UPMC Magee Womens Hospital
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 9 Trials 
65 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Simhan, Hyagriv N
ASPIRIN, NCT06468202: Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: TRIAL

Recruiting
4
10742
US
Aspirin 81 mg, Aspirin 162 mg
Ohio State University, Patient-Centered Outcomes Research Institute, Northwestern University, Preeclampsia Foundation
Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
01/29
02/30
NCT06069102: Optimal Blood Pressure Treatment Thresholds Postpartum

Active, not recruiting
4
60
US
Usual care, Tight blood pressure control, Tight control
Alisse Hauspurg
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic
03/25
12/25
PRECEDE, NCT06605118: Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

Recruiting
3
8000
US
Azithromycin Injection, Placebo, Standard of Care Preoperative antibiotics
The George Washington University Biostatistics Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Alabama at Birmingham
Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery
11/27
03/28
PROSPECT, NCT02518594: A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

Terminated
3
437
US
Vaginal progesterone, Prometrium, Placebo, Arabin Pessary
The George Washington University Biostatistics Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Short Cervical Length
10/24
12/24
NCT03487185: Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Recruiting
N/A
1500
US
Continuous Positive Airway Pressure, CPAP, Sleep Advice Control
The George Washington University Biostatistics Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute (NHLBI)
Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
12/26
12/26
NCT05172024: Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)

Active, not recruiting
N/A
15178
US
NYU Langone Health, National Heart, Lung, and Blood Institute (NHLBI)
SARS-CoV2 Infection
04/25
05/25
NCT05172011: Understanding the Long-term Impact of COVID on Children and Families

Active, not recruiting
N/A
15028
US
NYU Langone Health, National Heart, Lung, and Blood Institute (NHLBI)
SARS-CoV-2 Infection
04/27
05/27
Mitch, Kelsey
ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer
Recruiting
3
220
Europe, Canada, US, RoW
Selinexor, KPT-330, Matching Placebo for selinexor
Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group
Endometrial Cancer
01/25
01/28
NCT05145569: Antitumor Activity of Neoadjuvant Chemotherapy with or Without HCW9218 in Metastatic Advanced Stage Ovarian Cancer

Withdrawn
2
33
NA
Carboplatin AUC 5 and paclitaxel, Carbo/Taxol, HCW9218
Haider Mahdi, HCW Biologics
Ovarian Cancer
05/26
01/28
NCT05538091: Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Recruiting
2
48
US
Vismodegib, ERIVEDGE, Atezolizumab, Tecentriq
Ronald Buckanovich, Genentech, Inc.
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, PARP Inhibitor, Hedgehog Inhibitor
04/28
04/28
NCT05467670: Safety and Efficacy of Anti-CD47, ALX148 in Combination with Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer

Recruiting
2
31
US
Pembrolizumab, Keytruda®, ALX148, evorpacept, Doxorubicin, (Pegylated Liposomal Doxorubicin (PLD)
Alexander B Olawaiye, MD, ALX Oncology, Merck Sharp & Dohme LLC
Ovarian Cancer
09/29
12/31
NCT05071937: ZEN003694 Combined with Talazoparib in Patients with Recurrent Ovarian Cancer

Recruiting
2
33
US
ZEN003694, Talazoparib
Alexander B Olawaiye, MD, Pfizer, Zenith Epigenetics
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
12/29
03/31
NCT06120972: Upfront Maintenance Olaparib in Advanced Ovarian Cancer BRCAwt Patients With Known Homologous Recombination Deficiency

Recruiting
2
80
US
Olaparib tablet, Lynparza
Alexander B Olawaiye, MD, AstraZeneca
Ovarian Cancer
12/27
12/29
HCC 21-166, NCT05200559: T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Recruiting
1/2
70
US
Pembrolizumab, Keytruda®, E7777, ONTAK®
Alexander B Olawaiye, MD, Dr. Reddys Laboratories, SA
Epithelial Ovarian Cancer
12/25
12/27
NCT06161493: ZEN003694 Combined With Niraparib in Patients With Metastatic or Recurrent Solid Tumors

Withdrawn
1
26
US
ZEN003694, Niraparib, MK-4827, Zejula
Haider Mahdi, GlaxoSmithKline, Zenith Epigenetics
Ovarian Cancer, Recurrent Solid Tumors
12/26
12/29
NCT06218303: Prototype DAA/TAA Vaccine Targeting MUC1 for Immune Interception and Prevention in Ductal Carcinoma In Situ

Recruiting
1
50
US
MUC1 Peptide Vaccine, Hiltonol®, POLY-ICLC, Aromatase Inhibitor, Anastrozole (Arimidex), Letrozole (Femara), Exemestane (Aromasin)
Finn, Olivera, PhD, A Glimmer of Hope Foundation, Breast Cancer Research Foundation
Ductal Carcinoma in Situ
01/26
08/28
NCT05942300: CPI-0209 Plus Carboplatin in Patients With Platinum Sensitive Recurrent Ovarian Cancer

Recruiting
1
30
US
CPI-0209, Tulmimetostat, carboplatin
Lan Coffman, MorphoSys AG, National Cancer Institute (NCI)
Recurrent Ovarian Cancer
01/27
08/29
LBC-Monitor, NCT06666439: Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer

Recruiting
N/A
20
US
circulating tumor DNA (ctDNA), Signatera
Julia Foldi
Metastatic Invasive Lobular Carcinoma (mILC)
10/26
10/26
Diego, Emilia
HERO, NCT05705401: Testing Radiation and HER2-targeted Therapy Versus HER2-targeted Therapy Alone for Low-risk HER2-positive Breast Cancer

Recruiting
3
1300
US
Standard of Care Adjuvant Breast Radiation, Standard of Care HER2-targeted Therapy Without Adjuvant Breast Radiation
NRG Oncology, National Cancer Institute (NCI), Alliance for Clinical Trials in Oncology, Eastern Cooperative Oncology Group, SWOG Cancer Research Network
HER2-positive Breast Cancer
02/34
02/37
PROMISE, NCT02694809: The Study: Duavee in Women With DCIS

Completed
2
142
US
Conjugated Estrogens/Bazedoxifene, Laboratory Biomarker Analysis, Pharmacological Study, Placebo, placebo therapy, PLCB, sham therapy, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
Northwestern University, National Cancer Institute (NCI), Pfizer, University of Chicago - Department for Cancer Research, University of California, San Francisco
Ductal Breast Carcinoma In Situ, Postmenopausal
06/24
06/24
NCT06218303: Prototype DAA/TAA Vaccine Targeting MUC1 for Immune Interception and Prevention in Ductal Carcinoma In Situ

Recruiting
1
50
US
MUC1 Peptide Vaccine, Hiltonol®, POLY-ICLC, Aromatase Inhibitor, Anastrozole (Arimidex), Letrozole (Femara), Exemestane (Aromasin)
Finn, Olivera, PhD, A Glimmer of Hope Foundation, Breast Cancer Research Foundation
Ductal Carcinoma in Situ
01/26
08/28
NCT02945579: Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

Recruiting
N/A
120
US
External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam Radiotherapy, External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Whole Breast Irradiation
M.D. Anderson Cancer Center, National Cancer Institute (NCI), Artidis
Estrogen Receptor Negative, HER2 Positive Breast Carcinoma, HER2/Neu Negative, Invasive Breast Carcinoma, Progesterone Receptor Negative, Stage I Breast Cancer AJCC V7, Stage IA Breast Cancer AJCC V7, Stage IB Breast Cancer AJCC V7, Stage II Breast Cancer AJCC V6 and V7, Stage IIA Breast Cancer AJCC V6 and V7, Stage IIB Breast Cancer AJCC V6 and V7, Triple-Negative Breast Carcinoma
01/26
01/26
Monroe, Amy L
NCT04208516: Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.

Terminated
4
17
US
Continuous Erector Spinae Plane Nerve Block, Continuous Quadratus Lumborum Nerve Block, Single Erector Spinae Plane Nerve Block, Single Quadratus Lumborum Nerve Block, Lidocaine IV, Ropivacaine 0.5% Injectable Solution, Dexamethasone, Dexmedetomidine, Lidocaine
Jeremy Kearns
Postoperative Pain
08/22
08/22
NCT03261193: ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain

Terminated
3
21
US
ITM + Sham QLB, Saline, ITM + Bupivacaine QLB, Bupivacaine
Nicholas Schott
Pain, Postoperative
06/18
11/22
OPSTAHT, NCT03341156: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation

Recruiting
3
60
US
Kcentra, prothrombin complex concentrate, Frozen Plasma Product, Human, Fresh Frozen Plasma
Kathirvel Subramaniam, University of Maryland, Baltimore, CSL Behring
Heart Disease End Stage, Heart Failure，Congestive
10/24
12/24
NCT06626503: Evaluation of Analgesia for Spine Fusion Elective Surgery in Children

Not yet recruiting
2
500
US
Methadone based ERAS, Methadone Based, SOC non-methadone based group, Standard Care
Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Idiopathic Scoliosis
09/25
09/25
NCT06626035: Prospective Randomized Evaluation of Analgesia for Cardiac Elective Surgery in Children

Not yet recruiting
2
500
US
Methadone based ERAS, Methadone-Based, SOC non-methadone based group, Standard Care
Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pediatric Cardiac Surgery
09/25
09/25
PREPARE-2, NCT06767566: Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

Not yet recruiting
1
50
US
Ketamine (Ketalar), 0.18 mg/kg/1hr loading dose Ketamine
Grace Lim, MD, MS, National Institute of Mental Health (NIMH)
Pain, Postpartum Depression
12/27
03/28
PREPARE 1, NCT05907213: Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery

Completed
1
12
US
Ketamine (Ketalar) Dose Level 1, 0.05 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 2, 0.08 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 3, 0.12 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 4, 0.18 mg/kg/1hr loading dose Ketamine
Grace Lim, MD, MS, National Institute of Mental Health (NIMH)
Pain, Postoperative, Depression, Postpartum
06/24
09/24
NCT06275308: Effect of Raised End-Tidal PCo2 on Choroidal Volume

Recruiting
N/A
20
US
Ventilation manipulation
University of Pittsburgh
Intraocular Pressure
04/25
04/25
NCT03633604: Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia

Available
N/A
US
HBOC-201, Hemopure, hemoglobin glutamer - 250 (bovine)
Jonathan H. Waters, HbO2 Therapeutics LLC
Anemia Severe
 
 
NCT02887820: Evaluating the Use of Thromboelastography (TEG) in Patient's Requiring Extracorporeal Membrane Oxygenation (ECMO)

Completed
N/A
15
US
Thromboelastograph, TEG 5000
Stephen Esper, American Heart Association
Heart Disease, Lung Disease
12/23
12/23
NCT04836936: Auriculotherapy in the Treatment of Pre-Operative Anxiety

Recruiting
N/A
60
US
Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas
Jacques E. Chelly
Anxiety Preoperative
06/25
06/25
NCT06071884: Bridge Device for Surgical Pain for Rotator Cuff Surgery

Recruiting
N/A
15
US
Bridge Percutaneous Nerve Field Stimulator, NSS-2 BRIDGE
Steven Orebaugh, Masimo Corporation
Pain, Rotator Cuff Injuries
02/25
12/25
NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study

Completed
N/A
79
US
Cardiac Performance System (CPS) Device
Stephen Esper, Sensydia Corporation
Heart Diseases
01/24
01/24
NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management

Recruiting
N/A
140
US
NEUROCUPLE™ Patch, Placebo Patch
nCap Medical, University of Pittsburgh
Total Knee Arthroplasty
09/25
09/26
NCT05452694: OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

Recruiting
N/A
200
US
OpalGenix, Inc
Lumbar Spine Stenosis, Lumbar Spine Degeneration
09/24
09/24
NCT05906368: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension

Recruiting
N/A
30
US
ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
Grace Lim, MD, MS, Edwards Lifesciences
Anesthesia, Epidural, Hypotension
10/24
04/25
NCT06648759: Vagal Stimulator to Reduce Nasogastric Tube Use

Recruiting
N/A
60
US
Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator
Jacques E. Chelly
Nasogastric Tube Intubation
09/26
09/26
NCT06665685: BioButton Among Nursing Home Residents

Not yet recruiting
N/A
70
US
BioButton Device, Providing Clinical Care with BioButton Device
Charles Lin, Jewish Healthcare Foundation
Gait, Medication Induced Gait Disturbances
12/25
02/26
NCT06661291: Pip Care to Improve Surgical Patient Outcomes - Phase II

Not yet recruiting
N/A
1300
US
Pip Care Digital Health Platform, Standard of Care Protocol
University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI)
Abdominal Surgery
09/28
09/28
PPAP Spine, NCT05367609: Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)

Recruiting
N/A
300
US
Preoperative Genotyping
Senthil Sadhasivam, National Institute on Drug Abuse (NIDA)
PPAP, Spine Fusion
08/25
09/25
NCT06042413: Prediction and Prevention of Postoperative Mortality and Morbidity

Not yet recruiting
N/A
1200
US
Personalized CPC Prehabilitation, Cognitive Training, Meditation, Daily Exercise, Enhanced Social Support, Proactive Bundle Interventions, Pre-operative Standard of Care, Intra-operative Standard of Care
University of Pittsburgh, National Institute on Aging (NIA)
Alzheimer Disease, Alzheimer Disease Related Dementias
09/25
09/25
PPAP C-Section, NCT05380531: Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Recruiting
N/A
600
US
Preoperative Genotyping
Senthil Sadhasivam, National Center for Advancing Translational Sciences (NCATS)
Cesarean Section Complications, Opioid Use
04/26
10/26
NCT05612399: Precision Analgesia for Cardiac Surgery

Not yet recruiting
N/A
400
US
Kathirvel Subramaniam
Analgesia, Cardiac Surgery
12/26
12/26
Gruss, Judy
REDUCTION, NCT05726318: Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women

Completed
4
70
US
Antibiotics
Megan Bradley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
UTI
08/24
08/24
RELIEF, NCT05512039: Reduced-dose Botox for Urgency Incontinence Among Elder Females

Recruiting
1/2
376
US
Botox 50 Unit Injection, OnabotulinumtoxinA 50 Unit Injection, Botox 100 Unit Injection, OnabotulinumtoxinA 100 Unit
Dartmouth-Hitchcock Medical Center, Patient-Centered Outcomes Research Institute, Dartmouth College, University of Alabama at Birmingham, University of Pittsburgh, University of Texas, Kaiser Permanente, Oregon Health and Science University, Stanford University, University of Connecticut
Overactive Bladder, Urinary Incontinence in Old Age, Urgency Urinary Incontinence
09/26
01/27
NCT04922255: Cystic Fibrosis and Urinary Incontinence

Terminated
N/A
15
US
Reusable Underwear, Disposable urethral support, Pelvic floor physical therapy
Megan Bradley, Cystic Fibrosis Foundation
Urinary Incontinence, Cystic Fibrosis
10/23
10/23
BUTTON, NCT03535857: Effectiveness of Bilateral PTNS Compared to Unilateral PTNS for the Treatment of Overactive Bladder/Urge Incontinence

Recruiting
N/A
50
US
PTNS
Gnankang Sarah Napoe
Overactive Bladder Syndrome, Urinary Incontinence, Urge
12/24
12/25
PREMIER, NCT05063331: Patient-Centered Outcomes in the Surgical Treatment of Uterovaginal Prolapse

Recruiting
N/A
320
US
Minimally invasive supracervical hysterectomy and sacrocolpopexy (MI-SCH+SCP), Vaginal hysterectomy with uterosacral ligament suspension (TVH+USLS)
University Hospitals Cleveland Medical Center, Case Western Reserve University, MetroHealth Medical Center, The Cleveland Clinic, Duke University, University of Pittsburgh
Uterine Prolapse
07/30
07/30
Mahdi, Haider
NCT05145569: Antitumor Activity of Neoadjuvant Chemotherapy with or Without HCW9218 in Metastatic Advanced Stage Ovarian Cancer

Withdrawn
2
33
NA
Carboplatin AUC 5 and paclitaxel, Carbo/Taxol, HCW9218
Haider Mahdi, HCW Biologics
Ovarian Cancer
05/26
01/28
NCT06126276: Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Recruiting
2
70
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Neratinib Maleate, 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1), HKI-272 Maleate, NERATINIB MALEATE ANHYDROUS, Nerlynx, Palbociclib, 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one, Ibrance, PD 0332991, PD 332991, PD 991, PD-0332991, PD0332991
National Cancer Institute (NCI)
Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm, Recurrent Malignant Solid Neoplasm
04/25
04/25
NCT05419817: Pembrolizumab With Sitravatinib in Recurrent Endometrial Cancer and Other Solid Tumors With Deficient Mismatch Repair System

Withdrawn
2
30
NA
pembrolizumab, Keytruda®, Sitravatinib
Haider Mahdi, Mirati Therapeutics Inc.
Recurrent Endometrial Cancer, Solid Tumors
07/25
12/26
ComboMATCH, NCT05554380: Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A Treatment Trial

Recruiting
2
33
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipatasertib, GDC 0068, GDC-0068, GDC0068, RG 7440, RG-7440, RG7440, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat
National Cancer Institute (NCI)
Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm
08/25
08/25
NCT05467670: Safety and Efficacy of Anti-CD47, ALX148 in Combination with Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer

Recruiting
2
31
US
Pembrolizumab, Keytruda®, ALX148, evorpacept, Doxorubicin, (Pegylated Liposomal Doxorubicin (PLD)
Alexander B Olawaiye, MD, ALX Oncology, Merck Sharp & Dohme LLC
Ovarian Cancer
09/29
12/31
NCT05071937: ZEN003694 Combined with Talazoparib in Patients with Recurrent Ovarian Cancer

Recruiting
2
33
US
ZEN003694, Talazoparib
Alexander B Olawaiye, MD, Pfizer, Zenith Epigenetics
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
12/29
03/31
NRG-GY025, NCT05112601: Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Recruiting
2
90
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS 734016, BMS-734016, BMS734016, Ipilimumab Biosimilar CS1002, MDX 010, MDX-010, MDX-CTLA4, MDX010, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo
National Cancer Institute (NCI), NRG Oncology
Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Mucinous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Endometrioid Adenocarcinoma, Recurrent Endometrial Carcinoma
04/26
04/26
HCC 21-166, NCT05200559: T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Recruiting
1/2
70
US
Pembrolizumab, Keytruda®, E7777, ONTAK®
Alexander B Olawaiye, MD, Dr. Reddys Laboratories, SA
Epithelial Ovarian Cancer
12/25
12/27
NCT04840589: Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors

Recruiting
1
66
US
BET Bromodomain Inhibitor ZEN-3694, BETi ZEN-3694, ZEN 3694, ZEN-3694, ZEN003694, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS 734016, BMS-734016, BMS734016, Ipilimumab Biosimilar CS1002, MDX 010, MDX-010, MDX-CTLA4, MDX010, Yervoy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI)
Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Platinum-Resistant Ovarian Carcinoma, Refractory Ovarian Carcinoma
01/26
01/26
NCT06161493: ZEN003694 Combined With Niraparib in Patients With Metastatic or Recurrent Solid Tumors

Withdrawn
1
26
US
ZEN003694, Niraparib, MK-4827, Zejula
Haider Mahdi, GlaxoSmithKline, Zenith Epigenetics
Ovarian Cancer, Recurrent Solid Tumors
12/26
12/29
NCI-2022-04099, NCT05372614: Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Suspended
1
30
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Neratinib Maleate, 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1), HKI-272 Maleate, NERATINIB MALEATE ANHYDROUS, Nerlynx, Trastuzumab Deruxtecan, DS-8201, DS-8201a, Enhertu, Fam-trastuzumab Deruxtecan-nxki, T-DXd, WHO 10516
National Cancer Institute (NCI)
Malignant Solid Neoplasm
06/25
06/25
SGNSTNV-001, NCT04665921: A Study of SGN-STNV in Advanced Solid Tumors

Terminated
1
111
Europe, Canada, US
SGN-STNV
Seagen Inc.
Carcinoma, Non-Small Cell Lung, HER2 Negative Breast Neoplasms, Ovarian Neoplasms, Uterine Cervical Neoplasms, Endometrial Neoplasms, Esophageal Neoplasms, Gastroesophageal Junction Carcinoma, Stomach Neoplasms, Colorectal Neoplasms, Exocrine Pancreatic Adenocarcinoma, Appendiceal Adenocarcinoma, Pseudomyxoma Peritonei
03/24
03/24
NCT05807126: Testing the Addition of Immunotherapy With Hu5F9-G4 (Magrolimab) to the Usual PARP Inhibitor, Olaparib for Treatment of Metastatic or Recurrent Breast or Castrate-Resistant Prostate Cancer With BRCA Mutations

Withdrawn
1
33
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Magrolimab, Hu5F9-G4, ONO-7913, Olaparib, AZD 2281, AZD-2281, AZD2281, KU-0059436, Lynparza, Olanib, Olaparix, PARP Inhibitor AZD2281
National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8, Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
12/26
12/26
Bradley, Megan
RELIEF, NCT05512039: Reduced-dose Botox for Urgency Incontinence Among Elder Females

Recruiting
1/2
376
US
Botox 50 Unit Injection, OnabotulinumtoxinA 50 Unit Injection, Botox 100 Unit Injection, OnabotulinumtoxinA 100 Unit
Dartmouth-Hitchcock Medical Center, Patient-Centered Outcomes Research Institute, Dartmouth College, University of Alabama at Birmingham, University of Pittsburgh, University of Texas, Kaiser Permanente, Oregon Health and Science University, Stanford University, University of Connecticut
Overactive Bladder, Urinary Incontinence in Old Age, Urgency Urinary Incontinence
09/26
01/27
NCT04922255: Cystic Fibrosis and Urinary Incontinence

Terminated
N/A
15
US
Reusable Underwear, Disposable urethral support, Pelvic floor physical therapy
Megan Bradley, Cystic Fibrosis Foundation
Urinary Incontinence, Cystic Fibrosis
10/23
10/23

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