| Wojakowski, Wojciech |
| Not yet recruiting | 4 | 350 | Europe | Levosimendan, Placebo | Medical University of Bialystok, Medical Research Agency, University of Opole, Medical Universtity of Lodz, Poznan University of Medical Sciences, Nicolaus Copernicus University, Institute of Cardiology, Warsaw, Poland, John Paul II Hospital, Krakow, Azienda Ospedaliera dei Colli | Heart Failure New York Heart Association Class III, Heart Failure New York Heart Association Class IV, Heart Failure, Systolic, Heart Failure With Reduced Ejection Fraction | 06/24 | 12/24 | | |
NCT04777513: Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive Cardiolens FFR-CT Pro Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities. |
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| Completed | N/A | 450 | Europe | CCTA (Coronary Computed Tomography Angiography), ICA (Invasive Coronary Angiography), FFR (Fractional Flow Reserve), CNBP measurement, Cardiolens FFR-CT Pro | Hemolens Diagnostics Sp. z o.o., GENELYTICA Sp. z o.o. | Stable Ischemic Heart Disease, Coronary Artery Disease | 09/22 | 05/23 | | |
SMART-VT, NCT04642963: Stereotactic Management of Arrhythmia - Radiosurgery in Treatment of Ventricular Tachycardia |
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| Completed | N/A | 11 | Europe | Cardiac Radiosurgery, Stereotactic Arrhythmia Radioablation (STAR) | Maria Sklodowska-Curie National Research Institute of Oncology | Ventricular Tachycardia | 01/23 | 01/23 | | |
HighFLO, NCT04888247: Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve |
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| Recruiting | N/A | 30 | Europe, RoW | CLARITY | HighLife SAS | Mitral Regurgitation | 12/24 | 02/30 | | |
NCT03361046: Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry |
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| Recruiting | N/A | 150 | Europe | Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI), Transcatheter Aortic Valve-in-Valve Replacement (ViV-TAVR) | Medical University of Warsaw | Aortic Valve Stenosis, Aortic Valve Insufficiency, Ventricular Outflow Obstruction, Left | 12/23 | 05/24 | | |
| Recruiting | N/A | 200 | Europe | Transcatheter Aortic Valve Implantation (TAVI), Transcatheter Aortic Valve Replacement (TAVR) | Medical University of Warsaw | Aortic Valve Stenosis, Ventricular Outflow Obstruction, Left | 12/23 | 05/24 | | |
| Recruiting | N/A | 768 | Europe, RoW | Myval THV Series, Myval/Myval Inception THVs or any subsequent advanced version commercially available at the study site., Contemporary Valves (Sapien THV Series and Evolut THV Series), Sapien THV Series (Sapien 3/Sapien 3 Ultra THVs) and Evolut THV Series (Evolut R/Evolut PRO THVs ) or any subsequent advanced version commercially available at the study site. | Meril Life Sciences Pvt. Ltd. | Aortic Valve Stenosis | 03/24 | 12/33 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/24 | 06/29 | | |
Reshape-HF2, NCT02444338: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation |
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| Completed | N/A | 506 | Europe, RoW | MitraClip, standard of care | University Medical Center Goettingen, University Medical Center Goettingen | Mitral Valve Insufficiency | 04/24 | 04/24 | | |
MILESTONE, NCT01311323: Revascularization Strategies in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) and Severe Coronary Artery Disease |
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| Not yet recruiting | N/A | 1000 | Europe | PCI, •Percutaneous coronary intervention, •Multivessel coronary disease, •Left main narrowing, CABG, Multivessel coronary artery disease, Coronary artery bypass graft, Left Main narrowing | American Heart of Poland, Andrzej Frycz Modrzewski Kraków University, Kraków, Poland, Upper Silesian Heart Center of Medical University of Silesia, Katowice, Poland, Silesian Centre for Heart Diseases, Clinical University Hospital, Białystok, Poland | Multivessel Coronary Artery Disease, Acute Coronary Syndrome | 01/25 | 06/25 | | |
EMPIRE-II, NCT05804903: Investigation of the NVT ALLEGRA Plus THV System in Patients With Severe Aortic Stenosis or Failed Surgical Aortic Bioprosthesis |
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| Recruiting | N/A | 177 | Europe | (ALLEGRA Plus Transcatheter Heart Valve) TAVI in severe calcified aortic stenosis or in failed surgical aortic bioprosthesis | NVT GmbH | Transcatheter Aortic Valve Implantation | 03/25 | 12/29 | | |
| Recruiting | N/A | 240 | Europe | LAAC procedure with the use of transcatheter cerebral protection system, LAAC procedure without the use of transcatheter cerebral protection system | Silesian Centre for Heart Diseases, Leszek Giec Upper-Silesian Medical Centre, Medical University of Silesia, Biostat Sp. z o.o. | Atrial Fibrillation, Silent Stroke, Cognitive Impairment, Depression | 12/25 | 09/26 | | |
SMARTER-VT, NCT05913375: Stereotactic Management of Arrhythmia - Radiosurgery Treatment and Evaluation of Response in Ventricular Tachycardia |
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| Recruiting | N/A | 20 | Europe | Stereotactic Body Radiotherapy, Stereotactic Arrhythmia Radioablation, Cardiac Radiosurgery | Maria Sklodowska-Curie National Research Institute of Oncology, Leszek Giec Upper Silesian Medical Center of the Medical University of Silesia in Katowice, Poland | Ventricular Tachycardia | 05/26 | 05/26 | | |
NCT05427370: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C) |
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| Recruiting | N/A | 754 | Europe, Canada, US, RoW | Revascularization by PCI, Revascularization by CABG | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR), Weill Medical College of Cornell University | Coronary Artery Disease, Heart Failure Systolic | 04/29 | 12/29 | | |
NCT05625607: Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) Registry |
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| Recruiting | N/A | 100 | Europe | Transcatheter mitral valve-in-valve implantation | Medical University of Warsaw, Institute of Cardiology, Warsaw, Poland, Medical University of Bialystok, University of Opole, Medical University of Gdańsk, Medical University of Silesia, Medical University of Lodz | Mitral Insufficiency, Mitral Stenosis, Mitral Stenosis With Insufficiency, Heart Failure, Bioprosthesis Failure | 12/25 | 05/26 | | |
| Nickenig, Georg |
| Not yet recruiting | 2 | 204 | Europe | Cyclosporine A, Placebo | University Hospital Heidelberg, German Centre of Cardiovascular Research (DZHK), Coordinating Centre for Clinical Studies (KKS) Heidelberg | Takotsubo Cardiomyopathy | 10/26 | 10/27 | | |
| Active, not recruiting | N/A | 85 | Europe, US | Tricuspid Valve Repair System | Abbott Medical Devices | Tricuspid Valve Insufficiency | 11/19 | 06/24 | | |
TriBAND, NCT03779490: Transcatheter Repair of Tricuspid Regurgitation With Edwards Cardioband TR System Post Market Study |
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| Active, not recruiting | N/A | 150 | Europe | Transcatheter Tricuspid Valve Repair | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Insufficiency | 09/22 | 12/27 | | |
AcChord, NCT04190602: Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System |
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| Recruiting | N/A | 500 | Europe | NeoChord Artificial Chordae Delivery System, Model DS1000, NeoChord DS1000, DS1000 | NeoChord | Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse, Heart Valve Diseases | 10/22 | 12/27 | | |
AHEAD, NCT03339115: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System |
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| Recruiting | N/A | 30 | Europe | Cardiovalve Transfemoral Mitral Valve | Cardiovalve Ltd., Meditrial Europe Ltd., Meditrial SrL | Mitral Regurgitation, Mitral Valve Disease | 12/24 | 12/29 | | |
TriCLASP, NCT04614402: Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System |
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| Active, not recruiting | N/A | 300 | Europe | Edwards PASCAL Transcatheter Valve Repair System, Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Tricuspid Valve Insufficiency | 04/23 | 03/28 | | |
| Recruiting | N/A | 1000 | Europe | Edwards PASCAL Transcatheter Valve Repair System and Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Mitral Regurgitation, Mitral Insufficiency | 02/25 | 04/30 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/24 | 06/29 | | |
| Recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
| Recruiting | N/A | 800 | Europe, Canada, US, RoW | | Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux | Mitral Regurgitation | 03/25 | 12/30 | | |
| Active, not recruiting | N/A | 200 | Europe, RoW | Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI) | Abbott Medical Devices | Mitral Valve Regurgitation | 05/25 | 05/29 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Recruiting | N/A | 360 | Europe | Transcatheter tricuspid valve treatment (TTVT) | LMU Klinikum, Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig | Heart Failure Attributable to Severe Tricuspid Regurgitation | 03/26 | 03/27 | | |
NCT05851209: Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans |
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| Not yet recruiting | N/A | 938 | Europe | | Heinrich-Heine University, Duesseldorf, German Research Foundation, University Bonn, University Cologne, Collaborative Research Center | Aortic Stenosis, Imaging, Pathogenesis, Disease Progression, Aortic Valve Calcification, Genetics | 07/26 | 07/31 | | |
| Recruiting | N/A | 100 | Europe | Cardiovalve TR valve replacement System | Cardiovalve Ltd. | Tricuspid Regurgitation | 08/26 | 12/26 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
