| Pili, Roberto |
| Recruiting | 3 | 738 | Europe, US, RoW | Docetaxel 75 mg/m2, Docetaxel 60 mg/m2, Radium-223 | Memorial Sloan Kettering Cancer Center, Bayer | Prostate Cancer | 06/26 | 06/26 | | |
NCT03552380: Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell Carcinoma |
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| Terminated | 2 | 12 | US | Entinostat, MS-275, SND-275, Nivolumab, Opdivo, Ipilimumab, Yervoy | Roberto Pili, Bristol-Myers Squibb, Syndax Pharmaceuticals, Indiana University School of Medicine | Renal Cell Carcinoma | 06/22 | 02/24 | | |
| Active, not recruiting | 2 | 46 | US | Entinostat, Interleukin-2, aldesleukin | Roberto Pili, Indiana University Melvin and Bren Simon Cancer Center, Syndax Pharmaceuticals, Clinigen, Inc. | Renal Cell Carcinoma | 01/23 | 04/24 | | |
BRCAAway, NCT03012321: Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects |
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| Active, not recruiting | 2 | 70 | US | Olaparib, Lynparza, Abiraterone Acetate, Prednisone | Northwestern University, AstraZeneca, National Cancer Institute (NCI) | Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer | 12/26 | 01/27 | | |
ADAPT-BLADDER, NCT03317158: Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder |
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| Recruiting | 1/2 | 55 | US | Durvalumab (Cohort 1-3), Imfinzi, External Beam Radiotherapy (EBRT), Bacillus Calmette-Guérin (BCG), Gemcitabine, Gemzar, Docetaxel, Taxotere, Tremelimumab, Durvalumab (Cohort 4/5), To be determined | Noah Hahn, M.D., AstraZeneca, Hoosier Cancer Research Network | Urothelial Carcinoma, Bladder Cancer | 12/25 | 12/26 | | |
| Lyden, Sean |
| Active, not recruiting | N/A | 220 | Europe, US | PQ Bypass System | PQ Bypass, Inc. | Peripheral Arterial Disease | 12/21 | 11/23 | | |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
| Active, not recruiting | N/A | 9 | US, RoW | Esprit BTK Device | Abbott Medical Devices | Critical Limb Ischemia (CLI) | 04/23 | 02/28 | | |
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Approved for marketing | N/A | | US | GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aneurysm | | | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) |
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| Active, not recruiting | N/A | 150 | Japan, US | GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure | W.L.Gore & Associates | Aortic Aneurysm, Thoracic, Aorta, Lesion | 03/24 | 03/28 | | |
| Recruiting | N/A | 500 | US | Pounce Thrombectomy System, Mechanical thrombectomy | SurModics, Inc. | Peripheral Arterial Disease, Acute Limb Ischemia | 05/25 | 07/25 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
| Active, not recruiting | N/A | 111 | Europe, US, RoW | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 01/25 | 01/29 | | |
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study |
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| Active, not recruiting | N/A | 165 | US | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 04/25 | 04/29 | | |
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Active, not recruiting | N/A | 102 | Europe, US | GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aortic Aneurysm | 01/23 | 09/26 | | |
| Recruiting | N/A | 5000 | Europe, Canada, US, RoW | Any eligible commercially available Boston Scientific Corporation (BSC) drug-eluting device. | Boston Scientific Corporation | Peripheral Vascular Diseases | 01/28 | 01/28 | | |
| Recruiting | N/A | 450 | US | Alto Abdominal Stent Graft System, FDA Approved EVAR AAA Graft Systems | Endologix | AAA, AAA - Abdominal Aortic Aneurysm | 12/28 | 12/28 | | |
NCT05409118: JAGUAR Trial (Outside United States; OUS): ObJective Analysis to GaUge EVAR Outcomes Through Randomization |
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| Not yet recruiting | N/A | 450 | NA | Alto Abdominal Stent Graft System, FDA Approved EVAR AAA Graft Systems, Medtronic Endurant, Cook Zenith, Gore Excluder | Endologix | AAA, AAA - Abdominal Aortic Aneurysm | 12/30 | 12/30 | | |
| Izzo, Joseph L |
SUMMIT, NCT04847557: A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The Trial |
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| Completed | 3 | 731 | US, RoW | Tirzepatide, LY3298176, Placebo | Eli Lilly and Company | Obesity, Heart Failure With Preserved Ejection Fraction (HFpEF) | 07/24 | 07/24 | | |
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NCT05968430: Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects with Hypertension |
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| Enrolling by invitation | 3 | 1400 | Europe, Canada, US, RoW | lorundrostat, Placebo | Mineralys Therapeutics Inc. | Hypertension | 12/25 | 12/26 | | |
NCT05769608: A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects with Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen |
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| Active, not recruiting | 2 | 285 | US | Placebo, lorundrostat Dose 1, lorundrostat Dose 2 | Mineralys Therapeutics Inc. | Hypertension | 01/25 | 02/25 | | |
| Flaherty, James |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 750 | Europe, Canada, US, RoW | Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) | Corvia Medical | Heart Failure, Heart Failure, Diastolic | 05/25 | 03/31 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Recruiting | N/A | 100 | Europe, Canada, US | Edwards APTURE transcatheter shunt system, Sham procedure | Edwards Lifesciences | Heart Failure | 01/26 | 07/30 | | |
NCT05907564: Aventus Thrombectomy System Pulmonary Embolism Clinical Study |
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| Recruiting | N/A | 120 | US | Thrombectomy | Inquis Medical, Inc. | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases, Cardiovascular Diseases, Lung Diseases, Respiratory Tract Diseases | 03/25 | 03/25 | | |
| Recruiting | N/A | 3784 | Europe, US, RoW | Coronary and peripheral stents, Pacing catheters, Vascular plugs, Measurement and imaging (FFR and OCT), Peripheral dilatation catheters, Coronary dilatation catheters, Coronary and peripheral guidewires, Vessel closure/compression devices, Vascular access introducers | Abbott Medical Devices | Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism | 11/30 | 11/31 | | |
| Ching, Marilou |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 2 | 300 | US | TS23 | Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona | Ischemic Stroke | 07/27 | 12/27 | | |
| Siddiqui, Adnan |
NCT02657707: Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis |
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| Active, not recruiting | N/A | 295 | US | Roadsaver™ Carotid Artery Stent Device, Nanoparasol® Embolic Protection System | Microvention-Terumo, Inc. | Carotid Artery Stenosis | 04/22 | 05/24 | | |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
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| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
EvaQ, NCT04437862: A Study to Evaluate the Q Revascularization System for Neurointervention in Acute Ischemic Stroke |
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| Completed | N/A | 121 | Europe, US | Q Revascularization System | MIVI Neuroscience, Inc. | Acute Stroke, Cerebral Ischemia | 04/23 | 08/23 | | |
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus |
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| Recruiting | N/A | 50 | US | eShunt Implant | CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC | Hydrocephalus, Normal Pressure, Hydrocephalus | 01/25 | 01/30 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Recruiting | N/A | 2000 | Europe, US, RoW | EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter, CEREGLIDE 71 Intermediate Catheter | Cerenovus, Part of DePuy Synthes Products, Inc. | Cerebral Stroke | 03/25 | 06/25 | | |
ATHENA, NCT06370182: Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA5 Device |
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| Recruiting | N/A | 250 | Europe | ANA Funnel Catheter, Control | Anaconda Biomed S.L. | Acute Ischemic Stroke From Large Vessel Occlusion | 12/25 | 03/26 | | |
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device |
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| Recruiting | N/A | 180 | US | WEB | Microvention-Terumo, Inc. | Wide Neck Bifurcation Intracranial Aneurysms | 12/25 | 12/29 | | |
ARTISSE, NCT02998229: The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs). |
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| Recruiting | N/A | 220 | US | Artisse™ Intrasaccular Device | Medtronic Neurovascular Clinical Affairs | Intracranial Aneurysm | 02/28 | 02/32 | | |
| Recruiting | N/A | 500 | US | Aurora Surgiscope System | Integra LifeSciences Corporation, Icahn School of Medicine at Mount Sinai, Oculus Imaging LLC | Supratentorial Hemorrhage | 10/28 | 10/29 | | |
NCT05409989: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study |
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| Recruiting | N/A | 154 | US | FRED™ X™, Flow Re-Direction Endoluminal Device X | Microvention-Terumo, Inc. | Intracranial Aneurysm | 09/29 | 11/29 | | |
| Recruiting | N/A | 2000 | Europe, US, RoW | EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter | Cerenovus, Part of DePuy Synthes Products, Inc. | Cerebral Stroke | 07/24 | 10/24 | | |
| Levy, Elad I |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
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| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
| Davis, Jason T |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
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| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Gray, William K |
| Active, not recruiting | 1/2 | 14 | Europe | intra-striatal rAAV5-miHTT, AMT-130 | UniQure Biopharma B.V., uniQure biopharma B.V. | Huntington Disease | 03/29 | 10/29 | | |
| Active, not recruiting | N/A | 446 | Europe, US, RoW | Surmodics SurVeil DCB, Medtronic IN.PACT Admiral DCB | SurModics, Inc. | Peripheral Arterial Disease, Peripheral Vascular Disease, Artery Disease, Peripheral, Femoropopliteal Artery Occlusion | 09/20 | 10/24 | | |
| Active, not recruiting | N/A | 64 | US | left atrial appendage closure | Conformal Medical, Inc, Yale Cardiovascular Research Group | Non-valvular Atrial Fibrillation | 05/22 | 06/25 | | |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 11/24 | 10/29 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 15 | US | Transcatheter Tricuspid Valve Replacement | Trisol Medical | Tricuspid Regurgitation | 01/25 | 07/27 | | |
| Active, not recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS) |
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| Recruiting | N/A | 15 | US | Trillium™ | Innoventric LTD, Innoventric Inc. | Tricuspid Regurgitation, Tricuspid Regurgitation Functional | 08/25 | 08/30 | | |
| Recruiting | N/A | 100 | Europe, Canada, US | Edwards APTURE transcatheter shunt system, Sham procedure | Edwards Lifesciences | Heart Failure | 01/26 | 07/30 | | |
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System |
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| Active, not recruiting | N/A | 71 | US | Transcatheter Atrial Shunt System | Edwards Lifesciences | Heart Failure | 12/23 | 11/28 | | |
| Recruiting | N/A | 870 | Canada, US | Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease | 12/27 | 12/31 | | |
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System |
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| Recruiting | N/A | 55 | US | Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair | Edwards Lifesciences | Tricuspid Regurgitation | 12/26 | 12/31 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
| Recruiting | N/A | 1600 | US, RoW | CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder | Conformal Medical, Inc | Atrial Fibrillation, Stroke | 06/28 | 12/31 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Gay, Jennifer L |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
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| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus |
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| Recruiting | N/A | 50 | US | eShunt Implant | CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC | Hydrocephalus, Normal Pressure, Hydrocephalus | 01/25 | 01/30 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System |
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| Completed | N/A | 328 | US | Zoom Reperfusion System | Imperative Care, Inc. | Ischemic Stroke, Acute Stroke | 05/24 | 05/24 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
| Recruiting | N/A | 1000 | US | Follow-up schedule: pre-operative baseline up to 24-months post-procedure | Medtronic Spinal and Biologics, Medtronic Bakken Research Center | Spinal Deformity, Spinal Degenerative Disorder, Spinal Fusion Failure, Spinal Trauma, Spinal Tumor Case | 05/31 | 05/31 | | |
| Recruiting | N/A | 500 | US | Aurora Surgiscope System | Integra LifeSciences Corporation, Icahn School of Medicine at Mount Sinai, Oculus Imaging LLC | Supratentorial Hemorrhage | 10/28 | 10/29 | | |
| Taqi, Muhammad A |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
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| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
APPLY, NCT04499508: Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System ( Study) |
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| Recruiting | N/A | 30 | US | Optima Coil System, Embolization of Intracranial Aneurysm, Optima Balt Coil System, Neurovascular Embolization Device | Vascular Neurology of Southern California Inc. | Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Aneurysm Unruptured | 04/23 | 04/23 | | |
STEM, NCT04410146: The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma |
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| Completed | N/A | 310 | Europe, US | SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation, Other: Medical Management | Balt USA, Balt Extrusion, Embo-Flüssigkeiten A.G., AXIOM Real Time Metrics | Subdural Hematoma, Chronic | 02/24 | 05/24 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Davies, Jason |
EMBOLISE, NCT04402632: Embolization of the Middle Meningeal Artery with ONYX™ Liquid Embolic System for Subacute and Chronic Subdural Hematoma |
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| Active, not recruiting | N/A | 600 | US | Surgical Management, Surgical Management + Treatment, No Treatment, Treatment | Medtronic Neurovascular Clinical Affairs | Subdural Hematoma | 12/24 | 03/25 | | |
| Stein, Robin |
| Completed | N/A | 19 | US | PPCI, Percutaneous PerQseal device closure, Cardiogenic shock | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 01/23 | 03/23 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
INTERRUPT AF, NCT03729830: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation |
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| Completed | N/A | 415 | Europe, Japan, US, RoW | Boston Scientific Open Irrigated Ablation Catheters | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 05/24 | 05/24 | | |
| Iyer, Vijay |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
| Completed | N/A | 19 | US | PPCI, Percutaneous PerQseal device closure, Cardiogenic shock | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 01/23 | 03/23 | | |
| Terminated | N/A | 17 | Canada, US | MANTA Vascular Closure Device | Essential Medical, Inc., Teleflex | Femoral Arteriotomy Closure | 01/23 | 01/23 | | |
| Enrolling by invitation | N/A | 556 | US | Impella ECP | Abiomed Inc. | High-Risk Percutaneous Coronary Intervention | 12/25 | 12/26 | | |
| Recruiting | N/A | 250 | Canada, US | MANTA Vascular Closure Device | Essential Medical, Inc., Essential Medical LLC a subsidiary of Teleflex, Incorporated | Femoral Arteriotomy Closure | 01/25 | 03/25 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Active, not recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 07/24 | 08/29 | | |
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 1948 | Canada, US | ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL | Boston Scientific Corporation | Aortic Stenosis | 06/24 | 09/34 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 05/24 | 06/28 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Active, not recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
| Active, not recruiting | N/A | 949 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 07/24 | 08/25 | | |
| Recruiting | N/A | 100 | Europe, Canada, US | Edwards APTURE transcatheter shunt system, Sham procedure | Edwards Lifesciences | Heart Failure | 01/26 | 07/30 | | |
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial |
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| Active, not recruiting | N/A | 527 | Europe, Canada, US | Impella CP® placement prior to reperfusion with Primary PCI | Abiomed Inc. | ST Elevation (STEMI) Myocardial Infarction of Anterior Wall | 09/24 | 10/30 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
| Recruiting | N/A | 870 | Canada, US | Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease | 12/27 | 12/31 | | |
