The SKCCC at Johns Hopkins
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 56 Trials 
85 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Armstrong, Deborah K
NRG-BR003, NCT02488967: Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

Active, not recruiting
3
782
Canada, US
Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, Nealorin, Novoplatinum, Paraplat, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Laboratory Biomarker Analysis, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat
NRG Oncology, National Cancer Institute (NCI)
Breast Adenocarcinoma, Estrogen Receptor Negative, HER2/Neu Negative, Progesterone Receptor Negative, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer, Stage IIIA Breast Cancer, Stage IIIC Breast Cancer, Triple-Negative Breast Carcinoma
10/26
10/26
Wolff, Antonio C
CompassHER2 RD, NCT04457596: T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the Trial

Calendar Jan 2028 - Dec 2028: From CompassHER2 RD trial in combination with Kadcyla for HER2+ breast cancer
Recruiting
3
1031
Canada, US
Trastuzumab Emtansine, Placebo Administration, Tucatinib, Questionnaire Administration, Quality-of-Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Seagen Inc.
Anatomic Stage IA Breast Cancer AJCC V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage IIA Breast Cancer AJCC V8, Anatomic Stage IIB Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Anatomic Stage IIIA Breast Cancer AJCC V8, Anatomic Stage IIIB Breast Cancer AJCC V8, Anatomic Stage IIIC Breast Cancer AJCC V8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC V8, Prognostic Stage IA Breast Cancer AJCC V8, Prognostic Stage IB Breast Cancer AJCC V8, Prognostic Stage II Breast Cancer AJCC V8, Prognostic Stage IIA Breast Cancer AJCC V8, Prognostic Stage IIB Breast Cancer AJCC V8, Prognostic Stage III Breast Cancer AJCC V8, Prognostic Stage IIIA Breast Cancer AJCC V8, Prognostic Stage IIIB Breast Cancer AJCC V8, Prognostic Stage IIIC Breast Cancer AJCC V8, Synchronous Bilateral Breast Carcinoma
01/28
05/35
OFSET, NCT05879926: Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Recruiting
3
3960
Canada, US
Ovarian Function Suppression + Aromatase Inhibitor, Adjuvant Chemotherapy + Ovarian Function Suppression
NRG Oncology, National Cancer Institute (NCI)
Breast Cancer
01/32
07/34
NCT03043794: Study of Stereotactic Radiotherapy for Breast Cancer

Terminated
2
4
US
Stereotactic Body Radiation Therapy SBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Robert L. Sloan Fund for Cancer Research
Breast Cancer
10/21
10/23
NCT04266249: CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Recruiting
2
2156
US
Docetaxel, Docecad, RP56976, Taxotere, Taxotere Injection Concentrate, Lumpectomy, Lumpectomy of Breast, Partial Mastectomy, Mastectomy, Mammectomy, Nab-paclitaxel, ABI 007, ABI-007, Abraxane, Albumin-bound Paclitaxel, Albumin-Stabilized Nanoparticle Paclitaxel, Nanoparticle Albumin-bound Paclitaxel, Nanoparticle Paclitaxel, Paclitaxel Albumin, paclitaxel albumin-stabilized nanoparticle formulation, protein-bound paclitaxel, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pertuzumab, 2C4, 2C4 Antibody, MoAb 2C4, Monoclonal Antibody 2C4, Omnitarg, Perjeta, rhuMAb2C4, RO4368451, Radiation Therapy, Cancer Radiotherapy, Irradiate, irradiated, irradiation, RADIATION, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Trastuzumab, ABP 980, ALT02, Anti-c-ERB-2, Anti-c-erbB2 Monoclonal Antibody, Anti-ERB-2, Anti-erbB-2, Anti-erbB2 Monoclonal Antibody, Anti-HER2/c-erbB2 Monoclonal Antibody, Anti-p185-HER2, c-erb-2 Monoclonal Antibody, HER2 Monoclonal Antibody, Herceptin, Herceptin Biosimilar PF-05280014, Herceptin Trastuzumab Biosimilar PF-05280014, Herzuma, MoAb HER2, Monoclonal Antibody c-erb-2, Monoclonal Antibody HER2, Ogivri, Ontruzant, PF-05280014, rhuMAb HER2, RO0452317, SB3, Trastuzumab Biosimilar ABP 980, Trastuzumab Biosimilar ALT02, trastuzumab biosimilar EG12014, Trastuzumab Biosimilar HLX02, Trastuzumab Biosimilar PF-05280014, Trastuzumab Biosimilar SB3, Trastuzumab-dkst, Trastuzumab-dttb, Trastuzumab-pkrb, Trastuzumab-QYYP, Trazimera, Trastuzumab Emtansine, Ado Trastuzumab Emtansine, ADO-Trastuzumab Emtansine, Kadcyla, PRO132365, RO5304020, T-DM1, Trastuzumab-DM1, Trastuzumab-MCC-DM1, Trastuzumab-MCC-DM1 Antibody-Drug Conjugate, Trastuzumab-MCC-DM1 Immunoconjugate
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Invasive Breast Carcinoma, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8
10/26
12/38
TBCRC040, NCT02743910: Monitoring Plasma Tumor DNA in Early-Stage Breast Cancer

Active, not recruiting
N/A
229
US
ptDNA, Blood sample, Tissue sample
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Translational Breast Cancer Research Consortium
Breast Cancer
02/19
07/25
NCT01937039: Johns Hopkins Breast Cancer Program Longitudinal Repository

Recruiting
N/A
1500
US
Sample collection
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Susan G. Komen Breast Cancer Foundation
Breast Cancer, Benign Breast Disease
01/30
01/30
Song, Danny Y
NCT02225925: Intraoperative Dosimetry for Prostate Brachytherapy Using Fluoroscopy and Ultrasound

Completed
2
45
US
Brachytherapy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer, Adenocarcinoma of the Prostate
12/16
02/23
NCT00809991: Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

Active, not recruiting
2
188
US
hypofractionation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
06/25
09/25
RAVENS, NCT04037358: RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers

Active, not recruiting
2
64
US
Radium-223, stereotactic ablative radiotherapy (SABR)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Defense Congressionally Directed Medical Research Program, Bayer
Prostate Cancer
12/26
12/28
NCT02420977: Evaluation of PSMA-based PET as an Imaging Biomarker in Prostate Cancer

Active, not recruiting
1
23
US
Pelvic DCFPyL PET-MRI fusion or PET/MRI
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI)
Advanced Prostate Cancer
03/24
03/25
NCT01607008: MRI for Assessing Prostate Cancer Response

Recruiting
N/A
20
US
MRI imaging
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
12/25
12/27
Emens, Leisha A
TBCRC 048, NCT03344965: Olaparib in Metastatic Breast Cancer

Active, not recruiting
2
114
US
Olaparib, AZD2281, KU-0059436
Beth Israel Deaconess Medical Center, Johns Hopkins University, AstraZeneca, Dana-Farber Cancer Institute
Metastatic Breast Cancer, Invasive Breast Cancer, Somatic Mutation Breast Cancer (BRCA1), Somatic Mutation Breast Cancer (BRCA2), CHEK2 Gene Mutation, ATM Gene Mutation, PALB2 Gene Mutation, RAD51 Gene Mutation, BRIP1 Gene Mutation, NBN Gene Mutation
07/25
12/25
NCT04563507: Combined Immunotherapies in Metastatic ER+ Breast Cancer

Recruiting
2
102
US
Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions), Letrozole 2.5Mg Tab, Palbociclib 125mg
Weill Medical College of Cornell University
Breast Cancer
10/27
10/28
NCT03804944: Converting HR+ Breast Cancer Into an Individualized Vaccine

Recruiting
2
100
US
Focal Radiation therapy, Pembrolizumab (200mg IV for 30 minutes, CDX-301
Weill Medical College of Cornell University, United States Department of Defense, Merck Sharp & Dohme LLC, Celldex Therapeutics
Breast Cancer
12/25
12/27
NCT04875806: A Safety and Tolerability Study of NC762 in Subjects with Advanced or Metastatic Solid Tumors

Terminated
1/2
40
US
NC762
NextCure, Inc.
Advanced or Metastatic Solid Tumors, Ovarian Cancer, Non-small Cell Lung Cancer, Breast Cancer
01/24
01/24
NCT04381650 / 2020-004325-23: A Study of TAK-981 Given With Pembrolizumab in Participants With Select Advanced or Metastatic Solid Tumors

Active, not recruiting
1/2
49
Europe, Japan, US, RoW
TAK-981, Pembrolizumab
Takeda, Takeda Development Center Americas, Inc.
Advanced or Metastatic Solid Tumors
11/25
11/25
Viswanathan, Akila N
NCT02993900: Image-Guided Gynecologic Brachytherapy

Recruiting
N/A
54
US
Image-Guided Brachytherapy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI)
Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, Bladder Cancer
12/25
12/28
NCT04376229: Proton Radiation Therapy Registry

Recruiting
N/A
5000
US
Registry
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cancer, Therapy-Related
12/30
12/40
NCT04530019: Brachytherapy Innovations in Gynecologic Cancer

Withdrawn
N/A
50
NA
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Gynecologic Cancer
12/30
12/32
Zellars, Richard C
TAILOR RT, NCT03488693: Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

Recruiting
3
2140
Canada, US
Radiation, No Radiation
Canadian Cancer Trials Group, Alliance for Clinical Trials in Oncology, Eastern Cooperative Oncology Group, NRG Oncology, SWOG Cancer Research Network
Breast Cancer
09/27
12/27
NCT03598257: Radiation Therapy With or Without Olaparib in Treating Patients With Inflammatory Breast Cancer

Active, not recruiting
2
300
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Olaparib, AZD 2281, AZD-2281, AZD2281, KU 0059436, KU-0059436, KU0059436, Lynparza, Olanib, Olaparix, PARP Inhibitor AZD2281, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Survey Administration
National Cancer Institute (NCI)
Breast Inflammatory Carcinoma
06/27
06/27
NCT01928589: Partial Irradiation and Sequential Vs. Concurrent Chemo Early Breast Cancer

Active, not recruiting
N/A
81
US
PBI with sequential chemotherapy, partial breast irradiation with sequential chemotherapy, PBI with concurrent chemotherapy, partial breast irradiation with chemotherapy
Richard Zellars
Breast Cancer, Adenocarcinoma of the Breast
12/23
12/28
Herman, Joseph
NCT00426738: Neoadjuvant Gemcitabine, Oxaliplatin, and Radiation Therapy for Pancreatic Cancer

Active, not recruiting
2
60
US
Gemcitabine, Gemzar, Oxaliplatin, Radiation Therapy
Sidney Kimmel Comprehensive Cancer Center, University of Michigan
Pancreatic Cancer
03/14
 
NCT05331131: Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial

Withdrawn
2
56
US
Ketamine Topical, Ketamine mouthwash
Northwell Health
Cancer of Head and Neck, Mucositis Oral, Pharyngeal Mucositis
05/25
11/25
CREDIT, NCT04960787: Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care for Patients and Their Spouses

Recruiting
N/A
522
US
Educational Intervention, Education for Intervention, Intervention by Education, Intervention through Education, Intervention, Educational, Patient Navigation, Patient Navigator Program, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
SWOG Cancer Research Network, National Cancer Institute (NCI)
Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
03/26
10/26
Frassica, Deborah
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
Asrari, Fariba
NCT03043794: Study of Stereotactic Radiotherapy for Breast Cancer

Terminated
2
4
US
Stereotactic Body Radiation Therapy SBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Robert L. Sloan Fund for Cancer Research
Breast Cancer
10/21
10/23
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
McNutt, Todd
NCT03372148: Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients

Withdrawn
N/A
40
US
pHRMi
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Cancer, Dysphagia
12/27
12/30
NCT04376229: Proton Radiation Therapy Registry

Recruiting
N/A
5000
US
Registry
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cancer, Therapy-Related
12/30
12/40
DiPasquale, Shirl
NCT02993900: Image-Guided Gynecologic Brachytherapy

Recruiting
N/A
54
US
Image-Guided Brachytherapy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI)
Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, Bladder Cancer
12/25
12/28
Redmond, Kristin
NCT01466686: Low Dose Radiation Therapy for Glioblastoma Multiforme

Completed
2
31
US
Low Dose Fractionated Radiation Therapy (LDFRT), Temozolomide
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
High Grade Glioma
12/21
12/22
NCT02177578: Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Recruiting
2
60
US
Temozolomide, Subventricular Zone radiation, Neural Progenitor Cell Sparing radiation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Reading Health System Foundation
Glioblastoma Multiforme
12/28
12/32
NCT05768919: Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

Recruiting
1/2
30
US
Treatment Period 1, Treatment Period 2, Treatment Period 3, Treatment Period 4a
SignPath Pharma, Inc., Avance Clinical Pty Ltd.
Glioblastoma
02/26
05/27
Canon, NCT06463262: Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma

Recruiting
N/A
40
US
ctDNA
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Canon Medical Systems, USA
Chordoma of Spine, Chordoma of Skull Base, Chordoma of Sacrum
07/29
07/31
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
NCT03377517: Radiosurgical Hypophysectomy for Bone Metasteses Pain

Recruiting
N/A
16
US
radiosurgical hypophysectomy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Accuray Incorporated
Bone Metastases
12/27
12/30
Kleinberg, Lawrence
NCT02177578: Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Recruiting
2
60
US
Temozolomide, Subventricular Zone radiation, Neural Progenitor Cell Sparing radiation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Reading Health System Foundation
Glioblastoma Multiforme
12/28
12/32
NCI-2018-01560, NCT03604978: Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Recruiting
1/2
38
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Echocardiography, EC, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS 734016, BMS-734016, BMS734016, Ipilimumab Biosimilar CS1002, MDX 010, MDX-010, MDX-CTLA4, MDX010, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Stereotactic Radiosurgery, SRS, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery
National Cancer Institute (NCI)
Grade 2 Meningioma, Grade 3 Meningioma, Recurrent Meningioma
11/25
11/25
NCT05768919: Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

Recruiting
1/2
30
US
Treatment Period 1, Treatment Period 2, Treatment Period 3, Treatment Period 4a
SignPath Pharma, Inc., Avance Clinical Pty Ltd.
Glioblastoma
02/26
05/27
NCT03961971: Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

Active, not recruiting
1
16
US
MBG453, spartalizumab, stereotactic radiosurgery
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Novartis Pharmaceuticals
Glioblastoma Multiforme
11/22
09/25
CA209-594, NCT02989636: Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma

Active, not recruiting
1
21
US
Laboratory Biomarker Analysis, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Stereotactic Radiosurgery, Stereotactic External Beam Irradiation, stereotactic external-beam radiation therapy, Stereotactic Radiation Therapy, Stereotactic Radiotherapy, stereotaxic radiation therapy, stereotaxic radiosurgery
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Bristol-Myers Squibb, Chordoma Foundation
Chordoma
04/24
11/26
NCT05083754: Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Recruiting
1
50
US
Retifanlimab, INCMGA00012, Temozolomide, Radiation Therapy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Incyte Corporation
Glioblastoma Multiforme
01/26
01/27
TRIDENT, NCT04471844: Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant with RT & TMZ for the Treatment of Newly Diagnosed GBM

Active, not recruiting
N/A
982
Europe, Canada, Japan, US, RoW
Optune®
NovoCure Ltd.
Glioblastoma Multiforme
01/26
01/26
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
NCT03377517: Radiosurgical Hypophysectomy for Bone Metasteses Pain

Recruiting
N/A
16
US
radiosurgical hypophysectomy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Accuray Incorporated
Bone Metastases
12/27
12/30
Quinones, Alfredo
NCT02177578: Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Recruiting
2
60
US
Temozolomide, Subventricular Zone radiation, Neural Progenitor Cell Sparing radiation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Reading Health System Foundation
Glioblastoma Multiforme
12/28
12/32
Hales, Russell
REACTION, NCT03610711: (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer

Active, not recruiting
1/2
21
US
Nivolumab, Optivo, Relatlimab, anti-LAG3
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bristol-Myers Squibb
Gastroesophageal Cancer, Immune Checkpoint Inhibition
12/25
12/25
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
Ellsworth, Susannah
NCT04166318: Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Recruiting
2
252
US
Capecitabine, Ro 09-1978/000, Xeloda, Fluorouracil, 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-FU, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Mitomycin, Ametycine, MITO, MITO-C, Mito-Medac, Mitocin, Mitocin-C, Mitolem, Mitomycin C, Mitomycin-C, Mitomycin-X, Mitomycine C, Mitosol, Mitozytrex, Mutamycin, Mutamycine, NCI-C04706, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma, Anal Canal Squamous Cell Carcinoma, Anal Margin Squamous Cell Carcinoma, Stage I Anal Cancer AJCC v8, Stage IIA Anal Cancer AJCC v8
12/29
12/29
NCT01360606: Stereotactic Body Radiation Therapy (SBRT) for Liver Mets

Completed
N/A
9
US
Stereotactic Body Radiation Therapy, CyberKnife, Trilogy, True Beam, Radiosurgery
Susannah Ellsworth
Liver Metastases
07/18
02/21
NCT06355895: Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies

Recruiting
N/A
17
US
Standardized high-carbohydrate meal
University of Pittsburgh, American College of Radiation Oncology
Upper Abdominal Malignancies
06/25
06/25
Vannorsdall, Tracy
NCT02177578: Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Recruiting
2
60
US
Temozolomide, Subventricular Zone radiation, Neural Progenitor Cell Sparing radiation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Reading Health System Foundation
Glioblastoma Multiforme
12/28
12/32
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
Wick, Elizabeth
NCT06090552: I CAN DO Surgical ACP

Not yet recruiting
N/A
6000
US
Letter, AD, PREPARE, Letter, AD, PREPARE, reminders, Letter, AD, PREPARE, reminders, healthcare navigator
University of California, San Francisco, University of California, Irvine, University of Minnesota, National Institute on Aging (NIA)
Surgical Advanced Care Planning
12/28
12/28
Holdhoff, Matthew
NCT02177578: Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

Recruiting
2
60
US
Temozolomide, Subventricular Zone radiation, Neural Progenitor Cell Sparing radiation
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Reading Health System Foundation
Glioblastoma Multiforme
12/28
12/32
Zhang, Zhe
TQB2102-II-04, NCT06767800: A Clinical Trial Evaluating TQB2102 for Injection in Combination With Benmelstobart/Penpulimab With or Without Capecitabine in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma

Not yet recruiting
2
168
RoW
TQB2102 for injection+Benmelstobart, TQB2102 for injection+Benmelstobart+Capecitabine
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Gastroesophageal Adenocarcinoma
09/26
09/27
YKP2023-02-04, NCT06445088: Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma

Recruiting
N/A
908
RoW
VCA-IgA, EBNA1-IgA, and EBV-DNA, EBV C Promoter Methylation Detection in nasopharyngeal swab samples
Sun Yat-sen University, Fujian Cancer Hospital, Wuzhou Red Cross Hospital, Zhongshan People's Hospital, Guangdong, China, First Affiliated Hospital of Guangxi Medical University
Nasopharyngeal Carcinoma
12/26
12/26
Narang, Amol K
NCT02017704: Chemoradiation or Brachytherapy for Rectal Cancer

Completed
2
9
US
Endo-HDR (if randomized to this arm), capecitabine and IMRT (if randomized to this arm), Xeloda, IMRT (intensity modulated radiation therapy), FOLFOX6, Oxaliplatin, Leucovorin, 5 Fluorouracil, Surgery
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Nucletron
Rectal Cancer
09/21
01/23
NCT00962520: Tarceva With Chemoradiation and Adjuvant Chemotherapy for Resectable Pancreatic Cancer

Checkmark ASCO-GI 2013
Jan 2013 - Jan 2013: ASCO-GI 2013
Checkmark P2 data
Nov 2011 - Nov 2011: P2 data
Active, not recruiting
2
40
US
Erlotinib, Tarceva, capecitabine, Xeloda, Radiation Therapy, gemcitabine, Gemzar, erlotinib
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Genentech, Inc.
Pancreatic Cancer
04/22
04/23
NCT01781728: Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma

Completed
2
48
US
Stereotactic Body Radiation Therapy (SBRT)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreatic Cancer, Periampullary Adenocarcinoma
03/21
06/24
NCT03767582: Trial of Neoadjuvant and Adjuvant Nivolumab and BMS-813160 With or Without GVAX for Locally Advanced Pancreatic Ductal Adenocarcinomas.

Completed
1/2
46
US
Stereotactic Body Radiation (SBRT), Nivolumab, OPDIVO, CCR2/CCR5 dual antagonist, BMS-813160, GVAX, PANC 10.05 pcDNA-1/GM-Neo vaccine, PANC 6.03 pcDNA-1/GM-Neo vaccine
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bristol-Myers Squibb
Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC), Pancreatic Ductal Adenocarcinoma
09/24
09/24
NCT05141513: Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

Recruiting
1
25
US
High Dose Rate Brachytherapy (HDR) Intraoperative Radiation Therapy (IORT)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreatic Cancer
06/25
04/28
NCT04843306: Breath-Hold Technique for Pancreatic Stereotactic Body Radiation Therapy (SBRT) Patients

Terminated
N/A
4
US
Biofeedback, Active Breathing Control Technique
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreas Cancer
08/23
08/23
Diaz, Luis
NCT03832569: Study of Pembrolizumab Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors

Active, not recruiting
1
17
US
Pembrolizumab
Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC
Solid Tumors, Identified by NGS, PCR or IHC
02/25
02/25
TARGET-HCC, NCT02954094: A Longitudinal Observational Study of the Natural History and Management of Patients With HCC

Recruiting
N/A
10000
Europe, US
Target PharmaSolutions, Inc.
Hepatocellular Cancer
10/25
10/25
NCT05612048: A Study of Tooth Erosion in People With Esophagogastric Cancer

Recruiting
N/A
300
US
Survey, Intra-oral camera, Optional Salvia sample
Memorial Sloan Kettering Cancer Center
Esophagogastric Cancer
11/25
11/25
NCT04533763: Living WELL: A Web-Based Program for Ovarian Cancer Survivors

Recruiting
N/A
292
US
Technology-based Mindful Living program, Technology-based Healthy Lifestyles program
Susan Lutgendorf, University of Washington, University of Miami, University of Iowa
Ovarian Cancer
01/26
01/26
Habibi, Mehran
NCT04129216: The Effects of Short-term Preoperative Treatment With Hormonal Therapy on Gene Profiles in Breast Cancer

Completed
2
30
US
Tamoxifen Citrate, Soltamox, Letrozole, Femara, Exemestane, Aromasin, Blueprint, Mammaprint
Johns Hopkins University, Agendia
Breast Cancer
11/22
11/22
NCT05236387: Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection

Terminated
N/A
14
US
99m Tc-TM, Lymphoseek
Johns Hopkins University, Cardinal Health
Breast Cancer
05/23
06/23
FLEX, NCT03053193: MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

Recruiting
N/A
30000
Europe, Canada, US, RoW
MammaPrint, BluePrint, and Full-Genome Testing, MammaPrint, BluePrint
Agendia
Breast Cancer
04/37
12/37
Janson, Kristin
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
Sair, Haris
NCT03487367: Clinical Trial Readiness for SCA1 and SCA3

Active, not recruiting
N/A
200
US
The Methodist Hospital Research Institute, University of Michigan, University of Minnesota, University of Utah, University of California, Los Angeles, University of Chicago, University of South Florida, Harvard University, Johns Hopkins University, University of Florida, Columbia University, Emory University, University of California, San Francisco, University of Alabama at Birmingham, University of Colorado, Denver, University of Rochester, Stanford University, Northwestern University, German Center for Neurodegenerative Diseases (DZNE), Institut de Recherche sur la Moelle épinière et l'Encéphale, University of Pennsylvania, Ohio State University, University of Iowa
Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia 3
12/23
12/23
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
Page, Brandi
NCT03223922: Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases

Recruiting
N/A
24
US
whole brain radiation therapy, WBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Brain Metastases
12/25
12/30
NCT03372148: Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients

Withdrawn
N/A
40
US
pHRMi
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Cancer, Dysphagia
12/27
12/30
Kiess, Ana
PSMA-DC, NCT05939414: An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

Recruiting
3
450
Europe, Canada, Japan, US, RoW
AAA617, (177Lu) vipivotide tetraxetan
Novartis Pharmaceuticals
Oligometastatic Prostate Cancer (OMPC)
12/27
07/30
RTOG 1216, NCT01810913: Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Recruiting
2/3
613
Canada, US, RoW
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cetuximab, C 225, C-225, C225, Cetuximab Biosimilar CDP-1, Cetuximab Biosimilar CMAB009, Cetuximab Biosimilar KL 140, Chimeric Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225, Chimeric Monoclonal Antibody C225, Erbitux, IMC-C225, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Docetaxel, Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate, Intensity-Modulated Radiation Therapy, IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Quality-of-Life Assessment, Quality of Life Assessment
National Cancer Institute (NCI), NRG Oncology
Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7, Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7, Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7
01/27
01/27
NCT02289209: Reirradiation With Pembrolizumab in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck

Active, not recruiting
2
51
US
Reirradiation, MK-3475, Keytruda, pembrolizumab
Dan Zandberg, Merck Sharp & Dohme LLC
Recurrent Head and Neck Cancer, Carcinoma, Squamous Cell of Head and Neck
08/23
08/24
NCT06322576: 177Lu-PSMA (177Lu-PNT2002) in PSMA-Positive Adenoid Cystic Carcinoma

Not yet recruiting
2
10
US
177Lu-PNT2002, 177Lu PSMA
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Adenoid Cystic Carcinoma Research Foundation, Progenics Pharmaceuticals, Inc.
Adenoid Cystic Carcinoma
03/30
02/35
RAVENS, NCT04037358: RAdium-223 and SABR Versus SABR for Oligometastatic Prostate Cancers

Active, not recruiting
2
64
US
Radium-223, stereotactic ablative radiotherapy (SABR)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Defense Congressionally Directed Medical Research Program, Bayer
Prostate Cancer
12/26
12/28
NCI-2020-04699, NCT04489719: Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

Recruiting
N/A
48
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Questionnaire Administration, Radium Ra 223 Dichloride, Alpharadin, BAY 88-8223, BAY88-8223, Radium 223 Dichloride, RADIUM RA-223 DICHLORIDE, Radium-223 Dichloride, Xofigo
University of Washington, Bayer
Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
08/25
08/28
(SEEtoTREAT), NCT06389097: SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

Not yet recruiting
N/A
80
NA
Radium-223, 177Lu-DOTATATE, 177Lu-PSMA-617
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI)
Prostate Cancer, Advanced Cancer
08/28
08/29
NCT03372148: Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients

Withdrawn
N/A
40
US
pHRMi
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Cancer, Dysphagia
12/27
12/30

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