| Calmy, Alexandra AC |
Shingr'HIV, NCT05575830: Immune Response of Shingrix Vaccine in People Living With HIV (> 50 y.o.) Compared to Age-matched Controls |
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| Recruiting | 4 | 225 | Europe | Recombinant Zoster Vaccine, (Shingrix® ) | Calmy Alexandra | RZV Vaccine (Shingrix ®) | 09/24 | 09/25 | | |
| Enrolling by invitation | 4 | 210 | Europe | DOR/DTG/3TC, Doravirine (Pifeltro®) + Dolutegravir/Lamivudine (Dovato®) | Insel Gruppe AG, University Hospital Bern, Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland, University of Bern | HIV, Drug Resistance, Drug Drug Interaction | 11/25 | 12/27 | | |
UNITY, NCT05597735: Assessment of the Efficacy and Safety of Tecovirimat in Patients with Monkeypox Virus Disease |
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| Recruiting | 3 | 150 | Europe, RoW | Tecovirimat, Placebo | ANRS, Emerging Infectious Diseases, University Hospital, Geneva, Oswaldo Cruz Foundation, Fundacion Huesped, Buenos Aires, Argentina | Monkeypox, Mpox | 03/25 | 08/26 | | |
CADOVID, NCT05305508: Assessment of the Efficacy of Calcium Dobesilate vs. Placebo on SARS-CoV-2 Viral Load Amongst Outpatients With COVID-19. |
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| Completed | 2 | 74 | Europe | Calcium Dobesilate, DOXIUM 500, OM Pharma, Mannitol, Placebo | Hervé SPECHBACH, OM Pharma SA | COVID-19 Virus Disease | 11/23 | 02/24 | | |
OPTICOV, NCT05587894: OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial |
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| Recruiting | 2 | 256 | Europe | Paxlovid 5 days, Nirmatrevlir/ritonavir, Paxlovid 10 days, Veklury, remdesivir | ANRS, Emerging Infectious Diseases, University Hospital, Geneva | COVID-19, Immunodeficiency | 03/25 | 05/25 | | |
| Burri, Haran |
| Not yet recruiting | N/A | 50 | Europe | His bundle pacing, Right ventricular pacing | University Hospital, Geneva, Elise Bakelants, Carine Stettler, Rene NKoulou | Pacing-Induced Cardiomyopathy | 02/23 | 06/23 | | |
NCT04496518: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS) |
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| Active, not recruiting | N/A | 2200 | Europe, US | Intrinsic Antitachycardia Pacing (iATP) Therapy | Medtronic | Ventricular Tachycardia | 01/25 | 01/27 | | |
NCT04489225: Personalized Therapy Study - HFRS (TriageHF) Post Approval Study |
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| Active, not recruiting | N/A | 2200 | Europe, US | Observational | Medtronic | Heart Failure | 01/25 | 01/27 | | |
| Recruiting | N/A | 470 | Europe, RoW | Left ventricular septal pacing, Right ventricular pacing | Maastricht University, ZonMw: The Netherlands Organisation for Health Research and Development, Medtronic | Cardiac Pacing, Pacing-Induced Cardiomyopathy, Conduction System Pacing, Left Ventricular Septal Pacing, Atrioventricular Block | 05/25 | 05/25 | | |
ASQ, NCT04024943: Personalized Therapy Study - Attain Stability Quad Post-Approval Study |
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| Active, not recruiting | N/A | 1092 | Europe, US | Quadripolar LV Lead, Medtronic CRT-P, Medtronic CRT-D | Medtronic | Heart Failure | 01/27 | 04/27 | | |
| Jung, Minoa |
| Recruiting | 4 | 120 | Europe, Canada, US, RoW | Metabolic surgery, Bariatric surgery, Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Incretin-Based Therapy, Glucagon-like Peptide-1 Receptor Agonist | Ali Aminian | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis, Obesity | 05/29 | 12/29 | | |
| Rehberg-Klug, Benno |
PREVENT, NCT03216187: Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery |
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| Active, not recruiting | 3 | 126 | Europe | Pregabalin, Pregabalin 150mg capsules, Placebos, placebo capsules | Benno Rehberg-Klug, University Hospital, Geneva, Centre Hospitalier Universitaire Vaudois, Insel Gruppe AG, University Hospital Bern | Persistent Postoperative Pain | 06/24 | 11/24 | | |
VALIDE, NCT05307380: Transcultural Validation of the French Version of the Functional Pain Scale "Defense and Veterans Pain Rating Scale" |
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| Completed | N/A | 232 | Europe | "functional pain scale" | Benno Rehberg-Klug, Hôpital du Valais | Pain | 05/23 | 05/23 | | |
| Completed | N/A | 165 | Europe | online questionnaire | Benno Rehberg-Klug | Endometriosis | 06/24 | 06/24 | | |
| Not yet recruiting | N/A | 350 | NA | nociceptive flexion reflex (NFR) threshold ("Paintracker", Dolosys GmbH, Berlin, Germany), R3 reflex | Benno Rehberg-Klug | Low Back Pain, Neck Pain, Chronic Pain | 09/27 | 09/27 | | |
| Bridevaux, Pierre-Olivier |
| Recruiting | N/A | 160 | Europe | Lung auscultation, Lung ultrasound, Quality of Life's questionnaires, Pulmonary functional tests | Pediatric Clinical Research Platform, University Hospital, Geneva, Swiss Federal Institute of Technology, Hôpital du Valais | Lung; Disease, Interstitial, With Fibrosis, Pulmonary Disease, Chronic Obstructive, Artificial Intelligence | 10/24 | 10/24 | | |
| Recruiting | N/A | 100 | Europe | | Prof. Dr. Jörg Leuppi, AstraZeneca, GlaxoSmithKline, Lungenliga Schweiz, Novartis | Severe Asthma | 02/34 | 02/34 | | |
NCT05217875: Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study |
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| Recruiting | N/A | 50 | Europe | | Hôpital du Valais | COVID-19, Dysfunctional Breathing | 06/22 | 08/22 | | |
| Zilli, Thomas |
PEGASUS, NCT02799706: Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer |
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| Active, not recruiting | 3 | 885 | Europe | Degarelix, approved GnRH agonist, Radiotherapy | European Organisation for Research and Treatment of Cancer - EORTC | Prostate Cancer | 08/23 | 06/26 | | |
NCT01764646: Hypofractionated Radiation Therapy in Prostate Cancer |
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| Active, not recruiting | 2 | 170 | Europe, RoW | Intensity modulated radiation therapy, Volumetric modulated arc therapy, Image guided radiation therapy | Thomas Zilli | Malignant Neoplasm of Prostate, Local Disease | 12/20 | 09/25 | | |
NCT03294889: ONE-SHOT Trial - Ultra-hypofractionated Single-dose SBRT for Prostate Cancer |
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| Recruiting | 1/2 | 45 | Europe | Stereotactic body radition (SBRT) | University Hospital, Geneva, Humanitas Hospital, Italy, University of Zurich, Kantonsspital Graubünden | Prostate Cancer | 10/22 | 10/30 | | |
NCT03262220: Total Marrow Irradiation With Volumetric Arc Therapy for Patients Unfit for a 12 Gy TBI |
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| Recruiting | N/A | 10 | Europe | Volumetric Arc Therapy (VMAT) | Thomas Zilli, University Hospital, Geneva | Haematological Malignancy | 04/21 | 04/25 | | |
NCT03352258: Effect of Low Dose Radiotherapy on Brain Amyloidosis in the Treatment of Alzheimer's Disease |
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| Recruiting | N/A | 20 | Europe | Low dose radiotherapy | Thomas Zilli | Alzheimer Disease | 12/21 | 12/21 | | |
| Recruiting | N/A | 2000 | Europe, RoW | | European Organisation for Research and Treatment of Cancer - EORTC | Cancer | 04/26 | 04/26 | | |
HypoFocal SRT, NCT05746806: Trial of Ultrahypofractionated Focal Salvage Radiotherapy for Isolated Prostate Bed Recurrence After Radical Prostatectomy |
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| Recruiting | N/A | 36 | Europe | Ultrahypofractionated salvage radiotherapy to a local recurrence after radical prostatectomy, Androgen deprivation therapy | Insel Gruppe AG, University Hospital Bern, University of Bern, Debiopharm International SA, Werner und Hedy Berger-Janser - Stiftung | Recurrent Prostate Cancer | 09/25 | 08/27 | | |
| Dereu, Domitille |
PREVENT, NCT03216187: Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery |
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| Active, not recruiting | 3 | 126 | Europe | Pregabalin, Pregabalin 150mg capsules, Placebos, placebo capsules | Benno Rehberg-Klug, University Hospital, Geneva, Centre Hospitalier Universitaire Vaudois, Insel Gruppe AG, University Hospital Bern | Persistent Postoperative Pain | 06/24 | 11/24 | | |
| Completed | N/A | 165 | Europe | online questionnaire | Benno Rehberg-Klug | Endometriosis | 06/24 | 06/24 | | |
| Lalive, Patrice |
| Recruiting | 4 | 100 | Europe | recombinant zoster vaccine, Shingrix® | Prof Patrice Lalive | Shingles, Zoster | 12/24 | 12/25 | | |
MS COVID-19, NCT04760990: A Study to Assess the Potential Impact of Disease Modifying Therapies on COVID-19 Outcomes and the Antibody Response Following an Infection With SARS-CoV-2 in Patients With Multiple Sclerosis Within the Swiss Multiple Sclerosis Cohort. |
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| Recruiting | N/A | 1400 | Europe | data collection, analysis of blood samples | University Hospital, Basel, Switzerland, Swiss Multiple Sclerosis Registry | Multiple Sclerosis, COVID-19 (Severe Coronavirus Disease 2019) | 12/23 | 12/23 | | |
NCT06095271: MultiSCRIPT-Cycle 1: Personalized Medicine in Multiple Sclerosis - Pragmatic Platform Trial Embedded Within the SMSC |
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| Recruiting | N/A | 915 | Europe | serum Neurofilament Filament Light chain (sNfL) monitoring | University Hospital, Basel, Switzerland | Multiple Sclerosis, Relapsing-Remitting | 11/26 | 05/27 | | |
| Recruiting | N/A | 1200 | Europe | | University Hospital, Basel, Switzerland, Cantonal Hospital of Aarau, Switzerland, Cantonal Hospital of St. Gallen, Insel Gruppe AG, University Hospital Bern, Regional Hospital Lugano (EOC), Switzerland, University Hospital, Geneva, University of Lausanne Hospitals, National Multiple Sclerosis Society | Multiple Sclerosis | 01/42 | 01/42 | | |
| Kössler, Thibaud |
| Recruiting | 2 | 25 | Europe | Pembrolizumab | University Hospital, Geneva | Rectum Cancer, Rectal Cancer | 06/22 | 03/28 | | |
| Roffi, Marco |
MATRIX-2, NCT05955365: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation |
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| Recruiting | 4 | 3010 | Europe | P2Y12 inhibitor, Aspirin, DOAC | Insel Gruppe AG, University Hospital Bern, Sahajanand Medical Technologies Limited | Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor | 09/26 | 12/26 | | |
| Zoric, Lana |
SMART ANGEL 2, NCT04068584: Evaluation of the Impact of the SMART ANGEL â„¢ Device on Follow-up at Home Following Major or Intermediate Outpatient Surgery |
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| Recruiting | N/A | 1260 | Europe | Smart Angel | Centre Hospitalier Universitaire de NÄ«mes, EVOLUCARE | Ambulatory Surgery | 08/22 | 08/22 | | |
| Coordinator, Site |
NCT05069597: Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon |
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| Completed | 4 | 30 | US | CREON, Pancrelipase | AbbVie | Cystic Fibrosis, Chronic Pancreatitis | 07/23 | 08/23 | | |
NCT05647551: A Study to Evaluate Satisfaction in Adult Participants With the Aesthetics of the Periorbital Area After JUVÉDERM® Fillers and BOTOX®/VISTABEL® Injections |
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| Completed | 4 | 73 | Europe, RoW | BOTOX®/VISTABEL®, Juvéderm® VOLBELLA® with Lidocaine, Juvéderm® VOLIFT® with Lidocaine, Juvéderm® VOLUMA® with Lidocaine | AbbVie | Facial Corrections, Facial Lines | 10/23 | 10/23 | | |
NCT01192568: Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder |
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| Completed | 4 | 52 | US | Oxybutynin, Gelnique, Placebo | AbbVie | Overactive Detrusor, Neurogenic Bladder | 08/23 | 10/23 | | |
NCT06218251: A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines |
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| Active, not recruiting | 4 | 100 | Canada, US | BOTOX, Botulinum Toxin Type A, OnabotulinumtoxinA | AbbVie | Upper Facial Lines | 07/24 | 04/25 | | |
IMMpactful, NCT06333860: A Study to Learn How Safe and Effective Risankizumab is When Compared to Deucravacitinib to Treat Participants With Moderate Plaque Psoriasis and Who Need to Try Systemic Treatment (Works Throughout the Whole Body) |
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| Recruiting | 4 | 336 | Europe, Canada, US, RoW | Risankizumab, Deucravacitinib | AbbVie | Moderate Plaque Psoriasis | 03/25 | 03/26 | | |
NCT05969223: Study to Assess the Safety and Efficacy of Subcutaneously Injected Risankizumab in Adult Participants With Genital or Scalp Psoriasis |
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| Active, not recruiting | 4 | 214 | US | Risankizumab, Skyrizi, ABBV-066, Placebo for Risankizumab | AbbVie | Genital Psoriasis, Scalp Psoriasis | 01/25 | 10/25 | | |
| Completed | 4 | 461 | Europe, Canada, Japan, RoW | Upadacitinib, RINVOQ, ABT-494 | AbbVie, AbbVie Inc. | Atopic Dermatitis | 07/24 | 08/24 | | |
VIALE-M, NCT04102020 / 2019-002217-19: A Study of Oral Venetoclax Tablets and Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy |
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| Active, not recruiting | 3 | 112 | Europe, Canada, Japan, US, RoW | Venetoclax, ABT-199, GDC-0199, Venclexta, Azacitidine | AbbVie, Roche-Genentech | Acute Myeloid Leukemia (AML) | 09/22 | 04/25 | | |
NCT04994535: A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence |
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| Completed | 3 | 426 | Europe, Canada, US | OnabotulinumtoxinA, BOTOX, Placebo | AbbVie | Platysma Prominence | 06/23 | 06/23 | | |
NCT05139121: Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles |
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| Active, not recruiting | 3 | 1321 | Canada, US | MR-100A-01, Transdermal contraceptive delivery system | Mylan Technologies Inc., Mylan Inc. | Contraception | 01/25 | 01/25 | | |
NCT02814916 / 2014-005281-30: Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA |
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| Completed | 3 | 199 | Europe, US, RoW | Dalbavancin, Xydalba, Vancomycin, Oxacillin, Flucloxacillin, Cefadroxil, Clindamycin | AbbVie | Methicillin-Resistant Staphylococcus Aureus, Bacterial Infections, Staphylococcal Skin Infections | 01/24 | 01/24 | | |
NCT06174688: A Study to Assess the Adverse Events and Effectiveness of BOTOX Injections for the Treatment of Moderate to Severe Forehead Lines in Chinese Adult Participants |
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| Completed | 3 | 140 | RoW | BOTOX, Botulinum Toxin Type A, Placebo | AbbVie | Forehead Lines | 09/24 | 09/24 | | |
EPCORE FL-2, NCT06191744: Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma |
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| Recruiting | 3 | 1080 | Europe, Japan, US, RoW | Epcoritamab, ABBV-GMAB-3013, GEN3013, Epkinly, Prednisone, Rituximab, Lenalidomide, Doxorubicin, Vincristine, Cyclophosphamide, Obinutuzumab, Bendamustine | Genmab, AbbVie | Follicular Lymphoma (FL) | 05/37 | 05/37 | | |
| Active, not recruiting | 3 | 429 | Europe, Canada, Japan, US, RoW | Upadacitinib, ABT-494, RINVOQ, Corticosteroid (CS), Placebo | AbbVie | Giant Cell Arteritis (GCA) | 02/24 | 03/25 | | |
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NCT04903626 / 2020-005777-27: Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB) |
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| Completed | 3 | 286 | Europe, Canada, US, RoW | Glecaprevir/Pibrentasvir (GLE/PIB), ABT-493/ABT-530, Mavyret | AbbVie | Hepatitis C Virus (HCV) | 09/24 | 09/24 | | |
Level Up, NCT05601882 / 2022-002482-15: A Study to Evaluate Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis |
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| Completed | 3 | 926 | Europe, Canada, Japan, US, RoW | Upadacitinib, RINVOQ, Dupilumab | AbbVie, AbbVie Inc. | Atopic Dermatitis | 03/24 | 08/24 | | |
NCT06387394: A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence |
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| Recruiting | 3 | 200 | US | BOTOX, OnabotulinumtoxinA, Placebo | AbbVie | Masseter Muscle Prominence | 12/25 | 12/25 | | |
NCT06158841: Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma |
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| Recruiting | 3 | 380 | Europe, Japan, US, RoW | ABBV-383, Carfilzomib, Pomalidomide, Elotuzumab, Selinexor, Bortezomib, Dexamethasone | AbbVie | Multiple Myeloma | 12/27 | 12/27 | | |
Switch-Up, NCT06389136: A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab |
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| Recruiting | 3 | 300 | Japan, US, RoW | Upadacitinib Dose A, ABT-494, RINVOQ, Dupilumab Dose A, Upadacitinib Dose B | AbbVie | Atopic Dermatitis | 08/25 | 03/26 | | |
NCT06468228: A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa |
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| Recruiting | 3 | 1280 | Canada, Japan, US, RoW | Lutikizumab, ABT-981, Placebo | AbbVie | Hidradenitis Suppurativa | 12/26 | 12/26 | | |
| Active, not recruiting | 3 | 775 | Europe, Canada, US, RoW | BOTOX, Botulinum Toxin Type A, Placebo | AbbVie | Episodic Migraine | 11/24 | 11/24 | | |
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NCT06428019: A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL) |
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| Recruiting | 3 | 120 | US, RoW | Venetoclax, ABT-199, Acalabrutinib, Obinutuzumab | AbbVie | Chronic Lymphocytic Leukemia | 10/26 | 10/26 | | |
EPCORE DLBCL-4, NCT06508658: A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma |
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| Recruiting | 3 | 320 | Europe, Japan, US, RoW | Epcoritamab, ABBV-GMAB-3013, Epkinly, Rituximab, Lenalidomide, Oxaliplatin, Gemcitabine | Genmab | Diffuse Large B-Cell Lymphoma | 01/28 | 01/28 | | |
TRANSFORM-2, NCT04468984 / 2020-000557-27: Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis |
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| Active, not recruiting | 3 | 295 | Europe, Canada, Japan, US, RoW | Navitoclax, ABT-263, Ruxolitinib, Best Available Therapy (BAT) | AbbVie | Myelofibrosis (MF) | 01/25 | 01/25 | | |
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Start Up, NCT06461897: A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis |
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| Recruiting | 3 | 675 | US | Upadacitinib, ABT-494, RINVOQ®, RINVOQ LQ, Dupilumab | AbbVie | Atopic Dermatitis | 08/27 | 06/30 | | |
UBRO MM, NCT06417775: Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine |
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| Recruiting | 3 | 450 | US | Ubrogepant, UBRELVY, Placebo for Ubrogepant | AbbVie | Migraine | 09/27 | 09/27 | | |
NCT05316220: A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years With Ulcerative Colitis |
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| Not yet recruiting | 3 | 80 | US | Mesalamine, Delzicol, Placebo | AbbVie | Ulcerative Colitis (UC) | 07/26 | 07/26 | | |
LINZESS, NCT04026113 / 2019-001500-38: Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) |
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| Completed | 3 | 438 | Europe, Canada, US, RoW | Linaclotide 72 μg (FC Participants), Placebo (FC Participants), Linaclotide 145 μg (IBS-C Participants), Linaclotide 290 μg (IBS-C Participants) | AbbVie, Ironwood Pharmaceuticals, Inc. | Functional Constipation, Irritable Bowel Syndrome With Constipation | 05/24 | 05/24 | | |
| Completed | 3 | 150 | Europe, Canada, Japan, US | Risankizumab, SKYRIZI, ABBV-066, Ustekinumab | AbbVie | Psoriasis | 02/24 | 10/24 | | |
NCT05439616: Study of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD |
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| Completed | 3 | 161 | US | Cariprazine, VRAYLAR, AGN-241780, Placebo | AbbVie | Autism Spectrum Disorder | 10/24 | 10/24 | | |
NCT05652205: A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation |
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| Recruiting | 3 | 116 | Europe, US | Linaclotide, Placebo for Linaclotide | AbbVie, Ironwood Pharmaceuticals, Inc. | Functional Constipation (FC), Chronic Idiopathic Constipation (CIC) | 08/25 | 11/25 | | |
NCT06629597: A Phase III Study of YL201 in Recurrent or Metastatic Nasopharyngeal Carcinoma |
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| Not yet recruiting | 3 | 400 | RoW | YL201, Docetaxel, Capecitabine, Gemcitabine | MediLink Therapeutics (Suzhou) Co., Ltd. | Nasopharyngeal Carcinoma | 12/27 | 12/28 | | |
NCT06612151: A Phase III Study of YL201 in Relapsed Small Cell Lung Cancer |
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| Not yet recruiting | 3 | 438 | RoW | YL201, topotecan hydrochloride for injection | MediLink Therapeutics (Suzhou) Co., Ltd. | Small Cell Lung Cancer | 12/27 | 12/30 | | |
NCT04333576: Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain |
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| Recruiting | 3 | 800 | US | Elagolix, ABT-620, Orilissa, Placebo, Combined Oral Contraceptive | AbbVie | Endometriosis | 03/29 | 06/30 | | |
NCT05216263: Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Chronic Migraine |
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| Active, not recruiting | 3 | 75 | US | Atogepant, QULIPTA | AbbVie | Chronic Migraine | 04/25 | 04/25 | | |
NCT05316233: A Study to Assess Adverse Events and Change in Disease Activity of JUVÉDERM® VOLITE™ XC Injectable Gel for Change in Neck Appearance in Adult Participants |
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| Completed | 3 | 159 | US | VOLITE XC, JUVÉDERM® VOLITE™ XC | AbbVie | Neck Lines | 09/24 | 09/24 | | |
NCT05452070: A Study to Assess Adverse Events and Change in Disease Activity of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation in Adult Participants |
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| Active, not recruiting | 3 | 171 | Europe, Canada | HArmonyCa Lidocaine Injectable Gel | Allergan | Mid Face Volume Deficit | 05/25 | 05/25 | | |
Up-AA, NCT06012240: A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata |
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| Recruiting | 3 | 1500 | Europe, Canada, Japan, US, RoW | Upadacitinib, Rinvoq, ABT-494, Placebo | AbbVie | Alopecia Areata | 01/28 | 01/28 | | |
TeliMET NSCLC-01, NCT04928846 / 2021-001811-94: A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC) |
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| Recruiting | 3 | 698 | Europe, Canada, Japan, US, RoW | Telisotuzumab Vedotin, ABBV-399, Docetaxel | AbbVie | Non Small Cell Lung Cancer | 03/28 | 03/28 | | |
NCT05995340: ELAPR002f Injectable Gel in the Treatment of Atrophic Acne Scars |
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| Recruiting | 3 | 156 | Europe, Canada | ELAPR002f Injectable Gel, Saline Active Control | AbbVie | Atrophic Acne Scars | 02/26 | 02/26 | | |
NCT04578756: Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder |
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| Active, not recruiting | 3 | 310 | US | Cariprazine Flexible Dose | AbbVie | Schizophrenia, Bipolar I Disorder, Autism Spectrum Disorder (ASD) | 09/25 | 09/25 | | |
| Completed | 3 | 1 | US | StrataGraft | Stratatech, a Mallinckrodt Company, Biomedical Advanced Research and Development Authority | Skin Wound, Burns, Trauma-related Wound | 05/24 | 05/24 | | |
NCT03850782 / 2018-002574-52: Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension |
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| Active, not recruiting | 3 | 515 | Europe, US, RoW | Bimatoprost (SR) | AbbVie | Open-Angle Glaucoma, Ocular Hypertension | 08/25 | 08/25 | | |
NCT05411198: Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma |
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| Recruiting | 3 | 65 | US, RoW | XEN45 (Glaucoma Gel Stent) | AbbVie | Open-Angle Glaucoma | 08/25 | 08/25 | | |
SELECT- SWITCH, NCT05814627: Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis |
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| Recruiting | 3 | 480 | Europe, Canada, Japan, US, RoW | Upadacitinib, RINVOQ, Adalimumab, Humira, Upadacitinib Matching Placebo, Adalimumab Matching Placebo | AbbVie | Rheumatoid Arthritis | 09/25 | 08/26 | | |
| Active, not recruiting | 3 | 490 | Europe, Japan, RoW | Trastuzumab deruxtecan, T-DXd, DS-8201a, ENHERTU®, Ramucirumab, CYRAMZA®, Paclitaxel | Daiichi Sankyo, AstraZeneca | Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | 10/25 | 02/26 | | |
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Step-Up HS, NCT05889182: A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy |
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| Recruiting | 3 | 1328 | Europe, Canada, Japan, US, RoW | Upadacitinib, ABT-494, RINVOQ, Placebo | AbbVie | Hidradenitis Suppurativa | 11/25 | 08/27 | | |
CANOVA, NCT03539744 / 2017-003838-88: A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma. |
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| Active, not recruiting | 3 | 265 | Europe, Canada, Japan, US, RoW | Pomalidomide, Pomalyst, Dexamethasone, Venetoclax, ABT-199, GDC-0199 | AbbVie, Roche-Genentech | Multiple Myeloma | 08/26 | 08/26 | | |
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NCT06063967: A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease. |
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| Recruiting | 3 | 276 | Europe, Canada, Japan, US, RoW | Risankizumab SC, ABBV-066, SKYRIZI, Placebo for risankizumab | AbbVie | Crohn's Disease | 07/27 | 02/29 | | |
NCT05125302: Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17) |
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| Recruiting | 3 | 1059 | US | Ubrogepant, Ubrelvy, Placebo-Matching Ubrogepant | AbbVie | Migraine | 05/26 | 05/26 | | |
TEMPLE, NCT05748483: Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine |
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| Active, not recruiting | 3 | 545 | Europe, Canada, RoW | Atogepant, QULIPTA, Placebo for Atogepant, Topiramate, Placebo for Topiramate | AbbVie | Migraine | 05/26 | 05/26 | | |
NCT04064827: A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD) |
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| Recruiting | 3 | 16 | US | Paricalcitol | AbbVie | Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT) | 06/26 | 10/26 | | |
NCT06100744: A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab |
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| Recruiting | 3 | 40 | Europe, Canada, US, RoW | Adalimumab, Risankizumab, ABBV-066, Skyrizi | AbbVie | Juvenile Psoriatic Arthritis | 09/26 | 10/28 | | |
SELECT-SLE, NCT05843643: Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus |
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| Recruiting | 3 | 1000 | Europe, Canada, Japan, US, RoW | Upadacitinib, RINVOQ, Placebo | AbbVie | Systemic Lupus Erythematosus | 10/26 | 10/27 | | |
VIALE-T, NCT04161885 / 2019-002621-30: A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML) |
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| Active, not recruiting | 3 | 465 | Europe, Canada, Japan, US, RoW | Venetoclax, ABT-199, GDC-0199, VENCLEXTA, Azacitidine, Best Supportive Care (BSC) | AbbVie | Acute Myeloid Leukemia (AML), Cancer | 11/26 | 11/26 | | |
EPCORE DLBCL-2, NCT05578976 / 2021-000168-31: A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) |
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| Recruiting | 3 | 900 | Europe, Canada, Japan, US, RoW | Epcoritamab, ABBV-GMAB-3013, Cyclophosphamide, Rituximab, Vincristine, Doxorubicin, Prednisone | Genmab, AbbVie | Diffuse Large B-Cell Lymphoma | 09/28 | 12/29 | | |
NCT05609630: Study of Oral Upadacitinib and Subcutaneous/Intravenous Tocilizumab to Evaluate Change in Disease Activity, Adverse Events and How Drug Moves Through the Body of Pediatric and Adolescent Participants With Active Systemic Juvenile Idiopathic Arthritis. |
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| Recruiting | 3 | 90 | Europe, Japan, US, RoW | Upadacitinib, RINVOQ, ABT-494, Tocilizumab | AbbVie | Juvenile Idiopathic Arthritis | 02/27 | 06/29 | | |
DESTINY-Breast15, NCT05950945: Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer |
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| Recruiting | 3 | 250 | Europe, US, RoW | Trastuzumab Deruxtecan, T-DXd, DS-8201a (trastuzumab derextecan), Enhertu® | Daiichi Sankyo, AstraZeneca | Breast Cancer | 10/27 | 10/27 | | |
NCT05711394: A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine |
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| Recruiting | 3 | 450 | Europe, Canada, Japan, US, RoW | Atogepant, QULIPTA, AGN-241689, Placebo-Matching Atogepant | AbbVie | Episodic Migraine | 03/28 | 05/28 | | |
NCT05782907: Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis. |
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| Recruiting | 3 | 110 | Europe, Canada, Japan, US, RoW | Upadacitinib, RINVOQ | AbbVie | Ulcerative Colitis | 08/28 | 10/33 | | |
RISE, NCT05995353: A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease |
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| Recruiting | 3 | 110 | Europe, Canada, US, RoW | Risankizumab, ABBV-066, SKYRIZI | AbbVie | Crohn's Disease | 04/29 | 04/29 | | |
NCT05707949: Long-term Extension Study to Assess Adverse Events of Oral Atogepant Tablets in Pediatric Participants (6 to 17 Years of Age) With Migraine |
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| Enrolling by invitation | 3 | 650 | Europe, Canada, Japan, US, RoW | Atogepant, QULIPTA, AGN-241689 | AbbVie | Migraine Prophylaxis | 11/29 | 11/29 | | |
EPCORE FL-1, NCT05409066 / 2021-000169-34: Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma |
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| Recruiting | 3 | 500 | Europe, Canada, Japan, US, RoW | Epcoritamab, GEN3013, Rituximab, Lenalidomide | Genmab, AbbVie | Follicular Lymphoma (FL) | 11/29 | 06/30 | | |
LIVIGNO-4, NCT06236438: Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) |
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| Recruiting | 2/3 | 840 | Japan, US, RoW | Livmoniplimab, ABBV-151, Budigalimab, ABBV-181, Pembrolizumab, Pemetrexed, Cisplatin, Carboplatin | AbbVie | Non-Small Cell Lung Cancer | 10/31 | 10/31 | | |
NCT06345339: A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants |
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| Recruiting | 2/3 | 2800 | US | Armour Thyroid, AGN-282176, Levothyroxine, Synthetic T4 | AbbVie | Hypothyroidism | 06/28 | 06/28 | | |
LIVIGNO-2, NCT06109272: A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC) |
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| Recruiting | 2/3 | 660 | Europe, US, RoW | Livmoniplimab, ABBV-151, Budigalimab, ABBV-181, Durvalumab, Atezolizumab, Bevacizumab, Tremelimumab | AbbVie | Hepatocellular Carcinoma | 09/30 | 09/30 | | |
