Recruiting

N/A

960

Europe, Canada, Japan, US, RoW

AO Innovation Translation Center, AO Foundation, AO Spine

Metastatic Spine Tumor

12/25

12/25

Recruiting

N/A

1500

Canada, US

No Treatment Given

Robert G. Grossman, MD, Christopher Reeve Paralysis Foundation, The Methodist Hospital Research Institute, The University of Texas Health Science Center, Houston, University of Virginia, University of Louisville, University of Toronto, University of Maryland, Baltimore, Walter Reed National Military Medical Center, Thomas Jefferson University, University of Miami, Brooke Army Medical Center, Louisiana State University Health Sciences Center in New Orleans, Vanderbilt University Medical Center, Medical College of Wisconsin, Duke University

Spinal Cord Injury

07/25

07/28

Completed

3

128

Europe, Canada, US, RoW

Ganaxalone, Placebo

Marinus Pharmaceuticals, Marinus Pharmaceuticals Inc., Marinus Pharmaceuticals, Inc.

Tuberous Sclerosis Complex

09/24

10/24

4

446

Europe, Canada, US, RoW

Faricimab

McMaster University, Hoffmann-La Roche

Diabetic Macular Edema

Not yet recruiting

4

100

Canada

Autologous platelet rich plasma eye drops

University Health Network, Toronto

Ocular Surface Disease, Dry Eye Syndromes

01/22

01/23

Recruiting

N/A

40

Europe, Canada, RoW

CorNeat KPro

CorNeat Vision Ltd.

Corneal Disease, Corneal Opacity, Corneal Injuries

03/25

03/26

Recruiting

3

20000

Europe, Canada, Japan, US, RoW

Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir

UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore

Community-acquired Pneumonia, Influenza, COVID-19

02/26

02/28

Completed

N/A

3622

Europe, Canada, US, RoW

7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.

Sunnybrook Health Sciences Centre

Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial

05/23

08/23

Completed

3

4800

Europe, Canada, US, RoW

Placebo (0.9% saline), normal saline; NaCl 0.9%, Pantoprazole, Protonix

McMaster University, Canadian Institutes of Health Research (CIHR), Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, National Health and Medical Research Council, Australia

Gastrointestinal Hemorrhage (Clinically Important, Upper)

10/23

01/24

Completed

3

850

Europe, Canada, US, RoW

Placebo, Nerinetide, NA-1

NoNO Inc., University of Calgary

Stroke, Acute

08/23

08/23

Recruiting

N/A

560

Canada

Doxycycline Hyclate

Jonathan Troy Grennan, Canadian Institutes of Health Research (CIHR)

Bacterial Sexually Transmitted Diseases

12/26

06/27

Recruiting

N/A

408

Canada

Diffusion-weighted Magnetic Resonance Imaging (DW-MRI), Transcranial Doppler (TCD), Transthoracic Echocardiogram (TTE)

University Health Network, Toronto, Peter Munk Cardiac Centre

Patent Foramen Ovale

07/25

07/25

Active, not recruiting

N/A

530

Europe, Canada, US

endovascular thrombectomy (EVT), solitaire X, Standarad medical care

Dr. Michael D Hill, University of Calgary

Acute Ischemic Stroke

12/25

06/26

Recruiting

N/A

106

Canada

Health technology-based intervention strategy

University Health Network, Toronto, Canadian Initiative for Outcomes in Rheumatology Care

Axial Spondyloarthritis

12/23

12/24

Active, not recruiting

4

15

Canada

Tapered doses of TNFi, etanercept 50 mg every 10 days (75% of baseline dose), 14 days (50%), 30 days (25%), adalimumab 40 mg every 3 weeks (75%), 4 weeks (50%), 16 weeks (25%), certolizumab pegol 200 mg 3 weeks (75%), 4 weeks (50%), 16 weeks (25%), golimumab 50 mg every 6 weeks (75%), 8 weeks (50%), 16 weeks (25%), infliximab 5 mg/kg every 8 weeks (75%), 12 weeks (50%), 16 weeks (25%), Standard dose of TNFi, etanercept 50 mg every 7 days, adalimumab 40 mg every 2 weeks, certolizumab pegol 200 mg every 2 weeks, golimumab 50 mg every 4 weeks, infliximab 5 mg/kg every 6 weeks

University Health Network, Toronto

Axial Spondyloarthritis

07/24

08/24

Recruiting

4

8000

Europe, Canada, RoW

Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging

University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute

Staphylococcus Aureus Bacteremia

12/28

12/28

Recruiting

N/A

60

Canada

Dorsal webspace combined corticosteroid and anesthetic injection, Palmar combined corticosteroid and anesthetic injection

Kevin Zuo

Trigger Finger Disorder

02/26

07/26