, Hoffmann-La Roche | Invasive Lobular Breast Carcinoma, ER+ Breast Cancer, HER2-negative Breast Cancer | 08/24 | 10/24 | | |
ABBICAR, NCT06365788: Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast Cancer |
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| Recruiting | 2 | 53 | Europe | Abemaciclib, Verzenios, Bicalutamide, Bicalutamide Teva | Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker, Eli Lilly and Company, Teva Pharma | Triple Negative Breast Neoplasms | 12/27 | 12/27 | | |
REMOTE, NCT06175208: Targeting Fear of Cancer Recurrence in Cancer Survivors: Evaluation of Internet-Based Emotional Freedom Techniques and Internet-Based Mindfulness Meditation as Intervention Strategies |
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| Enrolling by invitation | N/A | 339 | Europe | Emotional Freedom Techniques, iEFT, Mindfulness Meditation, iMMI | General Hospital Groeninge, Kom Op Tegen Kanker, az Glorieux, AZ Klina, AZ Vesalius, Imeldaziekenhuis, Jessa Hospital, University Hospital, Antwerp, Universitair Ziekenhuis Brussel, University Hospital, Ghent, Universitaire Ziekenhuizen KU Leuven, Vitaz | Fear of Cancer Recurrence | 08/28 | 10/28 | | |
| Poelaert, Jan |
MAPOVAS, NCT04679077: Preoperative Microcirculation and Postoperative Outcome After Major Vascular Surgery |
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| Withdrawn | N/A | 100 | Europe | Cytocam-IDF imaging device | Universitair Ziekenhuis Brussel | Surgery--Complications | 12/21 | 02/22 | | |
| Recruiting | N/A | 300 | Europe | Survey | Universitair Ziekenhuis Brussel | Brugada Syndrome | 12/21 | 12/21 | | |
| Completed | N/A | 30 | Europe | Neurowave and Sedline indices in view | Universitair Ziekenhuis Brussel | RASS-score, Deep Sedation, Post-cardiac Surgery | 06/23 | 06/23 | | |
NCT04939753: Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis |
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| Completed | N/A | 1000 | Europe | Sevoflurane | Universitair Ziekenhuis Brussel | Nephrogenic Diabetes Insipidus | 04/23 | 04/23 | | |
FLOMIC, NCT04913493: Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS |
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| Active, not recruiting | N/A | 22 | Europe | Cytocam-IDF | Universitair Ziekenhuis Brussel | Carotid Artery Plaque, Aortic Aneurysm, Aneurysm | 04/23 | 12/23 | | |
| Waele, Elisabeth De |
NCT04290767: Brain Ultrasound With Contrast Microbubbles Injection in Shock Status |
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| Recruiting | N/A | 40 | Europe | Sulphur hexafluoride microbubbles SONOVUE (BRACCO, Milan, Italy) | Universitair Ziekenhuis Brussel | Shock, Microcirculation | 12/22 | 12/22 | | |
| Completed | N/A | 935 | Europe | PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal | Maastricht University Medical Center, Ziekenhuis Oost-Limburg, Zuyderland Medisch Centrum, Gelderse Vallei Hospital, Medisch Spectrum Twente, Centre Hospitalier Universitaire de Liege, Centre Hospitalier Régional de la Citadelle, Universitair Ziekenhuis Brussel, General Hospital Groeninge, Catharina Ziekenhuis Eindhoven | Critical Illness, Intensive Care Unit Acquired Weakness | 10/23 | 10/23 | | |
