| Kleiman, Neal S |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN with the Symplicity Spyral RDN System in Subjects with Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Recruiting | N/A | 15 | US | TricValve® Transcatheter Bicaval Valve System, TricValve System | P+F Products + Features USA Inc., P+F Products + Features GmbH, Meditrial USA Inc. | Tricuspid Regurgitation, Tricuspid Valve Disease | 11/25 | 09/29 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Reardon, Michael |
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (). |
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| Active, not recruiting | N/A | 1746 | Europe, Canada, US | Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI) | Medtronic Cardiovascular | Severe Aortic Stenosis | 07/18 | 11/26 | | |
NCT03635424: Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study |
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| Active, not recruiting | N/A | 150 | US | Medtronic TAVR Systems | Medtronic Cardiovascular | Bicuspid Aortic Valve | 11/19 | 12/30 | | |
NCT02701283: Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients |
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| Active, not recruiting | N/A | 2223 | Europe, Canada, Japan, US, RoW | Medtronic Transcatheter Aortic Valve Replacement Systems, Surgical Aortic Valve Replacement (SAVR) | Medtronic Cardiovascular | Aortic Valve Stenosis | 04/21 | 03/26 | | |
| Active, not recruiting | N/A | 15 | US | DurAVRTM THV System | Anteris Technologies Ltd. | Aortic Stenosis, Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis, Aortic Valve Calcification | 12/23 | 12/33 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Active, not recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 07/24 | 08/29 | | |
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 1948 | Canada, US | ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL | Boston Scientific Corporation | Aortic Stenosis | 06/24 | 09/34 | | |
| Not yet recruiting | N/A | 264 | NA | TAVR-explant, Redo-TAVR, Valve-in-Valve, TAV-in-TAV | Medstar Health Research Institute | Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure | 05/34 | 05/36 | | |
| Recruiting | N/A | 194 | US | J-Valve Transfemoral (TF) System | JC Medical, Inc., Bright Research Partners, Minneapolis Heart Institute Foundation, Cardiovascular Research Foundation, New York | Aortic Valve Regurgitation, Aortic Valve Disease Mixed | 12/27 | 12/31 | | |
| Recruiting | N/A | 800 | Europe, Canada, US, RoW | | Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux | Mitral Regurgitation | 03/25 | 12/30 | | |
| Recruiting | N/A | 590 | Europe, RoW | Navitor Transcatheter Aortic Valve and FlexNav Delivery System | Abbott Medical Devices | Symptomatic Severe Aortic Stenosis | 06/25 | 02/36 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
ENVISION, NCT05932615: IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation |
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| Enrolling by invitation | N/A | 1500 | Canada, US | Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System | Abbott Medical Devices | Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder | 04/27 | 04/36 | | |
