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| Recruiting | 4 | 1000 | Europe | Oxygen | University of Modena and Reggio Emilia | Critical Illness, Respiration, Artificial, Hyperoxia, Hyperoxemia | 12/22 | 03/23 | | |
STAUNCH-19, NCT04528888: Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection |
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| Recruiting | 3 | 210 | Europe | Enoxaparin, Inhixa, Methylprednisolone, solu-medrol, unfractionated heparin, Veracer | Massimo Girardis | Covid19, SARS-CoV Infection, Pneumonia, Viral, Coagulopathy | 06/21 | 07/21 | | |
| Recruiting | 3 | 1252 | Europe | Albumin, Balanced, Ringer Lactate, Ringer Acetate, Crystalsol | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Istituto Di Ricerche Farmacologiche Mario Negri | Septic Shock | 12/21 | 02/22 | | |
IgM-FAT, NCT04182737: Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock. |
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| Recruiting | 3 | 356 | Europe | IgM-enriched polyclonal immunoglobulins titer-based treatment, Pentaglobin®, IgM-enriched polyclonal immunoglobulins, IgM-enriched polyclonal immunoglobulins Flat treatment | Massimo Girardis | Shock, Septic, Sepsis, Hypoglobulinemia | 02/22 | 03/22 | | |
NCT05403320: Cuff Pressure Control and Evacuation of Subglottic Secretions To Prevent Pneumonia |
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| Completed | N/A | 270 | Europe, RoW | Continuous cuff pressure regulation, Intermittent cuff pressure regulation, Automatic subglottic secretion drainage, Manual subglottic secretion drainage, Tracheobronchial colonization assessment, Microaspiration assessment, VAP assessment | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of the Sacred Heart | Respiratory Failure | 01/24 | 04/24 | | |
HISTAP, NCT05637606: HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery |
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| Recruiting | N/A | 636 | Europe | Ephedrine, Ephedrine bolus, Norepinephrine, norepinephrine infusion, Etilefrine Hydrochloride bolus, Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC), Hemodynamic optimization | Humanitas Clinical and Research Center, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva | Blood Pressure, Complication,Postoperative, Intraoperative Hypotension | 02/25 | 03/25 | | |
| Recruiting | N/A | 126 | Europe | Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture, Blood sample standard culture | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of the Sacred Heart | HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia | 04/25 | 04/25 | | |
