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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
HO, James Chung-man
NCT04322929: Roflumilast in Non-CF Bronchiectasis Study (2019)	Completed	2	42	RoW	Roflumilast Oral Tablet, Daxas	The University of Hong Kong	Non-cystic Fibrosis Bronchiectasis	06/24	11/24
TRIDENT-1, NCT03093116 / 2016-003616-13: A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements Jan 2023 - Dec 2023 : Data readout from P1/2 TRIDENT-1 trial for ROS1 NSCLC and NTRK+ solid tumors Jan 2023 - Dec 2023: Approval in US for 2L NSCLC Jul 2023 - Dec 2023 : Approval for ROS1+ NSCLC Top line data across ROS1-positive TKI-naïve and TKI-pretreated NSCLC cohorts in TRIDENT-1 trial Apr 2022 - Apr 2022: Top line data across ROS1-positive TKI-naïve and TKI-pretreated NSCLC cohorts in TRIDENT-1 trial NMPA granted in patients with for the treatment of patients with ROS1-positive NSCLC Feb 2022 - Feb 2022: NMPA granted in patients with for the treatment of patients with ROS1-positive NSCLC Presentation of Trident -1 data for the treatment of NSCLC in AACR-NCI-EORTC 2021 Oct 2021 - Oct 2021: Presentation of Trident -1 data for the treatment of NSCLC in AACR-NCI-EORTC 2021 Granted in patients with NTRK-positive, TKI-pretreated advanced solid tumors Oct 2021 - Oct 2021: Granted in patients with NTRK-positive, TKI-pretreated advanced solid tumors Granted for ROS1-positive advanced NSCLC Aug 2021 - Aug 2021: Granted for ROS1-positive advanced NSCLC For TKI-naive ROS1-positive NSCLC from TRIDENT-1 study Jan 2021 - Jan 2021: For TKI-naive ROS1-positive NSCLC from TRIDENT-1 study For ROS1+ve metastatic NSCLC based on TRIDENT-1 study Dec 2020 - Dec 2020: For ROS1+ve metastatic NSCLC based on TRIDENT-1 study For 2L treatment of patients with advanced solid tumors Aug 2020 - Aug 2020: For 2L treatment of patients with advanced solid tumors Interim data from P2 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors Aug 2020 - Aug 2020: Interim data from P2 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors From TRIDENT-1 trial [screenshot] Sep 2019 - Sep 2019: From TRIDENT-1 trial [screenshot] From P1 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors Jun 2019 - Jun 2019: From P1 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors From P1 portion of P1/2 TRIDENT-1 trial at ASCO 2019 [screenshot] May 2019 - May 2019: From P1 portion of P1/2 TRIDENT-1 trial at ASCO 2019 [screenshot] FromTRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors [screenshot] Sep 2018 - Sep 2018: FromTRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors [screenshot] Interim data for ROS1 fusion +ve NSCLC Sep 2018 - Sep 2018: Interim data for ROS1 fusion +ve NSCLC From TRIDENT-1 trial in patients with advanced ALK/ROS1/NTRK+ Cancers at ASCO 2018 [screenshot] Jun 2018 - Jun 2018: From TRIDENT-1 trial in patients with advanced ALK/ROS1/NTRK+ Cancers at ASCO 2018 [screenshot] More	Recruiting	1/2	500	Europe, Canada, Japan, US, RoW	Oral repotrectinib (TPX-0005), repotrectinib	Turning Point Therapeutics, Inc., Zai Lab (Shanghai) Co., Ltd.	Locally Advanced Solid Tumors, Metastatic Solid Tumors	02/28	02/28
EXTRACT, NCT05207423: A Chart Review Study of Adults With Advanced NSCLC	Completed	N/A	179	Europe, Canada, RoW		Takeda	Non-small Cell Lung Cancer (NSCLC)	02/23	02/23
STEM, NCT04410146: The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma	Completed	N/A	310	Europe, US	SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation, Other: Medical Management	Balt USA, Balt Extrusion, Embo-Flüssigkeiten A.G., AXIOM Real Time Metrics	Subdural Hematoma, Chronic	02/24	05/24