| Landmesser, Ulf |
| Recruiting | 4 | 1512 | Europe | CE-mark approved LAA closure devices, Acetylsalicylic acid, ASS, Clopidogrel, Dabigatran, Pradaxa®, Rivaroxaban, Xarelto®, Apixaban, Eliquis®, Edoxaban, LIXIANA®, Phenprocoumon, Marcumar®, Warfarin, Coumadin® | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Atrial Fibrillation Network, Stiftung Institut fuer Herzinfarktforschung | Atrial Fibrillation | 09/23 | 03/25 | | |
EXAMINE-CAD, NCT05294887: Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease |
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| Recruiting | 4 | 132 | Europe | Bisoprolol, beta blocker, Diltiazem, Placebo | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina, Prinzmetal Angina, Coronary Artery Disease | 06/24 | 06/24 | | |
EPIDAURUS, NCT04981041: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI |
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| Recruiting | 4 | 2334 | Europe | Prasugrel or Ticagrelor, Clopidogrel | Ludwig-Maximilians - University of Munich | Acute Coronary Syndrome, Atrial Fibrillation | 12/24 | 06/25 | | |
| Terminated | 3 | 8 | Europe | Ferric carboxymaltose, Saline | Dr. med. Mahir Karakas | Cardiovascular Diseases, Anemia, Iron-deficiency, Acute Myocardial Infarction, Atrial Fibrillation, Systolic Heart Failure | 12/21 | 12/21 | | |
| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
NCT03507777: ILUMIEN IV: OPTIMAL Percutaneous Coronary Intervention (PCI) |
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| Completed | N/A | 2487 | Europe, Canada, Japan, US, RoW | Coronary PCI guided by OCT, Optical Coherence Tomography, Coronary PCI guided by Angiography | Abbott Medical Devices, Abbott | Coronary Artery Disease, Coronary Stenosis, Atherosclerosis, STEMI, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI) | 02/23 | 02/23 | | |
| Active, not recruiting | N/A | 2001 | Europe | QFR-based diagnostic strategy, FFR-based diagnostic strategy | Aarhus University Hospital Skejby, Medis Medical Imaging Systems | Coronary Artery Disease | 07/23 | 12/25 | | |
| Active, not recruiting | N/A | 414 | Europe | | Charite University, Berlin, Germany, Berlin Institut of Health (BIH), Germany | Acute Coronary Syndrome, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI, Atherosclerosis, Coronary | 03/24 | 03/24 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
FAST III, NCT04931771: Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization |
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| Recruiting | N/A | 2228 | Europe | vFFR guided revascularization, FFR guided revascularization | ECRI bv, Siemens Healthineers AG, Pie Medical Imaging | Coronary Artery Disease | 05/25 | 05/25 | | |
| Recruiting | N/A | 360 | Europe | Transcatheter tricuspid valve treatment (TTVT) | LMU Klinikum, Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig | Heart Failure Attributable to Severe Tricuspid Regurgitation | 03/26 | 03/27 | | |
| Skurk, Carsten |
NCT05331001: Quality of Care in Centers Providing Extracorporeal Membrane Oxygenation |
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| Not yet recruiting | N/A | 100 | NA | | Charite University, Berlin, Germany | Cardiogenic Shock, Myocardial Infarction, Cardiac Arrest, Extracorporeal Circulation; Complications | 12/22 | 03/23 | | |
Omega, NCT04829929: Evaluation od Safety and Performance of the ™ LAA (Left Atrial Appendage) Occluder and ™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk |
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| Recruiting | N/A | 150 | Europe | Omega™LAA Occluder implantation | Eclipse Medical Ltd., KCRI | Non-Valvular Atrial Fibrillation | 05/23 | 11/23 | | |
NCT06599424: IntraRenal HEmoDynamics to IntegraTE CA-AKI Risk and Monitor NephroprotectiIoN by ImpElla Support. |
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| Recruiting | N/A | 550 | Europe | Observational | Heinrich-Heine University, Duesseldorf, German Heart Center, Charite University, Berlin, Germany | Chronic Kidney Diseases, Renal Failure, Coronary Artery Disease | 10/24 | 06/25 | | |
| Not yet recruiting | N/A | 30 | Europe | VA-ECMO or ECMELLA | Charite University, Berlin, Germany, Universitätsklinikum Düsseldorf | Cardiac Arrest, Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation Complication, Myocardial Infarction, Cardiogenic Shock | 12/23 | 03/24 | | |
| Recruiting | N/A | 475 | Europe, Canada, US | Amulet™ 2 Left Atrial Appendage (LAA) Occluder | Abbott Medical Devices | Atrial Fibrillation (AF), Stoke | 07/26 | 07/28 | | |
ARISE RCT, NCT06793033: A Randomized Controlled Study of the NEURESCUE Device As an Adjunct to Advanced Cardiac Life Support |
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| Not yet recruiting | N/A | 84 | Europe | Advanced Cardiac Life Support (ACLS), Aortic balloon occlusion (ABO) | neurescue | Cardiac Arrest (CA), Cardiopulmonary Arrest | 01/27 | 03/27 | | |
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function |
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| Recruiting | N/A | 1252 | Europe, Canada, US | Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump | Abiomed Inc. | Left Ventricular Dysfunction, Coronary Artery Disease | 03/26 | 10/27 | | |
CLEARANCE, NCT04298723: Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding. |
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| Recruiting | N/A | 530 | Europe | Percutaneous closure of the LAA (Watchman / Watchman FLX) | Jena University Hospital | Atrial Fibrillation (AF), Intracranial Bleed | 06/27 | 06/27 | | |
| Enrolling by invitation | N/A | 60 | Europe | VA-ECMO, ECMELLA | Charite University, Berlin, Germany | Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock, Acute Myocardial Infarction | 10/22 | 11/22 | | |
| Not yet recruiting | N/A | 100 | NA | ECG patch (Philips ePatch® 2.0) | Charite University, Berlin, Germany | Heart Arrest, Arrhythmias, Cardiac, Electrocardiography | 03/23 | 05/23 | | |
