| SERRANO, CARLOS V |
SAFE-PCI, NCT05037695: SGLT-2 Inhibitors in Prevention of Post-procedural Renal and Cardiovascular Complications aFter PCI Among Patients With Diabetes Mellitus and Coronary Artery Disease: a Prospective, Randomized, Pilot Study |
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| Recruiting | 4 | 40 | RoW | empagliflozin 25 MG | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Acute Kidney Injury | 07/22 | 12/22 | | |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Recruiting | 4 | 2270 | Europe, Canada, RoW | Non-vitamin K oral anticoagulant (NOAC), Apixaban, Dabigatran, Edoxaban, Rivaroxaban | Population Health Research Institute, Hamilton Health Sciences Corporation | Stroke, Atrial Fibrillation | 12/26 | 12/28 | | |
| Active, not recruiting | 2 | 145 | Europe, Canada, Japan, US, RoW | GSK3858279, Placebo | GlaxoSmithKline | Pain | 10/24 | 01/25 | | |
| Recruiting | 1 | 40 | RoW | Colchicine | University of Sao Paulo General Hospital | Atherosclerosis, Inflammatory Response, Coronary Disease | 03/23 | 03/25 | | |
| Jr, Carlos A Camargo |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Jr, José M Baggio |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
DIRECT-TNK, NCT05199194: Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke |
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| Recruiting | 3 | 390 | RoW | Tenecteplase, TNK, Placebo | Hospital Moinhos de Vento, Ministry of Health, Brazil, Boehringer Ingelheim, Medtronic | Stroke, Ischemic, Stroke, Acute | 07/26 | 07/27 | | |
EXTEND-IV, NCT05199662: Randomization to Extend Stroke Intravenous ThromboLysis In Evolving Non-Large Vessel Occlusion With TNK (RESILIENT |
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| Recruiting | 3 | 360 | RoW | Intravenous tenecteplase, TNK, Metalyse, Placebo | Hospital Moinhos de Vento, Ministry of Health, Brazil, Boehringer Ingelheim, Brainomix Limited, iSchemaView, Inc | Ischemic Stroke, Acute | 07/26 | 07/27 | | |
| Recruiting | N/A | 1100 | RoW | ICD implantation, ICD, amiodarone hydrochloride, amiodarone | InCor Heart Institute, Ministry of Health, Brazil, Abbott Medical Devices | Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death | 07/22 | 07/22 | | |
| Dallan, Luis Alberto O |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
MINICABG, NCT06794359: Minimally Invasive Coronary Artery Bypass Surgery in Patients with Multi Vessel Coronary Disease |
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| Enrolling by invitation | N/A | 100 | RoW | Minimally Invasive Coronary Artery Bypass Grafting, Coronary artery bypass surgery | University of Sao Paulo General Hospital, Medtronic, Fundação de Amparo à Pesquisa do Estado de São Paulo | Coronary Arterial Disease (CAD), Coronary Artery Bypass | 07/26 | 12/26 | | |
| Pitta, Fabio |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Recruiting | N/A | 105 | RoW | Daily physical activity levels, 6-minute walk test, Cardiopulmonary exercise testing, Muscle Function, Lung Function, Body composition, HRQoL - SGRQ-I, Symptoms - UCSD/SOBQ, HRQoL - SF36, Anxiety and depression, Symptoms - mMRC, Sleep quality, Sleepiness, Inflammatory markers and oxidative stress, Functional performance tests | Universidade Estadual de Londrina, Universidade Norte do Paraná | Interstitial Lung Disease | 10/23 | 10/23 | | |
NCT06648421: Reference Values for the One Repetition Maximum Test of Knee Extensors for Brazilians. |
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| Recruiting | N/A | 72 | RoW | | Universidade Estadual de Londrina | Healthy | 02/26 | 04/26 | | |
| Lima, Eduardo G |
TASK-POAF, NCT05300555: Cost-effectiveness Analysis Between Two Anticoagulation Strategies for Atrial Fibrillation in the Postoperative Period of Coronary Artery Bypass Graft Surgery |
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| Recruiting | 4 | 50 | RoW | Rivaroxaban 20 MG Oral Tablet, Rivaroxaban, Warfarin | University of Sao Paulo General Hospital | Atrial Fibrillation New Onset | 01/22 | 11/22 | | |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
OPTION TREAT, NCT05920005: Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension |
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| Recruiting | 3 | 698 | RoW | candesartan cilexetil + chlorthalidone + amlodipine, Exforge HCT® (valsartan 160mg + hydrochlorothiazide 12.5mg + amlodipine 5mg) | Hospital Israelita Albert Einstein, Libbs Farmacêutica LTDA | Hypertension | 12/23 | 07/24 | | |
NEOMINDSET, NCT04360720: PercutaNEOus Coronary Intervention Followed by Monotherapy INstead of Dual Antiplatelet Therapy in the SETting of Acute Coronary Syndromes: The NEO-MINDSET Trial |
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| Recruiting | 3 | 3400 | RoW | Antiplatelet Monotherapy | Hospital Israelita Albert Einstein | Acute Coronary Syndrome | 01/24 | 01/24 | | |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) |
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| Recruiting | 3 | 10000 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD) | 02/29 | 02/29 | | |
ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk |
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| Active, not recruiting | 3 | 2749 | Europe, US, RoW | Orforglipron, LY3502970, Insulin Glargine | Eli Lilly and Company | Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease | 09/25 | 01/26 | | |
COCAR, NCT05726019: Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome |
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| Recruiting | 2 | 100 | RoW | Colchicine | University of Sao Paulo General Hospital | Coronary Artery Disease, Acute Coronary Syndrome, Coronary Artery Bypass, Myocardial Reperfusion, Postpericardiotomy Syndrome, Postoperative Atrial Fibrilation, Perioperative Myocardial Infarction | 02/25 | 02/25 | | |
NCT04730466: Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients With Parkinson's Disease |
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| Completed | N/A | 46 | Europe | Neuropsychological rehabilitation | Universidad Francisco de Vitoria, Hospital Beata María Ana | Parkinson Disease | 06/22 | 07/22 | | |
GNOSIS, NCT06768528: Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft |
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| Recruiting | N/A | 90 | RoW | Galectin-3 dosage | University of Sao Paulo General Hospital | Post-operative Atrial Fibrillation, Cardiovascular Diseases, Post-pericardiotomy Syndrome | 02/25 | 12/26 | | |
| Fernandes, Fabio |
ANSWER-HF, NCT04853758: Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: . |
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| Recruiting | 3 | 200 | RoW | Sacubitril / Valsartan Oral Tablet [Entresto], Angiotensin receptor-neprilisin inhibitor (ARNI), Enalapril, Angiotensin converting enzyme inhibitors (ACE inhibitors) | University of Sao Paulo General Hospital, InCor Heart Institute | Chagas Cardiomyopathy | 12/24 | 12/24 | | |
FABRY, NCT04893889: Substudy (NCT04456582): Noninvasive Assessment of Myocardial Stiffness by 2D-SWE Ultrasound Technique (Two-dimensional Shear Wave Elastography) in Patients With Amyloidosis and Fabry Disease. |
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| Recruiting | N/A | 60 | RoW | Shear-wave elastography | University of Sao Paulo General Hospital, Pfizer | Fabry Disease, Amyloidosis | 08/21 | 03/22 | | |
AMIAT, NCT05196594: Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis |
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| Recruiting | N/A | 60 | RoW | collection of stools for genetic analysis | University of Sao Paulo General Hospital | Amyloidosis, Hereditary, Transthyretin-Related, Microbial Colonization | 05/23 | 05/23 | | |
| Cesar, Luis Antonio M |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Strunz, Celia |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Bolta, Paula |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
| Moreira, Eduardo M |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
NCT06267222: Trans-spinal Electrical Stimulation in Individuals With Spinocerebellar Ataxia |
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| Enrolling by invitation | N/A | 45 | RoW | TRANSCRANIAL DIRECT CURRENT STIMULATION + exercises, tDCS and exercises | Laura Alice Santos de Oliveira, Federal Institute of Rio de Janeiro | SCA, Postural Balance, Gait Ataxia | 06/24 | 07/24 | | |
| Neto, Aristoteles C |
AMIAT, NCT05196594: Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis |
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| Recruiting | N/A | 60 | RoW | collection of stools for genetic analysis | University of Sao Paulo General Hospital | Amyloidosis, Hereditary, Transthyretin-Related, Microbial Colonization | 05/23 | 05/23 | | |
| Cafezeiro, Caio |
AMIAT, NCT05196594: Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis |
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| Recruiting | N/A | 60 | RoW | collection of stools for genetic analysis | University of Sao Paulo General Hospital | Amyloidosis, Hereditary, Transthyretin-Related, Microbial Colonization | 05/23 | 05/23 | | |
| Rissato, Joao H |
AMIAT, NCT05196594: Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis |
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| Recruiting | N/A | 60 | RoW | collection of stools for genetic analysis | University of Sao Paulo General Hospital | Amyloidosis, Hereditary, Transthyretin-Related, Microbial Colonization | 05/23 | 05/23 | | |
