Unity Health Toronto
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 56 Trials 
116 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Marshall, John L
NCT03950817: Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

Completed
4
80
US
Nebulized Sub-dissociative Dose Ketamine at either 0.75 mg/kg, Nebulized Sub-dissociative Dose Ketamine at 1 mg/kg, Nebulized Sub-dissociative Dose Ketamine at 1.5 mg/kg.
Antonios Likourezos
Pain
09/24
09/24
ARBs CORONA II, NCT04606563: Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?

Terminated
3
341
Europe, Canada
Losartan, Cozaar, Valsartan, Diovan, Azilsartan, Edarbi, Candesartan, Atacand, Eprosartan, Teventen, Irbesartan, Avapro, Olmesartan, Olmetec, Telmisartan, Micardis
University of British Columbia, Canadian Institutes of Health Research (CIHR)
Covid19, SARS-CoV Infection
04/22
04/22
REVISE, NCT03374800 / 2020-000483-27: Re-EValuating the Inhibition of Stress Erosions () Trial

Completed
3
4800
Europe, Canada, US, RoW
Placebo (0.9% saline), normal saline; NaCl 0.9%, Pantoprazole, Protonix
McMaster University, Canadian Institutes of Health Research (CIHR), Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, National Health and Medical Research Council, Australia
Gastrointestinal Hemorrhage (Clinically Important, Upper)
10/23
01/24
REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting
3
20000
Europe, Canada, Japan, US, RoW
Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir
UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore
Community-acquired Pneumonia, Influenza, COVID-19
02/26
02/28
MRD-GI, NCT05482516: Evaluating Novel Therapies in ctDNA Positive GI Cancers

Recruiting
3
20
US
Atezolizumab, TECENTRIQ, Bevacizumab, Avastin
Georgetown University, Genentech, Inc., Natera, Inc.
Colon Adenocarcinoma, Rectal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma, Hepatocellular Carcinoma, Adenocarcinoma of Biliary Tract, Gallbladder Adenocarcinoma
12/26
12/28
RADAR-Canada, NCT06326112: Role of Active Deresuscitation After Resuscitation:

Not yet recruiting
2
120
Canada
Furosemide Injection, Metolazone Tablets
Unity Health Toronto, Canadian Institutes of Health Research (CIHR)
Fluid Overload, Critical Illness, Sepsis, ARDS, Trauma
03/25
06/25
Proton-PANC, NCT03885284: Study of Proton Therapy in Adjuvant Pancreatic Cancer

Completed
1
9
US
mFOLFIRINOX, Proton beam radiation
Georgetown University
Resected Pancreatic Adenocarcinoma
05/22
11/23
NCT01428089: Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

Recruiting
1
40
US
Progesterone, Placebo
University of Virginia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
12/24
12/24
NCT01422746: Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess

Recruiting
1
20
US
Metformin, Glucophage
University of Virginia
Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
12/24
12/24
CRM009, NCT03401047: Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome

Recruiting
1
37
US
Estradiol, Vivelle
University of Virginia
Polycystic Ovary Syndrome
04/25
12/25
BALANCE, NCT03005145: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

Completed
N/A
3622
Europe, Canada, US, RoW
7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
Sunnybrook Health Sciences Centre
Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial
05/23
08/23
NanoCOAT, NCT04717024: The Nanowear Wearable Covid-19 Observational and Analysis Trend

Recruiting
N/A
100
US
Observational Study - no intervention
Nanowear Inc.
Covid19
12/23
12/23
SODA-SWAP, NCT06427915: Studying Glucose and Appetite Response With Alternatives to Soda Pop

Recruiting
N/A
30
US
OLIPOP prebiotic soda, Traditional sugar-sweetened cola
Olipop, PBC, BioFortis
Healthy Nutrition
07/24
08/24
NCT05473702: Smart Textile Sensor System for Health Monitoring

Recruiting
N/A
200
US
Nanowear SimpleSense Wearable monitoring device
Nanowear Inc.
Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive, Blood Pressure, Heart Rhythm Disorder
06/24
06/24
NCT01421797: Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation

Active, not recruiting
N/A
84
US
Dexamethasone, Cortrosyn, ACTH
University of Virginia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of California, San Diego
Hyperandrogenemia, Polycystic Ovary Syndrome, Obesity
08/24
12/24
NCT01422759: Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess

Recruiting
N/A
20
US
Spironolactone, Aldactone
University of Virginia
Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
12/24
12/24
NCT02155933: Assessment of Day-night Secretion of Progesterone and LH Across Puberty

Recruiting
N/A
75
US
Blood sampling
University of Virginia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Puberty, Hyperandrogenism
02/25
02/25
NCT01650311: Investigating Serotonin Signalling in IBD Patients

Recruiting
N/A
60
Canada
McMaster University
Inflammatory Bowel Disease
05/25
05/25
ARBS CORONA I, NCT04510623: Host Response Mediators in Coronavirus (COVID-19) Infection

Recruiting
N/A
500
Canada
ARBs and/or ACE inhibitors, Usual Care
University of British Columbia, Canadian Institutes of Health Research (CIHR), British Columbia Centre for Disease Control, McGill University Health Centre/Research Institute of the McGill University Health Centre, University of Toronto, University of Ottawa, University of Calgary, University of Alberta, University of Victoria, Wuhan University, Peking Union Medical College, University of Pennsylvania
COVID-19, SARS-CoV2
06/21
06/22
Papaioannou, Alexandra
NCT05202522: Virtual GERAS DANCE Feasibility RCT

Active, not recruiting
N/A
46
Canada
Virtual GERAS DANCE
McMaster University
Aging
06/22
06/22
Fit-Joints, NCT02885337: Getting Fit for Hip or Knee Replacement

Completed
N/A
41
Canada
Multi-Modal Frailty Intervention, Usual Care
McMaster University, Hamilton Health Sciences Corporation
Hip Osteoarthritis, Knee Osteoarthritis
12/22
12/22
iCARE, NCT05445336: The Study: Education Modules for Fracture Prevention

Completed
N/A
40
Canada
PREVENT Program
Canadian Institutes of Health Research (CIHR), McMaster University, Hamilton Health Sciences Corporation
Osteoporosis, Frailty, Chronic Conditions, Multiple, Fracture
08/23
08/23
NCT03824106: Frailty Rehabilitation

Recruiting
N/A
324
Canada
Control, Group Exercise, Nutrition and Medication review, Protein Supplement, Vitamin D
McMaster University
Frailty
05/25
10/25
NCT04947722: The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care

Recruiting
N/A
3060
Canada
PREVENT Program
McMaster University
Fracture, Fractures, Hip, Osteoporosis
03/25
03/27
NCT05100966: FitJoints: Getting Fit for Hip and Knee Replacement

Recruiting
N/A
192
Canada
FitJoints Multi-modal Intervention
McMaster University, Hamilton Health Sciences Corporation, St. Joseph's Health Care London, London Health Sciences Centre, Alberta Health services
Hip Osteoarthritis, Knee Osteoarthritis
11/24
11/24
VIVA, NCT06650410: Virtual Intervention for Vertebral frActure: a Pilot, Feasibility Study for a Multicentre Randomized Controlled Trial

Not yet recruiting
N/A
32
Canada
Virtual Intervention for Vertebral Fractures (VIVA)
University of Waterloo, Unity Health, Arthritis Research Centre of Canada, Hamilton Health Sciences Corporation, McGill University Health Centre/Research Institute of the McGill University Health Centre
Osteoporosis, Fractures, Spinal
12/25
12/25
MisterFIt, NCT05927623: Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older Men

Recruiting
N/A
60
Canada
Multifaceted Virtual Fracture Prevention Program, Attention Control
McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR)
Osteoporosis, Osteoporotic Fractures, Osteoporosis, Age-Related, Muscle Loss, Men, Aging
03/26
03/26
Chan, Anthony TC
FiXET, NCT02486666: Pilot Feasibility and Safety of Administering Weight Adjusted Fixed LMWH Dose

Recruiting
3
20
Canada, US
Enoxaparin, Enoxaparin sodium
Hamilton Health Sciences Corporation, IWK Health Centre, Children's Hospital of Philadelphia, Children's Hospital of Eastern Ontario
Venous Thromboembolism
12/22
12/22
NRG-HN001, NCT02135042: Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Active, not recruiting
2/3
685
Canada, US, RoW
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Clinical Observation, Fluorouracil, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-FU, AccuSite, Actino-Hermal, Adrucil, Arumel, Cytosafe, Efudex, Efurix, Fiverocil, Fluoro Uracil, Fluoroplex, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Flurox, Ribofluor, Ro 2-9757, Ro-2-9757, Timazin, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemzar, LY-188011, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Quality-of-Life Assessment, Quality of Life Assessment
NRG Oncology, National Cancer Institute (NCI)
Epstein-Barr Virus Infection, Stage II Nasopharyngeal Carcinoma, Stage III Nasopharyngeal Carcinoma, Stage IVA Nasopharyngeal Carcinoma, Stage IVB Nasopharyngeal Carcinoma
02/26
02/31
PRESent-2, NCT05789524: The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B

Active, not recruiting
2
60
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
02/25
AXEL, NCT04562441: NPC - Study : Axitinib-Avelumab

Completed
2
13
RoW
Axitinib, Avelumab
Chinese University of Hong Kong
Recurrent or Metastatic NPC
10/24
11/24
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease

Recruiting
N/A
3600
Europe, Canada, RoW
Liberal phosphate target, Intensive phosphate target
The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago
Kidney Failure, Chronic, Hyperphosphatemia
12/27
12/28
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Protect-NOW, NCT03695978: Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia a Patients

Recruiting
N/A
200
Europe, Canada, US, RoW
Octapharma
Haemophilia a
06/30
06/30
Booth, Gillian L
T1ME, NCT05756829: Type 1 Diabetes Virtual Self-management Education and Support

Recruiting
N/A
580
Canada
High frequency, low touch virtual health care
Unity Health Toronto
type1diabetes
12/26
03/27
Griesdale, Donald EG
PROTEST, NCT03559114: PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury

Recruiting
3
1100
Canada
Dalteparin, Fragmin, Saline, Sodium Chloride
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Traumatic Brain Injury
12/26
12/27
NCT04291235: The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)

Not yet recruiting
N/A
332
Canada
Airway Management Pathway, Usual Care
Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR)
Acute Brain Injury
01/23
01/23
BALANCE, NCT03005145: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

Completed
N/A
3622
Europe, Canada, US, RoW
7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
Sunnybrook Health Sciences Centre
Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial
05/23
08/23
Hull, Mark A
PLATINUM-CAN, NCT05534165: Tecovirimat in Non-hospitalized Patients With Monkeypox

Recruiting
3
120
Canada
Tecovirimat, TPOXX, Placebo
Marina Klein, McGill University Health Centre/Research Institute of the McGill University Health Centre, University Health Network, Toronto, Unity Health Toronto, University of British Columbia, CIHR Canadian HIV Trials Network
Monkeypox
06/24
03/25
EMT2, NCT03428477 / 2016-000628-24: EPA for Metastasis Trial 2

Active, not recruiting
3
418
Europe
Icosapent Ethyl, Vascepa, Placebo
Mark A Hull, PhD FRCP, Yorkshire Cancer Research, Amarin Pharma Inc.
Liver Metastasis, Colon Cancer
11/25
04/26
MPOCS, NCT06291259: Mpox Prospective Observational Cohort Study

Recruiting
N/A
250
Canada
Unity Health Toronto
Monkeypox
09/24
09/24
NCT04682665: Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases

Completed
N/A
81
Europe
Icosapent Ethyl Oral Capsule, Placebo
University of Leeds, National Cancer Institute (NCI), Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard School of Public Health (HSPH), University of Bradford
Colon Cancer Liver Metastasis
07/24
07/24
Simpson, Robert
NCT05997082: A Mindful Self-compassion Based Intervention for Specialist Rehabilitation Providers

Completed
N/A
26
Canada
Mindfulness Self-Compassion Course
Sunnybrook Health Sciences Centre
Burnout, Professional, Compassion Fatigue, Secondary Traumatic Stress
03/24
05/24
NCT06337903: Self-compassion for People with Multiple Sclerosis: an Exploratory Feasibility Study

Not yet recruiting
N/A
45
Canada
Self-compassion intervention (the Mindful Self-Compassion course)
Robert Simpson
Multiple Sclerosis, Self-Compassion
04/25
04/25
NCT06538597: Online Mindful Self-Compassion Training for Medical Students: an Exploratory Feasibility Study

Not yet recruiting
N/A
45
Canada
Self-compassion intervention (Self-Compassion for Healthcare Communities course)
Robert Simpson
Self-Compassion
08/25
08/25
Elalfy, Mohsen S
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
Freeman, Sloane
SBHC, NCT04534595: Data Collection on the Model Schools Pediatric Health Initiative at 5 Sites: COVID-19 Questionnaire

Completed
N/A
851
Canada
COVID-19
Unity Health Toronto
COVID-19 Experience
11/21
11/21
Chan
NCT06149494: RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Recruiting
2
100
Europe
Vapendavir, Placebo
Altesa Biosciences, Inc., Virtus Respiratory Research
COPD Exacerbation Acute, COPD With Acute Lower Respiratory Infection, Rhinovirus, Virus Diseases, Virus Infection, RNA, Enterovirus, Enterovirus Infections, Rhinovirus Infection, Infection Viral, Respiratory Complication, Respiratory Disease, Respiratory Tract Infections, Respiratory Tract Diseases, Respiratory Viral Infection, Upper Resp Tract Infection, Upper Respiratory Tract Infections, Upper Respiratory Disease, Upper Respiratory Disorder, Upper Respiratory Disease, Acute, Upper Respiratory Infection Viral, Infections, Respiratory, Infections, Copd, Viral Infection, Emphysema or COPD, Lower Respiratory Disease, Lower Respiratory Disorder, Lower Respiratory Tract and Lung Infections, Pulmonary Disease, Pulmonary Disease, Chronic Obstructive, Respiratory Disease Chronic, Lung Diseases, Lung Disease Chronic, Obstructive Pulmonary Disease, Chronic Lower Respiratory Diseases, Chronic Respiratory Disease
12/24
03/25
NCT05288686: Use of Superparamagnetic Iron Oxide (SPIO) in Sentinel Lymph Node Detection for Breast Cancer

Active, not recruiting
N/A
282
RoW
sentinel lymph node biopsy procedure
The University of Hong Kong
Breast Cancer, Sentinel Lymph Node
02/24
06/24
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Terminated
N/A
108
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
11/24
FARA1000, NCT05501873: Real World Data Collection in Subjects Treated with the FARAPULSE Pulsed Field Ablation System

Active, not recruiting
N/A
1173
Europe, RoW
FARAPULSE Pulsed Field Ablation system
Boston Scientific Corporation
Atrial Fibrillation
08/27
08/27
Pavenski, Katerina
FiiRST-2, NCT04534751: Factor In the Initial Resuscitation of Severe Trauma 2 Patients

Recruiting
4
350
Canada
Fibrinogen + PCC, Fibryga + Octaplex, Frozen Plasma
University Health Network, Toronto, Sunnybrook Health Sciences Centre, Octapharma, Canadian Institutes of Health Research (CIHR), Canadian Institute for Military and Veteran Health Research Defense Research & Development Canada
Traumatic Hemorrhage, Coagulopathy, Massive Hemorrhage
12/23
01/24
PLEXSIS, NCT05093075: Therapeutic Plasma Exchange in Septic Shock: a Pilot Study

Recruiting
2
80
NA
Therapeutic Plasma Exchange
University of Manitoba, Canadian Institutes of Health Research (CIHR), Health Sciences Centre Foundation, Manitoba, McMaster University, University of Toronto
Septic Shock
03/26
12/26
NCT05714969 / 2022-001940-36: A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)

Active, not recruiting
2
40
Europe, US, RoW
TAK-755, rADAMTS13, recombinant ADAMTS13, SHP-655, BAX 930
Takeda, Takeda Development Center Americas, Inc.
Thrombotic Thrombocytopenic Purpura (TTP)
03/25
03/25
TADPOL, NCT04267029: Transfusion Associated Dyspnea Profiling

Completed
N/A
151
Canada
TADPOL battery (deep clinicolaboratory profile)
Toronto Transfusion Medicine Collaborative, University Health Network, Toronto, Sunnybrook Health Sciences Centre, MOUNT SINAI HOSPITAL, Unity Health Toronto, Canadian Blood Services
Transfusion Reaction
10/22
12/22
AlbACS-1R, NCT06322537: Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective

Recruiting
N/A
500
Canada
University Health Network, Toronto, Queen's University, Unity Health Toronto, McMaster University, Sunnybrook Health Sciences Centre, London Health Sciences Centre, The Ottawa Hospital, Vancouver General Hospital, Royal Columbian Hospital, Nova Scotia Health Authority
Cardiovascular Surgical Procedures, Albumin
11/25
11/25
Cusimano, Michael
TRACE, NCT05713630: The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma

Not yet recruiting
3
130
Canada
Tranexamic acid (TXA), Cyklokapron, Placebo
Unity Health Toronto, Canadian Institutes of Health Research (CIHR), The Physicians' Services Incorporated Foundation, Ozmosis Research Inc.
Subdural Hematoma
03/26
11/26
PROTEST, NCT03559114: PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury

Recruiting
3
1100
Canada
Dalteparin, Fragmin, Saline, Sodium Chloride
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Traumatic Brain Injury
12/26
12/27
TRACE-2, NCT04898712: Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2

Not yet recruiting
2
90
Canada
Tranexamic Acid 500 MG, Placebo
Unity Health Toronto, The Physicians' Services Incorporated Foundation
Chronic Subdural Hematoma
12/23
12/23
Baxter, Nancy
NCT04296630: Social Media for Colorectal Cancer Screening

Enrolling by invitation
N/A
56000
Canada
Social media message #1, Social media message #2, Social media message #3, Social Media Message #4, Tailored Social Media Message
Unity Health Toronto, Canadian Institutes of Health Research (CIHR)
Colorectal Cancer, Cancer Screening
11/24
12/24
Pinto, Andrew D
CanTreatCOVID, NCT05614349: Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings

Recruiting
3
10000
Canada
Paxlovid, Other
Unity Health Toronto, Health Canada, Canadian Institutes of Health Research (CIHR)
COVID-19
03/26
03/26
IGNITE, NCT02459184: addressInG iNcome securITy in Primary carE

Active, not recruiting
N/A
284
Canada
Income Security Health Promotion
Unity Health Toronto
Poverty, Income, Social Determinants of Health
07/21
01/22
ANTICIPATE, NCT05197608: At-risk and vulNerable Individuals To Infection With COVID-19 and ProActive inTervention With intEgrated Health and Social Care

Recruiting
N/A
180
Canada
System Navigator, Tailored list of resources
Unity Health Toronto, Ontario Ministry of Health and Long Term Care, Ontario Medical Association, Platinum Medical Clinic, Markham Family Health Team, Barrie and Community Family Health Team, University of Toronto Practice Based Research Network
Emotional Distress, Quality of Life, Mental Health
01/24
03/24
SPARK, NCT04461080: Screening for Poverty And Related Social Determinants to Improve Knowledge of and Links to Resources

Not yet recruiting
N/A
110
NA
Community Health Worker
Unity Health Toronto, Memorial University of Newfoundland, Dalhousie University, University of Manitoba, University of Saskatchewan
Poverty
05/25
12/25
AFTERMATH, NCT05823805: Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities

Not yet recruiting
N/A
52
NA
Community Health Worker
Unity Health Toronto
Schizophrenia, Bipolar Disorder
01/25
03/25
Tan, Darrell
VPrEP, NCT05159531: Virtual PrEP: Rendering PrEP Delivery More Efficient

Terminated
4
2
Canada
PrEP, Descovy® 200/25mg (DIN= 02454424), TAF/FTC, tenofovir alafenamide/emtricitabine, mHealth Model of Care, GoFreddie®, Standard of Care, PrEP standard of care
Unity Health Toronto, CIHR Canadian HIV Trials Network, Gilead Sciences
HIV Infections
06/23
06/23
CORIPREV-LR, NCT04321174: COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir

Active, not recruiting
3
123
Canada
Lopinavir/ritonavir, Kaletra, Aluvia
Unity Health Toronto
Coronavirus Infections, Post-exposure Prophylaxis
08/21
03/22
PLATINUM-CAN, NCT05534165: Tecovirimat in Non-hospitalized Patients With Monkeypox

Recruiting
3
120
Canada
Tecovirimat, TPOXX, Placebo
Marina Klein, McGill University Health Centre/Research Institute of the McGill University Health Centre, University Health Network, Toronto, Unity Health Toronto, University of British Columbia, CIHR Canadian HIV Trials Network
Monkeypox
06/24
03/25
CATCO, NCT04330690: Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial

Active, not recruiting
3
2900
Canada
Artesunate, Imatinib, Infliximab, Dexamethasone, LSALT Peptide
Sunnybrook Health Sciences Centre, AbbVie, Apotex Inc., World Health Organization, University of British Columbia, Arch Biopartners Inc.
COVID-19
03/24
05/24
VOLITION, NCT05917509: A Study to Evaluate the Efficacy, Safety, Participant Choice and Preference of an Oral Once-daily Regimen or a Long-acting Injectable Regimen Every Two Months for Treatment of Human Immunodeficiency Virus (HIV-1) in Adults Who Have Not Previously Taken Antiretroviral Therapy

Active, not recruiting
3
171
Europe, Canada, US, RoW
DTG/3TC, Dovato, Cabotegravir (CAB) LA, Vocabria, Rilpivirine (RPV) LA, Rekambys
ViiV Healthcare, GlaxoSmithKline, PPD DEVELOPMENT, LP
HIV Infections
10/25
10/26
NCT03259698: Optimizing the Delivery of HIV nPEP

Recruiting
2
434
Canada
nPEP, Biktarvy, Bictegravir/emtricitabine/tenofovir alafenamide, BIC/FTC/TAF, Text Messaging Support, Nurse-Led nPEP
Unity Health Toronto, Canadian Institutes of Health Research (CIHR), CIHR Canadian HIV Trials Network
HIV Infections
12/22
08/23
MPOCS, NCT06291259: Mpox Prospective Observational Cohort Study

Recruiting
N/A
250
Canada
Unity Health Toronto
Monkeypox
09/24
09/24
LAMP, NCT06353737: Looking for Asymptomatic Mpox in a Population at High Risk

Recruiting
N/A
450
Canada
Unity Health Toronto
Mpox (Monkeypox)
03/26
03/26
NCT06710171: Filling Gaps in the HIV Pre-exposure Prophylaxis Cascade Through Counseling

Not yet recruiting
N/A
200
Canada
Counseling, List of resources
Unity Health Toronto
Pre-Exposure Prophylaxis (PrEP), Counseling, Sexual and Gender Minorities
03/25
03/25
NCT04762134: Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO)

Recruiting
N/A
560
Canada
Doxycycline Hyclate
Jonathan Troy Grennan, Canadian Institutes of Health Research (CIHR)
Bacterial Sexually Transmitted Diseases
12/26
06/27
Mazer, David
EMPA-HEART 2, NCT04461041: Empagliflozin and Cardiac Remodelling in People Without Diabetes

Completed
4
169
Canada, RoW
Empagliflozin, Jardiance, Placebo
Unity Health Toronto, Canadian Medical and Surgical Knowledge Translation Research Group, Boehringer Ingelheim, Applied Health Research Centre
Cardiovascular Diseases, Left Ventricular Hypertrophy
07/22
07/22
NEWTON-CABG, NCT03900026: Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

Recruiting
4
766
Canada, US
Evolocumab, Repatha®, Placebo, Control
Unity Health Toronto, Applied Health Research Centre
Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
12/23
12/23
SEMA-VR, NCT05870462: Semaglutide and Vascular Regeneration

Recruiting
4
100
Canada
Semaglutide Pen Injector, Ozempic, Wegovy
Canadian Medical and Surgical Knowledge Translation Research Group, Unity Health Toronto, Western University, Canada
Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
12/24
12/24
CODEX, NCT04289142: Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Recruiting
4
2400
Canada
Dexmedetomidine Hydrochloride Group, Dexmedetomidine Hydrochloride
Sunnybrook Health Sciences Centre, London Health Sciences Centre, University Health Network, Toronto, McMaster University
Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders, Mental Disorders, Confusion, Neurobehavioral Manifestations, Neurologic Manifestations, Nervous System Diseases, Signs and Symptoms, Dexmedetomidine, Hypnotics and Sedatives, Central Nervous System Depressants, Physiological Effects of Drugs, Analgesics, Non-Narcotic, Analgesics, Molecular Mechanisms of Pharmacological Action
03/26
03/26
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
AKITA, NCT05126303: Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery

Terminated
2
177
Europe, Canada, US, RoW
RMC-035, ROSgard, Placebo
Guard Therapeutics AB
Acute Kidney Injury
04/23
07/23
POINTER, NCT06475274: A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery

Recruiting
2
161
Europe, Canada
RMC-035, Placebo
Guard Therapeutics AB
Kidney Injury Following Open-Chest Cardiac Surgery
10/25
10/25
NCT05879432: LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Recruiting
2
240
Canada, RoW
LSALT Peptide, Metablok, Placebo
Arch Biopartners Inc.
Acute Kidney Injury, Cardiac Surgery
08/25
11/25
TRICS-IV, NCT04754022: Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Recruiting
N/A
1440
Europe, Canada, US, RoW
Restrictive Transfusion Strategy, Liberal transfusion strategy
Unity Health Toronto
Disorder, Heart, Postoperative, Cardiac Surgery
12/25
06/26
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
Santos, Marlene S
MAGNAM, NCT05287191: Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care

Recruiting
3
200
Canada
Magnesium sulfate and then Digoxin, Amiodarone
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Atrial Fibrillation New Onset
10/25
04/26
PROTEST, NCT03559114: PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury

Recruiting
3
1100
Canada
Dalteparin, Fragmin, Saline, Sodium Chloride
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Traumatic Brain Injury
12/26
12/27
FISSH, NCT03677102: Fluids in Septic Shock

Recruiting
2/3
1096
Canada, RoW
higher chloride crystalloid, lower chloride crystalloid
McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR)
Sepsis, Septic Shock
11/25
03/26
COLOBILI, NCT04747782: COVID-19 Longitudinal Biomarkers in Lung Injury

Recruiting
N/A
200
Canada
no interventions performed. Just collecting data, blood samples and post-mortem biopsies.
Dr. Andrew Baker
Covid19, Respiratory Disease, Critical Illness
10/21
12/21
Ladha, Karim
CARES, NCT05722002: Comparing Analgesic Regimen Effectiveness and Safety for Surgery () Trial

Recruiting
4
900
Canada, US
NSAID, Opioid, Acetaminophen
University of Michigan, Patient-Centered Outcomes Research Institute
Surgery, Pain, Postoperative
04/25
10/25
KAPA, NCT04646694: The Ketamine for Acute Postoperative Analgesia () Trial

Completed
3
40
Canada
Ketamine, Ketamine Group, Placebo, Placebo group
University Health Network, Toronto, MOUNT SINAI HOSPITAL
Postoperative Pain
03/23
06/23
PLAN, NCT04874038: Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery

Recruiting
3
1602
Canada, RoW
Lidocaine 20mg/ml, Lidocaine 2%, Placebo, 0.9% sodium chloride solution
University Health Network, Toronto, Canadian Institutes of Health Research (CIHR)
Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic
06/25
06/26
NCT03674671: Ketamine Versus Electroconvulsive Therapy in Depression

Suspended
3
240
Canada
Intravenous Ketamine, Ketalar, Electroconvulsive Therapy, ECT
University of Ottawa, McGill University, Queen's University, University Health Network, Toronto, Ontario Shores Centre for Mental Health Sciences
Depressive Disorder, Major, Bipolar Depression
12/25
12/25
PEACE-PAIN, NCT06731335: Psilocybin for Enhanced Analgesia in Chronic NEuropathic PAIN

Not yet recruiting
2
30
Canada
Psilocybin, Psychotherapy, Active Placebo
Unity Health Toronto
Chronic Neuropathic Pain, Pain Management
08/26
12/26
RECOUP, NCT03675386: Reducing Opioid Use for Chronic Pain Patients Following Surgery

Recruiting
N/A
210
Canada
Interventional Group, Transitional Pain Service Program, Control Intervention
University Health Network, Toronto
Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
05/24
05/24
CLEAN Wound, NCT04548661: Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation

Recruiting
N/A
2500
Canada
Intraoperative incisional wound irrigation with povidone-iodine solution, Intraoperative incisional wound irrigation with saline
Sunnybrook Health Sciences Centre
Surgical Site Infection
08/25
08/25
Thulien, Naomi S
NCT05781503: Transitioning Youth Out of Homelessness 2.0 (TYOH 2.0)

Completed
N/A
40
Canada
Identity Capital Intervention (Coach + Co-designed Leadership Guide), Monthly Rent Subsidies
Unity Health Toronto, Covenant House Toronto, StepStones for Youth, Living Rock Youth Resources, The Resource Association for Teens (RAFT)
Homelessness, Youth
06/24
06/24
Hosseini, Benita
CanTreatCOVID, NCT05614349: Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings

Recruiting
3
10000
Canada
Paxlovid, Other
Unity Health Toronto, Health Canada, Canadian Institutes of Health Research (CIHR)
COVID-19
03/26
03/26
McFarlin, Kellie
CARES, NCT05722002: Comparing Analgesic Regimen Effectiveness and Safety for Surgery () Trial

Recruiting
4
900
Canada, US
NSAID, Opioid, Acetaminophen
University of Michigan, Patient-Centered Outcomes Research Institute
Surgery, Pain, Postoperative
04/25
10/25
EXPEDITE, NCT06560307: Study of Enhanced Programming Stimulation with the Enterra® Therapy System

Recruiting
N/A
50
US
Enterra Therapy System, Gastric electrical stimulation
Enterra Medical, Inc.
Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
10/26
12/26
 

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