| Toledo, Frederico G |
PEP-DM, NCT06729996: Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis Associated Diabetes Mellitus |
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| Recruiting | 2 | 40 | US | Pioglitazone (PIO), Empagliflozin (EMPA) | Mayo Clinic, University of Pittsburgh Medical Center | Pancreatitis, Chronic, Pancreatitis, Acute, Diabetes Mellitus | 12/25 | 12/26 | | |
| Active, not recruiting | 2 | 140 | Europe, US, RoW | Ladarixin, allosteric inhibitor of CXCL8 (IL-8), CXCR1 and CXCR2 receptors, Placebo | Dompé Farmaceutici S.p.A, Dompe farmaceutici s.p.a. | Recent Onset type1 Diabetes | 04/24 | 04/26 | | |
DREAM-ON, NCT06401577: Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics |
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| Not yet recruiting | N/A | 800 | US | Dexcom Continuous Glucose Monitor (CGM) | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh | Acute Pancreatitis | 12/26 | 03/27 | | |
| Recruiting | N/A | 800 | US | | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh | Acute Pancreatitis | 04/25 | 04/25 | | |
| Gladwin, Mark T |
| Recruiting | 3 | 160 | Europe, US, RoW | Red Blood Cell, Red blood cell (RBC), Standard of care | University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI) | Sickle Cell Disease | 05/26 | 05/26 | | |
| Steel, Jennifer |
NCT01360606: Stereotactic Body Radiation Therapy (SBRT) for Liver Mets |
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| Completed | N/A | 9 | US | Stereotactic Body Radiation Therapy, CyberKnife, Trilogy, True Beam, Radiosurgery | Susannah Ellsworth | Liver Metastases | 07/18 | 02/21 | | |
NCT02944136: Collaborative Care Intervention for Cancer Caregivers |
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| Completed | N/A | 1 | US | enhanced usual care, control, stepped collaborative care, treatment | University of Pittsburgh | Depression, Advanced Cancer | 03/23 | 03/23 | | |
| Completed | N/A | 459 | US | Stepped collaborative care intervention, treatment, Enhanced Usual Care, control | University of Pittsburgh | Cancer, Depression, Fatigue, Pain | 07/23 | 07/23 | | |
NCT04969146: A Sleep Intervention for Cancer Patients and Their Caregivers |
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| Suspended | N/A | 50 | US | Dyadic Intervention, Patient Only Intervention | University of Pittsburgh | Intervention, Control | 12/24 | 01/25 | | |
| Suspended | N/A | 40 | US | Stepped collaborative care intervention, Treatment, Enhanced Usual Care, Control | University of Pittsburgh | Cancer, Depression, Fatigue, Pain, Sleep | 02/25 | 06/27 | | |
| Recruiting | N/A | 100 | US | cognitive behavioral therapy | University of Pittsburgh | Cognitive Behavioral Therapy | 08/25 | 08/26 | | |
| Not yet recruiting | N/A | 512 | US | Stepped collaborative care intervention, Treatment, Enhanced Usual Care, Control | University of Pittsburgh, National Cancer Institute (NCI) | Depression, Quality of Life, Social Support, Sleep, Stress | 09/30 | 12/31 | | |
| Esper, Stephen A |
NCT04606264: Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data |
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| Recruiting | 3 | 2500 | US | Neuraxial Analgesia, Intrathecal morphine/hydromorphone, IT morphine/hydromorphine, Regional Block 1: Paravertebral, Nerve Block, Perphenazine, Aprepitant, Dimenhydrinate, Ondansetron 4 MG, Dexamethasone, Regional Block 2: QL1 | Jennifer Holder-Murray, Berry Consultants | Perioperative Optimization | 06/25 | 06/25 | | |
NCT02887820: Evaluating the Use of Thromboelastography (TEG) in Patient's Requiring Extracorporeal Membrane Oxygenation (ECMO) |
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| Completed | N/A | 15 | US | Thromboelastograph, TEG 5000 | Stephen Esper, American Heart Association | Heart Disease, Lung Disease | 12/23 | 12/23 | | |
NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study |
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| Completed | N/A | 79 | US | Cardiac Performance System (CPS) Device | Stephen Esper, Sensydia Corporation | Heart Diseases | 01/24 | 01/24 | | |
| Forman, Daniel |
| Recruiting | 4 | 20000 | US | Atorvastatin 40 Mg Oral Tablet, Lipitor, Placebo oral tablet | Duke University, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI), Wake Forest University Health Sciences | Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases | 12/26 | 12/26 | | |
| Completed | 2 | 64 | US | Placebos, Placebo, 20mg sodium nitrite tid | Gladwin, Mark, MD, National Institutes of Health (NIH), National Institute on Aging (NIA) | Aging, Sedentary Lifestyle, Frailty | 07/23 | 07/23 | | |
| Recruiting | 2 | 30 | US | 210 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK) | VA Office of Research and Development, University of Pittsburgh | Long COVID, Cardiorespiratory Fitness | 02/25 | 03/25 | | |
RETRO, NCT06576297: Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure |
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| Recruiting | N/A | 30 | US | Inspiratory Muscle Training (IMT), Standard of Care | University of Pittsburgh, The Pittsburgh Foundation | Aging, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Frailty, Physical Function, Quality of Life | 10/25 | 10/26 | | |
| Completed | N/A | 350 | US | MACRO-I, Usual Care | University of Pittsburgh, National Institute on Aging (NIA), Washington University School of Medicine | Cardiovascular Diseases, Cardiac Rehabilitation, Transition of Care | 08/24 | 08/24 | | |
T2CR, NCT06244199: Transition to Cardiac Rehabilitation () to Address Barriers of Multimorbidity and Frailty |
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| Recruiting | N/A | 250 | US | T2CR Intervention, Usual Care | VA Office of Research and Development | Cardiovascular Diseases, Cardiac Rehabilitation, Transition of Care | 03/27 | 08/27 | | |
MCNAIR, NCT05933083: Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation |
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| Recruiting | N/A | 516 | US | In-person cardiac rehabilitation, Telehealth cardiac rehabilitation | University of California, San Francisco, Patient-Centered Outcomes Research Institute, Mayo Clinic, University of Michigan, University of Pittsburgh, Johns Hopkins University | Myocardial Infarction, Heart Failure, Systolic, Heart Valve Diseases, Angina, Stable, Coronary Artery Disease, Heart Transplant | 10/26 | 10/27 | | |
| Monroe, Amy L |
NCT04208516: Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain. |
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| Terminated | 4 | 17 | US | Continuous Erector Spinae Plane Nerve Block, Continuous Quadratus Lumborum Nerve Block, Single Erector Spinae Plane Nerve Block, Single Quadratus Lumborum Nerve Block, Lidocaine IV, Ropivacaine 0.5% Injectable Solution, Dexamethasone, Dexmedetomidine, Lidocaine | Jeremy Kearns | Postoperative Pain | 08/22 | 08/22 | | |
NCT03261193: ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain |
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| Terminated | 3 | 21 | US | ITM + Sham QLB, Saline, ITM + Bupivacaine QLB, Bupivacaine | Nicholas Schott | Pain, Postoperative | 06/18 | 11/22 | | |
OPSTAHT, NCT03341156: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation |
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| Recruiting | 3 | 60 | US | Kcentra, prothrombin complex concentrate, Frozen Plasma Product, Human, Fresh Frozen Plasma | Kathirvel Subramaniam, University of Maryland, Baltimore, CSL Behring | Heart Disease End Stage, Heart Failure，Congestive | 10/24 | 12/24 | | |
NCT06626503: Evaluation of Analgesia for Spine Fusion Elective Surgery in Children |
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| Not yet recruiting | 2 | 500 | US | Methadone based ERAS, Methadone Based, SOC non-methadone based group, Standard Care | Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Idiopathic Scoliosis | 09/25 | 09/25 | | |
NCT06626035: Prospective Randomized Evaluation of Analgesia for Cardiac Elective Surgery in Children |
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| Not yet recruiting | 2 | 500 | US | Methadone based ERAS, Methadone-Based, SOC non-methadone based group, Standard Care | Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Pediatric Cardiac Surgery | 09/25 | 09/25 | | |
PREPARE-2, NCT06767566: Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery |
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| Not yet recruiting | 1 | 50 | US | Ketamine (Ketalar), 0.18 mg/kg/1hr loading dose Ketamine | Grace Lim, MD, MS, National Institute of Mental Health (NIMH) | Pain, Postpartum Depression | 12/27 | 03/28 | | |
| Completed | 1 | 12 | US | Ketamine (Ketalar) Dose Level 1, 0.05 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 2, 0.08 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 3, 0.12 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 4, 0.18 mg/kg/1hr loading dose Ketamine | Grace Lim, MD, MS, National Institute of Mental Health (NIMH) | Pain, Postoperative, Depression, Postpartum | 06/24 | 09/24 | | |
NCT06275308: Effect of Raised End-Tidal PCo2 on Choroidal Volume |
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| Recruiting | N/A | 20 | US | Ventilation manipulation | University of Pittsburgh | Intraocular Pressure | 04/25 | 04/25 | | |
NCT03633604: Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia |
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| Available | N/A | | US | HBOC-201, Hemopure, hemoglobin glutamer - 250 (bovine) | Jonathan H. Waters, HbO2 Therapeutics LLC | Anemia Severe | | | | |
NCT02887820: Evaluating the Use of Thromboelastography (TEG) in Patient's Requiring Extracorporeal Membrane Oxygenation (ECMO) |
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| Completed | N/A | 15 | US | Thromboelastograph, TEG 5000 | Stephen Esper, American Heart Association | Heart Disease, Lung Disease | 12/23 | 12/23 | | |
NCT04836936: Auriculotherapy in the Treatment of Pre-Operative Anxiety |
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| Recruiting | N/A | 60 | US | Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas | Jacques E. Chelly | Anxiety Preoperative | 06/25 | 06/25 | | |
NCT06071884: Bridge Device for Surgical Pain for Rotator Cuff Surgery |
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| Recruiting | N/A | 15 | US | Bridge Percutaneous Nerve Field Stimulator, NSS-2 BRIDGE | Steven Orebaugh, Masimo Corporation | Pain, Rotator Cuff Injuries | 02/25 | 12/25 | | |
NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study |
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| Completed | N/A | 79 | US | Cardiac Performance System (CPS) Device | Stephen Esper, Sensydia Corporation | Heart Diseases | 01/24 | 01/24 | | |
NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management |
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| Recruiting | N/A | 140 | US | NEUROCUPLE™ Patch, Placebo Patch | nCap Medical, University of Pittsburgh | Total Knee Arthroplasty | 09/25 | 09/26 | | |
NCT05452694: OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults |
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| Recruiting | N/A | 200 | US | | OpalGenix, Inc | Lumbar Spine Stenosis, Lumbar Spine Degeneration | 09/24 | 09/24 | | |
NCT05906368: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension |
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| Recruiting | N/A | 30 | US | ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring | Grace Lim, MD, MS, Edwards Lifesciences | Anesthesia, Epidural, Hypotension | 10/24 | 04/25 | | |
NCT06648759: Vagal Stimulator to Reduce Nasogastric Tube Use |
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| Recruiting | N/A | 60 | US | Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator | Jacques E. Chelly | Nasogastric Tube Intubation | 09/26 | 09/26 | | |
| Not yet recruiting | N/A | 70 | US | BioButton Device, Providing Clinical Care with BioButton Device | Charles Lin, Jewish Healthcare Foundation | Gait, Medication Induced Gait Disturbances | 12/25 | 02/26 | | |
NCT06661291: Pip Care to Improve Surgical Patient Outcomes - Phase II |
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| Not yet recruiting | N/A | 1300 | US | Pip Care Digital Health Platform, Standard of Care Protocol | University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI) | Abdominal Surgery | 09/28 | 09/28 | | |
| Recruiting | N/A | 300 | US | Preoperative Genotyping | Senthil Sadhasivam, National Institute on Drug Abuse (NIDA) | PPAP, Spine Fusion | 08/25 | 09/25 | | |
NCT06042413: Prediction and Prevention of Postoperative Mortality and Morbidity |
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| Not yet recruiting | N/A | 1200 | US | Personalized CPC Prehabilitation, Cognitive Training, Meditation, Daily Exercise, Enhanced Social Support, Proactive Bundle Interventions, Pre-operative Standard of Care, Intra-operative Standard of Care | University of Pittsburgh, National Institute on Aging (NIA) | Alzheimer Disease, Alzheimer Disease Related Dementias | 09/25 | 09/25 | | |
| Recruiting | N/A | 600 | US | Preoperative Genotyping | Senthil Sadhasivam, National Center for Advancing Translational Sciences (NCATS) | Cesarean Section Complications, Opioid Use | 04/26 | 10/26 | | |
| Not yet recruiting | N/A | 400 | US | | Kathirvel Subramaniam | Analgesia, Cardiac Surgery | 12/26 | 12/26 | | |
| Abuelkasem, Ezeldeen |
| Completed | 1 | 26 | US | Sevoflurane, Isoflurane | Kathirvel Subramaniam | Heart Diseases | 12/18 | 05/23 | | |
| Not yet recruiting | 1 | 30 | US | Cryoprecipitate Intercept Fibrinogen Complex (IFC), Cryoprecipitate Antihemophilic Factor (AHF) | Ezeldeen Abuelkasem | Liver Transplant Surgery | 03/26 | 03/26 | | |
| Zharichenko, Nika |
NCT05768789: Buoy Electrolyte Study on Hydration Status of Active Men and Women |
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| Completed | N/A | 34 | US | Buoy Electrolyte, Nuun, Water | University of Pittsburgh | Dehydration, Electrolyte Imbalance, Electrolyte Depletion, Fluid and Electrolyte Imbalance | 04/24 | 04/24 | | |
