| Waksman, Ron |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
V-PLAQUE, NCT05360446: Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events |
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| Recruiting | 3 | 600 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Coronary Artery Disease | 01/27 | 01/27 | | |
VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease |
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| Active, not recruiting | 3 | 17006 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Atherosclerotic Cardiovascular Disease | 10/27 | 10/27 | | |
| Recruiting | N/A | 1150 | US, RoW | Portico transcatheter aortic valve, Commercially available transcatheter aortic valve | Abbott Medical Devices | Aortic Valve Stenosis | 10/19 | 07/25 | | |
NCT02799823: Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial |
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| Terminated | N/A | 11 | US | HLT Transcatheter Aortic Valve System | HLT Inc. | Aortic Valve Stenosis | 01/23 | 01/23 | | |
NCT03557242: Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 124 | US | TAVR, Warfarin plus Aspirin, Aspirin Only | Medstar Health Research Institute | Aortic Stenosis | 07/23 | 07/23 | | |
CAMEO, NCT04076813: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry |
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| Recruiting | N/A | 4000 | US | | Chiesi USA, Inc., Duke University | Myocardial Infarction | 10/24 | 10/24 | | |
| Recruiting | N/A | 418 | Europe, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd | Coronary Restenosis | 07/24 | 11/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT03002272: Transcatheter Aortic Prosthesis Function: A Long-term Follow-up Study |
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| Recruiting | N/A | 100 | US | TAVR, SAVR | Medstar Health Research Institute | Aortic Valve Replacement | 01/24 | 01/28 | | |
| Recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 03/24 | 06/29 | | |
| Not yet recruiting | N/A | 264 | NA | TAVR-explant, Redo-TAVR, Valve-in-Valve, TAV-in-TAV | Medstar Health Research Institute | Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure | 05/34 | 05/36 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 12/24 | 11/25 | | |
| Recruiting | N/A | 910 | US | PCI with SELUTION SLR DCB, PCI with FDA approved "-limus" DES | M.A. Med Alliance S.A. | Coronary Artery Disease | 08/25 | 08/29 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 1000 | Canada, US | | Medstar Health Research Institute | Mitral Valve Disease | 02/27 | 02/27 | | |
| Recruiting | N/A | 1000 | US | Outcomes for Patients with CMD | Medstar Health Research Institute | Coronary Microvascular Dysfunction | 01/33 | 01/33 | | |
| Ali, Syed |
NCT01041703: Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia |
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| Recruiting | 3 | 747 | US, RoW | clofarabine, cytarabine, daunorubicin hydrochloride, decitabine | Eastern Cooperative Oncology Group, National Cancer Institute (NCI) | Leukemia | 02/19 | | | |
SCALP2, NCT05914805: A Study to Evaluate the Efficacy and Safety of Clascoterone Solution in Treatment of Male Pattern Hair Loss |
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| Recruiting | 3 | 726 | Europe, US | Clascoterone 5% solution, CB-03-01 5% solution, Vehicle solution, Vehicle | Cassiopea SpA, Ergomed PLC, Pharmapace Inc, Canfield Scientific Inc., ICON Clinical Research | Alopecia, Androgenetic | 08/24 | 03/25 | | |
NCT03376477: Allogeneic Myeloma GM-CSF Vaccine With Lenalidomide in Multiple Myeloma Patients in Complete or Near Complete Remission |
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| Active, not recruiting | 2 | 54 | US | GM-CSF vaccine, GVAX, Lenalidomide, Revlimid, Prevnar13, pneumococcal vaccine, Placebo Prevnar13, Placebo GM-CSF Vaccine | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Celgene, Aduro Biotech, Inc. | Multiple Myeloma | 01/24 | 09/24 | | |
NCT05772520: The Efficacy and Safety of TLL018 in Moderate-to-severe Plaque Psoriasis |
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| Recruiting | 2 | 120 | US | TLL018 tablets, TLL018 Placeboes | Hangzhou Highlightll Pharmaceutical Co., Ltd | Plaque Psoriasis | 04/24 | 05/24 | | |
NCT04843241: Translation of Neck Disability Index Into Local Pakistani Languages of Pakistan |
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| Recruiting | N/A | 500 | RoW | | Riphah International University | Neck Pain | 12/21 | 12/21 | | |
nHFOV, NCT04914715: Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome |
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| Withdrawn | N/A | 1200 | RoW | Non-invasive High Frequency Oscillatory Ventilation, Conventional Invasive Ventilation | Indus Hospital and Health Network | Respiratory Distress Syndrome in Premature Infant | 06/23 | 12/23 | | |
CAMEO, NCT04076813: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry |
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| Recruiting | N/A | 4000 | US | | Chiesi USA, Inc., Duke University | Myocardial Infarction | 10/24 | 10/24 | | |
NCT06267404: Effectiveness of Iliopsoas Positional Release Versus Conventional Exercises in the Management of Sub-acute Back Pain. |
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| Recruiting | N/A | 100 | RoW | Iliopsoas Positional release therapy, Strain Counter-strain therapy, Conventional exercises, conventional physical therapy treatment | University of Karachi, Sindh Institute of Physical Medicine and Rehabilitation | Back Pain | 02/25 | 02/25 | | |
| Shults, Christian |
PACES, NCT04045665: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG |
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| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
| Recruiting | N/A | 585 | US | NeoChord DS1000, Surgical Mitral Valve Repair | NeoChord | Mitral Valve Insufficiency | 07/22 | 07/27 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
| Completed | N/A | 140 | Canada, US | DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator | CytoSorbents, Inc | Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative | 08/23 | 08/23 | | |
NCT03033043: Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection |
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| Active, not recruiting | N/A | 56 | US | Relay Pro Stent-Graft, Relay Pro Stent Graft System | Bolton Medical | Aortic Dissection Type B | 10/21 | 10/26 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 200 | Europe, US | Thoraflex Hybrid, RelayPro NBS | Vascutek Ltd., Bolton Medical | Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection | 12/35 | 12/36 | | |
| Moriarty, Terry |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia. |
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| Recruiting | 2a | 120 | US | AV-001 Injection, AV-001 Placebo Injection | Vasomune Therapeutics, Inc. | Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome | 12/24 | 03/25 | | |
NCT05046158: Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care |
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| Recruiting | N/A | 200 | US | Transforming Powder Dressing, Altrazeal, Standard of care topical wound agents and dressings | ULURU Inc., Naval Medical Research Center, Military Technology Enterprise Consortium (US) | Diabetic Foot Ulcer | 12/23 | 12/23 | | |
| Burton, Andrea |
| Recruiting | N/A | 315 | Europe, US | CGuard Carotid Stent implantation, Carotid stenting | InspireMD | Carotid Artery Stenosis | 07/22 | 10/25 | | |
CAMEO, NCT04076813: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry |
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| Recruiting | N/A | 4000 | US | | Chiesi USA, Inc., Duke University | Myocardial Infarction | 10/24 | 10/24 | | |
| Recruiting | N/A | 1492 | US | | Baylor Research Institute, Chiesi USA, Inc. | Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications | 03/25 | 03/25 | | |
