University of Kentucky Research Foundation
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 25 Trials 
91 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Inglessis, Ignacio
PARADIGM, NCT04489823: Amplatzer Valvular Plug for PVL Closure

Recruiting
N/A
200
Europe, Canada, US
AVP III
Abbott Medical Devices
Paravalvular Aortic Regurgitation
07/25
06/26
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
MITRAL-II, NCT04408430: The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Recruiting
N/A
210
US
Transseptal ViMAC, ViMAC
Mayra Guerrero
Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
12/24
12/24
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
12/26
12/29
MVSS, NCT04736667: Mitral Valve Screening Survey

Recruiting
N/A
1000
Canada, US
Medstar Health Research Institute
Mitral Valve Disease
02/27
02/27
Dodick, David
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
Roth, Scott
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Lin, Michael
ADapt, NCT05369403: A Study of Lebrikizumab (LY3650150) in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumab

Active, not recruiting
3
120
US
Lebrikizumab, LY3650150, DRM06
Eli Lilly and Company
Atopic Dermatitis
01/24
02/25
NCT05372419: A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Color

Active, not recruiting
3
80
US
Lebrikizumab, LY3650150, DRM06
Eli Lilly and Company
Atopic Dermatitis
05/24
02/25
TOGETHER-PsO, NCT06588283: Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight

Recruiting
3
250
US
Ixekizumab, LY2439821, Tirzepatide, LY3298176
Eli Lilly and Company
Psoriasis, Obesity
12/25
05/26
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
3
640
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
NCT06436183: A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis

Recruiting
2
60
Canada, US
Camoteskimab, APL-9109, AVTX-007, CERC-007, AEVI-007, MEDI2338, Placebo
Apollo Therapeutics Ltd
Atopic Dermatitis, Atopic, Dermatitis, Dermatologic Disease, Eczema, Eczema Atopic Dermatitis, Eczema, Atopic
02/25
06/25
NCT06587828: A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease

Recruiting
N/A
300
US
Companion blood samples with procedure
TScan Therapeutics, Inc.
Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma, Ankylosing Spondylitis, Celiac Disease, Non-radiographic Axial Spondyloarthritis (nr-axSpA), Crohn's Disease, Birdshot Chorioretinitis
01/25
06/25
Sommer, Robert
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
12/26
12/29
Sherman, Seth
NCT04636229: Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee

Active, not recruiting
3
474
US
Amniotic Suspension Allograft, Placebo
Organogenesis, Premier Research Group plc
Knee Osteoarthritis
07/23
03/24
NCT01957722: NOVOCART®3D for Treatment of Articular Cartilage of the Knee

Active, not recruiting
3
233
Canada, US
Microfracture, NOVOCART 3D
Aesculap Biologics, LLC
Articular Cartilage of the Femoral Condyle Between 2-6cm2
12/25
12/27
NCT03467919: The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

Completed
3
40
US
Micro Fragmented Adipose Tissue, MFAT, Corticosteroid injection
Stanford University
Osteoarthritis, Knee, Knee Pain
10/24
10/24
NCT04528992: Effects of Blood Flow Restriction (BFR) Therapy on ACL Graft Maturation

Withdrawn
N/A
40
US
Blood Flow Restriction Therapy, Standard Postoperative Physical Therapy
Stanford University
Knee Injuries, Anterior Cruciate Ligament Injuries
09/24
09/24
NCT05428332: Spring Loaded Tri-Compartment Unloader Knee Brace Study

Completed
N/A
20
US
Tri-Compartment Unloader Brace, TCU Brace
Stanford University, Spring Loaded Tech
Anterior Knee Pain
11/24
11/24
COCA-OCA-001, NCT06216756: Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee

Recruiting
N/A
68
US
osteochondral transplant on the femoral condyle
AlloSource
Osteochondral Defect
03/31
03/31
NCT06138548: Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee

Not yet recruiting
N/A
10
US
Ossiofiber® Trimmable Fixation Nail
Stanford University
Subchondral Insufficiency Fracture
08/25
12/25
STABILITY 2, NCT03935750: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

Recruiting
N/A
1236
Europe, Canada, US
Anterior cruciate ligament reconstruction (ACLR), Lateral extra-articular tenodesis (LET)
University of Pittsburgh, University of Western Ontario, Canada, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Canadian Institutes of Health Research (CIHR)
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
02/26
02/26
NCT02090140: Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

Recruiting
N/A
17
US
ADSC Application, Microfracture
University of Colorado, Denver, University of Kentucky, Stanford University
Degenerative Lesion of Articular Cartilage of Knee
12/25
12/25
NCT03014401: The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

Recruiting
N/A
29
US
Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
University of Colorado, Denver, Stanford University
Knee Osteoarthritis
12/25
12/25
NCT05398341: A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)

Recruiting
N/A
750
US
The BEAR® Implant
Miach Orthopaedics
Anterior Cruciate Ligament Injuries
10/26
01/27
Gurley, John
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Isaacs, Jennifer
REBIRTH, NCT05180773: Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

Recruiting
4
250
US
Bromocriptine, Parlodel, Cycloset, Placebo, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban, Xarelto, Second Placebo
Dennis M. McNamara, MD, MS, National Heart, Lung, and Blood Institute (NHLBI)
Peripartum Cardiomyopathy, Postpartum
06/26
12/28
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
MUSIC-CPX, NCT05537467: Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

Recruiting
N/A
40
US
Music
Maya Ignaszewski
Heart Failure
12/27
12/27
REVERSE-HF, NCT05318105: Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Recruiting
N/A
372
US
Aquadex Smartflow® System, IV Loop Diuretics
Nuwellis, Inc.
Heart Failure (for Example, Fluid Overload)
07/25
10/25
NCT04977310: TARGET-LOAD Pilot Study Comparing Hemodynamics-guided LVAD Unloading Vs. Standard of Care

Withdrawn
N/A
10
US
CardioMEMS
STAVROS G DRAKOS, Abbott
Heart Failure
09/26
09/26
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
CARP, NCT05521503: Biopsy Collection and Repository Database

Recruiting
N/A
400
US
Andrew Kolodziej
Cardiovascular Diseases
12/30
12/30
OHP-II, NCT05915299: US National OCS Heart Perfusion (OHP) Registry

Recruiting
N/A
100000
US
OCS Heart
TransMedics
Heart Transplant
08/29
08/33
Bartholomew, Delainna
TARGET-HCC, NCT02954094: A Longitudinal Observational Study of the Natural History and Management of Patients With HCC

Recruiting
N/A
10000
Europe, US
Target PharmaSolutions, Inc.
Hepatocellular Cancer
10/25
10/25
MAPLE, NCT04793360: Molecular Assessment and Profiling of Liver Transplant Recipients

Active, not recruiting
N/A
1500
US
LiverCare
CareDx
Liver Transplantation, Biomarkers
12/27
03/28
NCT05159466: Tulane Abdominal Transplant Institute (TATI) of Solid Organ Transplantation of HIV-Positive Recipients From HIV-Positive Donors

Recruiting
N/A
30
US
Kidney transplant, Nephrectomy
Tulane University
Human Immunodeficiency Virus, End Stage Renal Disease
11/26
11/26
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
NCT02815891: A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)

Recruiting
N/A
15000
Europe, US
Target PharmaSolutions, Inc.
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
07/36
07/36
Matouk, Charles
NITE1, NCT04881162: Feasibility Study of the Treatment of Acute Ischemic Stroke Using the NOVIS Transcarotid Neuroprotection System

Terminated
N/A
12
US
NOVIS Transcarotid Neuroprotection System (NPS)
Silk Road Medical
Acute Ischemic Stroke
12/23
12/23
NCT05501002: Pilot Study to Evaluate the CereVasc® EShunt® System in the Treatment of Communicating Hydrocephalus

Terminated
N/A
4
US
eShunt® Implant, eShunt®, eShunt® system
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Hydrocephalus, Communicating
09/23
09/23
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus

Recruiting
N/A
50
US
eShunt Implant
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Normal Pressure, Hydrocephalus
01/25
01/30
VANTAGE, NCT04391803: EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms with the Pipeline™ Flex Embolization Device with Shield TEchnology™ (ELEVATE)

Recruiting
N/A
200
NA
Pipeline™ Flex Embolization Device with Shield Technology™, Pipeline™ Shield Device
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm, Ruptured Aneurysm
01/26
01/27
NCT05071963: INSPIRE Pipeline™ Shield Post Approval Study

Active, not recruiting
N/A
246
US
Treatment of Intracranial Aneurysms
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
03/26
04/28
MARRS, NCT05714501: Millipede AspiRation for Revascularization in Stroke () Study

Recruiting
N/A
225
Europe, US
Millipede System
Perfuze
Acute Ischemic Stroke
07/25
10/25
ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients with Significant Carotid Artery Disease

Active, not recruiting
N/A
344
US
Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting
Silk Road Medical
Carotid Artery Diseases
09/25
09/25
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
STAR, NCT04994756: Stroke Thrombectomy and Aneurysm Registry

Recruiting
N/A
40000
Europe, Canada, Japan, US, RoW
Stroke/Thrombectomy/Aneurysm-specific surgical procedures
Medical University of South Carolina
Stroke, Thromboses, Intracranial, Aneurysm, Brain
01/55
01/55
Wang, Jennifer
NCT04963062: Moses vs. Thulium Laser Study

Completed
4
114
US
Holmium laser with Moses lasers, Holmium laser with thulium lasers
University of Wisconsin, Madison
Urinary Tract Stone
05/22
05/23
NCT05894577: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm F (Montelukast)

Completed
3
1453
US
Placebo, Montelukast
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
07/23
01/24
NCT04885530: ACTIV-6: COVID-19 Study of Repurposed Medications

Completed
3
10956
US
Ivermectin, Ivermectin Tablets, Fluvoxamine, Fluvoxamine Maleate Tablets, Fluticasone, Fluticasone Furoate, Placebo, Montelukast, Metformin
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
04/24
04/24
NCT06042855: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

Completed
3
3214
US
Placebo, Metformin
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
06/24
11/24
BLAZE-1, NCT04427501: A Study of LY3819253 (LY-CoV555) and LY3832479 (LY-CoV016) in Participants With Mild to Moderate COVID-19 Illness

Completed
2/3
3307
US
LY3819253, LY-CoV555, Bamlanivimab, LY3832479, LY-CoV016, Etesevimab, LY3853113, bebtelovimab, Placebo
Eli Lilly and Company, AbCellera Biologics Inc., Shanghai Junshi Bioscience Co., Ltd.
COVID-19
02/23
02/23
NCT06404086: RECOVER-SLEEP: Platform Protocol

Recruiting
2
1074
US
Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo
Duke University
Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
07/25
07/25
NCT03959163: The Validity of the Quick Renal MRI in Pediatric Kidney Disease

Recruiting
N/A
100
US
Quick MRI
University of Wisconsin, Madison
Pyelonephritis, Pyelonephritis Acute, Renal Sclerosis
01/25
01/25
Smith, Ronald Theodore
NCT03963817: Snapshot Camera for AMD

Recruiting
N/A
50
US
adaptive optics AO-OCT/AF instrument, Normals, AMD
Icahn School of Medicine at Mount Sinai, University of California, Los Angeles, National Eye Institute (NEI)
Age Related Macular Degeneration
02/25
02/25
AIM HIGHer, NCT05064709: Assessment of CCM in HF with Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/25
02/26
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Recruiting
N/A
620
US
OPTIMIZER Smart System
Impulse Dynamics
Heart Failure
03/26
03/26
Stone, Austin
NCT05505747: Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair

Not yet recruiting
2/3
38
US
Fisetin, Novusetin, 7,3',4'-flavon-3-ol, 3,3',4',7-tetrahydroxyflavone, Placebo oral capsule
Austin V Stone
Meniscus Tear, Meniscus; Derangement, Meniscus Lesion, Meniscus Disorder
02/26
02/26
PROPER, NCT05149287: Trial of Pain and Inflammation After Knee Arthroscopy

Terminated
2
5
US
Ceftriaxone, Placebo, Lidocaine and Saline
Austin V Stone
Meniscus Tear, Meniscus Lesion, Cartilage Injury
04/22
04/22
PIKASO, NCT06096259: Preventing Injured Knees From osteoArthritis: Severity Outcomes

Recruiting
2
512
US
Metformin, Glumetza, Fortamet, Glucophage extended release (XR), Placebo
Brigham and Women's Hospital, Arthritis Foundation
Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
12/28
12/29
MOCHA, NCT04572256: MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction ( Trial)

Recruiting
1
30
US
Montelukast, Singulair, Placebo
Austin V Stone, Duke University, The Cleveland Clinic, University of California, San Francisco
ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
04/25
04/25
NCT04301258: ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry

Terminated
N/A
48
US
Articular cartilage repair, ProChondrix CR
AlloSource
Cartilage Injury, Cartilage Damage
09/23
09/23
COCA-OCA-001, NCT06216756: Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee

Recruiting
N/A
68
US
osteochondral transplant on the femoral condyle
AlloSource
Osteochondral Defect
03/31
03/31
NCT03873545: Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella

Active, not recruiting
N/A
34
US
Cryopreserved Osteochondral Allograft, ProChondrix CR
AlloSource
Cartilage Injury, Cartilage Damage
10/28
12/28
Elliott, Trisha
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Recruiting
3
5350
US
AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
07/29
07/29
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation

Recruiting
N/A
520
Europe, Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone
Boston Scientific Corporation
Persistent Atrial Fibrillation
12/25
12/27
INTERRUPT AF, NCT03729830: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation

Completed
N/A
415
Europe, Japan, US, RoW
Boston Scientific Open Irrigated Ablation Catheters
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
05/24
05/24
AIM HIGHer, NCT05064709: Assessment of CCM in HF with Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/25
02/26
Virgin, Erica
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Hunt, Emily
OR3O, NCT04325022: Safety and Effectiveness Study of ™ Dual Mobility System in THA

Active, not recruiting
N/A
177
Canada, US, RoW
Primary Total Hip Arthroplasty, Revision Total Hip Arthroplasty
Smith & Nephew, Inc.
Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
12/26
01/35
Nwokemodo-Ihejirika, Chinemerem
AIM HIGHer, NCT05064709: Assessment of CCM in HF with Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/25
02/26
DEFINE AFib, NCT04926857: (Atrial Fibrillation)

Completed
N/A
973
US
Non-Interventional
Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
01/24
01/24
Ebersole, Koji
NECC, NCT04852783: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair

Active, not recruiting
4
250
US
Contour Neurovascular System
Cerus Endovascular, Inc.
Aneurysm, Intracranial
12/25
12/29
STEM, NCT04410146: The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma

Completed
N/A
310
Europe, US
SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation, Other: Medical Management
Balt USA, Balt Extrusion, Embo-Flüssigkeiten A.G., AXIOM Real Time Metrics
Subdural Hematoma, Chronic
02/24
05/24
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus

Recruiting
N/A
50
US
eShunt Implant
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Normal Pressure, Hydrocephalus
01/25
01/30
CHESS, NCT06347796: Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

Recruiting
N/A
520
US
Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
The University of Texas Medical Branch, Galveston, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Subdural Hematoma
09/28
09/28
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device

Recruiting
N/A
180
US
WEB
Microvention-Terumo, Inc.
Wide Neck Bifurcation Intracranial Aneurysms
12/25
12/29
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
NCT04057352: Citadel Embolization Device Study

Recruiting
N/A
150
US
Citadel Embolization Device
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
06/26
06/26
NCT05409989: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study

Recruiting
N/A
154
US
FRED™ X™, Flow Re-Direction Endoluminal Device X
Microvention-Terumo, Inc.
Intracranial Aneurysm
09/29
11/29
Rotondo, Sabrina
ASCENT, NCT06129240: An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

Recruiting
N/A
60
US
LIQ861
Liquidia Technologies, Inc.
Pulmonary Hypertension, Interstitial Lung Disease
07/26
10/26
AIM HIGHer, NCT05064709: Assessment of CCM in HF with Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Mid Range Ejection Fraction, Heart Failure with Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/25
02/26
Brown, Liz
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus

Recruiting
N/A
50
US
eShunt Implant
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Normal Pressure, Hydrocephalus
01/25
01/30
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26

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