| Pili, Roberto |
| Recruiting | 3 | 738 | Europe, US, RoW | Docetaxel 75 mg/m2, Docetaxel 60 mg/m2, Radium-223 | Memorial Sloan Kettering Cancer Center, Bayer | Prostate Cancer | 06/26 | 06/26 | | |
NCT03552380: Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell Carcinoma |
|
|
| Terminated | 2 | 12 | US | Entinostat, MS-275, SND-275, Nivolumab, Opdivo, Ipilimumab, Yervoy | Roberto Pili, Bristol-Myers Squibb, Syndax Pharmaceuticals, Indiana University School of Medicine | Renal Cell Carcinoma | 06/22 | 02/24 | | |
| Active, not recruiting | 2 | 46 | US | Entinostat, Interleukin-2, aldesleukin | Roberto Pili, Indiana University Melvin and Bren Simon Cancer Center, Syndax Pharmaceuticals, Clinigen, Inc. | Renal Cell Carcinoma | 01/23 | 04/24 | | |
BRCAAway, NCT03012321: Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects |
|
|
| Active, not recruiting | 2 | 70 | US | Olaparib, Lynparza, Abiraterone Acetate, Prednisone | Northwestern University, AstraZeneca, National Cancer Institute (NCI) | Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer | 12/26 | 01/27 | | |
NCT06222593: Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination with Sunitinib in Patients with TKIs-resistant RCC |
|
|
| Not yet recruiting | 1/2 | 28 | NA | Bicalutamide in combination with Sunitinib, (RS)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl sulfonyl]-2-hydroxy-2-methylpropanamide, UNII: A0Z3NAU9DP, CASODEX | State University of New York at Buffalo | Carcinoma, Renal Cell | 07/25 | 07/26 | | |
ADAPT-BLADDER, NCT03317158: Modern Immunotherapy in BCG-Unresponsive, BCG-Relapsing and High Risk BCG-Naive Non-Muscle Invasive Urothelial Carcinoma of the Bladder |
|
|
| Recruiting | 1/2 | 55 | US | Durvalumab (Cohort 1-3), Imfinzi, External Beam Radiotherapy (EBRT), Bacillus Calmette-Guérin (BCG), Gemcitabine, Gemzar, Docetaxel, Taxotere, Tremelimumab, Durvalumab (Cohort 4/5), To be determined | Noah Hahn, M.D., AstraZeneca, Hoosier Cancer Research Network | Urothelial Carcinoma, Bladder Cancer | 12/25 | 12/26 | | |
NCT02619253: Phase I/Ib Study of Pembrolizumab With Vorinostat for Patients With Advanced Renal or Urothelial Cell Carcinoma |
|
|
| Completed | 1 | 52 | US | Pembrolizumab, Keytruda, Vorinostat, Zolinza | Nabil Adra | Renal Cell Carcinoma, Urinary Bladder Neoplasms | 03/23 | 03/23 | | |
NCT05359848: A Pilot, Feasibility Study of Intermittent Caloric Restriction Plus Plant-based Diet in Cancer Patients Receiving Chemotherapy |
|
|
| Recruiting | N/A | 30 | US | Diet | State University of New York at Buffalo | Medical Oncology, Integrative Oncology, Medical Nutrition Therapy | 12/24 | 06/25 | | |
NCT06172283: Intermittent Fasting in Prostate Cancer Patients Receiving Androgen Deprivation Therapy |
|
|
| Recruiting | N/A | 30 | US | Intermittent Fasting | State University of New York at Buffalo | Prostate Cancer | 01/27 | 12/28 | | |
NCT05356182: A Pilot and Feasibility Study of a Dietary Intervention with Low-protein Meals in Cancer Patients Receiving Immunotherapies |
|
|
| Recruiting | N/A | 30 | US | Diet | State University of New York at Buffalo | Medical Oncology, Integrative Oncology, Medical Nutrition Therapy | 04/25 | 04/25 | | |
| Huang, Taosheng |
NCT04594590: Natural History Study of SLC25A46 Mutation-related Mitochondriopathy |
|
|
| Completed | N/A | 9 | US | Mutation analysis | State University of New York at Buffalo, Hadley Jo Foundation | Neurodegenerative Disease, Hereditary, Mitochondrial Diseases, Optic Atrophy | 08/23 | 08/23 | | |
NCT04580979: Natural History Study of FDXR Mutation-related Mitochondriopathy |
|
|
| Completed | N/A | 33 | US | Mutation analysis | State University of New York at Buffalo, The Callum McKeefery and Nikki Albano McKeefery Pediatric Division of Genetics Fund | Neurodegenerative Disease, Hereditary, Mitochondrial Diseases, Optic Atrophy | 08/23 | 08/23 | | |
| Lyden, Sean |
| Active, not recruiting | N/A | 220 | Europe, US | PQ Bypass System | PQ Bypass, Inc. | Peripheral Arterial Disease | 12/21 | 11/23 | | |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
| Active, not recruiting | N/A | 9 | US, RoW | Esprit BTK Device | Abbott Medical Devices | Critical Limb Ischemia (CLI) | 04/23 | 02/28 | | |
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms |
|
|
| Approved for marketing | N/A | | US | GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aneurysm | | | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) |
|
|
| Active, not recruiting | N/A | 150 | Japan, US | GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure | W.L.Gore & Associates | Aortic Aneurysm, Thoracic, Aorta, Lesion | 03/24 | 03/28 | | |
| Recruiting | N/A | 500 | US | Pounce Thrombectomy System, Mechanical thrombectomy | SurModics, Inc. | Peripheral Arterial Disease, Acute Limb Ischemia | 05/25 | 07/25 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
| Active, not recruiting | N/A | 111 | Europe, US, RoW | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 01/25 | 01/29 | | |
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study |
|
|
| Active, not recruiting | N/A | 165 | US | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 04/25 | 04/29 | | |
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms |
|
|
| Active, not recruiting | N/A | 102 | Europe, US | GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aortic Aneurysm | 01/23 | 09/26 | | |
| Recruiting | N/A | 5000 | Europe, Canada, US, RoW | Any eligible commercially available Boston Scientific Corporation (BSC) drug-eluting device. | Boston Scientific Corporation | Peripheral Vascular Diseases | 01/28 | 01/28 | | |
| Recruiting | N/A | 450 | US | Alto Abdominal Stent Graft System, FDA Approved EVAR AAA Graft Systems | Endologix | AAA, AAA - Abdominal Aortic Aneurysm | 12/28 | 12/28 | | |
NCT05409118: JAGUAR Trial (Outside United States; OUS): ObJective Analysis to GaUge EVAR Outcomes Through Randomization |
|
|
| Not yet recruiting | N/A | 450 | NA | Alto Abdominal Stent Graft System, FDA Approved EVAR AAA Graft Systems, Medtronic Endurant, Cook Zenith, Gore Excluder | Endologix | AAA, AAA - Abdominal Aortic Aneurysm | 12/30 | 12/30 | | |
| Recruiting | N/A | 500 | US | | The Cleveland Clinic | Cardiovascular Diseases, Metabolic Disease, Peripheral Artery Disease, Carotid Disease, Aneurysmal Disease, Venous Disease, Thrombosis, Lymphedema, Lipedema, Non-Atherosclerotic Chronic Arterial Occlusive Disease, Vasculitis, Fibromuscular Dysplasia, Arterial Dissection, May-Thurner Syndrome, Thoracic Outlet Syndrome, Vasospasm | 12/30 | 06/31 | | |
| Izzo, Joseph L |
SUMMIT, NCT04847557: A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The Trial |
|
|
| Completed | 3 | 731 | US, RoW | Tirzepatide, LY3298176, Placebo | Eli Lilly and Company | Obesity, Heart Failure With Preserved Ejection Fraction (HFpEF) | 07/24 | 07/24 | | |
|
NCT05968430: Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects with Hypertension |
|
|
| Enrolling by invitation | 3 | 1400 | Europe, Canada, US, RoW | lorundrostat, Placebo | Mineralys Therapeutics Inc. | Hypertension | 12/25 | 12/26 | | |
NCT05769608: A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects with Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen |
|
|
| Active, not recruiting | 2 | 285 | US | Placebo, lorundrostat Dose 1, lorundrostat Dose 2 | Mineralys Therapeutics Inc. | Hypertension | 01/25 | 02/25 | | |
| Flaherty, James |
NCT04472299: Paravertebral Block to Reduce the Incidence of New Onset Atrial Fibrillation After Cardiac Surgery |
|
|
| Recruiting | 4 | 30 | US | Ropivacaine 0.2% Injectable Solution | University of Minnesota | New Onset Atrial Fibrillation, Anesthesia, Local, Cardiac Disease | 07/25 | 07/25 | | |
NCT06411795: Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy |
|
|
| Recruiting | 2 | 78 | US | Bupivacaine, AH 250, Hydromorphone, (-)-Hydromorphone, Dihydromorphinone, Hydromorphon, Iopamidol, Isovue, Niopam, Solutrast, Liposomal Bupivacaine, Bupivacaine Liposome Injectable Suspension, Exparel, Medical Chart Review, Chart Review, Questionnaire Administration, Thoracic Epidural Analgesia, TEA, Thoracic Epidural, Ultrasound Imaging, 2-Dimensional Grayscale Ultrasound Imaging, 2-Dimensional Ultrasound Imaging, 2D-US, Ultrasonography, Ultrasound, Ultrasound Test, Ultrasound, Medical, US, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray | Masonic Cancer Center, University of Minnesota, National Cancer Institute (NCI) | Duodenal Neoplasm, Pancreatic Neoplasm | 01/26 | 01/26 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 750 | Europe, Canada, US, RoW | Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) | Corvia Medical | Heart Failure, Heart Failure, Diastolic | 05/25 | 03/31 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
|
|
| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Recruiting | N/A | 100 | Europe, Canada, US | Edwards APTURE transcatheter shunt system, Sham procedure | Edwards Lifesciences | Heart Failure | 01/26 | 07/30 | | |
| Recruiting | N/A | 10000 | US, RoW | TAVR | Duk-Woo Park, MD, CardioVascular Research Foundation, Korea | Heart Valve Diseases, Aortic Valve Insufficiency | 12/35 | 12/36 | | |
NCT05907564: Aventus Thrombectomy System Pulmonary Embolism Clinical Study |
|
|
| Recruiting | N/A | 120 | US | Thrombectomy | Inquis Medical, Inc. | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases, Cardiovascular Diseases, Lung Diseases, Respiratory Tract Diseases | 03/25 | 03/25 | | |
| Recruiting | N/A | 3784 | Europe, US, RoW | Coronary and peripheral stents, Pacing catheters, Vascular plugs, Measurement and imaging (FFR and OCT), Peripheral dilatation catheters, Coronary dilatation catheters, Coronary and peripheral guidewires, Vessel closure/compression devices, Vascular access introducers | Abbott Medical Devices | Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism | 11/30 | 11/31 | | |
| Ching, Marilou |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
|
|
| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 2 | 300 | US | TS23 | Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona | Ischemic Stroke | 07/27 | 12/27 | | |
| Siddiqui, Adnan |
NECC, NCT04852783: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair |
|
|
| Active, not recruiting | 4 | 250 | US | Contour Neurovascular System | Cerus Endovascular, Inc. | Aneurysm, Intracranial | 12/25 | 12/29 | | |
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics |
|
|
| Active, not recruiting | 3 | 385 | Canada, US | Revascularization, Intensive Medical Management (IMM) alone | Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles | Internal Carotid Artery Stenosis, Cognitive Impairment | 01/27 | 07/27 | | |
| Recruiting | 2/3 | 200 | Europe, Canada, US | Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM) | Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati | Cerebral Ischemia | 12/24 | 12/24 | | |
NCT05367362: Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke |
|
|
| Not yet recruiting | 2 | 134 | NA | Minocyclin, Minocycline HCL 200mg Daily (Oral or Intravenous) | State University of New York at Buffalo | Acute Ischemic Stroke | 03/25 | 06/26 | | |
| Recruiting | N/A | 15 | US | thrombectomy, Delphi Revascularization Device | University at Buffalo | Ischemic Stroke | 12/21 | 01/22 | | |
NCT02657707: Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis |
|
|
| Active, not recruiting | N/A | 295 | US | Roadsaver™ Carotid Artery Stent Device, Nanoparasol® Embolic Protection System | Microvention-Terumo, Inc. | Carotid Artery Stenosis | 04/22 | 05/24 | | |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
NCT02661672: INVEST-REGISTRY: Minimally Invasive Endoscopic Surgical Treatment With Apollo/Artemis in Patients With Brain Hemorrhage |
|
|
| Completed | N/A | 38 | US | Apollo Device, ICH - Apollo System, Artemis Device | J. Mocco, MOUNT SINAI HOSPITAL, University at Buffalo | Intracranial Hemorrhage | 11/22 | 11/22 | | |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
|
|
| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
EvaQ, NCT04437862: A Study to Evaluate the Q Revascularization System for Neurointervention in Acute Ischemic Stroke |
|
|
| Completed | N/A | 121 | Europe, US | Q Revascularization System | MIVI Neuroscience, Inc. | Acute Stroke, Cerebral Ischemia | 04/23 | 08/23 | | |
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus |
|
|
| Recruiting | N/A | 50 | US | eShunt Implant | CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC | Hydrocephalus, Normal Pressure, Hydrocephalus | 01/25 | 01/30 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Recruiting | N/A | 2000 | Europe, US, RoW | EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter, CEREGLIDE 71 Intermediate Catheter | Cerenovus, Part of DePuy Synthes Products, Inc. | Cerebral Stroke | 03/25 | 06/25 | | |
ATHENA, NCT06370182: Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA5 Device |
|
|
| Recruiting | N/A | 250 | Europe | ANA Funnel Catheter, Control | Anaconda Biomed S.L. | Acute Ischemic Stroke From Large Vessel Occlusion | 12/25 | 03/26 | | |
NCT05074186: Assessing the Safety and Effectiveness of a Neurological Thrombectomy Medical Device for Acute Ischemic Stroke |
|
|
| Completed | N/A | 8 | US | neurological thrombectomy device is an investigational device. | University at Buffalo, Jacobs institute | Ischemic Stroke | 07/24 | 07/24 | | |
| Not yet recruiting | N/A | 2000 | NA | Endovascular thrombectomy with any FDA-approved category POL or NRY device, EVT, Endovascular Recanalization Therapy, Endovascular Therapy, Medical Management | Medical University of South Carolina, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, University of Virginia, Berry Consultants, University of California, Los Angeles, MOUNT SINAI HOSPITAL, The Cooper Health System, University of Pittsburgh Medical Center, Stony Brook University, University at Buffalo | Ischemic Stroke | 01/29 | 12/30 | | |
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device |
|
|
| Recruiting | N/A | 180 | US | WEB | Microvention-Terumo, Inc. | Wide Neck Bifurcation Intracranial Aneurysms | 12/25 | 12/29 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
|
|
| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
ARTISSE, NCT02998229: The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs). |
|
|
| Recruiting | N/A | 220 | US | Artisse™ Intrasaccular Device | Medtronic Neurovascular Clinical Affairs | Intracranial Aneurysm | 02/28 | 02/32 | | |
| Recruiting | N/A | 500 | US | Aurora Surgiscope System | Integra LifeSciences Corporation, Icahn School of Medicine at Mount Sinai, Oculus Imaging LLC | Supratentorial Hemorrhage | 10/28 | 10/29 | | |
NCT05409989: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study |
|
|
| Recruiting | N/A | 154 | US | FRED™ X™, Flow Re-Direction Endoluminal Device X | Microvention-Terumo, Inc. | Intracranial Aneurysm | 09/29 | 11/29 | | |
VERiTASII, NCT03729817: REstoring Flow by REvascularization with Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis |
|
|
| Not yet recruiting | N/A | 159 | US | Submaximal balloon angioplasty | Case Western Reserve University, National Institute of Neurological Disorders and Stroke (NINDS) | Intracranial Atherosclerotic Disease, Stroke, Angioplasty, Balloon, Hemodynamics, Device Safety | 10/29 | 10/30 | | |
| Recruiting | N/A | 2000 | Europe, US, RoW | EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter | Cerenovus, Part of DePuy Synthes Products, Inc. | Cerebral Stroke | 07/24 | 10/24 | | |
| Levy, Elad I |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
|
|
| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
| Active, not recruiting | N/A | 10 | US | Pipeline™ Flex Embolization Device with Shield Technology™ | State University of New York at Buffalo, Jacobs institute | Intracranial Aneurysms | 09/25 | 09/25 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
| Davis, Jason T |
NCT04432259: Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty |
|
|
| Not yet recruiting | 4 | 300 | NA | Dexamethasone, Placebo | Henry Ford Health System | Arthritis Knee, Postoperative Nausea, Postoperative Pain | 06/22 | 12/22 | | |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
|
|
| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
| Gray, William K |
| Active, not recruiting | 1/2 | 14 | Europe | intra-striatal rAAV5-miHTT, AMT-130 | UniQure Biopharma B.V., uniQure biopharma B.V. | Huntington Disease | 03/29 | 10/29 | | |
| Active, not recruiting | N/A | 446 | Europe, US, RoW | Surmodics SurVeil DCB, Medtronic IN.PACT Admiral DCB | SurModics, Inc. | Peripheral Arterial Disease, Peripheral Vascular Disease, Artery Disease, Peripheral, Femoropopliteal Artery Occlusion | 09/20 | 10/24 | | |
| Active, not recruiting | N/A | 64 | US | left atrial appendage closure | Conformal Medical, Inc, Yale Cardiovascular Research Group | Non-valvular Atrial Fibrillation | 05/22 | 06/25 | | |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 11/24 | 10/29 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 15 | US | Transcatheter Tricuspid Valve Replacement | Trisol Medical | Tricuspid Regurgitation | 01/25 | 07/27 | | |
| Active, not recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS) |
|
|
| Recruiting | N/A | 15 | US | Trillium™ | Innoventric LTD, Innoventric Inc. | Tricuspid Regurgitation, Tricuspid Regurgitation Functional | 08/25 | 08/30 | | |
| Recruiting | N/A | 100 | Europe, Canada, US | Edwards APTURE transcatheter shunt system, Sham procedure | Edwards Lifesciences | Heart Failure | 01/26 | 07/30 | | |
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System |
|
|
| Active, not recruiting | N/A | 71 | US | Transcatheter Atrial Shunt System | Edwards Lifesciences | Heart Failure | 12/23 | 11/28 | | |
| Recruiting | N/A | 870 | Canada, US | Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease | 12/27 | 12/31 | | |
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System |
|
|
| Recruiting | N/A | 55 | US | Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair | Edwards Lifesciences | Tricuspid Regurgitation | 12/26 | 12/31 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
|
|
| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
| Recruiting | N/A | 1600 | US, RoW | CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder | Conformal Medical, Inc | Atrial Fibrillation, Stroke | 06/28 | 12/31 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
|
|
| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Gay, Jennifer L |
NECC, NCT04852783: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair |
|
|
| Active, not recruiting | 4 | 250 | US | Contour Neurovascular System | Cerus Endovascular, Inc. | Aneurysm, Intracranial | 12/25 | 12/29 | | |
| Recruiting | 2/3 | 200 | Europe, Canada, US | Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM) | Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati | Cerebral Ischemia | 12/24 | 12/24 | | |
NCT06217068: Comparative Analysis of Biomarkers in Response to Acute Moderate-Intensity Activity |
|
|
| Recruiting | 1/2 | 56 | US | Elliptical Activity | University of Georgia | Acute Exercise, Aerobic Exercise, Biomarkers | 12/24 | 05/25 | | |
| Recruiting | N/A | 15 | US | thrombectomy, Delphi Revascularization Device | University at Buffalo | Ischemic Stroke | 12/21 | 01/22 | | |
| Active, not recruiting | N/A | 305 | Europe, US, RoW | Carotid artery stenting with Neuroguard IEP System | Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions | Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis | 10/23 | 12/25 | | |
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS) |
|
|
| Completed | N/A | 90 | US | Comaneci Embolization Assist Device | Rapid Medical | Intracranial Aneurysm | 05/24 | 07/24 | | |
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus |
|
|
| Recruiting | N/A | 50 | US | eShunt Implant | CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC | Hydrocephalus, Normal Pressure, Hydrocephalus | 01/25 | 01/30 | | |
| Recruiting | N/A | 168 | Europe, US | Tigertriever 13 | Rapid Medical | Ischemic Stroke, Neovascularization | 03/25 | 03/25 | | |
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System |
|
|
| Completed | N/A | 328 | US | Zoom Reperfusion System | Imperative Care, Inc. | Ischemic Stroke, Acute Stroke | 05/24 | 05/24 | | |
| Recruiting | N/A | 229 | US | Neuroguard IEP Direct System | Contego Medical, Inc., Yale Cardiovascular Research Group, CardioMed Device Consultants, LLC, Advance Research Associates, iMedNet, AG Mednet | Carotid Stenosis, Carotid Artery Diseases | 06/25 | 07/25 | | |
NCT05074186: Assessing the Safety and Effectiveness of a Neurological Thrombectomy Medical Device for Acute Ischemic Stroke |
|
|
| Completed | N/A | 8 | US | neurological thrombectomy device is an investigational device. | University at Buffalo, Jacobs institute | Ischemic Stroke | 07/24 | 07/24 | | |
