| Amathieu, Roland |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
| Plantefeve, Gaëtan |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
| Completed | N/A | 1066 | Europe, RoW | Quantification of IV drugs wastage | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, Sainte-Anne Military Teaching Hospital | Drug Use | 03/23 | 03/23 | | |
NUTRIREA-4, NCT06581939: Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU |
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| Recruiting | N/A | 830 | Europe | Rehabilitation group, Control group | Nantes University Hospital | Mechanical Ventilation | 06/27 | 12/27 | | |
| Brochard, Karine |
| Recruiting | 3 | 300 | Europe | Colchicine Pill, Colchicine, Placebo | Assistance Publique - Hôpitaux de Paris, Hospices Civils de Lyon, Fonds de Dotation ACTION | Acute Myocarditis | 01/28 | 07/28 | | |
| Recruiting | 2 | 16 | Europe | Baricitinib, pharmacokinetics study, dosage of cytokines, transcriptomic analysis, Parent version of the Child Health Questionnaire (CHQ), Childhood Health Assessment Questionnaire, Pregnancy test | Assistance Publique - Hôpitaux de Paris, DGOS | Juvenile Dermatomyositis | 05/26 | 09/26 | | |
| BADIE, Julio |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
PLATINIUM, NCT06774235: Prevention of Secondary Infections by Interferon Gamma in ICU-acquired Sustained Immune-suppression |
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| Not yet recruiting | 3 | 326 | Europe | Interferon Gamma 1-b, Placebo | University Hospital, Limoges | Sustained Immunosuppression | 09/28 | 09/28 | | |
NCT05962606: Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia. |
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| Recruiting | 2 | 150 | Europe | AON-D21, Placebo | Aptarion Biotech AG | Community-acquired Pneumonia | 05/26 | 06/26 | | |
| Completed | N/A | 1066 | Europe, RoW | Quantification of IV drugs wastage | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, Sainte-Anne Military Teaching Hospital | Drug Use | 03/23 | 03/23 | | |
| Not yet recruiting | N/A | 60 | Europe | Measures performed on all subjects | F2D Medical, Clinact Multihealth, Digital Medical Hub | Temperature Change, Body, Emergency Department Visit | 01/25 | 03/25 | | |
NCT04494074: Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock |
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| Recruiting | N/A | 820 | Europe | External Cooling | Centre Hospitalier Intercommunal Creteil | Septic Shock | 12/26 | 12/26 | | |
NUTRIREA-4, NCT06581939: Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU |
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| Recruiting | N/A | 830 | Europe | Rehabilitation group, Control group | Nantes University Hospital | Mechanical Ventilation | 06/27 | 12/27 | | |
| MAIZEL, Julien |
| Recruiting | 3 | 310 | Europe | Nicotinamide treatment, placebo treatment | Centre Hospitalier Universitaire, Amiens, Centre Hospitalier de Dieppe, Centre Hospitalier d'Abbeville, Centre Hospitalier de Laon, University Hospital, Caen, Centre Hospitalier de Cherbourg, University Hospital, Rouen, Centre Hospitalier de Roubaix, Centre Hospitalier de Bethune, Hôpital Saint Philibert, Lomme, Tourcoing Hospital, Centre Hospitalier de Valenciennes, Centre Hospitalier Arras, Centre Hospitalier de Lens, Centre Hospitalier de Calais | Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality | 10/23 | 01/24 | | |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
REITAB-2, NCT05204563: Imipenem/Cilastatin-XNW4107 Versus Imipenem/Cilastatin/Relebactam for Treatment of Participants With Bacterial Pneumonia (XNW4107-302, ) |
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| Recruiting | 3 | 450 | Europe, US, RoW | Combination of Imipenem/Cilastatin and XNW4107, Imipenem/Cilastatin/Relebactam, Recarbrio | Evopoint Biosciences Inc. | Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia | 04/25 | 12/25 | | |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
DASSOH, NCT06020495: Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia |
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| Recruiting | 3 | 260 | Europe | DDAVP, Standard hyponatremia treatment | Assistance Publique - Hôpitaux de Paris | Hyponatremia | 09/26 | 11/26 | | |
COTRIVAP, NCT05696093: Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit |
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| Recruiting | 3 | 628 | Europe | cotrimoxazole, standard antibiotic therapy | Assistance Publique - Hôpitaux de Paris | Ventilator Associated Pneumonia | 10/26 | 12/26 | | |
| Recruiting | 2 | 234 | Europe | Vitamin C (Laroscorbine) + Vitamin B1 (Bevitine), Laroscorbine + Bevitine, standard treatment | Centre Hospitalier de Bethune, Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, University Hospital, Lille | Cardiac Arrest | 12/25 | 01/26 | | |
MYOCOVID, NCT04375748: Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID19) Cases |
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| Completed | N/A | 756 | Europe, RoW | Performing routine care (clinical and paraclinical tests), Examinations for the research: | University Hospital, Toulouse | Acute Myocarditis | 12/21 | 12/21 | | |
| Recruiting | N/A | 170 | Europe | | Centre Hospitalier Universitaire, Amiens | Septic Shock | 11/24 | 12/24 | | |
HyperBetashock, NCT04748796: Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility |
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| Recruiting | N/A | 360 | Europe | echocardiography, Landiolol | Centre Hospitalier Universitaire, Amiens, CH Dieppe, CH Elbeuf, CH Le Havre, Centre Hospitalier de Beauvais, CH Compiègne, CH Laon, University Hospital, Caen, CH Cherbourg, University Hospital, Lille, CH Douai, CH Montreuil, Centre Hospitalier de Roubaix, Centre Hospitalier de Bethune, CH Lomme, Centre Hospitalier de Lens, Tourcoing Hospital, Centre Hospitalier VALENCIENNES, Centre Hospitalier Arras, Hospital Ambroise Paré Paris, University Hospital, Brest, Henri Mondor University Hospital, Hospital Avicenne, University Hospital, Montpellier, CH Calais, Hôpital Edouard Herriot, Centre Hospitalier Universitaire de Nīmes, Groupe Hospitalier Pitié-Salpêtrière | Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker | 02/24 | 03/24 | | |
NCT04494074: Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock |
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| Recruiting | N/A | 820 | Europe | External Cooling | Centre Hospitalier Intercommunal Creteil | Septic Shock | 12/26 | 12/26 | | |
NUTRIREA-4, NCT06581939: Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU |
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| Recruiting | N/A | 830 | Europe | Rehabilitation group, Control group | Nantes University Hospital | Mechanical Ventilation | 06/27 | 12/27 | | |
| Recruiting | N/A | 50 | Europe | Blood sampling | Centre Hospitalier Universitaire, Amiens, Centre Hospitalier Abbeville | Sepsis, Acute Kidney Injury | 02/25 | 03/25 | | |
| Recruiting | N/A | 60 | Europe | | Centre Hospitalier Universitaire, Amiens | Weaning, Spontaneous Breathing Trial, Mechanical Ventilation, Speckle Tracking, Strains, Diaphragm | 06/25 | 06/25 | | |
POSTPONE, NCT06743529: Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia |
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| Not yet recruiting | N/A | 686 | Europe, RoW | control group, Conservative strategy | Nantes University Hospital | Ventilator-Associated Pneumonia (VAP) | 10/28 | 01/29 | | |
| LORBER, Julien |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
| Recruiting | N/A | 608 | Europe | | Nantes University Hospital | Cardiac Arrest, Neurologic Symptoms, Intensive Care Neurological Disorder | 05/27 | 05/27 | | |
| KONTAR, Loay |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
| Slama, Michel |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
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| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 12/25 | 12/25 | | |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
TOX-AKI, NCT03920982: Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients. |
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| Recruiting | N/A | 90 | Europe | Determination of the blood concentration of indoxyl sulfate (IS) | Centre Hospitalier Universitaire, Amiens | Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality | 04/23 | 07/23 | | |
MAPIC, NCT05515484: Improvement of Lung and Thoracic Compliance in ARDS Patients in Prone Position by Using Inflatable Air Bag |
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| Recruiting | N/A | 20 | Europe | prone position with airbags, prone position without airbags | Centre Hospitalier Universitaire, Amiens | ARDS, Prone Position, Mechanical Ventilation, Airbag | 08/23 | 08/23 | | |
| Recruiting | N/A | 100 | Europe | venous ultrasound, blood sample | Centre Hospitalier Universitaire, Amiens | COVID-19, Hemostasis, Coagulation | 10/23 | 11/23 | | |
MAPSE, NCT04963686: Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients |
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| Recruiting | N/A | 60 | Europe | | Centre Hospitalier Universitaire, Amiens | Left Ventricular Systolic Dysfunction, Septic Shock | 11/23 | 11/23 | | |
HyperBetashock, NCT04748796: Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility |
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| Recruiting | N/A | 360 | Europe | echocardiography, Landiolol | Centre Hospitalier Universitaire, Amiens, CH Dieppe, CH Elbeuf, CH Le Havre, Centre Hospitalier de Beauvais, CH Compiègne, CH Laon, University Hospital, Caen, CH Cherbourg, University Hospital, Lille, CH Douai, CH Montreuil, Centre Hospitalier de Roubaix, Centre Hospitalier de Bethune, CH Lomme, Centre Hospitalier de Lens, Tourcoing Hospital, Centre Hospitalier VALENCIENNES, Centre Hospitalier Arras, Hospital Ambroise Paré Paris, University Hospital, Brest, Henri Mondor University Hospital, Hospital Avicenne, University Hospital, Montpellier, CH Calais, Hôpital Edouard Herriot, Centre Hospitalier Universitaire de Nīmes, Groupe Hospitalier Pitié-Salpêtrière | Septic Shock, Tachycardia, Mortality During Septic Shock, Beta-blocker | 02/24 | 03/24 | | |
| Recruiting | N/A | 65 | Europe | contrast assessment of cardiac output (CO), cardiac Doppler technique | Centre Hospitalier Universitaire, Amiens | Echocardiography | 03/24 | 03/24 | | |
| Recruiting | N/A | 740 | Europe, Canada, US, RoW | Respiratory Mechanics, Standard Ventilation Strategy | Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre | ARDS | 11/25 | 03/26 | | |
| Recruiting | N/A | 60 | Europe | | Centre Hospitalier Universitaire, Amiens | Weaning, Spontaneous Breathing Trial, Mechanical Ventilation, Speckle Tracking, Strains, Diaphragm | 06/25 | 06/25 | | |
| BERNA, Pascal |
thoracoscopic, NCT04222010: Serratus Plain Block Versus Paravertebral Block Versus Serratus Plain Block and Paravertebral Block for Postoperative Pain Following Thoracoscopic Surgery |
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| Completed | N/A | 155 | Europe | loco-regional anesthesia serratus plane bloc (Ropivacaine 2 mg/mL, 40 mL) and paravertebral placebo bloc (saline, 20 mL), Loco-regional anesthesia : paravertebral bloc (Ropivacaine 4 mg/mL, 20 mL) and serratus plane placebo bloc (saline, 40 mL), Loco-regional anesthesia : serratus plane bloc (Ropivacaine 1,3 mg/mL, 40 mL) and paravertebral bloc (Ropivacaine 1,3 mg/mL, 20 mL) | Centre Hospitalier Universitaire, Amiens | Anesthesia, Local, Pain, Postoperative | 07/21 | 09/23 | | |
| Varillon, Caroline |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
| Recruiting | 2/3 | 90 | Europe | Sodium Lactate light dose, Sodium Lactate high dose, Normal saline | University Hospital, Lille | Septic Shock | 11/23 | 11/23 | | |
| Berrouba, Aziz |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
HospiFlow, NCT05311007: Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study |
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| Completed | N/A | 175 | Europe | Evaluation of the incidence and nature of adverse events | Centre Hospitalier Régional d'Orléans | Critical Illness | 05/24 | 05/24 | | |
| Brégeaud, Delphine |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
| SALAMEH, Abdallah AL |
GLUCOGEN, NCT06570278: Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes |
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| Recruiting | N/A | 1020 | Europe | WGS coupled with MCM | Institut National de la Santé Et de la Recherche Médicale, France, Commissariat A L'energie Atomique, Rennes University Hospital, Central Hospital, Nancy, France, Nantes University Hospital, Imagine Institute, APHP, Hospices Civils de Lyon, Université Lumière Lyon 2, Toulouse University Hospital | Diabetes Mellitus | 11/31 | 11/34 | | |
