UPMC Shadyside Trials - LARVOL Sigma

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63 Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Saba, Samir

AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Active, not recruiting

N/A

484

Europe, Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone

Boston Scientific Corporation

Persistent Atrial Fibrillation

02/26

02/28

AID MI, NCT05073419: Arrhythmia Detection After MI

Recruiting

N/A

200

Standard of Care, Control, ICM Implantation, ICM

Samir Saba, Abbott

Acute Myocardial Infarction

10/25

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

Smith, Anson Jay C

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease

05/24

06/28

Singh, Michael

SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1)

Active, not recruiting

N/A

150

Japan, US

GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure

W.L.Gore & Associates

Aortic Aneurysm, Thoracic, Aorta, Lesion

03/24

03/28

TREO PAS, NCT04697784: Post-Approval Study of the TREO Abdominal Stent-Graft System

Recruiting

N/A

300

TREO Abdominal Stent-Graft System

Bolton Medical

Abdominal Aortic Aneurysm

07/27

Manager, Project

LANTERN, NCT06702878: Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections

Recruiting

4514

nasal antimicrobial photodisinfection therapy

Ondine Biomedical Inc.

Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents

07/25

08/25

PEMDA-HN, NCT05814666: Activity and Safety of Danvatirsen and Pembrolizumab in HNSCC

Recruiting

Europe, US, RoW

Danvatirsen, ISIS 481464, AZD9150, Pembrolizumab, Keytruda

Flamingo Therapeutics NV

HNSCC

05/25

05/26

TILS-022, NCT06890923: Nasal Foralumab in Patients with Non-Active Secondary Progressive Multiple Sclerosis

Recruiting

Foralumab TZLS-401 100 µg

Tiziana Life Sciences LTD

Non-Active Secondary Progressive Multiple Sclerosis

04/26

08/26

TRAK-ER, NCT04985266 / 2020-004022-36: A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer

Recruiting

1100

Europe

Palbociclib 125Mg Tab, Fulvestrant injection, Tamoxifen, Letrozole, Exemestane, Anastrozole

Royal Marsden NHS Foundation Trust, Pfizer, AstraZeneca, Institute of Cancer Research, United Kingdom, UNICANCER, Gustave Roussy, Cancer Campus, Grand Paris, Invitae Corporation

ER+ Breast Cancer, HER2-negative Breast Cancer

09/27

09/30

PROSPER, NCT06244771: A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Recruiting

1/2

403

FMC-376

Frontier Medicines Corporation

Advanced Solid Tumors With KRAS G12C Mutations, Solid Tumor, Adult, Unresectable Solid Tumor, Metastatic Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer, KRAS G12C, Pancreatic Cancer

10/27

04/28

APT-CUBE, NCT05473156: A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies

Recruiting

1/2

168

RoW

AP203

AP Biosciences Inc.

Locally Advanced or Metastatic Solid Tumors, Non Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC), Esophageal Squamous Cell Carcinoma (ESCC)

12/26

12/27

NCT05450549: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL919 in Healthy Participants

Completed

Europe

DNL919, Placebo

Denali Therapeutics Inc., Takeda

Healthy Participant

06/23

MV371 LAI FiH, NCT06558643: Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants

Recruiting

Europe

MMV371 LAI, Placebo for MMV371

Medicines for Malaria Venture, Quotient Sciences, The Doctors Laboratory Ltd

Malaria,Falciparum

08/25

NCT06639724: Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer

Recruiting

Fostamatinib in combination with chemotherapy (gemcitabine and nab-paclitaxel)

University of California, San Diego, Rigel Pharmaceuticals

Pancreatic Ductal Adenocarcinoma (PDAC)

06/27

12/28

NCT06833268: Real-world Outcomes of Patients With HER2+ Metastatic Breast Cancer After Treatment With Trastuzumab Deruxtecan

Recruiting

N/A

220

No drug

Daiichi Sankyo

HER2-positive Breast Cancer

06/25

NCT06812117: A Study to Evaluate the Safety and Effectiveness of Mirogabalin in Chinese Adult Patients With Diabetic Peripheral Neuropathic Pain (DPNP) in Real-world Clinical Practice Setting (ReMIssion Study)

Recruiting

N/A

720

RoW

No Drug

Daiichi Sankyo

Diabetic Peripheral Neuropathic Pain

02/26

04/26

RERUN, NCT06809764: Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC

Recruiting

N/A

150

RoW

No drug

Daiichi Sankyo

Non-small Cell Lung Cancer

02/27

RECOVER, NCT06846996: Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China

Recruiting

N/A

260

RoW

Trastuzumab deruxtecan (T-DXd)

Daiichi Sankyo

HER2-positive Gastric Cancer, HER2-positive Gastroesophageal Junction

07/27

Safe-De, NCT05058183: Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer

Recruiting

N/A

400

Europe

ctDNA

Royal Marsden NHS Foundation Trust, Massachusetts General Hospital, Natera, Inc.

Breast Cancer

12/25

12/28

Doshi, Ankur

ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting

2749

Europe, US, RoW

Orforglipron, LY3502970, Insulin Glargine

Eli Lilly and Company

Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease

09/25

01/26

VICTORION-1 PREVENT, NCT05739383: A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Active, not recruiting

14013

Europe, Canada, US, RoW

Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml

Novartis Pharmaceuticals

Primary Prevention of Atherosclerotic Cardiovascular Disease

04/29

NCT06233461: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Recruiting

268

Europe, Canada, Japan, US, RoW

TAK-279, Zasocitinib, Placebo

Takeda

Crohn's Disease

09/26

07/27

NCT06254950: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Recruiting

207

Europe, Canada, Japan, US, RoW

TAK-279, Zasocitinib, Placebo

Takeda

Ulcerative Colitis

09/26

08/27

NCT05936151: A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Active, not recruiting

146

Europe, Canada, US

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Overweight or Obesity, CKD, Type 2 Diabetes

11/25

NCT05569005: Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

Terminated

N/A

715

Europe, Japan, US, RoW

THS use, Tobacco Heating System 3.0, Cigarette, Smoking Abstinence

Philip Morris Products S.A.

COPD, Smoking, Tobacco Use

09/24

Monroe, Amy L

OPSTAHT, NCT03341156: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation

Terminated

Kcentra, prothrombin complex concentrate, Frozen Plasma Product, Human, Fresh Frozen Plasma

University of Maryland, Baltimore, CSL Behring

Heart Disease End Stage, Heart Failure，Congestive

09/20

02/25

NCT03633604: Expanded Access IND Administration of HBOC-201 in Patients with Severe Acute Anemia

Available

N/A

HBOC-201, Hemopure, hemoglobin glutamer - 250 (bovine)

Jonathan H. Waters, HbO2 Therapeutics LLC

Anemia Severe

NCT06071884: Bridge Device for Surgical Pain for Rotator Cuff Surgery

Completed

N/A

Bridge Percutaneous Nerve Field Stimulator, NSS-2 BRIDGE

Steven Orebaugh, Masimo Corporation

Pain, Rotator Cuff Injuries

09/24

NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study

Completed

N/A

Cardiac Performance System (CPS) Device

Stephen Esper, Sensydia Corporation

Heart Diseases

01/24

NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management

Recruiting

N/A

140

NEUROCUPLE™ Patch, Placebo Patch

nCap Medical, University of Pittsburgh

Total Knee Arthroplasty

09/25

09/26

NCT05452694: OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

Recruiting

N/A

235

OpalGenix, Inc

Lumbar Spine Stenosis, Lumbar Spine Degeneration

07/25

07/27

NCT05525923: Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

Recruiting

N/A

200

OpalGenix, Inc

Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy

03/26

03/28

NCT05906368: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension

Completed

N/A

ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring

Grace Lim, MD, MS, Edwards Lifesciences

Anesthesia, Epidural, Hypotension

08/24

NCT05506878: Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement

Recruiting

N/A

286

NSS-2 BRIDGE, Bridge, Sham NSS-2 BRIDGE, Placebo

Jacques E. Chelly, Masimo Corporation, National Institute on Drug Abuse (NIDA)

Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant

06/26

09/26

Policastro, Patricia

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

Castillo, Manuel J

PARADIGM, NCT04489823: Amplatzer Valvular Plug for PVL Closure

Recruiting

N/A

200

Europe, Canada, US

AVP III

Abbott Medical Devices

Paravalvular Aortic Regurgitation

07/25

06/26

NCT05425459: RESPONDER-HF Trial

Recruiting

N/A

750

Europe, Canada, US, RoW

Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)

Corvia Medical

Heart Failure, Heart Failure, Diastolic

05/25

03/31

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

EFACT, NCT06699056: AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Recruiting

N/A

1500

15-minutes of sitting during COR ECG Acquistion

Peerbridge Health, Inc

Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement, Conduction Defect, Heart Failure, Valvular Heart Disease, Ischemic Heart Disease, Cardiotoxicity, Myocardial Infarction, Dilated Cardiomyopathy, HFrEF - Heart Failure with Reduced Ejection Fraction, HFpEF - Heart Failure with Preserved Ejection Fraction, Syncope, Remodeling, Cardiac

09/25

NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting

N/A

300

Europe, Canada, US

Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication

Cardiac Dimensions, Inc.

Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases

12/26

12/30

Sultan, Ibrahim

NCT04091048: Optimize PRO Study

Completed

N/A

1127

Europe, Canada, US, RoW

Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)

Medtronic Cardiovascular

Symptomatic Aortic Stenosis

12/23

11/24

NCT06203054: CLIP-IT Post-Market Study

Active, not recruiting

N/A

150

Penditure™ Left Atrial Appendage (LAA) Exclusion System

Medtronic Cardiac Surgery

Left Atrial Appendage Exclusion

11/25

02/29

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

10/26

09/36

ENVISION, NCT05932615: IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

Enrolling by invitation

N/A

1500

Canada, US

Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System

Abbott Medical Devices

Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder

04/27

04/36

MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting

N/A

500

Europe, Canada, US

MITRIS RESILIA Mitral Valve, Model 11400M

Edwards Lifesciences

Mitral Stenosis, Mitral Valve Insufficiency

01/28

12/35

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

EXTEND, NCT05639400: Thoraflex Hybrid and Relay Extension Post-Approval Study

Recruiting

N/A

200

Europe, US

Thoraflex Hybrid, RelayPro NBS

Vascutek Ltd., Bolton Medical

Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection

12/35

12/36

Konopka, Kristin

NCT04091048: Optimize PRO Study

Completed

N/A

1127

Europe, Canada, US, RoW

Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)

Medtronic Cardiovascular

Symptomatic Aortic Stenosis

12/23

11/24

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting

N/A

141

Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)

XVIVO Perfusion

Heart Failure, Transplant; Failure, Heart

11/25

11/29

MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting

N/A

500

Europe, Canada, US

MITRIS RESILIA Mitral Valve, Model 11400M

Edwards Lifesciences

Mitral Stenosis, Mitral Valve Insufficiency

01/28

12/35

Ghodadra, Anish

MOTION, NCT05818150: GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA

Recruiting

N/A

264

Europe, Canada, US, RoW

Embosphere Microspheres, Genicular artery embolization, Corticosteroid injection, Triamcinolone or methylprednisolone

Merit Medical Systems, Inc.

Knee Osteoarthritis

04/26

10/27

Linger, Melissa Sanders

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Annunziato, Samantha

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Huang, Karen

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Saba, Samir

AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Active, not recruiting

N/A

484

Europe, Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone

Boston Scientific Corporation

Persistent Atrial Fibrillation

02/26

02/28

AID MI, NCT05073419: Arrhythmia Detection After MI

Recruiting

N/A

200

Standard of Care, Control, ICM Implantation, ICM

Samir Saba, Abbott

Acute Myocardial Infarction

10/25

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

Smith, Anson Jay C

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

Singh, Michael

SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1)

Active, not recruiting

N/A

150

Japan, US

GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure

W.L.Gore & Associates

Aortic Aneurysm, Thoracic, Aorta, Lesion

03/24

03/28

TREO PAS, NCT04697784: Post-Approval Study of the TREO Abdominal Stent-Graft System

Recruiting

N/A

300

TREO Abdominal Stent-Graft System

Bolton Medical

Abdominal Aortic Aneurysm

07/27

Manager, Project

LANTERN, NCT06702878: Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections

Recruiting

4514

nasal antimicrobial photodisinfection therapy

Ondine Biomedical Inc.

Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents

07/25

08/25

PEMDA-HN, NCT05814666: Activity and Safety of Danvatirsen and Pembrolizumab in HNSCC

Recruiting

Europe, US, RoW

Danvatirsen, ISIS 481464, AZD9150, Pembrolizumab, Keytruda

Flamingo Therapeutics NV

HNSCC

05/25

05/26

TILS-022, NCT06890923: Nasal Foralumab in Patients with Non-Active Secondary Progressive Multiple Sclerosis

Recruiting

Foralumab TZLS-401 100 µg

Tiziana Life Sciences LTD

Non-Active Secondary Progressive Multiple Sclerosis

04/26

08/26

Recruiting

1100

Europe

Palbociclib 125Mg Tab, Fulvestrant injection, Tamoxifen, Letrozole, Exemestane, Anastrozole

Royal Marsden NHS Foundation Trust, Pfizer, AstraZeneca, Institute of Cancer Research, United Kingdom, UNICANCER, Gustave Roussy, Cancer Campus, Grand Paris, Invitae Corporation

ER+ Breast Cancer, HER2-negative Breast Cancer

09/27

09/30

PROSPER, NCT06244771: A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Recruiting

1/2

403

FMC-376

Frontier Medicines Corporation

Advanced Solid Tumors With KRAS G12C Mutations, Solid Tumor, Adult, Unresectable Solid Tumor, Metastatic Solid Tumor, Non Small Cell Lung Cancer, Colorectal Cancer, KRAS G12C, Pancreatic Cancer

10/27

04/28

Recruiting

1/2

168

RoW

AP203

AP Biosciences Inc.

Locally Advanced or Metastatic Solid Tumors, Non Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC), Esophageal Squamous Cell Carcinoma (ESCC)

12/26

12/27

NCT05450549: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL919 in Healthy Participants

Completed

Europe

DNL919, Placebo

Denali Therapeutics Inc., Takeda

Healthy Participant

06/23

MV371 LAI FiH, NCT06558643: Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV371 LAI in Healthy Participants

Recruiting

Europe

MMV371 LAI, Placebo for MMV371

Medicines for Malaria Venture, Quotient Sciences, The Doctors Laboratory Ltd

Malaria,Falciparum

08/25

NCT06639724: Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer

Recruiting

Fostamatinib in combination with chemotherapy (gemcitabine and nab-paclitaxel)

University of California, San Diego, Rigel Pharmaceuticals

Pancreatic Ductal Adenocarcinoma (PDAC)

06/27

12/28

NCT06833268: Real-world Outcomes of Patients With HER2+ Metastatic Breast Cancer After Treatment With Trastuzumab Deruxtecan

Recruiting

N/A

220

No drug

Daiichi Sankyo

HER2-positive Breast Cancer

06/25

Recruiting

N/A

720

RoW

No Drug

Daiichi Sankyo

Diabetic Peripheral Neuropathic Pain

02/26

04/26

RERUN, NCT06809764: Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC

Recruiting

N/A

150

RoW

No drug

Daiichi Sankyo

Non-small Cell Lung Cancer

02/27

Recruiting

N/A

260

RoW

Trastuzumab deruxtecan (T-DXd)

Daiichi Sankyo

HER2-positive Gastric Cancer, HER2-positive Gastroesophageal Junction

07/27

Safe-De, NCT05058183: Safe De-escalation of Chemotherapy for Stage 1 Breast Cancer

Recruiting

N/A

400

Europe

ctDNA

Royal Marsden NHS Foundation Trust, Massachusetts General Hospital, Natera, Inc.

Breast Cancer

12/25

12/28

Doshi, Ankur

ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting

2749

Europe, US, RoW

Orforglipron, LY3502970, Insulin Glargine

Eli Lilly and Company

Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease

09/25

01/26

VICTORION-1 PREVENT, NCT05739383: A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Active, not recruiting

14013

Europe, Canada, US, RoW

Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml

Novartis Pharmaceuticals

Primary Prevention of Atherosclerotic Cardiovascular Disease

04/29

NCT06233461: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Recruiting

268

Europe, Canada, Japan, US, RoW

TAK-279, Zasocitinib, Placebo

Takeda

Crohn's Disease

09/26

07/27

NCT06254950: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Recruiting

207

Europe, Canada, Japan, US, RoW

TAK-279, Zasocitinib, Placebo

Takeda

Ulcerative Colitis

09/26

08/27

NCT05936151: A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Active, not recruiting

146

Europe, Canada, US

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Overweight or Obesity, CKD, Type 2 Diabetes

11/25

NCT05569005: Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

Terminated

N/A

715

Europe, Japan, US, RoW

THS use, Tobacco Heating System 3.0, Cigarette, Smoking Abstinence

Philip Morris Products S.A.

COPD, Smoking, Tobacco Use

09/24

Monroe, Amy L

OPSTAHT, NCT03341156: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation

Terminated

Kcentra, prothrombin complex concentrate, Frozen Plasma Product, Human, Fresh Frozen Plasma

University of Maryland, Baltimore, CSL Behring

Heart Disease End Stage, Heart Failure，Congestive

09/20

02/25

NCT03633604: Expanded Access IND Administration of HBOC-201 in Patients with Severe Acute Anemia

Available

N/A

HBOC-201, Hemopure, hemoglobin glutamer - 250 (bovine)

Jonathan H. Waters, HbO2 Therapeutics LLC

Anemia Severe

NCT06071884: Bridge Device for Surgical Pain for Rotator Cuff Surgery

Completed

N/A

Bridge Percutaneous Nerve Field Stimulator, NSS-2 BRIDGE

Steven Orebaugh, Masimo Corporation

Pain, Rotator Cuff Injuries

09/24

NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study

Completed

N/A

Cardiac Performance System (CPS) Device

Stephen Esper, Sensydia Corporation

Heart Diseases

01/24

NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management

Recruiting

N/A

140

NEUROCUPLE™ Patch, Placebo Patch

nCap Medical, University of Pittsburgh

Total Knee Arthroplasty

09/25

09/26

NCT05452694: OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

Recruiting

N/A

235

OpalGenix, Inc

Lumbar Spine Stenosis, Lumbar Spine Degeneration

07/25

07/27

NCT05525923: Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

Recruiting

N/A

200

OpalGenix, Inc

Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy

03/26

03/28

NCT05906368: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension

Completed

N/A

ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring

Grace Lim, MD, MS, Edwards Lifesciences

Anesthesia, Epidural, Hypotension

08/24

NCT05506878: Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement

Recruiting

N/A

286

NSS-2 BRIDGE, Bridge, Sham NSS-2 BRIDGE, Placebo

Jacques E. Chelly, Masimo Corporation, National Institute on Drug Abuse (NIDA)

Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant

06/26

09/26

Policastro, Patricia

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

Castillo, Manuel J

PARADIGM, NCT04489823: Amplatzer Valvular Plug for PVL Closure

Recruiting

N/A

200

Europe, Canada, US

AVP III

Abbott Medical Devices

Paravalvular Aortic Regurgitation

07/25

06/26

NCT05425459: RESPONDER-HF Trial

Recruiting

N/A

750

Europe, Canada, US, RoW

Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)

Corvia Medical

Heart Failure, Heart Failure, Diastolic

05/25

03/31

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

EFACT, NCT06699056: AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Recruiting

N/A

1500

15-minutes of sitting during COR ECG Acquistion

Peerbridge Health, Inc

09/25

NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting

N/A

300

Europe, Canada, US

Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication

Cardiac Dimensions, Inc.

Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases

12/26

12/30

Sultan, Ibrahim

NCT04091048: Optimize PRO Study

Completed

N/A

1127

Europe, Canada, US, RoW

Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)

Medtronic Cardiovascular

Symptomatic Aortic Stenosis

12/23

11/24

NCT06203054: CLIP-IT Post-Market Study

Active, not recruiting

N/A

150

Penditure™ Left Atrial Appendage (LAA) Exclusion System

Medtronic Cardiac Surgery

Left Atrial Appendage Exclusion

11/25

02/29

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

10/26

09/36

ENVISION, NCT05932615: IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

Enrolling by invitation

N/A

1500

Canada, US

Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System

Abbott Medical Devices

Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder

04/27

04/36

MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting

N/A

500

Europe, Canada, US

MITRIS RESILIA Mitral Valve, Model 11400M

Edwards Lifesciences

Mitral Stenosis, Mitral Valve Insufficiency

01/28

12/35

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

EXTEND, NCT05639400: Thoraflex Hybrid and Relay Extension Post-Approval Study

Recruiting

N/A

200

Europe, US

Thoraflex Hybrid, RelayPro NBS

Vascutek Ltd., Bolton Medical

Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection

12/35

12/36

Konopka, Kristin

NCT04091048: Optimize PRO Study

Completed

N/A

1127

Europe, Canada, US, RoW

Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)

Medtronic Cardiovascular

Symptomatic Aortic Stenosis

12/23

11/24

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting

N/A

141

Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)

XVIVO Perfusion

Heart Failure, Transplant; Failure, Heart

11/25

11/29

MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting

N/A

500

Europe, Canada, US

MITRIS RESILIA Mitral Valve, Model 11400M

Edwards Lifesciences

Mitral Stenosis, Mitral Valve Insufficiency

01/28

12/35

Ghodadra, Anish

MOTION, NCT05818150: GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA

Recruiting

N/A

264

Europe, Canada, US, RoW

Embosphere Microspheres, Genicular artery embolization, Corticosteroid injection, Triamcinolone or methylprednisolone

Merit Medical Systems, Inc.

Knee Osteoarthritis

04/26

10/27

Linger, Melissa Sanders

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Annunziato, Samantha

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Huang, Karen

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

05/24

06/28

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