| Block, Christophe De |
| Completed | 4 | 282 | Europe, US, RoW | Tirzepatide, LY3298176, Dulaglutide, LY2189265 | Eli Lilly and Company | Type 2 Diabetes | 07/24 | 08/24 | | |
| Active, not recruiting | 3 | 15374 | Europe, Canada, Japan, US, RoW | Tirzepatide, LY3298176, Placebo | Eli Lilly and Company | Obesity, Overweight | 10/27 | 10/27 | | |
| Completed | 2 | 114 | Europe | Anti-Human Thymocyte Immunoglobulin, Rabbit, ATG | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/24 | 12/24 | | |
| Active, not recruiting | 2 | 138 | Europe | Verapamil SR 120 mg, VeraHEXAL KHK 120 mg, Isoptin retard 120 mg, Placebo, Matching Placebo for Verapamil SR 120 mg | Medical University of Graz, Juvenile Diabetes Research Foundation | Diabetes Mellitus, Type 1 | 05/25 | 05/26 | | |
| Recruiting | N/A | 50 | Europe | euglycaemic clamp test, 13C glucose breath test | University Hospital, Antwerp | Insulin Resistance, Type 1 Diabetes | 12/22 | 03/23 | | |
MELINDA, NCT03559621: Mobile-based Lifestyle Intervention in Women With Glucose Intolerance After Gestational Diabetes |
|
|
| Completed | N/A | 240 | Europe | mobile-based lifestyle intervention | Universitaire Ziekenhuizen KU Leuven | Gestational Diabetes, Type 2 Diabetes Mellitus, Glucose Intolerance, Healthy Lifestyle | 05/23 | 06/23 | | |
| Recruiting | N/A | 700 | Europe | ultrasound, elastography, controlled attenuation parameter (CAP), FLI, FIB-4, NFS | University Hospital, Antwerp | NAFLD, Type 1 Diabetes, Cardiovascular Diseases | 07/23 | 07/25 | | |
ACT-ONE, NCT05429359: cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstances |
|
|
| Not yet recruiting | N/A | 50 | NA | CPET: CardioPulmonary Exercise Test for CSII users, AEX1: Aerobic Exercise Test 1 for CSII users, AEX2: Aerobic Exercise Test 2 for CSII users, CPET: CardioPulmonary Exercise Test for MDI users, AEX1: Aerobic Exercise Test 1 for MDI users, AEX2: Aerobic Exercise Test 2 for MDI users | University Hospital, Antwerp, Universiteit Antwerpen, York University | Diabetes Mellitus, Type 1 | 08/23 | 03/24 | | |
NCT05597605: The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects |
|
|
| Completed | N/A | 6 | Europe | The SHINE SYSTEM | Indigo Diabetes NV | Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Ketoacidosis, Diabetic, Hyperglycaemia (Diabetic), Hypoglycemia | 12/23 | 01/24 | | |
INRANGE, NCT04414280: The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs |
|
|
| Recruiting | N/A | 1150 | Europe | Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/24 | 12/24 | | |
NCT05777330: Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes |
|
|
| Recruiting | N/A | 75 | Europe | Oral glucose tolerance test (OGTT), OGTT, Hyperglycemic clamp test, clamp, Continuous glucose monitoring, Dexcom G6, CGM | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Juvenile Diabetes Research Foundation | Type1 Diabetes Mellitus | 04/26 | 04/27 | | |
| Benhalima, Katrien |
SERENA, NCT05569772: Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes |
|
|
| Recruiting | 3 | 252 | Europe | Semaglutide Pen Injector, Ozempic, Semaglutide placebo | Universitaire Ziekenhuizen KU Leuven, University Hospital, Antwerp, Universitair Ziekenhuis Brussel, General Hospital Groeninge, Onze Lieve Vrouw Hospital, AZ Delta, Jessa Hospital, Ziekenhuis Netwerk Antwerpen (ZNA), Vitaz, Centre Hospitalier Universitaire de Liege, Erasme University Hospital, Centre Hospitalier Mouscron | Glucose Intolerance After a Recent History of Gestational Diabetes | 07/28 | 12/28 | | |
| Completed | N/A | 95 | Europe | 780G, standard of care | Universitaire Ziekenhuizen KU Leuven, University Hospital, Ghent, Universitair Ziekenhuis Brussel, University Hospital, Antwerp, Imelda Hospital, Bonheiden, AZ Sint-Jan AV, AZ Delta, Onze Lieve Vrouw Hospital, General Hospital Groeninge, AZ Nikolaas, AZ Turnhout, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, Amsterdam UMC | Type1 Diabetes | 04/23 | 05/23 | | |
MELINDA, NCT03559621: Mobile-based Lifestyle Intervention in Women With Glucose Intolerance After Gestational Diabetes |
|
|
| Completed | N/A | 240 | Europe | mobile-based lifestyle intervention | Universitaire Ziekenhuizen KU Leuven | Gestational Diabetes, Type 2 Diabetes Mellitus, Glucose Intolerance, Healthy Lifestyle | 05/23 | 06/23 | | |
| Completed | N/A | 630 | Europe | GDM | Universitaire Ziekenhuizen KU Leuven, University Hospital, Antwerp, Onze Lieve Vrouw Hospital, Imelda Bonheiden | Gestational Diabetes, Type2 Diabetes, Obesity | 10/23 | 10/23 | | |
| Recruiting | N/A | 386 | Europe | Freestyle Libre 3, Glucometer | Universitaire Ziekenhuizen KU Leuven, University Hospital, Antwerp, General Hospital Groeninge, Onze Lieve Vrouw Hospital, Ziekenhuis Netwerk Antwerpen (ZNA), Vitaz, Centre Hospitalier Universitaire de Liege, Erasme University Hospital, Université Catholique de Louvain, University Hospital, Ghent, AZ Sint-Lucas Gent, AZ St- Jan Brugge, AZ St Maarten Mechelen, Imelda Hospital, Bonheiden, AZ Oostende | Gestational Diabetes | 09/25 | 02/27 | | |
GLORIA, NCT05084339: Glucose Homeostasis, Metabolomics and Pregnancy Outcomes After Bariatric Surgery |
|
|
| Recruiting | N/A | 190 | Europe | CGM | Universitaire Ziekenhuizen KU Leuven, University Hospital, Antwerp, University Hospital, Ghent, Ziekenhuis Netwerk Antwerpen (ZNA), Onze Lieve Vrouw Hospital, Imelda Hospital, Bonheiden, AZ St- Jan Brugge, General Hospital Groeninge | Bariatric Surgery Status Complicating Pregnancy | 09/25 | 12/25 | | |
| Peeters, Marc |
SAUNA, NCT05701241: Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients |
|
|
| Recruiting | 4 | 270 | Europe | Somatostatin analog, lanreotide, octreotide, sandostatin, somatuline | University Hospital, Antwerp, Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Belgium Health Care Knowledge Centre | Gastroenteropancreatic Neuroendocrine Tumor | 04/29 | 04/34 | | |
BALLAD, NCT04257461: A Trial to Evaluate the Potential Benefit of Adjuvant Chemotherapy for Small Bowel Adenocarcinoma |
|
|
| Recruiting | 3 | 30 | Europe | Fluoropyrimidine, Capecitabine, LV5FU2, Oxaliplatin, Xeloda | Belgian Group of Digestive Oncology, Kom Op Tegen Kanker, Cancer Research UK | Small Bowel Adenocarcinoma | 12/25 | 12/25 | | |
| Active, not recruiting | 3 | 148 | Europe | acetylsalicylic acid, Placebo | University Hospital, Antwerp, Kom Op Tegen Kanker, Anticancerfund | Colon Cancer | 12/27 | 12/27 | | |
NCT04735900: lead-in FOLICOLOR Trial: Following Therapy Response Through Liquid Biopsy in Metastatic Colorectal Cancer Patients |
|
|
| Recruiting | N/A | 60 | Europe | Liquid biopsy sampling | University Hospital, Antwerp, Amgen | Metastatic Colorectal Cancer | 03/22 | 03/22 | | |
| Active, not recruiting | N/A | 60 | Europe | Onivyde® + 5-FULV, Nanoliposomal irinotecan | University Hospital, Antwerp, Universitair Ziekenhuis Brussel, AZ Nikolaas, General Hospital Groeninge, University Hospital St Luc, Brussels, ASZ Aalst, Erasme University Hospital, Centre Hospitalier Universitaire de Liege, OLVZ Ziekenhuis Aalst | Metastatic Pancreatic Ductal Adenocarcinoma | 03/22 | 03/22 | | |
NCT04641676: A Study to Examine the Value of Broad Agnostic Next Generation Sequencing (NGS) Panel Testing Versus Reimbursed Organ-directed NGS: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Center |
|
|
| Recruiting | N/A | 1000 | Europe | NGS testing | The Belgian Society of Medical Oncology, Foundation Medicine, Sciensano, Roche Pharma AG | Metastatic Cancer, Local Tumor Invasion | 09/22 | 12/22 | | |
REAL-V, NCT05033158: The Immune Reaction Upon COVID-19 Vaccination in the Belgian Cancer Population. |
|
|
| Completed | N/A | 402 | Europe | Blood sampling | University Hospital, Antwerp, KomOpTegenKanker (non-profit organization) | Cancer | 12/22 | 06/23 | | |
| Recruiting | N/A | 14 | Europe | Whole body hyperthermia, Standard of Care (SOC) chemotherapy according to the NCCN guidelines. | ElmediX | Advanced Cancer, Pancreatic Cancer Metastatic | 06/25 | 06/25 | | |
| Vanhaesebrouck, Eveline |
| Recruiting | 3 | 200 | Europe | Ebastine, Duspatalin | Guy Boeckxstaens, Fund for Scientific Research, Flanders, Belgium | IBS - Irritable Bowel Syndrome, IBS | 10/27 | 01/28 | | |
| Vandamme, Timon |
SAUNA, NCT05701241: Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients |
|
|
| Recruiting | 4 | 270 | Europe | Somatostatin analog, lanreotide, octreotide, sandostatin, somatuline | University Hospital, Antwerp, Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Belgium Health Care Knowledge Centre | Gastroenteropancreatic Neuroendocrine Tumor | 04/29 | 04/34 | | |
| Recruiting | 3 | 800 | Europe | Futibatinib, Ivosidenib, Tibsovo, Zanidatamab, Trastuzumab, Zercepac, Neratinib, Nerlynx, Encorafenib, Braftovi, Binimetinib, Mektovi, Niraparib, Zejula, Cisplatin, Gemcitabine | UNICANCER, Cancer Research UK & UCL Cancer Trials Centre, Belgian Group of Digestive Oncology, National Cancer Institute, France, Cancer Research UK, Taiho Oncology, Inc., Servier, Zymeworks BC Inc., Accord Healthcare, Inc., Pierre Fabre Medicament | Biliary Tract Neoplasms | 06/27 | 06/28 | | |
| Active, not recruiting | 2 | 350 | Europe, Canada, US | 9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar | Actuate Therapeutics Inc., Actuate Therapeutics Inc | Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma | 01/25 | 01/26 | | |
| Recruiting | 2 | 134 | Europe | Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin | Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels | Metastatic Pancreatic Ductal Adenocarcinoma | 06/25 | 12/27 | | |
STEREOPAC, NCT05083247: Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma |
|
|
| Recruiting | 2 | 256 | Europe | mFOLFIRINOX or Gemcitabine nab-paclitaxel, mFFX or Gem/Nab-p, Isotoxic High-Dose (iHD)-SBRT, Surgery | Erasme University Hospital, Jules Bordet Institute, Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels | Pancreatic Neoplasm, Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma | 12/27 | 12/30 | | |
IL15-TransDC, NCT05964361: First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients |
|
|
| Recruiting | 1/2 | 10 | Europe | IL15-transpresenting WT1-targeted Dendritic Cell Vaccine, IL15/IL15Ra/WT1 DC vaccine, IL15-transpresenting WT1-targeting DC vaccine | University Hospital, Antwerp, Kom Op Tegen Kanker, Stichting tegen Kanker | Esophageal Cancer, Pancreas Cancer, Ovarian Cancer, Liver Cancer | 04/25 | 09/25 | | |
BE-FORCE, NCT06541080: Collection of Liquid Biopsy Samples of Neuroendocrine Neoplasms (NEN) Patients - Collection of NET (CollectNET) 2.0, a Study by the Consortium |
|
|
| Recruiting | N/A | 550 | Europe | Shallow Whole Genome Sequencing (sWGS)-GIPXplore, methylation-sensitive restriction enzymes (MSRE)-Single-molecule molecular inversion probes (smMIP)-seq assay | University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, Universiteit Antwerpen, KU Leuven | Neuroendocrine Neoplasms | 12/28 | 12/30 | | |
TORPEDO, NCT06691425: Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma |
|
|
| Recruiting | N/A | 160 | Europe | Stereotactic Body Radiation Therapy (SBRT), Chemotherapy | Cancer Research Antwerp, Kom Op Tegen Kanker, Naslund Medical AB, Varian Medical Systems | Non-metastasized Unresectable Pancreatic Carcinoma | 07/30 | 07/30 | | |
eCAN, NCT06007001: Telerehabilitation and Tele-psychological Support in Cancer Patients JA |
|
|
| Recruiting | N/A | 354 | Europe, RoW | Telemedicine | Sciensano, European Commission | Cancer | 09/24 | 09/24 | | |
NCT05268952: A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0) |
|
|
| Recruiting | N/A | 100 | Europe, RoW | Liquid biopsies, Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT) | University Hospital, Antwerp, Universiteit Antwerpen | Neuroendocrine Tumors | 05/25 | 12/25 | | |
| Recruiting | N/A | 248 | Europe | Blood sample | Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker | Esophageal Cancer | 09/25 | 12/26 | | |
| Recruiting | N/A | 103 | Europe | Blood Sample Collection | Jules Bordet Institute, Hoffmann-La Roche | Unresectable Locally Advanced Colorectal Cancer, Metastatic Colorectal Cancer, Candidate for Third-line or Subsequent Lines of Therapy | 04/26 | 12/26 | | |
SHAPERS, NCT06052332: Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer |
|
|
| Recruiting | N/A | 230 | Europe | Short course radiotherapy, Adjuvant chemotherapy (optional), Total mesorectal excision, Total neoadjuvant therapy | Jules Bordet Institute | Locally Advanced Rectal Cancer, Older People | 12/29 | 12/33 | | |
Quali-NET, NCT05268783: Patient-reported Outcomes in Neuroendocrine Neoplasms: a Prospective Quality of Life and Quality of Care Study Within NETwerk |
|
|
| Recruiting | N/A | 1000 | Europe | EORTC QLQ-C30, EORTC QLQ-GI.NET21, Satisfaction survey | University Hospital, Antwerp | Quality of Life | 12/29 | 12/29 | | |
| Os, Luc van |
E-CLAIR, NCT05391659: Efficiency and Cost-effectiveness of Artificial Intelligence Based Diabetic Retinopathy Screening in Flanders |
|
|
| Recruiting | N/A | 1200 | Europe | deep learning, remote grading of fundus images, gold standard | Universitaire Ziekenhuizen Leuven | Diabetic Retinopathy | 11/22 | 12/22 | | |
| Recruiting | N/A | 12 | Europe | FLACS using FEMTO LDV-Z8 | Ziemer Ophthalmic Systems AG | Cataract in Child | 01/23 | 01/23 | | |
| Glorieux, Mary |
| Recruiting | 3 | 200 | Europe | Ebastine, Duspatalin | Guy Boeckxstaens, Fund for Scientific Research, Flanders, Belgium | IBS - Irritable Bowel Syndrome, IBS | 10/27 | 01/28 | | |
| Schepper, Heiko De |
| Recruiting | 3 | 200 | Europe | Ebastine, Duspatalin | Guy Boeckxstaens, Fund for Scientific Research, Flanders, Belgium | IBS - Irritable Bowel Syndrome, IBS | 10/27 | 01/28 | | |
| Anguille |
CARTITUDE-6, NCT05257083 / 2021-003284-10: A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma |
|
|
| Recruiting | 3 | 750 | Europe, Canada, Japan, US, RoW | Daratumumab, Bortezomib, Lenalidomide, Dexamethasone, Cilta-cel, JNJ-68284528, Cyclophosphamide, Fludarabine | Stichting European Myeloma Network, Janssen Research & Development, LLC | Multiple Myeloma | 06/33 | 08/40 | | |
