Unity Health Toronto
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 56 Trials 
30 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Marshall, John L
MRD-GI, NCT05482516: Evaluating Novel Therapies in ctDNA Positive GI Cancers

Recruiting
3
20
US
Atezolizumab, TECENTRIQ, Bevacizumab, Avastin
Georgetown University, Genentech, Inc., Natera, Inc.
Colon Adenocarcinoma, Rectal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma, Hepatocellular Carcinoma, Adenocarcinoma of Biliary Tract, Gallbladder Adenocarcinoma
12/26
12/28
NanoCOAT, NCT04717024: The Nanowear Wearable Covid-19 Observational and Analysis Trend

Recruiting
N/A
100
US
Observational Study - no intervention
Nanowear Inc.
Covid19
12/23
12/23
NCT05473702: Smart Textile Sensor System for Health Monitoring

Recruiting
N/A
200
US
Nanowear SimpleSense Wearable monitoring device
Nanowear Inc.
Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive, Blood Pressure, Heart Rhythm Disorder
06/24
06/24
Chan, Anthony TC
PRESent-2, NCT05789524: The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B

Active, not recruiting
2
60
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
02/25
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Protect-NOW, NCT03695978: Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia a Patients

Recruiting
N/A
200
Europe, Canada, US, RoW
Octapharma
Haemophilia a
06/30
06/30
Hull, Mark A
EMT2, NCT03428477 / 2016-000628-24: EPA for Metastasis Trial 2

Active, not recruiting
3
418
Europe
Icosapent Ethyl, Vascepa, Placebo
Mark A Hull, PhD FRCP, Yorkshire Cancer Research, Amarin Pharma Inc.
Liver Metastasis, Colon Cancer
11/25
04/26
Elalfy, Mohsen S
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Chan
NCT06149494: RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Recruiting
2
100
Europe
Vapendavir, Placebo
Altesa Biosciences, Inc., Virtus Respiratory Research
COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection, Rhinovirus, Virus Diseases, Virus Infection, RNA, Enterovirus, Enterovirus Infections, Rhinovirus Infection, Infection Viral, Respiratory Complication, Respiratory Disease, Respiratory Tract Infections, Respiratory Tract Diseases, Respiratory Viral Infection, Upper Resp Tract Infection, Upper Respiratory Tract Infections, Upper Respiratory Disease, Upper Respiratory Disorder, Upper Respiratory Disease, Acute, Upper Respiratory Infection Viral, Infections, Respiratory, Infections, Copd, Viral Infection, Emphysema or COPD, Lower Respiratory Disease, Lower Respiratory Disorder, Lower Respiratory Tract and Lung Infections, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Respiratory Disease Chronic, Lung Diseases, Lung Disease Chronic, Obstructive Pulmonary Disease, Chronic Lower Respiratory Diseases, Chronic Respiratory Disease
12/24
03/25
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
FARA1000, NCT05501873: Real World Data Collection in Subjects Treated with the FARAPULSE Pulsed Field Ablation System

Active, not recruiting
N/A
1173
Europe, RoW
FARAPULSE Pulsed Field Ablation system
Boston Scientific Corporation
Atrial Fibrillation
08/27
08/27
Pavenski, Katerina
FiiRST-2, NCT04534751: Factor In the Initial Resuscitation of Severe Trauma 2 Patients

Recruiting
4
350
Canada
Fibrinogen + PCC, Fibryga + Octaplex, Frozen Plasma
University Health Network, Toronto, Sunnybrook Health Sciences Centre, Octapharma, Canadian Institutes of Health Research (CIHR), Canadian Institute for Military and Veteran Health Research Defense Research & Development Canada
Traumatic Hemorrhage, Coagulopathy, Massive Hemorrhage
12/23
01/24
NCT05714969 / 2022-001940-36: A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)

Active, not recruiting
2
40
Europe, US, RoW
TAK-755, rADAMTS13, recombinant ADAMTS13, SHP-655, BAX 930
Takeda, Takeda Development Center Americas, Inc.
Thrombotic Thrombocytopenic Purpura (TTP)
03/25
03/25
Cusimano, Michael
TRACE, NCT05713630: The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma

Not yet recruiting
3
130
Canada
Tranexamic acid (TXA), Cyklokapron, Placebo
Unity Health Toronto, Canadian Institutes of Health Research (CIHR), The Physicians' Services Incorporated Foundation, Ozmosis Research Inc.
Subdural Hematoma
03/26
11/26
Tan, Darrell
VPrEP, NCT05159531: Virtual PrEP: Rendering PrEP Delivery More Efficient

Terminated
4
2
Canada
PrEP, Descovy® 200/25mg (DIN= 02454424), TAF/FTC, tenofovir alafenamide/emtricitabine, mHealth Model of Care, GoFreddie®, Standard of Care, PrEP standard of care
Unity Health Toronto, CIHR Canadian HIV Trials Network, Gilead Sciences
HIV Infections
06/23
06/23
CATCO, NCT04330690: Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial

Active, not recruiting
3
2900
Canada
Artesunate, Imatinib, Infliximab, Dexamethasone, LSALT Peptide
Sunnybrook Health Sciences Centre, AbbVie, Apotex Inc., World Health Organization, University of British Columbia, Arch Biopartners Inc.
COVID-19
03/24
05/24
VOLITION, NCT05917509: A Study to Evaluate the Efficacy, Safety, Participant Choice and Preference of an Oral Once-daily Regimen or a Long-acting Injectable Regimen Every Two Months for Treatment of Human Immunodeficiency Virus (HIV-1) in Adults Who Have Not Previously Taken Antiretroviral Therapy

Active, not recruiting
3
171
Europe, Canada, US, RoW
DTG/3TC, Dovato, Cabotegravir (CAB) LA, Vocabria, Rilpivirine (RPV) LA, Rekambys
ViiV Healthcare, GlaxoSmithKline, PPD DEVELOPMENT, LP
HIV Infections
10/25
10/26
Mazer, David
EMPA-HEART 2, NCT04461041: Empagliflozin and Cardiac Remodelling in People Without Diabetes

Completed
4
169
Canada, RoW
Empagliflozin, Jardiance, Placebo
Unity Health Toronto, Canadian Medical and Surgical Knowledge Translation Research Group, Boehringer Ingelheim, Applied Health Research Centre
Cardiovascular Diseases, Left Ventricular Hypertrophy
07/22
07/22
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
AKITA, NCT05126303: Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery

Terminated
2
177
Europe, Canada, US, RoW
RMC-035, ROSgard, Placebo
Guard Therapeutics AB
Acute Kidney Injury
04/23
07/23
POINTER, NCT06475274: A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery

Recruiting
2
161
Europe, Canada
RMC-035, Placebo
Guard Therapeutics AB
Kidney Injury Following Open-Chest Cardiac Surgery
10/25
10/25
NCT05879432: LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Recruiting
2
240
Canada, RoW
LSALT Peptide, Metablok, Placebo
Arch Biopartners Inc.
Acute Kidney Injury, Cardiac Surgery
08/25
11/25
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
McFarlin, Kellie
EXPEDITE, NCT06560307: Study of Enhanced Programming Stimulation with the Enterra® Therapy System

Recruiting
N/A
50
US
Enterra Therapy System, Gastric electrical stimulation
Enterra Medical, Inc.
Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
10/26
12/26
Teitel, Jerome
PRESent-2, NCT05789524: The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B

Active, not recruiting
2
60
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
02/25
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Doorsian, Mona
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
Swarup
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Al
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Matangi, Murray
CIRCE, NCT05416385: Carotid Intraplaque Neovascularization Combined with Stress Echo

Recruiting
N/A
1500
Canada
Carotid Contrast Enhanced Ultrasound, Contrast injection, DEFINITY®, Perflutren Lipid Microsphere
Dr. Amer Johri, Lantheus Medical Imaging
Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease, Myocardial Infarction, Carotid Artery Diseases
08/26
08/26

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