University of Kentucky Hospital
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 43 Trials 
106 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Lee, Jong Mog
OPTIMIZE-APT, NCT05418556: Tailored Versus Coventional AntiPlaTelet Strategy Intended After OPTIMIZEd Drug Eluting Stent

Recruiting
4
3944
RoW
aspirin, clopidogrel, prasugrel, ticagrelor
Asan Medical Center
Coronary Artery Disease
08/27
12/28
NCT04497142: Effect of Perampanel on Peritumoral Hyperexcitability in HGG

Completed
1/2
12
US
Perampanel, E2007, Fycompa, Standard of Care, Standard treatment (typically the anti-seizure medication levetiracetam)
Dana-Farber Cancer Institute, National Cancer Institute (NCI), Eisai Inc.
Glioma, Malignant, Surgery, Seizures
05/23
05/23
NCT04409080 / 2020-002031-29: REGN7257 in Adult Patients With Severe Aplastic Anemia That Is Refractory to or Relapsed on Immunosuppressive Therapy

Suspended
1/2
33
Europe, US, RoW
REGN7257
Regeneron Pharmaceuticals, Regeneron Pharmaceuticals, Inc
Severe Aplastic Anemia (SAA)
01/26
07/26
CENOBITE, NCT06352723: Cenobamate in the Intensive Care Unit

Not yet recruiting
1
10
US
Cenobamate
Brigham and Women's Hospital
Epilepsy, Neurologic Disorder
12/24
06/25
ASSURE, NCT03306901: Chemoradiotherapy Versus Esophagectomy After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinoma

Active, not recruiting
N/A
240
RoW
Esophagectomy, 5-fluorouracil, 5-FU, Cisplatin, Radiation therapy
Samsung Medical Center, Ministry of Health & Welfare, Korea
Esophageal Cancer
12/25
12/33
ICARUS, NCT05805280: IntravasCular Imaging-Guided Versus AngiogRaphy-GUided Drug-Eluting Stent Implantation for Fermoropopliteal Artery Disease

Recruiting
N/A
100
RoW
intravascular ultrasound-guided group, angiography-guided group
Asan Medical Center
Femoropopliteal Disease
12/25
12/25
Korus, NCT06135285: a Device to Prevent Sudden Unexpected Death in Epilepsy (SUDEP)

Not yet recruiting
N/A
10
US
Control subjects
Brigham and Women's Hospital
Epilepsy
06/27
06/27
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
Sexton, Travis R
REBIRTH, NCT05180773: Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

Recruiting
4
250
US
Bromocriptine, Parlodel, Cycloset, Placebo, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban, Xarelto, Second Placebo
Dennis M. McNamara, MD, MS, National Heart, Lung, and Blood Institute (NHLBI)
Peripartum Cardiomyopathy, Postpartum
06/26
12/28
Hanel, Ricardo A
NECC, NCT04852783: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair

Active, not recruiting
4
250
US
Contour Neurovascular System
Cerus Endovascular, Inc.
Aneurysm, Intracranial
12/25
12/29
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
ENDOLOW, NCT04167527: Endovascular Therapy for Low NIHSS Ischemic Strokes

Recruiting
2/3
200
Europe, Canada, US
Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM)
Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati
Cerebral Ischemia
12/24
12/24
HEMERA-1, NCT04677777: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Recruiting
1
24
US
PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT), Sanguinate
Prolong Pharmaceuticals
Acute Ischemic Stroke
12/24
02/25
NCT04518670: Success in Comaneci-assist Coils Embolization Surveillance Study (SUCCESS)

Completed
N/A
90
US
Comaneci Embolization Assist Device
Rapid Medical
Intracranial Aneurysm
05/24
07/24
CARO, NCT03663257: Study to Evaluate Cerebral AneurysmFlow Results in Occlusion

Completed
N/A
121
Canada, US, RoW
AneurysmFlow
Philips Clinical & Medical Affairs Global
Intracranial Aneurysm
11/23
11/23
STEM, NCT04410146: The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma

Completed
N/A
310
Europe, US
SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation, Other: Medical Management
Balt USA, Balt Extrusion, Embo-Flüssigkeiten A.G., AXIOM Real Time Metrics
Subdural Hematoma, Chronic
02/24
05/24
NCT05018650: A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)

Active, not recruiting
N/A
250
US, RoW
Route 92 Medical Reperfusion System
Route 92 Medical, Inc.
Acute Ischemic Stroke
06/24
06/24
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus

Recruiting
N/A
50
US
eShunt Implant
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Normal Pressure, Hydrocephalus
01/25
01/30
VANTAGE, NCT04391803: EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms with the Pipeline™ Flex Embolization Device with Shield TEchnology™ (ELEVATE)

Recruiting
N/A
200
NA
Pipeline™ Flex Embolization Device with Shield Technology™, Pipeline™ Shield Device
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm, Ruptured Aneurysm
01/26
01/27
EMBOLISE, NCT04402632: Embolization of the Middle Meningeal Artery with ONYX™ Liquid Embolic System for Subacute and Chronic Subdural Hematoma

Active, not recruiting
N/A
600
US
Surgical Management, Surgical Management + Treatment, No Treatment, Treatment
Medtronic Neurovascular Clinical Affairs
Subdural Hematoma
12/24
03/25
EXCELLENT, NCT03685578: CERENOVUS Neurothrombectomy Devices Registry

Recruiting
N/A
2000
Europe, US, RoW
EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter, CEREGLIDE 71 Intermediate Catheter
Cerenovus, Part of DePuy Synthes Products, Inc.
Cerebral Stroke
03/25
06/25
CHESS, NCT06347796: Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

Recruiting
N/A
520
US
Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
The University of Texas Medical Branch, Galveston, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Subdural Hematoma
09/28
09/28
NCT04701684: WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)

Recruiting
N/A
564
Europe, US, RoW
Direct to Angio Suite (DTAS) Philips' CBCT triage, Conventional CT/MR triage
Philips Clinical & Medical Affairs Global
Stroke, Acute
12/25
12/25
NCT05071963: INSPIRE Pipeline™ Shield Post Approval Study

Active, not recruiting
N/A
246
US
Treatment of Intracranial Aneurysms
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
03/26
04/28
MARRS, NCT05714501: Millipede AspiRation for Revascularization in Stroke () Study

Recruiting
N/A
225
Europe, US
Millipede System
Perfuze
Acute Ischemic Stroke
07/25
10/25
CLASS, NCT05636124: Kaneka IED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms

Recruiting
N/A
50
US
Kaneka i-ED coil
Icahn School of Medicine at Mount Sinai, Kaneka Corporation
Intracranial Aneurysms, Wide Neck Intracranial Aneurysms
07/25
07/25
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
NCT04057352: Citadel Embolization Device Study

Recruiting
N/A
150
US
Citadel Embolization Device
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
06/26
06/26
CAPTIVA-MRI, NCT05907629: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Recruiting
N/A
300
US
MRI
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Intracranial Atherosclerotic Stenosis (ICAS)
03/29
03/29
EXCELLENT, NCT05591183: CERENOVUS Neurothrombectomy Devices Registry

Recruiting
N/A
2000
Europe, US, RoW
EmboTrap® Revascularization Device, CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter
Cerenovus, Part of DePuy Synthes Products, Inc.
Cerebral Stroke
07/24
10/24
Concha, Mauricio
MOST, NCT03735979: Multi-arm Optimization of Stroke Thrombolysis

Active, not recruiting
3
514
US
Argatroban, Eptifibatide, Placebo
Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
12/23
04/25
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
REFOCUS-ALZ, NCT05026177: Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease

Terminated
3
1125
Canada, US, RoW
Simufilam, PTI-125, Placebo
Cassava Sciences, Inc., Premier Research Group plc
Alzheimer Disease
12/24
12/24
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
ReMEDy2, NCT05065216: Treatment of Acute Ischemic Stroke ( Trial)

Recruiting
2/3
728
US
Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection
DiaMedica Therapeutics Inc
Acute Stroke, Ischemic Stroke, Stroke
12/26
12/26
NCT06538116: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease

Recruiting
2
300
Japan, US
Mevidalen, LY3154207, Placebo
Eli Lilly and Company
Alzheimer Disease
12/25
01/26
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Rosenbaum, David P
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
NCT05643534: Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

Recruiting
3
180
US
Tenapanor 50 MG, Tenapanor 25 mg bid, Placebo
Ardelyx
Irritable Bowel Syndrome With Constipation (IBS-C)
12/25
12/25
NCT05905926: Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C

Enrolling by invitation
3
150
US
Tenapanor, Ibsrela
Ardelyx
Irritable Bowel Syndrome With Constipation (IBS-C)
07/31
10/31
NCT06553547: 4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs

Recruiting
2
72
US
Tenapanor, IBSRELA, Placebo
Ardelyx
Irritable Bowel Syndrome with Constipation (IBS-C)
06/26
06/26
DISTALS, NCT05152524: Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever

Recruiting
N/A
168
Europe, US
Tigertriever 13
Rapid Medical
Ischemic Stroke, Neovascularization
03/25
03/25
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System

Completed
N/A
328
US
Zoom Reperfusion System
Imperative Care, Inc.
Ischemic Stroke, Acute Stroke
05/24
05/24
Gurley, John
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Nahab, Fadi
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
SCORE, NCT05300737: Symptomatic Carotid Outcomes Registry

Recruiting
N/A
114
Canada, US
intensive medical therapy
University of Maryland, Baltimore
Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
04/25
10/25
Pettigrew, L Creed
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
Kampp, Michael
I-ACQUIRE, NCT03910075: Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation

Active, not recruiting
3
216
US
I-ACQUIRE - High Dosage, ACQUIRE, Pediatric Constraint-Induced Movement Therapy, P-CIMT, I-ACQUIRE - Moderate Dosage, Usual & Customary Treatment (U&CT)
Virginia Polytechnic Institute and State University, Ohio State University, Nationwide Children's Hospital, Stanford University, University of Cincinnati, Medical University of South Carolina
Perinatal Stroke, Hemiparesis
10/25
05/26
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
SISTER, NCT05948566: Strategy for Improving Stroke Treatment Response

Recruiting
2
300
US
TS23
Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona
Ischemic Stroke
07/27
12/27
Isaacs, Jennifer
REBIRTH, NCT05180773: Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

Recruiting
4
250
US
Bromocriptine, Parlodel, Cycloset, Placebo, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban, Xarelto, Second Placebo
Dennis M. McNamara, MD, MS, National Heart, Lung, and Blood Institute (NHLBI)
Peripartum Cardiomyopathy, Postpartum
06/26
12/28
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
MUSIC-CPX, NCT05537467: Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients

Recruiting
N/A
40
US
Music
Maya Ignaszewski
Heart Failure
12/27
12/27
REVERSE-HF, NCT05318105: Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Recruiting
N/A
372
US
Aquadex Smartflow® System, IV Loop Diuretics
Nuwellis, Inc.
Heart Failure (for Example, Fluid Overload)
07/25
10/25
NCT04977310: TARGET-LOAD Pilot Study Comparing Hemodynamics-guided LVAD Unloading Vs. Standard of Care

Withdrawn
N/A
10
US
CardioMEMS
STAVROS G DRAKOS, Abbott
Heart Failure
09/26
09/26
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
CARP, NCT05521503: Biopsy Collection and Repository Database

Recruiting
N/A
400
US
Andrew Kolodziej
Cardiovascular Diseases
12/30
12/30
OHP-II, NCT05915299: US National OCS Heart Perfusion (OHP) Registry

Recruiting
N/A
100000
US
OCS Heart
TransMedics
Heart Transplant
08/29
08/33
Ziada, Khaled
NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting
N/A
418
Europe, Canada, US, RoW
SELUTION SLR™ DEB, Control
M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation
Coronary Restenosis
07/25
08/29
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting
N/A
1400
Europe, US, RoW
Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
11/26
11/29
MICRO2, NCT06212466: MCG as a Noninvasive Diagnostic Strategy for Suspected INOCA

Recruiting
N/A
135
US
CardioFlux
Genetesis Inc.
Ischemic Heart Disease, Coronary Microvascular Disease, Angina, Myocardial Ischemia
12/24
12/24
STEMI-CST, NCT06795035: A New Technique to Measure the Heart's Microvascular Function in Patients Experiencing Heart Attack

Not yet recruiting
N/A
70
US
Continuous Saline Thermodilution
Khaled Ziada, MD, Abbott, The Cleveland Clinic
ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction, Microvascular Obstruction
12/26
12/26
Hatton, Kevin
RADICAL, NCT05004077: Repeated Amiodarone Dosing In Cardiac surgicaL Procedures

Terminated
4
3
US
AMIODARONE
Kevin W Hatton, MD, PhD
Atrial Fibrillation
10/22
10/22
NCT06119061: Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With Subarachnoid Hemorrhage

Recruiting
4
20
US
Telavancin Injection, Vibativ
Aaron Cook, Cumberland Pharmaceuticals
Subarachnoid Hemorrhage, Aneurysmal
12/25
01/26
BEACH, NCT05020535: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage

Recruiting
2
120
US
MW189, Saline
Johns Hopkins University, University of Kentucky, National Institute on Aging (NIA)
Intracerebral Hemorrhage
12/25
10/26
HOBIT, NCT02407028: Hyperbaric Oxygen Brain Injury Treatment Trial

Recruiting
2
200
Canada, US
Hyperbaric oxygen (1.5 ATA, no NBH), HBO, Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), NBH, Usual Care, Standard of Care
Hennepin Healthcare Research Institute, National Institute of Neurological Disorders and Stroke (NINDS), Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network
Traumatic Brain Injury
10/26
06/27
NCT04855396: The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

Recruiting
N/A
150
NA
University of Michigan
Traumatic Brain Injury
03/25
08/25
Borrego, Robert
HOBIT, NCT02407028: Hyperbaric Oxygen Brain Injury Treatment Trial

Recruiting
2
200
Canada, US
Hyperbaric oxygen (1.5 ATA, no NBH), HBO, Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), NBH, Usual Care, Standard of Care
Hennepin Healthcare Research Institute, National Institute of Neurological Disorders and Stroke (NINDS), Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network
Traumatic Brain Injury
10/26
06/27
NCT04855396: The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

Recruiting
N/A
150
NA
University of Michigan
Traumatic Brain Injury
03/25
08/25
Khan
NCT05128344 / 2021-003015-26: A Study to Evaluate Safety and Efficacy of AMZ002 Treatment, Compared With Vigabatrin in Participants With Infantile Spasms

Withdrawn
3
150
Europe, US, RoW
AMZ002 injectable solution, 0.5mg/mL, Vigabatrin, oral
Amzell
Spasms, Infantile
06/25
12/25
PREVAIL, NCT05202509 / 2021-005092-39: Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

Active, not recruiting
3
9541
Europe, Canada, Japan, US, RoW
Obicetrapib, Placebo
NewAmsterdam Pharma, Monash University
Atherosclerotic Cardiovascular Disease
11/26
11/26
CARTITUDE-6, NCT05257083 / 2021-003284-10: A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma

Recruiting
3
750
Europe, Canada, Japan, US, RoW
Daratumumab, Bortezomib, Lenalidomide, Dexamethasone, Cilta-cel, JNJ-68284528, Cyclophosphamide, Fludarabine
Stichting European Myeloma Network, Janssen Research & Development, LLC
Multiple Myeloma
06/33
08/40
Naravetla, Bharath R
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
PICASSO, NCT05611242: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Recruiting
3
404
US
MT+CAS with IV-AP, Thrombectomy, MT+CAS with PO-AP, MT+CAT with PO-AP
Mercy Health Ohio
Acute Ischemic Stroke
03/26
05/27
Escobar, Andrea
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics

Active, not recruiting
3
385
Canada, US
Revascularization, Intensive Medical Management (IMM) alone
Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles
Internal Carotid Artery Stenosis, Cognitive Impairment
01/27
07/27
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
SISTER, NCT05948566: Strategy for Improving Stroke Treatment Response

Recruiting
2
300
US
TS23
Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona
Ischemic Stroke
07/27
12/27
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Arnold, Patricia
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Pettigrew, Creed
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Hsu, Cindy
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
Arnold, Pat
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Gupta, Vedant
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
Cho, Sung-Min
AFTERCOR, NCT05175339: Long-term Impact in Intensive Care Survivors of Coronavirus Disease (COVID-19)

Completed
N/A
26
US
Johns Hopkins University, Gilead Sciences
COVID-19
11/23
11/23
ICECAP, NCT04217551: Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Recruiting
N/A
1800
US
Therapeutic Hypothermia
University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
07/28
08/28
PETREY, Ronda A Ronda
BRAVO, NCT04996264: Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite

Completed
2
96
US, RoW
Varespladib Methyl, LY333013, Placebo, Standard of care (SOC)
Ophirex, Inc., Premier Research Group plc
Snakebites, Envenoming, Envenoming, Snake, Envenomation, Snake
06/23
06/23
BRAVIO, NCT05717062: Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite

Recruiting
2
140
US
Varespladib intravenous form, LY315920, varespladib-methyl- oral form, LY333013, Placebo intravenous form, Placebo - oral form
Ophirex, Inc.
Snakebite, Envenoming, Snake
03/25
07/25
HOBIT, NCT02407028: Hyperbaric Oxygen Brain Injury Treatment Trial

Recruiting
2
200
Canada, US
Hyperbaric oxygen (1.5 ATA, no NBH), HBO, Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH), Hyperbaric oxygen (1.5 ATA + NBH), Hyperbaric oxygen (2.0 ATA + NBH), Hyperbaric oxygen (2.5 ATA + NBH), Normobaric Hyperoxia (NBH), NBH, Usual Care, Standard of Care
Hennepin Healthcare Research Institute, National Institute of Neurological Disorders and Stroke (NINDS), Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network
Traumatic Brain Injury
10/26
06/27
Das, Saurav
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
O'Connor, Kevin
MOST, NCT03735979: Multi-arm Optimization of Stroke Thrombolysis

Active, not recruiting
3
514
US
Argatroban, Eptifibatide, Placebo
Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
12/23
04/25
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
Somani, Sana
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
Brutto, Victor Del
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
CAPTIVA-MRI, NCT05907629: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Recruiting
N/A
300
US
MRI
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Intracranial Atherosclerotic Stenosis (ICAS)
03/29
03/29
Neurologist
NCT05128344 / 2021-003015-26: A Study to Evaluate Safety and Efficacy of AMZ002 Treatment, Compared With Vigabatrin in Participants With Infantile Spasms

Withdrawn
3
150
Europe, US, RoW
AMZ002 injectable solution, 0.5mg/mL, Vigabatrin, oral
Amzell
Spasms, Infantile
06/25
12/25
Antzoulatos, Eleni
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

Recruiting
3
1683
US
Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management
University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca
Intracranial Arteriosclerosis, Stroke
05/28
05/28
 

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