Academic Medical Center Amsterdam Trials

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47 Trials

Active Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Wykrzykowska, Joanna J

MATRIX-2, NCT05955365: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting

3010

Europe

P2Y12 inhibitor, Aspirin, DOAC

Insel Gruppe AG, University Hospital Bern, Sahajanand Medical Technologies Limited

Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor

09/26

12/26

NCT04703699: Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis.

Recruiting

N/A

200

Europe, RoW

Myval Transcatheter Heart Valve Series, Myval THV

Meril Life Sciences Pvt. Ltd.

Aortic Valve Stenosis

05/24

11/28

NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting

N/A

418

Europe, Canada, US, RoW

SELUTION SLR™ DEB, Control

M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation

Coronary Restenosis

07/25

08/29

LANDMARK, NCT04275726: Trial: a Randomised Controlled Trial of Myval THV

Recruiting

N/A

988

Europe, RoW

Myval THV Series, Myval/Myval Inception THVs or any subsequent advanced version commercially available at the study site., Contemporary Valves (Sapien THV Series and Evolut THV Series), Sapien THV Series (Sapien 3/Sapien 3 Ultra THVs) and Evolut THV Series (Evolut R/Evolut PRO THVs ) or any subsequent advanced version commercially available at the study site.

Meril Life Sciences Pvt. Ltd.

Aortic Valve Stenosis

03/24

12/33

PRO-TAVI, NCT05078619: Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation

Active, not recruiting

N/A

466

Europe

No PCI

UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development

Valvular Heart Disease, Aortic Valve Stenosis, Coronary Artery Disease

12/25

12/29

NCT04859985: The SELUTION DeNovo Study

Active, not recruiting

N/A

3326

Europe, RoW

SELUTION SLR, DES

M.A. Med Alliance S.A.

Coronary Artery Disease

08/25

07/30

PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis

Active, not recruiting

N/A

1043

Europe

Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.

University of Leipzig, National University of Ireland, Galway

Aortic Stenosis

04/25

PIONEER-IV, NCT04923191: The Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent

Recruiting

N/A

2540

Europe

Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care

National University of Ireland, Galway, Ireland

Coronary Artery Disease

01/26

01/29

NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting

N/A

650

Europe, Canada, Japan, US, RoW

Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)

Medtronic Cardiovascular

Moderate Aortic Valve Stenosis

02/26

12/34

Preckel, Benedikt

NCT05797116: Practice Variation in Preoperative MDT Meetings

Completed

N/A

Europe

Survey

Rijnstate Hospital

Multidisciplinary Communication, Preoperative Care, Patient Care Team

03/23

05/23

NCT05305053: Practice Variation in Preoperative Multidisciplinary Team Discussions

Completed

N/A

225

Europe

preoperative MDT discussion

Rijnstate Hospital

Pre-operative, High-risk Patient, Frailty

06/24

Knops, Reinoud E

PRAETORIAN, NCT01296022: A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy

Active, not recruiting

N/A

850

Europe, US, RoW

Implantation of subcutaneous ICD, Implantation of transvenous ICD

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrhythmias

12/19

12/23

CRT-DRIVE, NCT05327062: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

Recruiting

N/A

150

Europe, US

CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment

XSpline S.p.A.

Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block

03/25

09/25

SyncAV, NCT04100148: Post-Market Trial

Active, not recruiting

N/A

1686

Europe, Canada, Japan, US, RoW

SyncAV programmed ON, Fixed AV delay

Abbott Medical Devices

Congestive Heart Failure

06/25

12/25

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing

Active, not recruiting

N/A

297

Europe, Canada, US, RoW

mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP)

Boston Scientific Corporation

Tachycardia, Ventricular, Arrhythmia, Ventricular

05/24

12/30

NCT06048731: Enlighten Study: the EV-ICD Post Approval Registry

Active, not recruiting

N/A

1000

Europe, Canada, US, RoW

Defibrillation using EV-ICD

Medtronic

Ventricular Arrhythmia, Tachycardia

05/30

10/37

Kersten, Marie JosÃ©

DALY 2-EU, NCT04844866 / 2020-003908-14: Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

Active, not recruiting

168

Europe, RoW

MB-CART2019.1, R-GemOx or BR plus polatuzumab vedotin, Rituximab, Gemcitabine, Oxaliplatin, Polatuzumab vedotin, Bendamustine, Rituximab

Miltenyi Biomedicine GmbH, ICON plc

Diffuse Large B-cell Lymphoma

01/25

07/29

RESILIENCE, NCT05223413: REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs

Recruiting

N/A

608

Europe

RIPC, Simulated RIPC (Sham)

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, European Commission

Anthracycline-induced Cardiac Toxicity, Lymphoma

08/25

05/26

Polderman, Jorinde

BIG APPLE, NCT06166706: Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Recruiting

N/A

10000

Europe, RoW

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications

12/25

01/26

Veelo, Denise P

MITIGATE, NCT05736289: Evaluation of Mitral Valve Insufficiency Under General Anesthesia

Recruiting

N/A

Europe

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency

07/25

Wilmink, J W

NAPAN, NCT03986294: Second Line Treatment With Nal-IRI and S1 in Pancreatic Cancer

Recruiting

122

Europe

S1 + Nal-IRI, Nal-IRI+Leucovorin+5-FU

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Isala, Maastricht University Medical Center, Vall de Hebron, Barcelona, Spain, University Hospital Verona, Italy, Odense University Hospital, Medical University of Vienna

Metastatic Pancreatic Cancer

01/22

TROJAN, NCT03379909: Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer

Recruiting

Europe

Metformin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Radboud University Medical Center

Superficial Bladder Cancer, Bladder Cancer

07/24

10/29

OPT-1, NCT03500068: Establishing Organoids From Metastatic Pancreatic Cancer Patients, the OPT-I Study.

Recruiting

N/A

Europe

biopsies & blood analyses

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center

Carcinoma, Pancreatic Ductal

09/22

Vlaar, Alexander

ImmunoSep, NCT04990232 / 2020-005768-74: Personalized Immunotherapy in Sepsis

Completed

280

Europe

Anakinra or rhIFNγ, Imukin, Kineret, Placebo

Hellenic Institute for the Study of Sepsis

Sepsis

02/24

04/24

HistoSeps, NCT05208112: Intravenously Administered M6229 in Critically Ill Sepsis Patients

Completed

Europe

M6229

A.P.J. Vlaar, Matisse Pharmaceuticals, Maastricht University, Maastricht University Medical Center

Sepsis, Septic Shock, Critical Illness

09/23

CURIE, NCT06444750: Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers

Not yet recruiting

N/A

210

Blood sample collection, Blood draw

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Transfusion-Related Acute Lung Injury, ARDS, Human

09/25

12/25

TREC, NCT06560164: Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO

Recruiting

N/A

526

Europe

Red Blood Cell transfusion, RBC transfusion, pRBCs, packed Red Blood Cells

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), ZonMw: The Netherlands Organisation for Health Research and Development

Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia, ECMO

10/28

10/29

NOTICE, NCT05303363: Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation

Recruiting

N/A

Europe

VV-ECMO

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure

06/25

08/25

Ruiter, Maurits de

QOMAS, NCT06386341: QoL in OSA patiënts Treated With MMA Surgery.

Recruiting

N/A

Europe

Maxillomandibular Advancement Surgery

Diakonessenhuis, Utrecht

Sleep Apnea, Obstructive, Quality of Life

08/26

BOMAMY, NCT06677216: Botulinum Toxin in the Management of Temporo-mandibular Related Myalgia: a Prospective Study

Enrolling by invitation

N/A

Europe

Botulinum Toxin, Type A

Diakonessenhuis, Utrecht, Fysiotherapie Utrecht Oost B.V.

TMD/Orofacial Pain, Myalgia of Mastication Muscle, Botulinum Toxin, Type a

12/24

02/25

Vogt, Liffert

PROMISE, NCT06256991: Potassium Correction for RAAS Optimization in Chronic Kidney Disease

Recruiting

Europe

Patiromer 8400 MG [Veltassa], Placebo

University Medical Center Groningen, Amsterdam University Medical Center, Medical Centre Leeuwarden, Isala, Vifor Pharma, Inc., Dutch Kidney Foundation, Health Holland

Chronic Kidney Diseases, Hyperkalemia, Hypertension

12/26

NCT06153693: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Completed

1083

Europe, Canada, US, RoW

Placebo, lorundrostat Dose 1, lorundrostat Dose 2

Mineralys Therapeutics Inc.

Hypertension

12/24

01/25

K+ in CKD, NCT03253172: Potassium Supplementation in CKD

Active, not recruiting

N/A

532

Europe

Potassium Chloride, Potassium Citrate, Placebo

Erasmus Medical Center, Dutch Kidney Foundation, University Medical Center Groningen, Leiden University Medical Center, Amsterdam UMC

Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia

05/26

10/26

Henriques, JosÃ© Paulo

LEGACY, NCT05125276: Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients

Recruiting

3090

Europe

No aspirin, Aspirin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Non ST Segment Elevation Acute Coronary Syndrome

07/25

NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting

N/A

418

Europe, Canada, US, RoW

SELUTION SLR™ DEB, Control

M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation

Coronary Restenosis

07/25

08/29

DISCO, NCT02309151: Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest

Recruiting

N/A

1006

Europe

Immediate coronary angiography

Uppsala University

Out-of-Hospital Cardiac Arrest

06/24

12/24

CLEAR-CAD, NCT05344612: Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD

Recruiting

N/A

6444

Europe

CT Coronary Angiography

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Chest Pain, CAD

09/25

09/26

PROCTOR, NCT03805048: PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

Active, not recruiting

N/A

221

Europe

Percutaneous coronary intervention

Amsterdam UMC, location VUmc

Coronary Artery Disease

01/28

06/28

Kaya, Abdullah

APPIRED-III, NCT03050476 / 2016-002663-33: Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Recruiting

2/3

1250

Europe, RoW

RESCAP®, placebo

Alloksys Life Sciences B.V., Aix Scientifics

Systemic Inflammation, Cardiopulmonary-bypass

09/25

03/26

SCARMICS, NCT05527756: Evaluation of the Cosmetic Outcomes of Totally Endoscopic Cardiac Surgery

Completed

N/A

Europe

Scar Cosmesis Assessment and Rating (SCAR) scale, Numerical rating scale (NRS)

Jessa Hospital

Minimally Invasive Cardiac Surgery, Scar

05/23

ProGlide-II, NCT05598385: Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery

Withdrawn

N/A

200

Open cannulation, Percutaneous cannulation

Jessa Hospital

Cardiovascular Diseases

11/24

AFMICS-II, NCT05633797: The Occurrence of Atrial Fibrillation After Totally Endoscopic Cardiac Surgery

Terminated

N/A

152

Europe

FibriCheck

Jessa Hospital

Atrial Fibrillation

11/24

VENTMICS-II, NCT05417217: The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia

Terminated

N/A

165

Europe

Discontinued ventilation, Continued ventilation

Jessa Hospital

Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Hypoxia

11/24

Knops, R E

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

Kersten, MJ

NCT05626764: QUALITOP - Monitoring Multidimensional Aspects of QUAlity of Life After Cancer ImmunoTherapy, an Open Smart Digital Platform for Personalized Prevention and Patient Management

Recruiting

N/A

3000

Europe

QoL & irAEs determinants

Hospices Civils de Lyon

Solid Tumor, Hematologic Cancer

12/23

12/24

Vertelman, L V

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

Hematology, Secretary

No trials found

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Wykrzykowska, Joanna J

MATRIX-2, NCT05955365: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting

3010

Europe

P2Y12 inhibitor, Aspirin, DOAC

Insel Gruppe AG, University Hospital Bern, Sahajanand Medical Technologies Limited

Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor

09/26

12/26

NCT04703699: Myval Global Study of Myval™ THV Series Implanted in Patients With Native Severe Aortic Valve Stenosis.

Recruiting

N/A

200

Europe, RoW

Myval Transcatheter Heart Valve Series, Myval THV

Meril Life Sciences Pvt. Ltd.

Aortic Valve Stenosis

05/24

11/28

NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting

N/A

418

Europe, Canada, US, RoW

SELUTION SLR™ DEB, Control

M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation

Coronary Restenosis

07/25

08/29

LANDMARK, NCT04275726: Trial: a Randomised Controlled Trial of Myval THV

Recruiting

N/A

988

Europe, RoW

Meril Life Sciences Pvt. Ltd.

Aortic Valve Stenosis

03/24

12/33

PRO-TAVI, NCT05078619: Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation

Active, not recruiting

N/A

466

Europe

No PCI

UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development

Valvular Heart Disease, Aortic Valve Stenosis, Coronary Artery Disease

12/25

12/29

NCT04859985: The SELUTION DeNovo Study

Active, not recruiting

N/A

3326

Europe, RoW

SELUTION SLR, DES

M.A. Med Alliance S.A.

Coronary Artery Disease

08/25

07/30

PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis

Active, not recruiting

N/A

1043

Europe

Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.

University of Leipzig, National University of Ireland, Galway

Aortic Stenosis

04/25

Recruiting

N/A

2540

Europe

Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care

National University of Ireland, Galway, Ireland

Coronary Artery Disease

01/26

01/29

NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting

N/A

650

Europe, Canada, Japan, US, RoW

Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)

Medtronic Cardiovascular

Moderate Aortic Valve Stenosis

02/26

12/34

Preckel, Benedikt

NCT05797116: Practice Variation in Preoperative MDT Meetings

Completed

N/A

Europe

Survey

Rijnstate Hospital

Multidisciplinary Communication, Preoperative Care, Patient Care Team

03/23

05/23

NCT05305053: Practice Variation in Preoperative Multidisciplinary Team Discussions

Completed

N/A

225

Europe

preoperative MDT discussion

Rijnstate Hospital

Pre-operative, High-risk Patient, Frailty

06/24

Knops, Reinoud E

PRAETORIAN, NCT01296022: A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy

Active, not recruiting

N/A

850

Europe, US, RoW

Implantation of subcutaneous ICD, Implantation of transvenous ICD

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrhythmias

12/19

12/23

CRT-DRIVE, NCT05327062: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

Recruiting

N/A

150

Europe, US

CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment

XSpline S.p.A.

Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block

03/25

09/25

SyncAV, NCT04100148: Post-Market Trial

Active, not recruiting

N/A

1686

Europe, Canada, Japan, US, RoW

SyncAV programmed ON, Fixed AV delay

Abbott Medical Devices

Congestive Heart Failure

06/25

12/25

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing

Active, not recruiting

N/A

297

Europe, Canada, US, RoW

mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP)

Boston Scientific Corporation

Tachycardia, Ventricular, Arrhythmia, Ventricular

05/24

12/30

NCT06048731: Enlighten Study: the EV-ICD Post Approval Registry

Active, not recruiting

N/A

1000

Europe, Canada, US, RoW

Defibrillation using EV-ICD

Medtronic

Ventricular Arrhythmia, Tachycardia

05/30

10/37

Kersten, Marie JosÃ©

DALY 2-EU, NCT04844866 / 2020-003908-14: Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients

Active, not recruiting

168

Europe, RoW

MB-CART2019.1, R-GemOx or BR plus polatuzumab vedotin, Rituximab, Gemcitabine, Oxaliplatin, Polatuzumab vedotin, Bendamustine, Rituximab

Miltenyi Biomedicine GmbH, ICON plc

Diffuse Large B-cell Lymphoma

01/25

07/29

RESILIENCE, NCT05223413: REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs

Recruiting

N/A

608

Europe

RIPC, Simulated RIPC (Sham)

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, European Commission

Anthracycline-induced Cardiac Toxicity, Lymphoma

08/25

05/26

Polderman, Jorinde

BIG APPLE, NCT06166706: Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Recruiting

N/A

10000

Europe, RoW

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications

12/25

01/26

Veelo, Denise P

MITIGATE, NCT05736289: Evaluation of Mitral Valve Insufficiency Under General Anesthesia

Recruiting

N/A

Europe

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency

07/25

Wilmink, J W

NAPAN, NCT03986294: Second Line Treatment With Nal-IRI and S1 in Pancreatic Cancer

Recruiting

122

Europe

S1 + Nal-IRI, Nal-IRI+Leucovorin+5-FU

Metastatic Pancreatic Cancer

01/22

TROJAN, NCT03379909: Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer

Recruiting

Europe

Metformin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Radboud University Medical Center

Superficial Bladder Cancer, Bladder Cancer

07/24

10/29

OPT-1, NCT03500068: Establishing Organoids From Metastatic Pancreatic Cancer Patients, the OPT-I Study.

Recruiting

N/A

Europe

biopsies & blood analyses

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center

Carcinoma, Pancreatic Ductal

09/22

Vlaar, Alexander

ImmunoSep, NCT04990232 / 2020-005768-74: Personalized Immunotherapy in Sepsis

Completed

280

Europe

Anakinra or rhIFNγ, Imukin, Kineret, Placebo

Hellenic Institute for the Study of Sepsis

Sepsis

02/24

04/24

HistoSeps, NCT05208112: Intravenously Administered M6229 in Critically Ill Sepsis Patients

Completed

Europe

M6229

A.P.J. Vlaar, Matisse Pharmaceuticals, Maastricht University, Maastricht University Medical Center

Sepsis, Septic Shock, Critical Illness

09/23

CURIE, NCT06444750: Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers

Not yet recruiting

N/A

210

Blood sample collection, Blood draw

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Transfusion-Related Acute Lung Injury, ARDS, Human

09/25

12/25

TREC, NCT06560164: Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO

Recruiting

N/A

526

Europe

Red Blood Cell transfusion, RBC transfusion, pRBCs, packed Red Blood Cells

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), ZonMw: The Netherlands Organisation for Health Research and Development

Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia, ECMO

10/28

10/29

NOTICE, NCT05303363: Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation

Recruiting

N/A

Europe

VV-ECMO

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure

06/25

08/25

Ruiter, Maurits de

QOMAS, NCT06386341: QoL in OSA patiënts Treated With MMA Surgery.

Recruiting

N/A

Europe

Maxillomandibular Advancement Surgery

Diakonessenhuis, Utrecht

Sleep Apnea, Obstructive, Quality of Life

08/26

BOMAMY, NCT06677216: Botulinum Toxin in the Management of Temporo-mandibular Related Myalgia: a Prospective Study

Enrolling by invitation

N/A

Europe

Botulinum Toxin, Type A

Diakonessenhuis, Utrecht, Fysiotherapie Utrecht Oost B.V.

TMD/Orofacial Pain, Myalgia of Mastication Muscle, Botulinum Toxin, Type a

12/24

02/25

Vogt, Liffert

PROMISE, NCT06256991: Potassium Correction for RAAS Optimization in Chronic Kidney Disease

Recruiting

Europe

Patiromer 8400 MG [Veltassa], Placebo

University Medical Center Groningen, Amsterdam University Medical Center, Medical Centre Leeuwarden, Isala, Vifor Pharma, Inc., Dutch Kidney Foundation, Health Holland

Chronic Kidney Diseases, Hyperkalemia, Hypertension

12/26

NCT06153693: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Completed

1083

Europe, Canada, US, RoW

Placebo, lorundrostat Dose 1, lorundrostat Dose 2

Mineralys Therapeutics Inc.

Hypertension

12/24

01/25

K+ in CKD, NCT03253172: Potassium Supplementation in CKD

Active, not recruiting

N/A

532

Europe

Potassium Chloride, Potassium Citrate, Placebo

Erasmus Medical Center, Dutch Kidney Foundation, University Medical Center Groningen, Leiden University Medical Center, Amsterdam UMC

Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia

05/26

10/26

LEGACY, NCT05125276: Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients

Recruiting

3090

Europe

No aspirin, Aspirin

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Non ST Segment Elevation Acute Coronary Syndrome

07/25

NCT04280029: SELUTION SLR™ 014 In-stent Restenosis

Active, not recruiting

N/A

418

Europe, Canada, US, RoW

SELUTION SLR™ DEB, Control

M.A. Med Alliance S.A., Iqvia Pty Ltd, Cordis Corporation

Coronary Restenosis

07/25

08/29

DISCO, NCT02309151: Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest

Recruiting

N/A

1006

Europe

Immediate coronary angiography

Uppsala University

Out-of-Hospital Cardiac Arrest

06/24

12/24

CLEAR-CAD, NCT05344612: Comparing a Diagnostic and Treatment Strategy of Upfront CTCA With SOC in Patients With Chest Pain and Suspected CAD

Recruiting

N/A

6444

Europe

CT Coronary Angiography

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Chest Pain, CAD

09/25

09/26

PROCTOR, NCT03805048: PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

Active, not recruiting

N/A

221

Europe

Percutaneous coronary intervention

Amsterdam UMC, location VUmc

Coronary Artery Disease

01/28

06/28

Kaya, Abdullah

APPIRED-III, NCT03050476 / 2016-002663-33: Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Recruiting

2/3

1250

Europe, RoW

RESCAP®, placebo

Alloksys Life Sciences B.V., Aix Scientifics

Systemic Inflammation, Cardiopulmonary-bypass

09/25

03/26

SCARMICS, NCT05527756: Evaluation of the Cosmetic Outcomes of Totally Endoscopic Cardiac Surgery

Completed

N/A

Europe

Scar Cosmesis Assessment and Rating (SCAR) scale, Numerical rating scale (NRS)

Jessa Hospital

Minimally Invasive Cardiac Surgery, Scar

05/23

ProGlide-II, NCT05598385: Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery

Withdrawn

N/A

200

Open cannulation, Percutaneous cannulation

Jessa Hospital

Cardiovascular Diseases

11/24

AFMICS-II, NCT05633797: The Occurrence of Atrial Fibrillation After Totally Endoscopic Cardiac Surgery

Terminated

N/A

152

Europe

FibriCheck

Jessa Hospital

Atrial Fibrillation

11/24

VENTMICS-II, NCT05417217: The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia

Terminated

N/A

165

Europe

Discontinued ventilation, Continued ventilation

Jessa Hospital

Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Hypoxia

11/24

Knops, R E

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

Kersten, MJ

NCT05626764: QUALITOP - Monitoring Multidimensional Aspects of QUAlity of Life After Cancer ImmunoTherapy, an Open Smart Digital Platform for Personalized Prevention and Patient Management

Recruiting

N/A

3000

Europe

QoL & irAEs determinants

Hospices Civils de Lyon

Solid Tumor, Hematologic Cancer

12/23

12/24

Vertelman, L V

PRAETORIAN-DFT, NCT03495297: A Randomised Trial of S-ICD Implantation with and Without Defibrillation Testing

Active, not recruiting

N/A

965

Europe, US

ommitence of defibrillation testing

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation

Ventricular Arrythmia

04/25

07/25

Hematology, Secretary

No trials found

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