Academic Medical Center Amsterdam
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 29 Trials 
47 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Wykrzykowska, Joanna J
MATRIX-2, NCT05955365: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting
4
3010
Europe
P2Y12 inhibitor, Aspirin, DOAC
Insel Gruppe AG, University Hospital Bern, Sahajanand Medical Technologies Limited
Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor
09/26
12/26
NCT04703699: Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis.

Recruiting
N/A
200
Europe, RoW
Myval Transcatheter Heart Valve Series, Myval THV
Meril Life Sciences Pvt. Ltd.
Aortic Valve Stenosis
05/24
11/28
NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting
N/A
418
Europe, Canada, US, RoW
SELUTION SLR™ DEB, Control
M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation
Coronary Restenosis
07/25
08/29
LANDMARK, NCT04275726: Trial: a Randomised Controlled Trial of Myval THV

Recruiting
N/A
768
Europe, RoW
Myval THV Series, Myval/Myval Inception THVs or any subsequent advanced version commercially available at the study site., Contemporary Valves (Sapien THV Series and Evolut THV Series), Sapien THV Series (Sapien 3/Sapien 3 Ultra THVs) and Evolut THV Series (Evolut R/Evolut PRO THVs ) or any subsequent advanced version commercially available at the study site.
Meril Life Sciences Pvt. Ltd.
Aortic Valve Stenosis
03/24
12/33
PRO-TAVI, NCT05078619: Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation

Recruiting
N/A
466
Europe
No PCI
UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development
Valvular Heart Disease, Aortic Valve Stenosis, Coronary Artery Disease
11/24
08/28
NCT04859985: The SELUTION DeNovo Study

Active, not recruiting
N/A
3326
Europe, RoW
SELUTION SLR, DES
M.A. Med Alliance S.A.
Coronary Artery Disease
08/25
07/30
PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis

Active, not recruiting
N/A
1043
Europe
Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.
University of Leipzig, National University of Ireland, Galway
Aortic Stenosis
04/25
04/25
PIONEER-IV, NCT04923191: The Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent

Recruiting
N/A
2540
Europe
Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care
National University of Ireland, Galway, Ireland
Coronary Artery Disease
01/26
01/29
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
Preckel, Benedikt
NCT05797116: Practice Variation in Preoperative MDT Meetings

Completed
N/A
54
Europe
Survey
Rijnstate Hospital
Multidisciplinary Communication, Preoperative Care, Patient Care Team
03/23
05/23
NCT05305053: Practice Variation in Preoperative Multidisciplinary Team Discussions

Completed
N/A
225
Europe
preoperative MDT discussion
Rijnstate Hospital
Pre-operative, High-risk Patient, Frailty
06/24
06/24
Knops, Reinoud E
PRAETORIAN, NCT01296022: A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy

Active, not recruiting
N/A
850
Europe, US, RoW
Implantation of subcutaneous ICD, Implantation of transvenous ICD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation
Ventricular Arrhythmias
12/19
12/23
CRT-DRIVE, NCT05327062: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

Recruiting
N/A
150
Europe, US
CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
XSpline S.p.A.
Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
03/25
09/25
SyncAV, NCT04100148: Post-Market Trial

Active, not recruiting
N/A
1686
Europe, Canada, Japan, US, RoW
SyncAV programmed ON, Fixed AV delay
Abbott Medical Devices
Congestive Heart Failure
06/25
12/25
PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing

Active, not recruiting
N/A
965
Europe, US
ommitence of defibrillation testing
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation
Ventricular Arrythmia
10/24
10/24
MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing

Active, not recruiting
N/A
297
Europe, Canada, US, RoW
mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP)
Boston Scientific Corporation
Tachycardia, Ventricular, Arrhythmia, Ventricular
03/25
12/30
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Kersten, Marie José
DALY 2-EU, NCT04844866 / 2020-003908-14: Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

Active, not recruiting
2
168
Europe, RoW
MB-CART2019.1, R-GemOx or BR plus polatuzumab vedotin, Rituximab, Gemcitabine, Oxaliplatin, Polatuzumab vedotin, Bendamustine, Rituximab
Miltenyi Biomedicine GmbH, ICON plc
Diffuse Large B-cell Lymphoma
12/24
07/29
RESILIENCE, NCT05223413: REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs

Recruiting
N/A
608
Europe
RIPC, Simulated RIPC (Sham)
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, European Commission
Anthracycline-induced Cardiac Toxicity, Lymphoma
08/25
05/26
Polderman, Jorinde
BIG APPLE, NCT06166706: Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Recruiting
N/A
10000
Europe, RoW
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications
04/25
05/25
Veelo, Denise P
MITIGATE, NCT05736289: Evaluation of Mitral Valve Insufficiency Under General Anesthesia

Recruiting
N/A
50
Europe
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency
07/25
07/25
Wilmink, J W
NAPAN, NCT03986294: Second Line Treatment With Nal-IRI and S1 in Pancreatic Cancer

Recruiting
2
122
Europe
S1 + Nal-IRI, Nal-IRI+Leucovorin+5-FU
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Isala, Maastricht University Medical Center, Vall de Hebron, Barcelona, Spain, University Hospital Verona, Italy, Odense University Hospital, Medical University of Vienna
Metastatic Pancreatic Cancer
01/22
01/22
TROJAN, NCT03379909: Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer

Recruiting
2
49
Europe
Metformin
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Radboud University Medical Center
Superficial Bladder Cancer, Bladder Cancer
07/24
10/29
OPT-1, NCT03500068: Establishing Organoids From Metastatic Pancreatic Cancer Patients, the OPT-I Study.

Recruiting
N/A
30
Europe
biopsies & blood analyses
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center
Carcinoma, Pancreatic Ductal
09/22
09/22
Vlaar, Alexander
ImmunoSep, NCT04990232 / 2020-005768-74: Personalized Immunotherapy in Sepsis

Active, not recruiting
2
280
Europe
Anakinra or rhIFNγ, Imukin, Kineret, Placebo
Hellenic Institute for the Study of Sepsis
Sepsis
01/25
04/25
HistoSeps, NCT05208112: Intravenously Administered M6229 in Critically Ill Sepsis Patients

Completed
1
10
Europe
M6229
A.P.J. Vlaar, Matisse Pharmaceuticals, Maastricht University, Maastricht University Medical Center
Sepsis, Septic Shock, Critical Illness
09/23
09/23
CURIE, NCT06444750: Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers

Not yet recruiting
N/A
210
NA
Blood sample collection, Blood draw
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Transfusion-Related Acute Lung Injury, ARDS, Human
09/25
12/25
TREC, NCT06560164: Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO

Not yet recruiting
N/A
526
Europe
Red Blood Cell transfusion, RBC transfusion, pRBCs, packed Red Blood Cells
Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), ZonMw: The Netherlands Organisation for Health Research and Development
Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia, ECMO
12/27
12/28
NOTICE, NCT05303363: Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation

Recruiting
N/A
15
Europe
VV-ECMO
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure
06/25
08/25
Ruiter, Maurits de
QOMAS, NCT06386341: QoL in OSA patiënts Treated With MMA Surgery.

Recruiting
N/A
80
Europe
Maxillomandibular Advancement Surgery
Diakonessenhuis, Utrecht
Sleep Apnea, Obstructive, Quality of Life
08/26
08/26
BOMAMY, NCT06677216: Botulinum Toxin in the Management of Temporo-mandibular Related Myalgia: a Prospective Study

Enrolling by invitation
N/A
30
Europe
Botulinum Toxin, Type A
Diakonessenhuis, Utrecht, Fysiotherapie Utrecht Oost B.V.
TMD/Orofacial Pain, Myalgia of Mastication Muscle, Botulinum Toxin, Type a
12/24
02/25
Vogt, Liffert
PROMISE, NCT06256991: Potassium Correction for RAAS Optimization in Chronic Kidney Disease

Recruiting
4
50
Europe
Patiromer 8400 MG [Veltassa], Placebo
University Medical Center Groningen, Amsterdam University Medical Center, Medical Centre Leeuwarden, Isala, Vifor Pharma, Inc., Dutch Kidney Foundation, Health Holland
Chronic Kidney Diseases, Hyperkalemia, Hypertension
12/26
12/26
NCT06153693: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Active, not recruiting
3
1083
Europe, Canada, US, RoW
Placebo, lorundrostat Dose 1, lorundrostat Dose 2
Mineralys Therapeutics Inc.
Hypertension
12/24
02/25
K+ in CKD, NCT03253172: Potassium Supplementation in CKD

Recruiting
N/A
532
Europe
Potassium Chloride, Potassium Citrate, Placebo
Erasmus Medical Center, Dutch Kidney Foundation, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Medical Center Groningen, Leiden University Medical Center
Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia
10/24
10/25
Henriques, José Paulo
LEGACY, NCT05125276: Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients

Recruiting
4
3090
Europe
No aspirin, Aspirin
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Non ST Segment Elevation Acute Coronary Syndrome
07/25
07/25
NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting
N/A
418
Europe, Canada, US, RoW
SELUTION SLR™ DEB, Control
M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation
Coronary Restenosis
07/25
08/29
DISCO, NCT02309151: Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest

Recruiting
N/A
1006
Europe
Immediate coronary angiography
Uppsala University
Out-of-Hospital Cardiac Arrest
06/24
12/24
CLEAR-CAD, NCT05344612: Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD

Recruiting
N/A
6444
Europe
CT Coronary Angiography
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chest Pain, CAD
09/25
09/26
PROCTOR, NCT03805048: PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

Recruiting
N/A
584
Europe
Percutaneous coronary intervention
Amsterdam UMC, location VUmc
Coronary Artery Disease
12/26
06/27
Kaya, Abdullah
APPIRED-III, NCT03050476 / 2016-002663-33: Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Recruiting
2/3
1250
Europe, RoW
RESCAP®, placebo
Alloksys Life Sciences B.V., Aix Scientifics
Systemic Inflammation, Cardiopulmonary-bypass
09/25
03/26
SCARMICS, NCT05527756: Evaluation of the Cosmetic Outcomes of Totally Endoscopic Cardiac Surgery

Completed
N/A
80
Europe
Scar Cosmesis Assessment and Rating (SCAR) scale, Numerical rating scale (NRS)
Jessa Hospital
Minimally Invasive Cardiac Surgery, Scar
05/23
05/23
ProGlide-II, NCT05598385: Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery

Withdrawn
N/A
200
NA
Open cannulation, Percutaneous cannulation
Jessa Hospital
Cardiovascular Diseases
11/24
11/24
AFMICS-II, NCT05633797: The Occurrence of Atrial Fibrillation After Totally Endoscopic Cardiac Surgery

Terminated
N/A
152
Europe
FibriCheck
Jessa Hospital
Atrial Fibrillation
11/24
11/24
VENTMICS-II, NCT05417217: The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia

Terminated
N/A
165
Europe
Discontinued ventilation, Continued ventilation
Jessa Hospital
Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Hypoxia
11/24
11/24
Knops, R E
PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing

Active, not recruiting
N/A
965
Europe, US
ommitence of defibrillation testing
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation
Ventricular Arrythmia
10/24
10/24
Kersten, MJ
NCT05626764: QUALITOP - Monitoring Multidimensional Aspects of QUAlity of Life After Cancer ImmunoTherapy, an Open Smart Digital Platform for Personalized Prevention and Patient Management

Recruiting
N/A
3000
Europe
QoL & irAEs determinants
Hospices Civils de Lyon
Solid Tumor, Hematologic Cancer
12/23
12/24
Vertelman, L V
PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing

Active, not recruiting
N/A
965
Europe, US
ommitence of defibrillation testing
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation
Ventricular Arrythmia
10/24
10/24
Hematology, Secretary
No trials found

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