| Barjaktarevic, Igor |
IKANOS, NCT05970263: Breztri Maintenance Versus Any Non-Triple Inhaled Therapy After Hospitalization for a COPD Exacerbation in the US |
|
|
| Withdrawn | 4 | 1000 | NA | Budesonide/glycopyrrolate/formoterol fumarate (Breztri Aerosphere) 320 μg/18 μg/9.6 μg administered as two inhalations, twice daily., External Comparator | AstraZeneca, Iqvia Pty Ltd, Premier Inc. | COPD | 12/25 | 12/25 | | |
NCT05677971: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein |
|
|
| Recruiting | 3 | 160 | Europe, Canada, US, RoW | Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo, Sodium chloride | Takeda, Takeda Development Center Americas, Inc. | Alpha1-Antitrypsin Deficiency | 03/27 | 03/29 | | |
| Recruiting | 2 | 21 | US | Revefenacin Inhalation Solution [Yupelri], Ipratropium Bromide | University of California, Los Angeles, Theravance Biopharma, Mylan Pharmaceuticals Inc | COPD, Acute Respiratory Failure | 04/25 | 06/25 | | |
| Completed | 2 | 63 | US | Alvelestat (MPH966), Placebo | University of Alabama at Birmingham, National Institutes of Health (NIH), Mereo BioPharma, National Center for Advancing Translational Sciences (NCATS) | Alpha-1 Antitrypsin Deficiency (AATD), Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations, Emphysema or COPD | 11/23 | 12/23 | | |
|
NCT04722887: A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency |
|
|
| Recruiting | 1/2 | 16 | US | Alpha-1 15%, Liquid Alpha1-Proteinase Inhibitor (Human), Prolastin®-C Liquid | Grifols Therapeutics LLC | Alpha1-Antitrypsin Deficiency | 03/25 | 03/25 | | |
| Recruiting | N/A | 40 | US | nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen, standard jet nebulization (SJN) with face mask | University of California, Los Angeles, Aerogen | Hypoxemic Respiratory Failure, Airway Obstruction | 12/24 | 12/24 | | |
| Adams, Brad |
| No trials found |
| Villarreal, Miguel |
| No trials found |
