MP 825 Southampton General Hospita
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 13 Trials 
12 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Berra, Lorenzo
MGHK23, NCT02836899: Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

Active, not recruiting
3
250
US
Nitric Oxide, Placebo
Massachusetts General Hospital, Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital, Kenneth, Shelton, M.D., Massachusetts General Hospital, Kacmarek, Robert M., Ph.D., Massachusetts General Hospital, Sundt, Thoralf M., M.D., Massachusetts General Hospital, Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital, Thompson, Boyd Taylor, M.D., Massachusetts General Hospital, Bonventre, Joseph V., M.D., Brigham Women Hospital, Shann, Kenneth G., Massachusetts General Hospital, Zapol, Warren M., M.D., Marrazzo, Francesco, M.D., Massachusetts General Hospital, Spina, Stefano, M.D., Massachusetts General Hospital, Zadek, Francesco, M.D., Massachusetts General Hospital, Rezoagli, Emanuele, M.D., Massachusetts General Hospital, National Heart, Lung, and Blood Institute (NHLBI)
Acute Kidney Injury
11/23
11/23
NCT03748082: Effects of Nitric Oxide on the Endothelium During Hemolysis.

Recruiting
2
40
US
Nitric Oxide, iNO, Reactive Hyperemia Index, Endothelial Cells Collection
Massachusetts General Hospital, Spina, Stefano, M.D., Massachusetts General Hospital, Marrazzo, Francesco, M.D., Massachusetts General Hospital, Zadek, Francesco, M.D., Massachusetts General Hospital, Jennifer En-Sian Ho M.D., Massachusetts General Hospital, Naomi M Hamburg, M.D., Boston University
Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases, Cardiovascular Risk Factor
11/23
11/23
NCT04022161: Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients

Recruiting
2
100
Europe, US
Nitrogen Gas for Inhalation, N2, Blood withdrawal, Nitric Oxide, iNO
Massachusetts General Hospital, Zadek, Francesco, M.D., Massachusetts General Hospital, Spina, Stefano, M.D., Massachusetts General Hospital, Marrazzo, Francesco, M.D., Massachusetts General Hospital, University of Southampton
Cardiovascular Diseases, Oxidative Stress, Endothelial Dysfunction
02/24
07/24
NoCovid, NCT04305457: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

Active, not recruiting
2
70
US
Nitric Oxide, Nitric Oxide inhalation
Massachusetts General Hospital, University of Alabama at Birmingham
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
04/25
04/25
NCT02598713: Validation of Aspiration Markers in Intubated Patients

Recruiting
1
20
US
Aspiration Marker
Massachusetts General Hospital
Pneumonia, Aspiration
06/24
06/24
NCT05612074: Methemoglobin Concentration in High Dose Inhaled Nitric Oxide

Active, not recruiting
1
10
US
Inhaled Nitric Oxide, Nitric Oxide, Gaseous Nitric Oxide
Massachusetts General Hospital
Healthy Subjects
06/25
12/25
NCT02492113: Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation

Recruiting
N/A
39
US
Positive end-expiratory pressure (PEEP), ZEEP
Massachusetts General Hospital
Obesity
06/21
06/22
NCT02503241: Open Lung Strategy in Critically Ill Morbid Obese Patients

Active, not recruiting
N/A
21
US
PEEP INCREMENTAL, PEEP_Titration, PEEP DECREMENTAL
Massachusetts General Hospital
Obesity, Respiratory Insufficiency, Right-Sided Heart Failure, Pulmonary Atelectasis, Respiratory Mechanics
06/21
06/22
NCT02523352: Effects of PEEP on Heart and Lungs in Obese Subjects

Enrolling by invitation
N/A
35
US
Non-Invasive Ventilation, Esophageal catheter positioning
Massachusetts General Hospital
Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging, Respiratory Mechanics, Electrical Impedance Tomography, Trans-Thoracic Echocardiography
12/21
12/22
NCT01969227: The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

Completed
N/A
15
US
Subanesthetic ketamine
Massachusetts General Hospital, Beth Israel Deaconess Medical Center
Mechanical Ventilation, Airway Patency, Respiratory Depression
12/22
12/22
NCT03202641: Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

Recruiting
N/A
50
US
PEEP ARDSnet, PEEP LRM
Massachusetts General Hospital
ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication, Alveolar Edema, Right Heart Failure, Right Ventricular Dysfunction
04/23
08/24
NCT02860975: Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

Active, not recruiting
N/A
12
US
Inhaled Nitrogen
Massachusetts General Hospital, Rezoagli, Emanuele, M.D., Massachusetts General Hospital, Harvard Medical School, Ferrari, Michele, M.D., Massachusetts General Hospital, Harvard Medical School, Patel, Sarvagna, B.A., Massachusetts General Hospital, Harvard Medical School, Zapol, Warren M., M.D., Massachusetts General Hospital, Harvard Medical School, Fisher, Daniel, R.R.T., Massachusetts General Hospital, Harvard Medical School, Jain, Isha, B.A., Massachusetts General Hospital, Harvard Medical School, Mootha, Vamsi, M.D., Massachusetts General Hospital, Harvard Medical School, Harris, Stuart N., M.D., Massachusetts General Hospital, Harvard Medical School, Karaa, Amel, M.D., Massachusetts General Hospital, Harvard Medical School
Healthy Volunteers
10/25
12/25

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