Unity Health Toronto, St. Michael's Hospital
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 13 Trials 
24 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Karkouti, Keyvan
NCT05879432: LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Recruiting
2
240
Canada, RoW
LSALT Peptide, Metablok, Placebo
Arch Biopartners Inc.
Acute Kidney Injury, Cardiac Surgery
08/25
11/25
NCT03861026: Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery

Completed
N/A
101
Canada
Bilateral NIRS (Masimo, O3TM Regional Oximetry)
University Health Network, Toronto
Cerebral Desaturation, Surgery
01/23
06/23
NCT04762550: Thrombin Generation in Liver Transplant Surgery

Recruiting
N/A
100
Canada
University Health Network, Toronto
Liver Transplantation, Thrombin, Hemostasis, Surgical, Blood Coagulation Disorder Due to Liver Disease, Blood Coagulation Disorders
01/22
01/22
NCT04762576: Thrombin in Cardiac Surgery

Recruiting
N/A
200
Canada
University Health Network, Toronto, McMaster University
Thrombin, Hemostatic Disorder, Surgical Blood Loss, Coagulation Disorder, Cardiovascular Surgical Procedures
01/23
01/23
AlbACS-1Pro, NCT06395480: Albumin Utilization in Adult Cardiac Surgical Patients : a Multicentre Prospective Cohort Study

Recruiting
N/A
100
Canada
University Health Network, Toronto, Queen's University
Antithrombin III Levels, Albumin Levels
11/25
11/25
AlbACS-1R, NCT06322537: Albumin Utilization in Adult Cardiac Surgical Patients: Retrospective

Recruiting
N/A
500
Canada
University Health Network, Toronto, Queen's University, Unity Health Toronto, McMaster University, Sunnybrook Health Sciences Centre, London Health Sciences Centre, The Ottawa Hospital, Vancouver General Hospital, Royal Columbian Hospital, Nova Scotia Health Authority
Cardiovascular Surgical Procedures, Albumin
11/25
11/25
Haq, Rashida
NCT03763604: Named Patient Use Program to Provide Abemaciclib (LY2835219) for the Treatment of Metastatic Breast Cancer

Approved for marketing
N/A
Europe, Canada, RoW
Abemaciclib, LY2835219
Eli Lilly and Company
Metastatic Breast Cancer
 
 
Mazer, David
EMPA-HEART 2, NCT04461041: Empagliflozin and Cardiac Remodelling in People Without Diabetes

Completed
4
169
Canada, RoW
Empagliflozin, Jardiance, Placebo
Unity Health Toronto, Canadian Medical and Surgical Knowledge Translation Research Group, Boehringer Ingelheim, Applied Health Research Centre
Cardiovascular Diseases, Left Ventricular Hypertrophy
07/22
07/22
NEWTON-CABG, NCT03900026: Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

Recruiting
4
766
Canada, US
Evolocumab, Repatha®, Placebo, Control
Unity Health Toronto, Applied Health Research Centre
Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
12/23
12/23
SEMA-VR, NCT05870462: Semaglutide and Vascular Regeneration

Recruiting
4
100
Canada
Semaglutide Pen Injector, Ozempic, Wegovy
Canadian Medical and Surgical Knowledge Translation Research Group, Unity Health Toronto, Western University, Canada
Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
12/24
12/24
CODEX, NCT04289142: Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Recruiting
4
2400
Canada
Dexmedetomidine Hydrochloride Group, Dexmedetomidine Hydrochloride
Sunnybrook Health Sciences Centre, London Health Sciences Centre, University Health Network, Toronto, McMaster University
Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders, Mental Disorders, Confusion, Neurobehavioral Manifestations, Neurologic Manifestations, Nervous System Diseases, Signs and Symptoms, Dexmedetomidine, Hypnotics and Sedatives, Central Nervous System Depressants, Physiological Effects of Drugs, Analgesics, Non-Narcotic, Analgesics, Molecular Mechanisms of Pharmacological Action
03/26
03/26
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
AKITA, NCT05126303: Efficacy and Safety of RMC-035 in Subjects at High Risk for Acute Kidney Injury Following Open-Chest Cardiac Surgery

Terminated
2
177
Europe, Canada, US, RoW
RMC-035, ROSgard, Placebo
Guard Therapeutics AB
Acute Kidney Injury
04/23
07/23
POINTER, NCT06475274: A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery

Recruiting
2
161
Europe, Canada
RMC-035, Placebo
Guard Therapeutics AB
Kidney Injury Following Open-Chest Cardiac Surgery
10/25
10/25
NCT05879432: LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery

Recruiting
2
240
Canada, RoW
LSALT Peptide, Metablok, Placebo
Arch Biopartners Inc.
Acute Kidney Injury, Cardiac Surgery
08/25
11/25
TRICS-IV, NCT04754022: Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Recruiting
N/A
1440
Europe, Canada, US, RoW
Restrictive Transfusion Strategy, Liberal transfusion strategy
Unity Health Toronto
Disorder, Heart, Postoperative, Cardiac Surgery
12/25
06/26
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
Atrey, Amit
NCT03825965: Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT

Recruiting
3
40
Canada
MPL-001 (CBD: THC 25:1), Placebo oil for oral use
McMaster University, St. Joseph's Healthcare Hamilton, Hamilton Health Sciences Corporation
Knee Osteoarthritis
08/24
08/24
REVISITS, NCT03741296: Revision Single or Two Stage Surgery

Not yet recruiting
N/A
110
NA
Single stage revision, Two-stage revision
Unity Health Toronto
Total Hip Replacement, Arthroplasty Complications
09/21
12/22
NCT05286996: Cryoneurolysis for TKA - a Pilot Study

Recruiting
N/A
20
Canada
Iovera - Cryoneurolysis, Local anesthetic, Placebo
Unity Health Toronto
Knee Pain Chronic, Osteoarthritis
10/23
12/23
NCT03564730: Staged Versus Simultaneous Bilateral Knee Arthroplasty

Active, not recruiting
N/A
224
Canada
Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
Orthopaedic Innovation Centre
Knee Osteoarthritis
11/25
12/26
NCT01420237: Restoration® Anatomic Dual Mobility (ADM) X3® Acetabular System Study

Active, not recruiting
N/A
352
Europe, Canada, US
Restoration ADM X3 Device
Stryker Orthopaedics
Arthroplasty, Replacement, Hip
06/26
06/26
OR3O, NCT04325022: Safety and Effectiveness Study of ™ Dual Mobility System in THA

Active, not recruiting
N/A
177
Canada, US, RoW
Primary Total Hip Arthroplasty, Revision Total Hip Arthroplasty
Smith & Nephew, Inc.
Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
12/26
01/35
Barnes, Tristan
NCT03763604: Named Patient Use Program to Provide Abemaciclib (LY2835219) for the Treatment of Metastatic Breast Cancer

Approved for marketing
N/A
Europe, Canada, RoW
Abemaciclib, LY2835219
Eli Lilly and Company
Metastatic Breast Cancer
 
 

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