| Schütte, Wolfgang |
| Recruiting | 2 | 50 | Europe | Osimertinib, Tagrisso, Pemetrexed, Cisplatin, Carboplatin | Goethe University | NSCLC Stage IIIB, NSCLC Stage IV | 11/23 | 11/26 | | |
NCT03188874: Clinical AML Registry and Biomaterial Database of the Study Alliance Leukemia (SAL) |
|
|
| Recruiting | N/A | 15000 | Europe | | Technische Universität Dresden | Acute Myeloid Leukemia (AML) | 09/30 | 09/30 | | |
| Müller, Lutz P |
GRAPPA, NCT05153226: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG |
|
|
| Active, not recruiting | 3 | 640 | Europe | Cyclophosphamide, all brands, ATG, ATG Grafalon | DKMS gemeinnützige GmbH | Graft Vs Host Disease, Peripheral Blood Stem Cell Transplantation, AML, MDS, MDS/MPN, CMML | 06/25 | 12/26 | | |
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy |
|
|
| Recruiting | 3 | 482 | Europe | Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD) | Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH | Multiple Myeloma | 03/28 | 03/33 | | |
| Completed | 2/3 | 98 | Europe | Peripheral blood stem cells, PBSC | DKMS gemeinnützige GmbH | AML, ALL, MDS | 04/24 | 04/24 | | |
NCT03188874: Clinical AML Registry and Biomaterial Database of the Study Alliance Leukemia (SAL) |
|
|
| Recruiting | N/A | 15000 | Europe | | Technische Universität Dresden | Acute Myeloid Leukemia (AML) | 09/30 | 09/30 | | |
| Westenfeld, Ralf |
| Completed | N/A | 360 | Europe | Conventional circulatory support, Conventional circulatory support will be employed according to enrolling sites usual management., Impella CP, Impella CP, Abiomed | Odense University Hospital, Aarhus University Hospital Skejby, Hannover Medical School, University Hospital, Bonn, Jena University Hospital, University Hospital Dresden, Heinrich-Heine University, Duesseldorf, Universitätsklinikum Hamburg-Eppendorf, Charite University, Berlin, Germany, Royal Brompton & Harefield NHS Foundation Trust, Wuerzburg University Hospital, Rigshospitalet, Denmark | Cardiogenic Shock Acute, Acute Myocardial Infarction | 07/23 | 04/24 | | |
| Recruiting | N/A | 500 | Europe | IASD Implant | Corvia Medical | Heart Failure | 07/26 | 07/28 | | |
| Recruiting | N/A | 400 | Europe | CMR, scintigraphy | Heinrich-Heine University, Duesseldorf | Amyloidosis, Aortic Valve Stenosis | 09/23 | 09/23 | | |
| Recruiting | N/A | 224 | Europe | standard of care PCI, Impella-protected PCI | Heinrich-Heine University, Duesseldorf, Profil Clinical Trials Coordination GmbH, Abiomed Inc. | Induced Acute Kidney Injury, High-risk Percutaneous Coronary Intervention | 12/23 | 12/23 | | |
| Recruiting | N/A | 400 | Europe | | Leipzig Heart Science gGmbH, Helios Health Institute GmbH, Heart Center Leipzig - University Hospital, IHF GmbH - Institut für Herzinfarktforschung, Universitätsklinikum Hamburg-Eppendorf, St. Antonius Hospital, Klinikum Ludwigshafen, University of Magdeburg, Charite University, Berlin, Germany, University Hospital of Cologne | Out-of-hospital Cardiac Arrest | 12/25 | 06/26 | | |
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function |
|
|
| Recruiting | N/A | 1252 | Europe, Canada, US | Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump | Abiomed Inc. | Left Ventricular Dysfunction, Coronary Artery Disease | 03/26 | 10/27 | | |
NCT01805739: Multi Modal Cardiac Imaging Prior Transcatheter Aortic Valve Implantation |
|
|
| Recruiting | N/A | 5000 | Europe | | Klinik für Kardiologie, Pneumologie und Angiologie | Aortic Valve Stenosis | 12/30 | 12/30 | | |
| Recruiting | N/A | 200 | Europe | | Klinik für Kardiologie, Pneumologie und Angiologie | Mitral Regurgitation | 12/30 | 12/30 | | |
| Treede, Hendrik |
| Completed | N/A | 68 | Europe | BIOVALVE prosthesis | Biotronik AG, Medstar Health Research Institute | Heart Valve Diseases, Aortic Valve Stenosis | 03/18 | 05/23 | | |
NCT02732691: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study |
|
|
| Active, not recruiting | N/A | 68 | Europe, US, RoW | JenaValve Pericardial TAVR System | JenaValve Technology, Inc. | Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction | 05/19 | 04/24 | | |
TAVIS, NCT05536310: Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease |
|
|
| Not yet recruiting | N/A | 600 | Europe | Transcatheter Aortic Valve Implantation (TAVI) | JenaValve Technology, Inc. | Aortic Valve Stenosis, Aortic Valve Regurgitation, Aortic Valve Stenosis With Insufficiency, Constriction, Pathologic, Aortic Valve Disease, Heart Valve Diseases, Cardiovascular Diseases in Old Age, Ventricular Outflow Obstruction, Aortic Stenosis, Severe | 10/23 | 10/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Not yet recruiting | N/A | 1016 | NA | Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR | JenaValve Technology, Inc. | Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency | 02/26 | 02/36 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
|
|
| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Sedding, Daniel |
| Recruiting | N/A | 400 | Europe | | Leipzig Heart Science gGmbH, Helios Health Institute GmbH, Heart Center Leipzig - University Hospital, IHF GmbH - Institut für Herzinfarktforschung, Universitätsklinikum Hamburg-Eppendorf, St. Antonius Hospital, Klinikum Ludwigshafen, University of Magdeburg, Charite University, Berlin, Germany, University Hospital of Cologne | Out-of-hospital Cardiac Arrest | 12/25 | 06/26 | | |
| Recruiting | N/A | 3390 | Europe | Culprit-lesion revascularization, Culprit-lesion PCI, Non-culprit-lesion revascularization, multivessel PCI | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, German Federal Ministry of Education and Research, IHF GmbH - Institut für Herzinfarktforschung, Stiftung IHF - Institut für Herzinfarktforschung | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | 01/27 | 07/27 | | |
| Wolf, Hans-Heinrich |
| Recruiting | N/A | 500 | Europe, RoW | Data collection and quality of life questionnaire | Centre Leon Berard | Cancer, Cancer Metastatic, NTRK Gene Fusion Overexpression, NTRK Family Gene Mutation, ATIC-ALK Fusion Protein Expression, ALK Fusion Protein Expression, BCR-FGFR1 Fusion Protein Expression, ROS1 Gene Translocation, COL1A1-PDGFB Fusion Protein Expression, RET Gene Translocation, Gene Fusion, ROS Gene Translocation, BRAF Gene Rearrangement, FGFR2 Gene Translocation, FGFR3 Gene Translocation, NTRK1 Gene Translocation | 06/25 | 06/25 | | |
| Al-Ali, Haifa Kathrin |
ROP-ET, NCT06514807: A Study to Evaluate the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythaemia Patients |
|
|
| Active, not recruiting | 3 | 117 | Europe, RoW | Ropeginterferon alfa-2b (BESREMi®) | AOP Orphan Pharmaceuticals AG | Essential Thrombocythaemia | 03/28 | 03/28 | | |
| Recruiting | 3 | 550 | Europe, Canada, US, RoW | Tamibarotene, SY-1425, Placebo, Azacitidine | Syros Pharmaceuticals | Myelodysplastic Syndromes | 11/24 | 02/29 | | |
| Recruiting | 3 | 322 | Europe, Canada, US | Crenolanib, Crenolanib besylate, Cytarabine, Mitoxantrone, Placebo Oral Tablet, Fludarabine, Idarubicin, G-CSF | Arog Pharmaceuticals, Inc. | Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations | 10/24 | 10/24 | | |
| Active, not recruiting | 2 | 30 | Europe | Fedratinib Oral Capsule [Inrebic], Nivolumab | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Prof. F. Heidel, MH Hannover, Celgene International II S.á.r.l. | Primary Myelofibrosis, Secondary Myelofibrosis | 12/25 | 06/26 | | |
| Recruiting | N/A | 617 | Europe, RoW | | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS, GlaxoSmithKline | Myelofibrosis | 12/25 | 12/28 | | |
| Recruiting | N/A | 500 | Europe, RoW | Data collection and quality of life questionnaire | Centre Leon Berard | Cancer, Cancer Metastatic, NTRK Gene Fusion Overexpression, NTRK Family Gene Mutation, ATIC-ALK Fusion Protein Expression, ALK Fusion Protein Expression, BCR-FGFR1 Fusion Protein Expression, ROS1 Gene Translocation, COL1A1-PDGFB Fusion Protein Expression, RET Gene Translocation, Gene Fusion, ROS Gene Translocation, BRAF Gene Rearrangement, FGFR2 Gene Translocation, FGFR3 Gene Translocation, NTRK1 Gene Translocation | 06/25 | 06/25 | | |
| Ludwig, Kathrin |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
|
|
| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Rosendahl, Jonas |
CARP, NCT05551299: Treatment of Non-resectable Bile Duct Cancer With Radiofrequency Ablation or Photodynamic Therapy |
|
|
| Recruiting | 4 | 258 | Europe | Photosensitizer, Photodynamic therapy (PDT), Radiofrequency ablation (RFA) | University of Leipzig, Zentrum für Klinische Studien Leipzig | Hilar Cholangiocarcinoma | 04/28 | 04/28 | | |
NCT04548778: BÜHLMANN FPELA in the Diagnosis of Exocrine Pancreatic Insufficiency |
|
|
| Completed | N/A | 201 | Europe | BÜHLMANN fPELA assay | Bühlmann Laboratories AG | Exocrine Pancreatic Insufficiency | 09/24 | 09/24 | | |
| Not yet recruiting | N/A | 1000 | NA | | University Medical Center Goettingen, University Medical Centre Maribor, Aalborg University Hospital, University Hospital Munich, Tartu University Hospital, University Hospital in Halle | Autoimmune Pancreatitis Type 1, Autoimmune Pancreatitis Type 2 | 09/24 | 04/25 | | |
| Binder, Mascha |
NCT05008809: Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418) |
|
|
| Recruiting | 3 | 507 | Europe | mFOLFOX6, Folinic acid, Oxaliplatin, 5-fluorouracil (FU), mFOLFOXIRI, Folinic acid, Oxaliplatin, 5-FU, Irinotecan, FOLFIRI, Folinic acid, 5-FU, CAPOX, Capecitaine, Oxaliplatin | Dominik Paul Modest, German Research Foundation, Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Colorectal Cancer | 11/27 | 11/30 | | |
FOCUS, NCT05075122 / 2020-005910-17: Tolerability and Efficacy of UV1 Vaccine in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Planned for First-line Treatment With Pembrolizumab |
|
|
| Recruiting | 2 | 75 | Europe | UV1, Sargramostim for Injection, Pembrolizumab injection | Martin-Luther-Universität Halle-Wittenberg, Ultimovacs ASA, Apotheke der Universitätsmedizin der Johannes Gutenberg-Universität Mainz (Germany), Axel Hinke. CCRC Cancer Clinical Research Consulting (Düsseldorf, Germany | Head and Neck Squamous Cell Carcinoma | 08/24 | 02/25 | | |
TARC, NCT04177602: Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II Trial |
|
|
| Terminated | 1/2 | 10 | Europe | Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation | Universitätsklinikum Hamburg-Eppendorf, Clinical Trial Center North (CTC North GmbH & Co. KG), Servier Affaires Médicales | Locally Advanced Rectal Cancer | 09/22 | 09/22 | | |
LIQPLAT, NCT06367751: Implementation of Liquid Biopsies During Routine Clinical Care in Patients With Advanced Malignancies |
|
|
| Recruiting | N/A | 150 | Europe | ctDNA measurement | University Hospital, Basel, Switzerland, Research Center for Clinical Neuroimmunology and Neuroscience Basel | Advanced Solid Tumor | 10/26 | 10/26 | | |
