| Jr, William N William |
NCT06383273: A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) |
|
|
| Recruiting | 3 | 528 | US | MELT-300 sublingual tablet, Midalozam sublingual tablet, Placebo sublingual tablet | Melt Pharmaceuticals, MedTrials Incorporated, Evolution Research Group, Catalent, Pharmalex | Cataract | 12/24 | 01/25 | | |
PANOVA-3, NCT03377491: Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel |
|
|
| Completed | 3 | 571 | Europe, Canada, US, RoW | NovoTTF-200T, TTFields, Gemcitabine, nab paclitaxel | NovoCure Ltd. | Pancreas Adenocarcinoma | 10/24 | 10/24 | | |
| Completed | 2a | 40 | US | Dupilumab, Dupixent, Placebo | University of Virginia, PBM C19 Research, LLC (a COVID-19 research entity of the Paul Manning Foundation), Virginia Catalyst, Virginia Biosciences Health Research Corporation (VBHRC) | COVID-19 | 04/23 | 04/23 | | |
SUVN-G3031, NCT04072380: A Study to Evaluate Safety, and Efficacy of (Samelisant) in Patients With Narcolepsy With and Without Cataplexy |
|
|
| Completed | 2 | 190 | Canada, US | SUVN-G3031, Samelisant, Placebo | Suven Life Sciences Limited | Narcolepsy | 06/23 | 06/23 | | |
| Recruiting | 2 | 340 | Europe, Japan, US, RoW | Pembrolizumab, Dostarlimab, GSK4057190, Belrestotug, EOS884448, GSK4428859A, Nelistotug, GSK6097608 | GlaxoSmithKline, iTeos Therapeutics | Lung Cancer, Non-Small Cell | 10/25 | 10/28 | | |
| Recruiting | 1 | 237 | US | QTX3544, Cetuximab | Quanta Therapeutics | Advanced Solid Tumors | 01/27 | 01/29 | | |
NCT03734393: HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients |
|
|
| Active, not recruiting | N/A | 80 | US | HIVD+/R+ | Johns Hopkins University, National Institute of Allergy and Infectious Diseases (NIAID) | Hiv | 04/25 | 06/25 | | |
| Abbate, Antonio |
| Recruiting | 4 | 30 | US | Colchicine 0.6 mg, Colcrys, Gloperba, Lodoco, Mitigare, Control/Placebo group | University of Virginia | Heart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection Fraction | 06/26 | 06/28 | | |
| Not yet recruiting | 3 | 110 | US | CardiolRx, Pharmaceutically produced cannabidiol | Cardiol Therapeutics Inc. | Recurrent Pericarditis | 06/26 | 07/26 | | |
| Recruiting | 3 | 288 | Europe, US, RoW | Methylprednisolone, saline solution | Niguarda Hospital, Ministry of Health, Italy, Istituto Di Ricerche Farmacologiche Mario Negri, University of Milano Bicocca, Regione Lombardia | Myocarditis Acute | 03/28 | 12/28 | | |
NCT05107934: Efficacy and Safety of RPH-104 Treatment in Patients With Recurrent Pericarditis |
|
|
| Suspended | 2/3 | 80 | US | RPH-104, Placebo | R-Pharm Overseas, Inc., Data Management 365, Keystat, LLC | Recurrent Pericarditis | 05/27 | 10/27 | | |
NCT04337216: Mavrilimumab to Reduce Progression of Acute Respiratory Failure in Patients With Severe COVID-19 Pneumonia and Systemic Hyper-inflammation |
|
|
| Not yet recruiting | 2 | 10 | US | Mavrilimumab | Virginia Commonwealth University | COVID-19 | 08/20 | 08/20 | | |
| Completed | 2 | 102 | US | Anakinra, Placebo | Virginia Commonwealth University | Heart Failure, Systolic, Inflammation | 07/24 | 07/24 | | |
| Recruiting | 2 | 84 | US | Anakinra, Kineret, Placebo | Virginia Commonwealth University, National Institute on Aging (NIA), University of Virginia | Heart Failure | 02/27 | 12/27 | | |
NCT06556810: IC14 for Treatment of Acute Decompensated Heart Failure |
|
|
| Recruiting | 1/2 | 10 | US | Atibuclimab (IC14), anti-CD14 monoclonal antibody | Implicit Bioscience, University of Virginia, Virginia Commonwealth University | Acute Decompensated Heart Failure | 09/25 | 01/26 | | |
| NAIK, BHIKEN |
THRIVE, NCT05991453: Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial |
|
|
| Recruiting | N/A | 12500 | US | Anesthetic technique Propofol TIVA, Propofol TIVA, Anesthetic technique inhaled agent, Inhaled agent | Washington University School of Medicine, Patient-Centered Outcomes Research Institute, University of Michigan | Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity | 07/27 | 07/28 | | |
| Bardia, Amit |
PANDORA, NCT04093219: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients |
|
|
| Recruiting | 3 | 900 | US | IV acetaminophen, ofirmev, Placebo | Beth Israel Deaconess Medical Center, National Institute on Aging (NIA) | Delirium in Old Age, Delirium, Coronary Artery Disease | 01/25 | 01/26 | | |
| Recruiting | 3 | 1800 | US | Intravenous Dexmedetomidine, Intravenous Precedex, Sublingual Dexmedetomidine, Sublingual Precedex, Intravenous Placebo, Placebo, Sublingual Placebo | Massachusetts General Hospital | Delirium | 10/27 | 03/29 | | |
THRIVE, NCT05991453: Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial |
|
|
| Recruiting | N/A | 12500 | US | Anesthetic technique Propofol TIVA, Propofol TIVA, Anesthetic technique inhaled agent, Inhaled agent | Washington University School of Medicine, Patient-Centered Outcomes Research Institute, University of Michigan | Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity | 07/27 | 07/28 | | |
| Wang, Shuo |
NCT05955209: Clinical Study on the Efficacy and Safety of RC48-ADC in the Treatment of Metastatic Castration Resistant Prostate Cancer (mCRPC) |
|
|
| Not yet recruiting | 2 | 40 | NA | Disitamab Vedotin（RC48-ADC）, RC48 | Peking University Cancer Hospital & Institute | Metastatic Castration-resistant Prostate Cancer | 08/24 | 08/25 | | |
NCT04135456: The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage |
|
|
| Active, not recruiting | 1/2 | 99 | RoW | Mannitol | Beijing Tiantan Hospital | Aneurysmal Subarachnoid Hemorrhage | 11/23 | 01/24 | | |
STRONG, NCT06600178: Study Targeting Myocardial Perfusion and Symptom Relief in Women with SGLT2 Inhibitors |
|
|
| Not yet recruiting | 1 | 150 | US | Dapagliflozin 10Mg Oral Tablet, Placebo | University of Virginia | Angina Patients with Non-obstructive Coronary Artery Disease, Coronary Microvascular Disease, Coronary Microvascular Dysfunction (CMD) | 01/26 | 07/26 | | |
NCT05766865: Effect and Safety of Surgical Intervention for Severe Spontaneous Intracerebral Hemorrhage Patients on Long-term Oral Antiplatelet Treatment |
|
|
| Completed | N/A | 450 | RoW | Emergency neurosurgery, Conservative treatment | Beijing Tiantan Hospital, Beijing Chao Yang Hospital, Beijing Shuyi Hospital, Beijing Anzhen Hospital, Guangzhou Red Cross Hospital, Beijing Pinggu District Hospital | Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications | 05/22 | 11/22 | | |
NCT05975398: China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH） |
|
|
| Recruiting | N/A | 450 | RoW | Emergency neurosurgery, Conservative treatment | Beijing Tiantan Hospital, Beijing Chao Yang Hospital, Beijing Shuyi Hospital, Beijing Anzhen Hospital, Guangzhou Red Cross Hospital, Beijing Pinggu District Hospital, Beijing Friendship Hospital, Wuxi No. 2 People's Hospital, Dezhou People's Hospital, Binzhou People's Hospital | Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications | 06/25 | 12/25 | | |
NCT04940091: Epidural Analgesia and Maternal Fever During Labor |
|
|
| Recruiting | N/A | 780 | RoW | Epidural analgesia, No other intervention | Peking University First Hospital, Guangdong Women and Children Hospital, Tangshan Maternal and Child Health Hospital, Dongguan Maternal and Child Health Hospital, Beijing Haidian Maternal and Child Health Hospital, Beijing Fuxing Hospital, Fourth Hospital of Shijiazhuang City, Xiamen Maternity & Child Care Hospital | Epidural Analgesia, Analgesic Effect, Fever | 09/22 | 10/22 | | |
NCT04820972: Early-Start Antiplatelet Treatment After Neurosurgery in Patients With Spontaneous Intracerebral Hemorrhage |
|
|
| Recruiting | N/A | 250 | RoW | Antiplatelet Agents | Beijing Tiantan Hospital, The Second Affiliated Hospital of Kunming Medical University, First Affiliated Hospital of Fujian Medical University, The Second Xiangya Hospital of Central South Medical University, First Affiliated Hospital of Harbin Medical University, Gangzhou Red Cross Hospital ，Jinan University, Beijing Chao Yang Hospital, RenJi Hospital, Sichuan Academy of Medical Sciences, Chongqing General Hospital, Binzhou Medical University, Fujian Medical University Union Hospital, Shanxi Provincial People Hospital, Beijing Friendship Hospital, Qilu Hospital of Shandong University, Second Affiliated Hospital, School of Medicine, Zhejiang University | Spontaneous Intracerebral Hemorrhage | 02/23 | 05/23 | | |
NCT06214767: Study on Treatment Decision-Making and Prognostic Follow-Up for Untreated Cerebral Cavernous Malformations |
|
|
| Recruiting | N/A | 1200 | RoW | | Beijing Tiantan Hospital, RenJi Hospital, Beijing Chao Yang Hospital, Beijing Friendship Hospital, Guangzhou Red Cross Hospital, Affiliated Hospital of Guangdong Medical University, Shanxi Provincipal People's Hospital, Qilu Hospital of Shandong University, Central South University, First Affiliated Hospital of Harbin Medical University | Hemangioma, Cavernous, Central Nervous System | 12/25 | 06/26 | | |
NCT05628987: The Association of Gut Microbiota and Spermatogenic Dysfunction |
|
|
| Recruiting | N/A | 306 | RoW | no intervention | Zhujiang Hospital, National Natural Science Foundation of China | Infertility, Male, Azoospermia, Oligozoospermia, Asthenozoospermia, Teratozoospermia | 06/25 | 06/25 | | |
ChTUIA, NCT05844163: Treatment Strategies for Unruptured Intracranial Aneurysms in the Chinese Population China Treatment Trial for Unruptured Intracranial Aneurysm |
|
|
| Recruiting | N/A | 21041 | RoW | observation | Beijing Tiantan Hospital, Huashan Hospital, The First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital of Fujian Medical University, Shanxi Provincial People's Hospital | Unruptured Intracranial Aneurysm | 12/24 | 12/24 | | |
NCT05941377: Enhanced Versus Standard Blood Pressure Lowering on Intracranial Aneurysm Rupture or Growth China Antihypertensive Trial for Intracranial Aneurysm (ChATIA-1) |
|
|
| Recruiting | N/A | 520 | RoW | blood pressure lowering | Beijing Tiantan Hospital, Shanghai Jiaotong University School of Medicine,Renji Hospital, Guangzhou Red Cross Hospital, Jiangnan University Medical Center, The First Dongguan Affiliated Hospital of Guangdong Medical University | Unruptured Intracranial Aneurysm | 07/25 | 07/26 | | |
| Recruiting | N/A | 100000 | RoW | Multi-disciplinary assessment | Beijing Tiantan Hospital | Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure, Aortic Diseases, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Cerebral Infarction, Occlusion and Stenosis of Precerebral Arteries, Occlusion and Stenosis of Cerebellar Arteries, Cerebral Aneurysm, Moyamoya Disease, Arteriovenous Malformation of Cerebral Vessels | 12/32 | 12/32 | | |
NCT05651425: A Retrospective, Multicenter, Controlled Clinical Trail: to Evaluate the Efficiency and Safety of Intracranial Aneurysm Assistive Software in the Preoperative Assessment |
|
|
| Recruiting | N/A | 600 | RoW | | Beijing Tiantan Hospital, RenJi Hospital, Shanxi Provincial People's Hospital | Intracranial Aneurysm | 01/23 | 04/23 | | |
| Recruiting | N/A | 5000 | RoW | Surgical clipping and endovascular coiling | Beijing Tiantan Hospital, Peking University International Hospital | Aneurysmal Subarachnoid Hemorrhage | 03/32 | 04/32 | | |
| Sturek, Jeffery M |
| Completed | 2/3 | 871 | US | TXA127, TRV027, Placebo, Fostamatinib | Sean Collins, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) | COVID-19, SARS-CoV-2 Infection, Coronavirus Infection | 10/23 | 12/23 | | |
| Hogwood, Austin |
| Recruiting | 4 | 30 | US | Colchicine 0.6 mg, Colcrys, Gloperba, Lodoco, Mitigare, Control/Placebo group | University of Virginia | Heart Failure, Decompensated Heart Failure, Heart Failure With Reduced Ejection Fraction | 06/26 | 06/28 | | |
NCT05131217: Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults |
|
|
| Completed | N/A | 13 | US | Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, HIIT, Control, Rest | University of Virginia | Aging Well | 05/23 | 05/23 | | |
| Shoemake, Rachel |
THRIVE, NCT05991453: Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial |
|
|
| Recruiting | N/A | 12500 | US | Anesthetic technique Propofol TIVA, Propofol TIVA, Anesthetic technique inhaled agent, Inhaled agent | Washington University School of Medicine, Patient-Centered Outcomes Research Institute, University of Michigan | Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity | 07/27 | 07/28 | | |
