| Vergote, Ignace B |
INNOVATE-3, NCT03940196: Effect of Tumor Treating Fields (TTFields, 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / ) |
|
|
| Completed | 3 | 540 | Europe, Canada, US, RoW | NovoTTF-100L(O), TTFields, Paclitaxel, Weekly Paclitaxel, Taxol | NovoCure Ltd. | Ovarian Cancer | 05/23 | 05/23 | | |
| Active, not recruiting | 2 | 160 | Europe | Olaparib, Lynparza, carboplatin + gemcitabine or carboplatin + paclitaxel or carboplatin + liposomal doxorubicin or liposomal doxorubicin 4-weekly or topotecan or paclitaxel weekly | Universitaire Ziekenhuizen Leuven, AstraZeneca | Ovarian Epithelial Cancer | 07/21 | 07/23 | | |
| Active, not recruiting | 2 | 48 | Europe | Atezolizumab, Doxorubicin | Universitaire Ziekenhuizen KU Leuven, Roche Pharma AG | Cervical Cancer | 09/25 | 09/25 | | |
NCT01763125: Establishment of a Tumor Bank for Blood Samples |
|
|
| Recruiting | N/A | 10000 | Europe | Blood collection | Medical University of Vienna | Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia, Lung Neoplasms, Endocrine Gland Neoplasms | 12/26 | 12/26 | | |
| Desmet, Walter JR |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Dubois, Christophe LF |
| Active, not recruiting | N/A | 116 | Europe | | Universitaire Ziekenhuizen KU Leuven, AZ Delta, University Hospital, Antwerp | Aortic Stenosis, Coronary Artery Disease | 04/24 | 07/24 | | |
HighFLO, NCT04888247: Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve |
|
|
| Recruiting | N/A | 30 | Europe, RoW | CLARITY | HighLife SAS | Mitral Regurgitation | 12/25 | 02/31 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
|
|
| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Active, not recruiting | N/A | 200 | Europe, RoW | Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI) | Abbott Medical Devices | Mitral Valve Regurgitation | 05/25 | 05/29 | | |
| Recruiting | N/A | 400 | Europe | Tendyne Mitral Valve System | Klinikum der Universitaet Muenchen | Mitral Regurgitation | 12/26 | 12/27 | | |
| Sinnaeve, Peter R |
| Completed | 4 | 609 | Europe, Canada, RoW | Tenecteplase, TNKase, Metalyse, Clopidogrel, Coronary angiography, Primary PCI | KU Leuven, Boehringer Ingelheim, Life Sciences Research Partners, Fund for Clinical Cardiovascular Research at LRD | Myocardial Infarction | 10/22 | 09/23 | | |
COL BE PCI, NCT06095765: Colchicine in Belgium in Patients With Coronary Artery Disease After Percutaneous Coronary Intervention |
|
|
| Recruiting | 3 | 2770 | Europe | Colchicine 0.5 MG Oral Tablet, Placebo | AZ Sint-Jan AV, University Hospital, Ghent, Belgium Health Care Knowledge Centre | Coronary Artery Disease | 11/27 | 03/28 | | |
NCT04431661: CAOCT: Intra CoronAry Optical Computerized Tomography in out-of Hospital Cardiac Arrest Patients |
|
|
| Terminated | N/A | 28 | Europe, RoW | Optical Coherence Tomography, Coronary Angiography, Per cutaneous coronary intervention | Ceric Sàrl, Abbott | Out of Hospital Cardiac Arrest | 01/23 | 01/23 | | |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Vansteenkiste, Johan |
| Active, not recruiting | 1/2 | 73 | Europe | PDC*lung01, Keytruda Injectable Product, Pembrolizumab, Alimta Injectable Product, Pemetrexed | PDC*line Pharma SAS | Non Small Cell Lung Cancer | 07/24 | 12/25 | | |
| Recruiting | N/A | 39 | Europe | Local ablative therapy, SBRT | Universitaire Ziekenhuizen KU Leuven | Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor | 10/25 | 10/25 | | |
| Gillard, Pieter |
| Recruiting | N/A | 6000 | Europe | | University of Cambridge, Innovative Medicines Initiative, Juvenile Diabetes Research Foundation, The Leona M. and Harry B. Helmsley Charitable Trust | Type 1 Diabetes Mellitus | 10/22 | 10/22 | | |
ENHANCED1, NCT05670366: The Integration of Physical Activity Into the Clinical Decision Process of People With Type 1 Diabetes |
|
|
| Recruiting | N/A | 25 | Europe | Activity tracker and chest strap, Diary app | prof dr Pieter Gillard, University Colleges Leuven Limburg | Type 1 Diabetes | 03/23 | 03/23 | | |
| Active, not recruiting | N/A | 200 | Europe | Omnipod 5 System | Insulet Corporation | Diabetes Mellitus, Type 1 | 08/24 | 08/25 | | |
INRANGE, NCT04414280: The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs |
|
|
| Recruiting | N/A | 1150 | Europe | Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/24 | 12/24 | | |
NCT05777330: Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes |
|
|
| Recruiting | N/A | 75 | Europe | Oral glucose tolerance test (OGTT), OGTT, Hyperglycemic clamp test, clamp, Continuous glucose monitoring, Dexcom G6, CGM | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Juvenile Diabetes Research Foundation | Type1 Diabetes Mellitus | 04/26 | 04/27 | | |
| Adriaenssens, Tom |
NCT04591938: FANTOM ENCORE Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study |
|
|
| Recruiting | N/A | 50 | Europe | Fantom Encore Bioresorbable scaffold implantation | Joost Daemen, Horizon 2020 - European Commission, REVA Medical, Inc. | Percutaneous Coronary Intervention, Myocardial Revascularization, Tomography, Optical Coherence | 06/21 | 12/25 | | |
RESTO, NCT04268875: Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT |
|
|
| Completed | N/A | 307 | Europe | Optical Coherence Tomography (OCT) | University Hospital, Clermont-Ferrand, Abbott, Corelab ISIT | In-stent Restenosis | 12/22 | 12/22 | | |
EUROSHOCK, NCT03813134: Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock |
|
|
| Recruiting | N/A | 428 | Europe | Percutaneous coronary intervention (PCI), Pharmacological Support, VA-ECMO, Veno-Arterial Extra Corporeal Membrane Oxygenation. | University of Leicester, European Commission, University of Glasgow, KU Leuven, University of East Anglia, Deutsches Herzzentrum Muenchen, A.O. Ospedale Papa Giovanni XXIII, Chalice Medical Ltd, Ludwig-Maximilians - University of Munich, University of Tromso, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Paula Stradina Liniska Universitates, Accelopment AG, Universiteit Antwerpen, Cardiovascular European Research Centre (CERC) | Cardiogenic Shock | 03/23 | 02/24 | | |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Recruiting | N/A | 650 | Europe | Coronary Function Test | University Hospital, Antwerp | Coronary Microvascular Dysfunction, Coronary Artery Vasospasm | 12/25 | 12/26 | | |
| Recruiting | N/A | 500 | Europe | RAP TAVI | AZ Sint-Jan AV | Aortic Valve Stenosis | 06/24 | 06/24 | | |
| casteels, kristina m |
NCT06452654: Anti-viral Action Against Type 1 Diabetes Autoimmunity |
|
|
| Recruiting | 4 | 2252 | Europe | Comirnaty Injectable Product, Comirnaty 3µg/dose for children for 6 month - 4 years, Sodium Chloride 0.9% Inj, Solution for Injection | Technical University of Munich, Helmholtz Zentrum München, University Hospital Carl Gustav Carus, Kinderkrankenhaus auf der Bult, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Newcastle-upon-Tyne Hospitals NHS Trust, Cambridge University Hospitals NHS Foundation Trust, Birmingham Women's and Children's NHS Foundation Trust | Diabetes Mellitus, Type 1 | 10/27 | 10/27 | | |
NCT06502990: Open-label Study to Evaluate Metreleptin in Children Under 6 Years of Age With Generalised Lipodystrophy |
|
|
| Recruiting | 3 | 15 | Europe | Metreleptin | Amryt Pharma | Generalized Lipodystrophy | 09/26 | 09/26 | | |
| Recruiting | N/A | 70 | Europe | | Universitaire Ziekenhuizen KU Leuven | Peripheral Artery Tonometry, Diabetes, Children, Obesity | 06/25 | 06/25 | | |
| Active, not recruiting | N/A | 232 | Europe | MetaSAMP | University Ghent, Universitaire Ziekenhuizen KU Leuven, Universitair Ziekenhuis Brussel, Algemeen Ziekenhuis Maria Middelares, AZ Jan Palfijn Gent, AZ Sint-Lucas Gent, University Hospital, Antwerp, AZ Alma, AZ Sint-Jan AV | Metabolic Disease, Obesity, Infant | 03/22 | 12/26 | | |
| Recruiting | N/A | 6000 | Europe | | University of Cambridge, Innovative Medicines Initiative, Juvenile Diabetes Research Foundation, The Leona M. and Harry B. Helmsley Charitable Trust | Type 1 Diabetes Mellitus | 10/22 | 10/22 | | |
COMBINE1, NCT06567158: The Impact of a Moderate Carbohydrate Diet in Children With Type 1 Diabetes on Hybrid Closed-loop Therapy |
|
|
| Recruiting | N/A | 28 | Europe | Moderate carbohydrate diet, Traditional diet | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/25 | 12/25 | | |
| Completed | N/A | 49 | Europe | Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control), Declaration of meals, No declaration of meals, Remote monitoring (Telemedicine) | Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète | Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old) | 02/24 | 05/24 | | |
NCT05777330: Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes |
|
|
| Recruiting | N/A | 75 | Europe | Oral glucose tolerance test (OGTT), OGTT, Hyperglycemic clamp test, clamp, Continuous glucose monitoring, Dexcom G6, CGM | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Juvenile Diabetes Research Foundation | Type1 Diabetes Mellitus | 04/26 | 04/27 | | |
SINT1A, NCT04769037: Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity |
|
|
| Active, not recruiting | N/A | 1149 | Europe | B. infantis, Placebo | Helmholtz Zentrum München, Technical University of Munich, Kinderkrankenhaus auf der Bult, University Hospital Carl Gustav Carus, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Medical University of Warsaw, Cambridge Biomedical Campus, Cambridge, UK, Royal Victoria Infirmary, Newcastle upon Tyne, UK | Diabetes Mellitus, Type 1 | 10/27 | 10/27 | | |
| Deprest, Jan A |
NCT03788122: Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery |
|
|
| Recruiting | N/A | 40 | Europe | In-depth interview | Universitaire Ziekenhuizen KU Leuven, University College, London, Wellcome Trust | Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia | 11/25 | 02/26 | | |
| Recruiting | N/A | 20 | Europe | | Universitaire Ziekenhuizen KU Leuven | Obstetric Labor | 03/25 | 12/25 | | |
| Recruiting | N/A | 320 | Europe | Questionnaire, Pelvic floor ultrasound, Transperineal ultrasound, Pelvic floor sonography | Universitaire Ziekenhuizen KU Leuven | Pelvic Floor Disorders, Obstetric Trauma, Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Pelvic Pain, Sexual Dysfunction, Constipation, Anal Sphincter Injury | 09/24 | 09/25 | | |
VELSUI, NCT04643353: Use of Non-ablative Vaginal Erbium YAG Laser for the Treatment of Stress Urinary Incontinence. |
|
|
| Completed | N/A | 60 | Europe | Non-ablative vaginal Erbium YAG laser treatment, PFE | Universitaire Ziekenhuizen KU Leuven | Urinary Incontinence,Stress | 12/23 | 12/23 | | |
LASI, NCT05713435: Use of Fractional CO2 Laser Versus Erbium:YAG Laser for the Treatment of GSM in Patients Using Aromatase Inhibitors |
|
|
| Recruiting | N/A | 162 | Europe | intravaginal laser | Universitaire Ziekenhuizen KU Leuven | Genitourinary Syndrome of Menopause | 12/24 | 12/25 | | |
| Recruiting | N/A | 25 | Europe | Fetoscopic Endoluminal Tracheal Occlusion with the Smart-TO Balloon, FETO | Universitaire Ziekenhuizen Leuven | Congenital Diaphragmatic Hernia | 08/26 | 11/26 | | |
| Braly, Patricia |
| Active, not recruiting | 3 | 615 | Europe, Canada, US, RoW | Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo | CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd | Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms | 09/25 | 08/27 | | |
| Completed | 2 | 150 | US, RoW | Paclitaxel, Afuresertib, LAE002 | Laekna Limited | Platinum-resistant Ovarian Cancer | 07/23 | 06/24 | | |
PICCOLO, NCT05041257: Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers |
|
|
| Completed | 2 | 79 | Europe, Canada, US, RoW | Mirvetuximab soravtansine, MIRV, IMGN853 | AbbVie | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | 01/24 | 12/24 | | |
|
|
|
|
NCI-2017-01672, NCT03660826: Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone |
|
|
| Active, not recruiting | 2 | 286 | Canada, US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspirate, BONE MARROW, LIQUID, Human Bone Marrow Aspirate, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Capivasertib, AZD 5363, AZD-5363, AZD5363, Truqap, Cediranib, AZ-D2171, AZD 2171, AZD2171, Cediranib Maleate, AZD2171 Maleate, Recentin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Durvalumab, Imfinzi, Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer, MEDI 4736, MEDI-4736, MEDI4736, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Olaparib, AZD 2281, AZD-2281, AZD2281, KU 0059436, KU-0059436, KU0059436, Lynparza, Olanib, Olaparix, PARP Inhibitor AZD2281 | National Cancer Institute (NCI), NRG Oncology | Endometrial Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Endometrioid Adenocarcinoma, Stage IV Uterine Corpus Cancer AJCC v8 | 12/24 | 01/26 | | |
NCT05456685: Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer |
|
|
| Active, not recruiting | 2 | 125 | Europe, Canada, US, RoW | Mirvetuximab soravtansine, MIRV, IGN853, Carboplatin | AbbVie | High Grade Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer | 05/26 | 05/26 | | |
|
| Active, not recruiting | 2 | 53 | Europe, Canada, US | Nirogacestat, PF-03084014 | SpringWorks Therapeutics, Inc., SpringWorks Therapeutics, Inc. | Ovarian Granulosa-Stromal Tumor, Ovarian Granulosa Cell Tumor, Ovarian Cancer | 07/26 | 12/27 | | |
| Boeckxstaens, Guy |
NCT02425774: Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway |
|
|
| Recruiting | 4 | 30 | Europe | Vagus stimulation, Sham stimulation, Prucalopride, Placebo | KU Leuven, Universitaire Ziekenhuizen KU Leuven | Postoperative Ileus | 12/25 | 12/25 | | |
| Recruiting | 3 | 200 | Europe | Ebastine, Duspatalin | Guy Boeckxstaens, Fund for Scientific Research, Flanders, Belgium | IBS - Irritable Bowel Syndrome, IBS | 10/27 | 01/28 | | |
NCT01601678: Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia |
|
|
| Completed | N/A | 240 | Europe, RoW | Peroral Endoscopic Myotomy (POEM), Laparoscopic Heller Myotomy (LHM) | Universitätsklinikum Hamburg-Eppendorf, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Karolinska University Hospital, University Hospital Prague (IKEM), Prague, Czech Republic, Universitaire Ziekenhuizen KU Leuven, Istituto Clinico Humanitas, Wuerzburg University Hospital, University Hospital Augsburg | Achalasia | 05/22 | 05/23 | | |
NCT01912313: Measuring Nerve Activity in Small Human Intestinal Biopsies in IBS (Irritable Bowel Syndrome) |
|
|
| Recruiting | N/A | 99999999 | Europe | Rectal biopsies from IBS patients or healthy subjects will be taken during proctoscopy | KU Leuven | IBS, Healthy | 08/25 | 08/25 | | |
| Recruiting | N/A | 80 | Europe | chromoendoscopy | KU Leuven | Dysplasia in Longstanding Achalasia, Relation Between Food Stasis and Dysplasia | 12/25 | 12/25 | | |
NCT02421705: Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome) |
|
|
| Recruiting | N/A | 99999999 | Europe | Sample collection | KU Leuven | IBS, Ulcerative Colitis, Active, Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms), Healthy Controls, Crohn's Disease, Active, Crohn's Disease, Remission (6a: With IBS Symptoms, 6b: Without IBS Symptoms) | 01/99 | 01/99 | | |
| Budts, Werner |
NCT02691689: Genes Associated with Development of Pulmonary Arterial Hypertension in Patients with Congenital Shunt Lesions |
|
|
| Recruiting | N/A | 21 | Europe | Genetic testing | Universitaire Ziekenhuizen KU Leuven | Heart Defects, Congenital, Pulmonary Arterial Hypertension, Genetic Testing | 02/25 | 02/25 | | |
NCT02588989: Fibrosis, Valvular and Ventricular Function in Patients With TGA |
|
|
| Active, not recruiting | N/A | 37 | Europe | | Universitaire Ziekenhuizen KU Leuven | Transposition of Great Vessels | 06/27 | 06/27 | | |
| Gerven, Laura H Van |
RELIBIO, NCT06683261: Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) |
|
|
| Recruiting | N/A | 300 | Europe | Omalizumab, Dupilumab, Mepolizumab 100 mg | Universitaire Ziekenhuizen KU Leuven | Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Chronic Rhinosinusitis (CRS) | 01/26 | 12/26 | | |
| Recruiting | N/A | 500 | Europe | Standard of care | Universitaire Ziekenhuizen KU Leuven | Olfactory Disorder, Taste Disorders, Smell Dysfunction, Smell Disorder | 01/25 | 12/35 | | |
NCT03910374: Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction |
|
|
| Recruiting | N/A | 220 | Europe | Dural closure | Universitaire Ziekenhuizen Leuven | Cranial Sutures; Closure | 12/22 | 12/23 | | |
NCT04670172: Real-Life Chronic Rhinosinusitis Outcome Registry |
|
|
| Recruiting | N/A | 4550 | Europe | | Change Accelerator in Respiratory Care | Chronic Rhinosinusitis (Diagnosis) | 06/24 | 12/24 | | |
| Enrolling by invitation | N/A | 38 | Europe | Nasal rinsing with saline 0.9%, Nasal rinsing with Xylitol | Universitaire Ziekenhuizen KU Leuven | Chronic Rhinosinusitis (Diagnosis) | 08/23 | 09/25 | | |
SPAT_AI, NCT05918354: Development and Evaluation of an Artificial Intelligence Model for the Diagnosis of Aeroallergies |
|
|
| Completed | N/A | 993 | Europe | Skin Prick Automated Test | Hippocreates | Allergy | 09/24 | 09/24 | | |
| Recruiting | N/A | 150 | Europe | Sampling of tissue | Universitaire Ziekenhuizen KU Leuven, Max Planck Research Unit for Neurogenetics, AZ Sint-Jan Brugge-Oostende AV, Universitair Ziekenhuis Brussel, Hospital Clinic of Barcelona | SARS-CoV-2 | 12/23 | 12/24 | | |
DysOSMIC, NCT06482138: Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation |
|
|
| Recruiting | N/A | 160 | Europe | Biopsy and Cytobrush | Universitaire Ziekenhuizen KU Leuven, University Hospital, Geneva, Max Planck Research Unit for Neurogenetics, University Hospital Carl Gustav Carus, University of Zurich | Covid19, Olfactory Dysfunction | 12/24 | 03/25 | | |
NCT04544774: The Role of the Nasal Allergen Provocation Test in Starting and Monitoring Allergen Immunotherapy |
|
|
| Recruiting | N/A | 200 | Europe | AIT, NAPT | Universitaire Ziekenhuizen Leuven, AZ Sint-Jan AV | Perennial Allergic Rhinitis, Seasonal Allergic Rhinitis, Local Allergic Rhinitis | 12/25 | 12/25 | | |
| Tack, Jan |
NCT03024879: The Effect of Motilin on the Frequency and Amount of Food Intake |
|
|
| Enrolling by invitation | 4 | 15 | NA | Erythromycin, Saline | Universitaire Ziekenhuizen KU Leuven | Healthy, Obesity | 03/25 | 03/25 | | |
| Completed | 4 | 15 | Europe | Naloxegol, Movantik, Moventig, codeine phosphate, Bronchodine, Placebo, Siripus simplex syrup | Universitaire Ziekenhuizen KU Leuven | Opioid-Induced Constipation | 05/19 | 05/19 | | |
NCT05071781: Effect of CRH on Duodenal Markers and Gastric Sensorimotor Function |
|
|
| Completed | 4 | 20 | Europe | Corticotropin-release hormone | Universitaire Ziekenhuizen KU Leuven | GI Motility Disorder | 12/22 | 12/22 | | |
NCT05629325: Buspirone for Weak or Absent Esophageal Peristalsis |
|
|
| Recruiting | 4 | 25 | Europe | Buspirone Hydrochloride 10 MG, Buspiron, Placebo | Universitaire Ziekenhuizen KU Leuven | Dysphagia, Esophageal | 09/24 | 09/24 | | |
| Recruiting | 4 | 724 | Europe | de-prescription of PPI via intermittent scheme, de-prescription of PPI via on-demand scheme, Alginate | Universitaire Ziekenhuizen KU Leuven | Heartburn, Dyspepsia, Reflux | 09/25 | 09/25 | | |
| Recruiting | 2 | 320 | Europe, US | Naronapride, Placebo | Dr. Falk Pharma GmbH, Dr. Falk Pharma GmbH | Gastroparesis | 01/25 | 04/25 | | |
| Recruiting | 2 | 72 | Europe, US | Pasireotide Diaspartate, Pasireotide | RECORDATI GROUP | Post-Bariatric Hypoglycemia | 04/25 | 04/26 | | |
CLE-EoE, NCT05695456: Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser Endomicroscopy |
|
|
| Recruiting | 1/2 | 25 | Europe | personalized exclusion diet based on CLE, empiric exclusion diet | Universitaire Ziekenhuizen KU Leuven | Eosinophilic Esophagitis | 12/24 | 12/24 | | |
NCT04873011: Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release |
|
|
| Recruiting | 1 | 40 | Europe | Quinine Hydrochloride, Placebo | Universitaire Ziekenhuizen KU Leuven | Obesity | 10/25 | 10/25 | | |
NCT05651386: The Six Food Elimination in Postprandial Distress Syndrome |
|
|
| Recruiting | N/A | 15 | Europe | Diet | Universitaire Ziekenhuizen KU Leuven | Functional Dyspepsia | 01/25 | 01/25 | | |
| Recruiting | N/A | 15 | Europe | Fermentable Oligo-, Di- Monosaccharides And Polyols (FODMAPs) | Universitaire Ziekenhuizen KU Leuven, University of Auckland, New Zealand | Irritable Bowel Syndrome | 09/24 | 09/24 | | |
| Recruiting | N/A | 12 | Europe | Ocaliva, obeticholic acid, Placebo, Placebo Oral Tablet (Starch) | Universitaire Ziekenhuizen KU Leuven, Intercept Pharmaceuticals | Healthy | 07/23 | 07/23 | | |
| Recruiting | N/A | 100 | Europe | Palmitoylethanolamide | Universitaire Ziekenhuizen KU Leuven | Dyspepsia and Other Specified Disorders of Function of Stomach | 01/25 | 03/25 | | |
| Recruiting | N/A | 30 | Europe | Low-FODMAP diet | Universitaire Ziekenhuizen KU Leuven | Functional Gastrointestinal Disorders | 01/25 | 02/25 | | |
| Recruiting | N/A | 100 | Europe | Dietary intervention: DOMINO app, Dietary intervention: low FODMAP diet | Universitaire Ziekenhuizen KU Leuven | Irritable Bowel Syndrome | 11/24 | 11/24 | | |
NCT05780749: A 14-week Pilot Prospective Clinical Trial With BiOkuris Product in Patients With Irritable Bowel Syndrome |
|
|
| Recruiting | N/A | 130 | Europe | DDI-IBS-001, DDDI-IBS-001 placebo | Biokuris s.a. | Irritable Bowel Syndrome | 12/24 | 12/24 | | |
| Stalmans, Ingeborg |
NCT02290795: Vitreopapillary Interface and Optic Disc Morphology |
|
|
| Recruiting | N/A | 350 | Europe | OCT imaging/HRT imaging | Universitaire Ziekenhuizen KU Leuven | Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction | 04/25 | 08/25 | | |
NCT06485128: Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease |
|
|
| Recruiting | N/A | 1000 | Europe | Optical coherence tomography(-angiography) OCT(A), Fundus pictures, DVA 3.0, Hyperspectral retinal images, SphygmoCor, Sphygmomanometer, Blood sample, Skin biopsy, Neuropsychological examination | Universitaire Ziekenhuizen KU Leuven | Kidney Diseases, Diastolic Heart Failure, Small Vessel Disease, Glaucoma | 12/24 | 12/24 | | |
| Completed | N/A | 1418 | Europe | AI algorithm for the detection of glaucoma | Universitaire Ziekenhuizen KU Leuven, Santen Oy | Glaucoma | 05/23 | 05/23 | | |
RetAD, NCT03466177: Multimodal Retinal Imaging in the Detection and Follow-up of Alzheimer's Disease |
|
|
| Recruiting | N/A | 320 | Europe | Non-invasive, multimodal retinal imaging | Universitaire Ziekenhuizen KU Leuven | Alzheimer Disease, Alzheimer Dementia, Mild Cognitive Impairment, Dementia, Glaucoma, Age-Related Macular Degeneration, Diabetic Retinopathy | 12/24 | 12/25 | | |
| Naulaers, Gunnar |
| Active, not recruiting | N/A | 174 | Europe | | Universitaire Ziekenhuizen KU Leuven, KU Leuven | Premature Birth of Newborn | 12/25 | 12/25 | | |
| Ongeval, Chantal Van |
| Recruiting | N/A | 100 | Europe | digital mammography | Universitaire Ziekenhuizen KU Leuven | Data Collection | 08/25 | 08/25 | | |
| Spriet, Isabel |
NCT01420562: Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis |
|
|
| Recruiting | N/A | 55 | Europe | blood sampling | Universitaire Ziekenhuizen KU Leuven | Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) | 03/25 | 03/25 | | |
NCT04045366: Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients |
|
|
| Recruiting | N/A | 60 | Europe | Sample collection | Universitaire Ziekenhuizen KU Leuven, KU Leuven | Critically Ill Patients | 07/25 | 12/25 | | |
NCT03529617: Pharmacokinetics of Liposomal Amphotericin B in Critically Ill vs. Non-critically Ill Hematological Patients: Exploration of Covariates |
|
|
| Recruiting | N/A | 60 | Europe | Sample collection | Universitaire Ziekenhuizen KU Leuven, KU Leuven | Pharmacokinetics, Liposomal Amphotericin B, Critically Ill Patients | 07/25 | 12/25 | | |
NCT04250038: Association of Cefepime Trough Levels With Clinical Efficacy and Neurotoxicity in Patients With Febrile Neutropenia |
|
|
| Active, not recruiting | N/A | 98 | Europe | | Universitaire Ziekenhuizen Leuven | Pharmacokinetics, Pharmacodynamics, Cefepime | 10/20 | 05/21 | | |
| Tomassetti, Carla |
ELENA, NCT05560646: A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain |
|
|
| Active, not recruiting | 2 | 380 | Europe, US, RoW | OG-6219, Placebo | Organon and Co, Iqvia Pty Ltd | Endometriosis | 05/25 | 05/25 | | |
| Recruiting | N/A | 92 | Europe | Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies). | Universitaire Ziekenhuizen KU Leuven, GZA Ziekenhuizen Campus Sint-Augustinus, Centre Hospitalier Régional de la Citadelle, Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Endometriosis Ovary, Endometrioma | 12/24 | 12/26 | | |
| Active, not recruiting | N/A | 294 | Europe | PROMS | Universitaire Ziekenhuizen KU Leuven, Semmelweis University | Endometriosis, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis; Bowel | 03/23 | 03/25 | | |
| Régal, Luc |
| Active, not recruiting | N/A | 125 | Europe | Blood draw, muscle biopsy | Universitaire Ziekenhuizen KU Leuven, KU Leuven | Hypotonia-Cystinuria Syndrome, Muscle Hypotonia, Healthy Volunteers, Dwarfism, Growth Hormone Deficiency, Obesity, Prader-Willi Syndrome | 01/25 | 01/25 | | |
| Morlion, Bart |
| Completed | 2 | 99 | Europe, RoW | AP-325, Placebo | Algiax Pharmaceuticals GmbH, FGK Clinical Research GmbH | Peripheral Post-surgical Neuropathic Pain | 10/24 | 10/24 | | |
NCT05482152: Nurse-led Pain Education Clinical Trial in Chronic Pain Patients |
|
|
| Completed | N/A | 39 | Europe | Nurse-led care by a nurse specialist in pain | Universiteit Antwerpen, Universitaire Ziekenhuizen KU Leuven | Pain, Chronic | 12/22 | 12/23 | | |
COGENIUS, NCT05407610: Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain |
|
|
| Recruiting | N/A | 400 | Europe | Conventional Radiofrequency ablation of the genicular nerves, Conventional Radiofrequency ablation, Cooled Radiofrequency ablation of the genicular nerves, Cooled Radiofrequency ablation, Sham procedure | Ziekenhuis Oost-Limburg, Belgium Health Care Knowledge Centre, Klinische Epidemiologie en Medical Technology Assessment | Knee Osteoarthritis, Persistent Postsurgical Pain, Chronic Knee Pain | 03/25 | 09/26 | | |
| Gabriels, Charlien |
NCT02691689: Genes Associated with Development of Pulmonary Arterial Hypertension in Patients with Congenital Shunt Lesions |
|
|
| Recruiting | N/A | 21 | Europe | Genetic testing | Universitaire Ziekenhuizen KU Leuven | Heart Defects, Congenital, Pulmonary Arterial Hypertension, Genetic Testing | 02/25 | 02/25 | | |
