University of Siena
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 18 Trials 
44 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Dotta, Francesco
ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting
3
2749
Europe, US, RoW
Orforglipron, LY3502970, Insulin Glargine
Eli Lilly and Company
Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
09/25
01/26
Coordinator, Research
CAMPLIFE, NCT06562296: Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers

Recruiting
4
292
US
Amnion-Intermediate-Chorion, AIC, Amnion-Chorion-Amnion, ACA, Standard of Care, SOC
Cellution Biologics, SerenaGroup, Inc., LifeCell
Diabetic Foot Ulcer, Venous Leg Ulcer
12/26
07/27
NCT05078827: Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis

Completed
3
458
US
Test Product (A): Fluorouracil Cream, 5% topical cream, Experimental, Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A., Active Comparator, Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India, Placebo Comparator
Encube Ethicals Pvt. Ltd., CBCC Global Research
Actinic Keratoses
11/22
12/22
ReMMi-D, NCT05853900: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine

Completed
3
558
US
ReMMi-D Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
05/24
OPERA-T, NCT05238116 / 2021-004554-32: Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis ( Study)

Recruiting
3
123
Europe, Canada, US, RoW
PC945, Placebo
Pulmocide Ltd
Refractory IPA
03/26
04/26
NCT06004388: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)

Completed
3
110
US
Click Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
06/24
CONVOKE, NCT05838625: Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia

Recruiting
3
432
US
Digital Therapeutic
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
06/25
07/25
NCT06067984: An Extension Study of a Second Course of a Digital Therapeutic for the Treatment of Experiential Negative Symptoms of Schizophrenia

Active, not recruiting
3
75
US
Study App
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia, Negative Symptoms in Schizophrenia
04/25
05/25
NCT06365437: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Completed
2
33
Europe
TCD601, Siplizumab, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
12/24
12/24
PHYOX8, NCT05001269 / 2021-001083-16: Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function

Recruiting
2
25
Europe, Canada, Japan, US, RoW
nedosiran, DCR-PHXC
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Primary Hyperoxaluria, Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3
12/24
12/24
CHASE, NCT05727878: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED

Recruiting
2
90
US, RoW
KPI-012, KPI-012 Vehicle
Combangio, Inc, Kala Pharmaceuticals, Inc.
Persistent Corneal Epithelial Defect
03/25
10/25
NCT05733546: A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder

Recruiting
2
102
US
Psilocybin, COMP360
COMPASS Pathways
Major Depressive Disorder
10/24
11/24
NCT04270175: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

Recruiting
2
21
US
Daratumumab SC, Faspro, Pomalidomide, Dexamethasone
Weill Medical College of Cornell University, Janssen Scientific Affairs, LLC
Amyloid, AL Amyloidosis, Refractory AL Amyloidosis
12/25
12/29
NCT04803058: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE)

Recruiting
2
18
US, RoW
TCD601
ITB-Med LLC
Kidney Transplantation
03/27
03/30
STRIDE, NCT06025110: A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients

Active, not recruiting
2
96
Europe
TCD601, Placebo
ITB-Med LLC
Diabetes Mellitus, Type 1
01/25
01/25
ASCEND, NCT05669001: A Study of TCD601 in de Novo Renal Transplant Recipients

Recruiting
2
90
US
TCD601, siplizumab, belatacept, ATG, antithymocyte globulin, TAC, tacrolimus, MPA, mycophenolic acid, Corticosteroids
ITB-Med LLC
Renal Transplantation
07/25
10/26
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation

Completed
2
13
US
TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
10/23
10/23
NCT04464980: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Recruiting
2
2190
US
SL-BUP, sublingual buprenorphine, Suboxone, XR-BUP, extended-release buprenorphine, CAM2038, Brixadi, XR-NTX, extended-release naltrexone, Vivitrol, MM, MMR, MMD
NYU Langone Health, New York State Psychiatric Institute, Columbia University, Harvard Medical School (HMS and HSDM), Mclean Hospital, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC
Opioid Use Disorder (OUD)
07/26
12/26
NCT04803006: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)

Recruiting
2
18
US
TCD601
ITB-Med LLC
Kidney Transplantation
07/27
07/30
AURORA, NCT06453668: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

Active, not recruiting
1
48
Europe
TCD601, siplizumab
ITB-Med LLC
ALS
11/26
11/26
PBL-0405-01, NCT06273852: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Recruiting
1
15
US
PBA-0405, PB004.22.0405.aF
Pure Biologics S.A., Presage Biosciences
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
03/25
03/25
MST01-AZN-05, NCT06366451: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475
Presage Biosciences, AstraZeneca
Head and Neck Squamous Cell Carcinoma
12/24
03/25
OP-1250-003, NCT05508906: Phase 1b Combo w/ Ribociclib, Alpelisib, or Everolimus

Recruiting
1
155
US, RoW
OP-1250, Ribociclib, KISQALI®, Alpelisib, PIQRAY®, Everolimus
Olema Pharmaceuticals, Inc., Novartis
Metastatic Breast Cancer, Advanced Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer
05/26
06/26
NCT06798454: Single Ascending Dose Study to Evaluate Safety Tolerability, Pharmacokinetics, and Pharmacodynamics of PVT201 in Healthy Subjects and Patients (PBC/PSC)

Recruiting
1
30
RoW
PVT201, Navacim, Placebo, normal saline, 0.9% NaCl
Parvus Therapeutics, Inc., Avance Clinical Pty Ltd.
Primary Biliary Cholangitis (PBC)
02/25
02/25
NCT04541108: Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475
Presage Biosciences, Merck Sharp & Dohme LLC
Solid Tumor
12/31
12/31
NCT06802328: Treatment Protocol: Intermediate-Size Patient Population Expanded Access

Available
N/A
US
Foralumab TZLS-401 50 µg
Tiziana Life Sciences LTD
Non-Active Secondary Progressive Multiple Sclerosis
 
 
NCT06136936: A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia

Completed
N/A
53
US
CT-156-C-001
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
01/24
02/24
NCT05222581: Engineering Evaluation of a Breast Pump Device

Recruiting
N/A
20
US
Prototypes of breast shield and Freedom Double Electric Breast Pump
Momtech Inc.
Healthy, Breast Pumping
09/24
11/24
NCT06136923: An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer

Completed
N/A
194
US
CT-100-D-004-A, CT-100-D-004-B
Click Therapeutics, Inc.
Multiple Sclerosis, Lung Cancer, Breast Cancer
04/24
05/24
LOCAL, NCT04968847: FemaSeed Artificial Insemination Trial

Completed
N/A
314
US
FemaSeed Localized Directional Insemination
Femasys Inc.
Infertility, Male Factor
12/23
04/24
CT-100-D-003, NCT06275659: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis

Active, not recruiting
N/A
120
US
CT-100-004-A, CT-100-004-B
Click Therapeutics, Inc.
Psoriasis, Atopic Dermatitis
02/24
03/24
NCT05119842: APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

Recruiting
N/A
30
Europe, US
APrevent® VOIS-Implant
APrevent Biotech GmbH
Paralysis, Unilateral, Vocal Cord
09/25
09/26
Lublin, NCT06217081: 3M™ Topical Tissue Adhesive Versus Commercially Available Tissue Adhesive for the Closure of Lacerations and Incisions

Recruiting
N/A
452
US
3M Topical Tissue Adhesive, Histoacryl® Blue Topical Skin Adhesive
Solventum US LLC, United States Department of Defense, The University of Texas Health Science Center at San Antonio, 3M
Trauma-related Wound, Surgical Incision, Surgical Wound, Laceration
11/25
12/25
CoMind EFS, NCT06368648: CoMind Early Feasibility Study

Recruiting
N/A
581
US
CoMind Technologies Limited, Lindus Health
Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage, Encephalitis, Encephalopathy, Hydrocephalus, Stroke, Autoregulation
10/25
10/25
NCT05006404: Autus Valve Pivotal Study

Recruiting
N/A
50
US
Pulmonary Valve Replacement Surgery
Autus Valve Technologies, Inc.
Congenital Heart Disease
08/26
02/36
MASTR, NCT05243966: Myriad™ Augmented Soft Tissue Reconstruction Registry

Recruiting
N/A
800
US
Myriad Matrix™ and Myriad Morcells™
Aroa Biosurgery Limited
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
01/28
01/29
NCT06770998: A Study of a Novel EEG Neurofeedback System for PTSD Treatment

Not yet recruiting
N/A
250
US
EEG-neurofeedback training, Prism training, amyg-EFP training, active Prism training, Sham training, sham Prism training
Foundation for Atlanta Veterans Education and Research, Inc., GrayMatters Health Ltd., Rochester Institute of Technology, New York University Grossman School of Medicine, Atlanta VA Medical Center, Birmingham VA Health Care System, Ralph H. Johnson VA Medical Center, VA Boston Healthcare System, CTP Inc, BioStats Statistical Consulting Ltd, ShareCRF, United States Department of Defense
Stress Disorders, Post-Traumatic
06/27
08/27
PHONES, NCT04662320: Promoting Healing of Nerves Through Electrical Stimulation

Active, not recruiting
N/A
100
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
12/25
12/25
FINALE, NCT05977751: Prospective Multi-Center Trial for FemBloc Permanent Birth Control

Recruiting
N/A
573
US
FemBloc
Femasys Inc.
Contraception
12/29
06/31
PHINEST, NCT05884125: Promoting Healing of Injured Nerves With Electrical Stimulation Therapy

Recruiting
N/A
60
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Nerve Injury, Peripheral Nerve Injuries, Peripheral Nerve Injury Upper Limb, Nerve Palsy
06/27
06/27
NCT05678530: Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)

Recruiting
N/A
400
Canada, US
Prolaio
Cardiopulmonary
06/25
06/25
Donato, Gianmarco de
NCT06758921: Prospective, Multicenter, Single-Arm Observational Study to Confirm the Safety and Clinical Performance of the Oscar Peripheral Multifunctional Catheter for the Dilatation of Lesions in the Femoral, Popliteal and Infrapopliteal Arteries (BIO-OSCAR First)

Recruiting
N/A
200
Europe
Oscar Peripheral Multifunctional Catheter
Biotronik AG
Peripheral Arterial Disease, Peripheral Arterial Disease(PAD)
12/25
01/26
Pulli, Raffaele
TiGER, NCT04246463: Terumo Aortic Global Endovascular Registry

Recruiting
N/A
1000
Europe, US
Thoracic, Abdominal, Custom Device, Illiac Artery
Vascutek Ltd., Bolton Medical
Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
11/29
11/30
Castagna, Maria Grazia
LIBRETTO-531, NCT04211337 / 2019-001978-28: A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

Active, not recruiting
3
291
Europe, Canada, Japan, US, RoW
Selpercatinib, LY3527723, LOXO-292, Cabozantinib, Vandetanib
Loxo Oncology, Inc., Eli Lilly and Company
Medullary Thyroid Cancer
05/23
02/26
Ercolini, Leonardo
No trials found
Ulivelli, Monica
No trials found
Mari, Francesca
No trials found
Renieri, Alessandra
No trials found
Michelagnoli, Stefano
No trials found
Cameli, Matteo
No trials found
Pasqui, Edoardo
No trials found
Listro, Francesco
No trials found
Filippi, Federico
No trials found
Pieraccini, Massimo
No trials found
Credi, Giovanni
No trials found
Auci, Alessio
No trials found
Invernizzi, Claudio
No trials found
Arpesani, Roberto
No trials found
Berchiolli, Raffaella
No trials found
Lorenzoni, Roberto
No trials found
Frosini, Pierfrancesco
No trials found
Palasciano, Giancarlo
No trials found
Meloni, Ilaria
No trials found
Grandini, Simone
No trials found

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