| Nickenig, Georg |
| Not yet recruiting | 2 | 204 | Europe | Cyclosporine A, Placebo | University Hospital Heidelberg, German Centre of Cardiovascular Research (DZHK), Coordinating Centre for Clinical Studies (KKS) Heidelberg | Takotsubo Cardiomyopathy | 10/26 | 10/27 | | |
| Completed | N/A | 98 | Europe, US | Tricuspid Valve Repair System | Abbott Medical Devices | Tricuspid Valve Insufficiency | 11/19 | 05/24 | | |
TriBAND, NCT03779490: Transcatheter Repair of Tricuspid Regurgitation With Edwards Cardioband TR System Post Market Study |
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| Active, not recruiting | N/A | 150 | Europe | Transcatheter Tricuspid Valve Repair | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Insufficiency | 09/22 | 12/27 | | |
AcChord, NCT04190602: Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System |
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| Recruiting | N/A | 500 | Europe | NeoChord Artificial Chordae Delivery System, Model DS1000, NeoChord DS1000, DS1000 | NeoChord | Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse, Heart Valve Diseases | 10/22 | 12/27 | | |
AHEAD, NCT03339115: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System |
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| Recruiting | N/A | 30 | Europe | Cardiovalve Transfemoral Mitral Valve | Cardiovalve Ltd., Meditrial Europe Ltd., Meditrial SrL | Mitral Regurgitation, Mitral Valve Disease | 12/24 | 12/29 | | |
TriCLASP, NCT04614402: Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System |
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| Active, not recruiting | N/A | 300 | Europe | Edwards PASCAL Transcatheter Valve Repair System, Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Tricuspid Valve Insufficiency | 04/23 | 03/28 | | |
| Recruiting | N/A | 1000 | Europe | Edwards PASCAL Transcatheter Valve Repair System and Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Mitral Regurgitation, Mitral Insufficiency | 12/25 | 03/31 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Active, not recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
| Recruiting | N/A | 800 | Europe, Canada, US, RoW | | Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux | Mitral Regurgitation | 03/25 | 12/30 | | |
| Active, not recruiting | N/A | 200 | Europe, RoW | Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI) | Abbott Medical Devices | Mitral Valve Regurgitation | 05/25 | 05/29 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Recruiting | N/A | 360 | Europe | Transcatheter tricuspid valve treatment (TTVT) | LMU Klinikum, Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig | Heart Failure Attributable to Severe Tricuspid Regurgitation | 03/26 | 03/27 | | |
NCT05851209: Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans |
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| Not yet recruiting | N/A | 938 | Europe | | Heinrich-Heine University, Duesseldorf, German Research Foundation, University Bonn, University Cologne, Collaborative Research Center | Aortic Stenosis, Imaging, Pathogenesis, Disease Progression, Aortic Valve Calcification, Genetics | 07/26 | 07/31 | | |
| Recruiting | N/A | 100 | Europe | Cardiovalve TR valve replacement System | Cardiovalve Ltd. | Tricuspid Regurgitation | 08/26 | 12/26 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Linke, Axel |
EPIDAURUS, NCT04981041: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI |
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| Recruiting | 4 | 2334 | Europe | Prasugrel or Ticagrelor, Clopidogrel | Ludwig-Maximilians - University of Munich | Acute Coronary Syndrome, Atrial Fibrillation | 12/24 | 06/25 | | |
NCT05491200 / 2021-005499-20: Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients |
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| Recruiting | 4 | 1608 | Europe, RoW | Prasugrel based short DAPT, Prasugrel based standard DAPT, OCT guided revascularization, Angio guided revascularization | Research Maatschap Cardiologen Rotterdam Zuid, Abbott Medical Devices | ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy | 08/26 | 08/28 | | |
| Completed | N/A | 360 | Europe | Conventional circulatory support, Conventional circulatory support will be employed according to enrolling sites usual management., Impella CP, Impella CP, Abiomed | Odense University Hospital, Aarhus University Hospital Skejby, Hannover Medical School, University Hospital, Bonn, Jena University Hospital, University Hospital Dresden, Heinrich-Heine University, Duesseldorf, Universitätsklinikum Hamburg-Eppendorf, Charite University, Berlin, Germany, Royal Brompton & Harefield NHS Foundation Trust, Wuerzburg University Hospital, Rigshospitalet, Denmark | Cardiogenic Shock Acute, Acute Myocardial Infarction | 07/23 | 04/24 | | |
| Recruiting | N/A | 500 | Europe | IASD Implant | Corvia Medical | Heart Failure | 07/26 | 07/28 | | |
MITAVI, NCT04009434: Treatment of Concomitant Mitral Regurgitation by Mitral Valve Clipping in Patients With Successful Transcatheter Aortic Valve Implantation. |
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| Recruiting | N/A | 1162 | Europe | Mitral Valve Clipping, TAVI | Technische Universität Dresden, KKS Dresden, Zentrum für Klinische Studien Leipzig, University Medical Center Mainz | Aortic Stenosis, Mitral Regurgitation | 08/23 | 08/23 | | |
NCT02710435: REDUCER-I: An Observational Study of the Neovasc Reducer™ System |
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| Active, not recruiting | N/A | 400 | Europe | Reducer System, Reducer | Neovasc Inc., Shockwave Medical, Inc. | Angina Pectoris, Angina Pectoris, Stable, Chronic Stable Angina | 11/23 | 12/28 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 768 | Europe, RoW | Myval THV Series, Myval/Myval Inception THVs or any subsequent advanced version commercially available at the study site., Contemporary Valves (Sapien THV Series and Evolut THV Series), Sapien THV Series (Sapien 3/Sapien 3 Ultra THVs) and Evolut THV Series (Evolut R/Evolut PRO THVs ) or any subsequent advanced version commercially available at the study site. | Meril Life Sciences Pvt. Ltd. | Aortic Valve Stenosis | 03/24 | 12/33 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Active, not recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
| Active, not recruiting | N/A | 3326 | Europe, RoW | SELUTION SLR, DES | M.A. Med Alliance S.A. | Coronary Artery Disease | 08/25 | 07/30 | | |
PiCSO-AMI-IV, NCT04566289: Observational Registry to Evaluate Real World Usage of PiCSO Impulse System in STEMI Patients as Part of Post-marketing Surveillance |
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| Withdrawn | N/A | 444 | Europe | PiCSO, PCI | Miracor Medical SA | STEMI - ST Elevation Myocardial Infarction, Anterior MI | 12/24 | 12/27 | | |
| Recruiting | N/A | 1500 | Europe | Fantom | REVA Medical, Inc. | Coronary Artery Disease | 05/25 | 05/25 | | |
| Recruiting | N/A | 590 | Europe, RoW | Navitor Transcatheter Aortic Valve and FlexNav Delivery System | Abbott Medical Devices | Symptomatic Severe Aortic Stenosis | 06/25 | 02/36 | | |
| Recruiting | N/A | 50 | Europe, Canada, RoW | MobiusHD | Vascular Dynamics, Inc. | Heart Failure With Reduced Ejection Fraction | 12/25 | 06/26 | | |
DEBATE, NCT04814212: Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI |
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| Recruiting | N/A | 546 | Europe | Percutaneous coronary intervention using drug-coated balloon, DCB, Percutaneous coronary intervention using drug-eluting stent, DES | North Karelia Central Hospital, Central Hospital of Lapland, Kuopio University Hospital, Central Finland Hospital District, Helsinki University Central Hospital, Turku University Hospital, Oulu University Hospital, Tampere University Hospital, Satakunta Central Hospital, Päijät Häme Central Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Centre Hospitalier de La Rochelle, Hospital Universitario de Cabuenes, University Hospital Carl Gustav Carus, University Hospital, Saarland | Coronary Artery Disease | 01/26 | 01/28 | | |
RIP-HIGH, NCT04844931: Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction |
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| Active, not recruiting | N/A | 250 | Europe | RIC + PostC + Standard PCI, Standard PCI | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | ST Elevation Myocardial Infarction | 12/25 | 07/30 | | |
| Recruiting | N/A | 3390 | Europe | Culprit-lesion revascularization, Culprit-lesion PCI, Non-culprit-lesion revascularization, multivessel PCI | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, German Federal Ministry of Education and Research, IHF GmbH - Institut für Herzinfarktforschung, Stiftung IHF - Institut für Herzinfarktforschung | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | 01/27 | 07/27 | | |
| Grygier, Marek |
| Recruiting | 4 | 2500 | Europe, RoW | Pressure Microcatheter guided strategy - PIOS MC, Pressure Wire guided strategy - PIOS - PW, Pressure Microcatheter guided strategy - Standard of care, Pressure Wire guided strategy - Standard of care | CoreAalst BV, Insight Lifetech Co., Ltd. | Coronary Artery Disease, Acute Coronary Syndrome | 06/26 | 06/30 | | |
| Completed | N/A | 64 | Europe | cerebral embolic protection during TAVR | Protembis GmbH, MAXIS Medical, LLC | Valvular Heart Disease | 11/22 | 11/22 | | |
NCT03361046: Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry |
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| Recruiting | N/A | 150 | Europe | Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI), Transcatheter Aortic Valve-in-Valve Replacement (ViV-TAVR) | Medical University of Warsaw | Aortic Valve Stenosis, Aortic Valve Insufficiency, Ventricular Outflow Obstruction, Left | 12/23 | 05/24 | | |
| Recruiting | N/A | 200 | Europe | Transcatheter Aortic Valve Implantation (TAVI), Transcatheter Aortic Valve Replacement (TAVR) | Medical University of Warsaw | Aortic Valve Stenosis, Ventricular Outflow Obstruction, Left | 12/23 | 05/24 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Recruiting | N/A | 240 | Europe | LAAC procedure with the use of transcatheter cerebral protection system, LAAC procedure without the use of transcatheter cerebral protection system | Silesian Centre for Heart Diseases, Leszek Giec Upper-Silesian Medical Centre, Medical University of Silesia, Biostat Sp. z o.o. | Atrial Fibrillation, Silent Stroke, Cognitive Impairment, Depression | 12/25 | 09/26 | | |
| Przepiora, Agnieszka |
| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | Ralinepag, APD811, Placebo | United Therapeutics | PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease | 12/25 | 12/25 | | |
