| Coordinator, Research |
NCT05733546: A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder |
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| Recruiting | 2 | 102 | US | Psilocybin, COMP360 | COMPASS Pathways | Major Depressive Disorder | 10/24 | 11/24 | | |
NCT04270175: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab |
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| Recruiting | 2 | 21 | US | Daratumumab SC, Faspro, Pomalidomide, Dexamethasone | Weill Medical College of Cornell University, Janssen Scientific Affairs, LLC | Amyloid, AL Amyloidosis, Refractory AL Amyloidosis | 12/25 | 12/29 | | |
NCT04803058: A Study of TCD601 in the Induction of Tolerance in de Novo Renal Transplantation (PERSPECTIVE) |
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| Recruiting | 2 | 12 | US, RoW | TCD601 | ITB-Med LLC | Kidney Transplantation | 12/24 | 12/27 | | |
| Recruiting | 2 | 96 | Europe | TCD601, Placebo | ITB-Med LLC | Diabetes Mellitus, Type 1 | 01/25 | 01/25 | | |
| Recruiting | 2 | 90 | US | TCD601, siplizumab, belatacept, ATG, antithymocyte globulin, TAC, tacrolimus, MPA, mycophenolic acid, Corticosteroids | ITB-Med LLC | Renal Transplantation | 07/25 | 10/26 | | |
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation |
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| Completed | 2 | 13 | US | TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG | ITB-Med LLC | Kidney Transplantation | 10/23 | 10/23 | | |
NCT04464980: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD) |
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| Recruiting | 2 | 2190 | US | SL-BUP, sublingual buprenorphine, Suboxone, XR-BUP, extended-release buprenorphine, CAM2038, Brixadi, XR-NTX, extended-release naltrexone, Vivitrol, MM, MMR, MMD | NYU Langone Health, New York State Psychiatric Institute, Columbia University, Harvard Medical School (HMS and HSDM), Mclean Hospital, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC | Opioid Use Disorder (OUD) | 07/26 | 12/26 | | |
NCT04803006: A Study of TCD601 in the Induction of Tolerance in de Novo Renal Transplantation (PANORAMA) |
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| Recruiting | 2 | 18 | US | TCD601 | ITB-Med LLC | Kidney Transplantation | 01/27 | 01/30 | | |
AURORA, NCT06453668: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients |
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| Recruiting | 1 | 48 | Europe | TCD601, siplizumab | ITB-Med LLC | ALS | 11/26 | 11/26 | | |
| Recruiting | 1 | 15 | US | PBA-0405, PB004.22.0405.aF | Pure Biologics S.A., Presage Biosciences | Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer | 03/25 | 03/25 | | |
MST01-AZN-05, NCT06366451: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, and Sabestomig in HNSCC |
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| Recruiting | 1 | 15 | US | Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475 | Presage Biosciences, AstraZeneca | Head and Neck Squamous Cell Carcinoma | 12/24 | 03/25 | | |
| Recruiting | 1 | 90 | US, RoW | OP-1250, Ribociclib, KISQALI, Alpelisib, PIQRAY | Olema Pharmaceuticals, Inc., Novartis | Metastatic Breast Cancer, Advanced Breast Cancer, HR-positive Breast Cancer, HER2-negative Breast Cancer | 08/24 | 08/24 | | |
NCT04541108: Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies |
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| Recruiting | 1 | 15 | US | Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475 | Presage Biosciences, Merck Sharp & Dohme LLC | Solid Tumor | 12/31 | 12/31 | | |
NCT06136936: A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia |
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| Completed | N/A | 53 | US | CT-156-C-001 | Click Therapeutics, Inc., Boehringer Ingelheim | Schizophrenia | 01/24 | 02/24 | | |
| Recruiting | N/A | 20 | US | Prototypes of breast shield and Freedom Double Electric Breast Pump | Momtech Inc. | Healthy, Breast Pumping | 09/24 | 11/24 | | |
NCT06136923: An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer |
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| Completed | N/A | 194 | US | CT-100-D-004-A, CT-100-D-004-B | Click Therapeutics, Inc. | Multiple Sclerosis, Lung Cancer, Breast Cancer | 04/24 | 05/24 | | |
| Active, not recruiting | N/A | 214 | US | FemaSeed Localized Directional Insemination | Femasys Inc. | Infertility, Male Factor | 12/23 | 04/24 | | |
CT-100-D-003, NCT06275659: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis |
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| Active, not recruiting | N/A | 120 | US | CT-100-004-A, CT-100-004-B | Click Therapeutics, Inc. | Psoriasis, Atopic Dermatitis | 02/24 | 03/24 | | |
| Recruiting | N/A | 50 | US | Pulmonary Valve Replacement Surgery | Autus Valve Technologies, Inc. | Congenital Heart Disease | 08/26 | 02/36 | | |
| Recruiting | N/A | 800 | US | Myriad Matrix™ and Myriad Morcells™ | Aroa Biosurgery Limited | Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury | 01/28 | 01/29 | | |
| Recruiting | N/A | 100 | US | Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy | Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs | Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies | 12/25 | 12/25 | | |
| Recruiting | N/A | 573 | US | FemBloc | Femasys Inc. | Contraception | 12/29 | 06/31 | | |
| Recruiting | N/A | 60 | US | Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy | Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs | Nerve Injury, Peripheral Nerve Injuries, Peripheral Nerve Injury Upper Limb, Nerve Palsy | 06/27 | 06/27 | | |
| Fatima, Javairiah |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Available | N/A | | US | GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aneurysm | | | | |
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) |
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| Active, not recruiting | N/A | 150 | Japan, US | GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure | W.L.Gore & Associates | Aortic Aneurysm, Thoracic, Aorta, Lesion | 03/24 | 03/28 | | |
| Recruiting | N/A | 102 | US | Zenith Fenestrated+ Endovascular Graft in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System and Unibody2 | Cook Research Incorporated | Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm | 06/26 | 04/31 | | |
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Recruiting | N/A | 122 | Europe, US | GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aortic Aneurysm | 06/26 | 09/26 | | |
| Recruiting | N/A | 300 | US | TREO Abdominal Stent-Graft System | Bolton Medical | Abdominal Aortic Aneurysm | 07/27 | 07/27 | | |
| Ben-Dor, Itsik |
| Recruiting | N/A | 418 | Europe, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd | Coronary Restenosis | 07/24 | 11/27 | | |
| Weinberg, Benjamin |
| Recruiting | 2/3 | 1912 | Canada, US | Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month, mFOLFIRINOX, mFOLFOX6 6 month, CAPOX 6 month | NRG Oncology, Natera, Inc., National Cancer Institute (NCI) | Stage III Colon Cancer | 03/29 | 03/30 | | |
| Recruiting | 2 | 44 | US | Nanoliposomal Irinotecan, Leucovorin, Fluorouracil | Georgetown University, Ipsen | Advanced Biliary Tract Cancer | 05/24 | 07/24 | | |
DARANIVOVAX, NCT06015724: Anti-CD38 Antibody With KRAS Vaccine and Anti-PD-1 Antibody in Subjects With Pancreatic Ductal Adenocarcinoma and Refractory Non-Small Cell Lung Cancer |
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| Recruiting | 2 | 54 | US | Daratumumab, Darzalex Faspro, KRAS vaccine, Nivolumab, BMS-936558 | Georgetown University, Bristol-Myers Squibb, Janssen, LP, Targovax ASA | Pancreatic Ductal Adenocarcinoma, Refractory Non-Small Cell Lung Cancer | 01/25 | 01/26 | | |
| Recruiting | 2 | 43 | US | BXCL701, Pembrolizumab, Keytruda | Georgetown University, BioXcel Therapeutics Inc, Merck Sharp & Dohme LLC | Metastatic Pancreatic Ductal Adenocarcinoma | 11/26 | 11/27 | | |
NCT02985125: LEE011 Plus Everolimus in Patients With Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy |
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| Active, not recruiting | 1/2 | 44 | US | LEE011, ribociclib, Everolimus, Afinitor® | Georgetown University, Novartis, University of Texas Southwestern Medical Center, Cedars-Sinai Medical Center, Virginia Mason Hospital/Medical Center | Metastatic Pancreatic Adenocarcinoma | 12/20 | 12/22 | | |
NCT05661201: NEROFE and Doxorubicin in KRAS-mutated ST2-positive Solid Tumors |
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| Recruiting | 1 | 24 | US | NEROFE, Doxorubicin, adriamycin | Georgetown University, Immune System Key Ltd | Solid Tumor, KRAS Mutation-Related Tumors | 01/26 | 01/26 | | |
NCT04566393: Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies |
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| Available | N/A | | US | Ulixertinib (BVD-523) | xCures, Cancer Commons | Pancreatic Cancer, Small Bowel Cancer, Colorectal Cancer, Melanoma, Non Small Cell Lung Cancer, Thyroid Cancer, Bladder Cancer, Head and Neck Cancer, Gastric Cancer, Esophageal Cancer, Cholangiocarcinoma, Ovarian Cancer, Hepatocellular Carcinoma, Glioblastoma, MAPK Gene Mutation, KRAS Activating Mutation, BRAF Gene Mutation, NRAS Gene Mutation, HRAS Gene Mutation, MEK Mutation, ERK Mutation | | | | |
| Singh, Suman |
| Recruiting | 2/3 | 400 | US | Nectero EAST System | Nectero Medical, Inc. | Abdominal Aortic Aneurysm | 03/27 | 12/29 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Not yet recruiting | N/A | 125 | US | Cleaner Pro Thrombectomy System, Cleaner Vac Thrombectomy System | Argon Medical Devices, NAMSA | Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism | 07/25 | 08/25 | | |
| Recruiting | N/A | 111 | Europe, US, RoW | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 01/25 | 01/29 | | |
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study |
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| Recruiting | N/A | 165 | US | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 04/25 | 04/29 | | |
| Murphy, Cary |
ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease |
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| Recruiting | N/A | 400 | US | Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting | Silk Road Medical | Carotid Artery Diseases | 05/25 | 05/25 | | |
| Laverty-Wilson, Eva |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Guebre-Xabiher, Hiwot |
ACTION-1, NCT05477576: Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy |
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| Active, not recruiting | 3 | 288 | Europe, Canada, US, RoW | RYZ101, Everolimus 10 mg, Sunitinib 37.5 MG, Octreotide LAR 60 MG Injection, Lanreotide 120Mg Sa Susp Inj Syringe | RayzeBio, Inc. | GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor, Gastroenteropancreatic Neuroendocrine Tumor Disease, Neuroendocrine Tumors, Carcinoid, Carcinoid Tumor, Pancreatic NET | 07/25 | 07/28 | | |
REFRaME-O1, NCT05870748: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1 |
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| Recruiting | 2/3 | 600 | Canada, US, RoW | Luveltamab tazevibulin, STRO-002, Luvelta, Pegfilgrastim, Neulasta, Gemcitabine, Paclitaxel, Pegylated liposomal doxorubicin, Topotecan | Sutro Biopharma, Inc., GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Asia-Pacific Gynecologic Oncology Trials Group (APGOT) | Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Platinum-resistant Ovarian Cancer | 09/25 | 02/26 | | |
| Okubagzi, Petros |
| Recruiting | 3 | 800 | Europe, US, RoW | Remibrutinib, LOU064, Teriflunomide | Novartis Pharmaceuticals, Novartis Pharma AG | Relapsing Multiple Sclerosis | 04/26 | 10/30 | | |
| Smith, Jamal |
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis |
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| Recruiting | 3 | 1683 | US | Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca | Intracranial Arteriosclerosis, Stroke | 05/27 | 05/27 | | |
NCT05663853: An Observational Biomarker Study in Multiple Sclerosis (MS) Patients |
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| Completed | N/A | 137 | US | | LAPIX Therapeutics Inc. | Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive | 04/24 | 04/24 | | |
| Boisvert, Marc E |
NCT01570998: Intraoperative Radiation Therapy in Treating Patients With Breast Cancer Undergoing Breast-Conserving Surgery |
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| Recruiting | N/A | 1500 | US | Intraoperative Radiation Therapy, Intraoperative Radiotherapy, IORT, radiotherapy, intraoperative, Laboratory Biomarker Analysis | University of California, San Francisco, Carl Zeiss Meditec AG | Stage IA Breast Cancer, Stage IIA Breast Cancer | 12/27 | 12/27 | | |
| Gallagher, Christopher J |
EMBER-4, NCT05514054: A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer |
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| Recruiting | 3 | 6000 | Europe, Canada, Japan, US, RoW | Imlunestrant, LY3484356, Tamoxifen, Anastrozole, Letrozole, Exemestane | Eli Lilly and Company | Breast Neoplasms | 10/27 | 03/32 | | |
WI223281, NCT03535506: Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery |
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| Terminated | 2 | 17 | US | Palbociclib, Ibrance | Georgetown University, Pfizer | DCIS | 12/23 | 12/23 | | |
| Kawakita, Tetsuya |
NCT04908982: Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension |
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| Recruiting | 4 | 60 | US | Aspirin 81mg | Eastern Virginia Medical School, AMAG Pharmaceuticals, Inc. | Pre-Eclampsia | 05/23 | 05/23 | | |
| Recruiting | N/A | 10 | US | DAISY Uterine Drain | Raydiant Oximetry, Inc. | Cesarean Section Complications, Post Partum Hemorrhage, Uterine Atony With Hemorrhage, Uterine Bleeding | 11/24 | 11/24 | | |
| Shults, Christian |
| Recruiting | N/A | 585 | US | NeoChord DS1000, Surgical Mitral Valve Repair | NeoChord | Mitral Valve Insufficiency | 07/22 | 07/27 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
| Completed | N/A | 140 | Canada, US | DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator | CytoSorbents, Inc | Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative | 08/23 | 08/23 | | |
NCT03033043: Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection |
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| Active, not recruiting | N/A | 56 | US | Relay Pro Stent-Graft, Relay Pro Stent Graft System | Bolton Medical | Aortic Dissection Type B | 10/21 | 10/26 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 200 | Europe, US | Thoraflex Hybrid, RelayPro NBS | Vascutek Ltd., Bolton Medical | Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection | 12/35 | 12/36 | | |
| Boyd, Jack |
| Recruiting | N/A | 585 | US | NeoChord DS1000, Surgical Mitral Valve Repair | NeoChord | Mitral Valve Insufficiency | 07/22 | 07/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Otte, Andrea |
NCT03103490: 18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation |
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| Terminated | 2 | 45 | US | 18F-FSPG | Stanford University, GE Healthcare | Cardiac Sarcoidosis, Myocardial Inflammation | 09/21 | 09/21 | | |
NCT03183570: Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT |
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| Recruiting | 1 | 30 | US | [18F]FP-R01-MG-F2 | Stanford University, Pliant Therapeutics, Inc. | Idiopathic Pulmonary Fibrosis, Primary Sclerosing Cholangitis, Covid19 Pneumonia | 04/25 | 04/25 | | |
| Recruiting | N/A | 280 | Europe, US, RoW | JETi Peripheral Thrombectomy System | Abbott Medical Devices | Peripheral Artery Thrombosis, Peripheral Venous Thrombosis | 08/24 | 08/25 | | |
NCT05838482: Clinical Feasibility and Evaluation of Silicon Photon Counting CT |
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| Recruiting | N/A | 100 | US | CT Photon-Counting | GE Healthcare, Stanford University | CT Photon-Counting | 05/25 | 05/25 | | |
| Recruiting | N/A | 111 | Europe, US, RoW | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 01/25 | 01/29 | | |
| Olano, Arrel |
NCT05176899: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting |
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| Recruiting | N/A | 1200 | US | Use of Eko CORE electronic stethoscope | Eko Devices, Inc. | Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur | 11/23 | 11/23 | | |
| Ramana, Ravi |
| Recruiting | N/A | 1150 | US, RoW | Portico transcatheter aortic valve, Commercially available transcatheter aortic valve | Abbott Medical Devices | Aortic Valve Stenosis | 10/19 | 07/25 | | |
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) |
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| Active, not recruiting | N/A | 178 | Europe, Canada, US | SAPIEN 3 THV, Optimal Heart Failure Therapy | Cardiovascular Research Foundation, New York, Cardialysis BV, Avania | Aortic Valve Stenosis | 02/23 | 02/25 | | |
| Recruiting | N/A | 418 | Europe, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd | Coronary Restenosis | 07/24 | 11/27 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 03/24 | 06/29 | | |
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement |
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| Recruiting | N/A | 2820 | Canada, US | ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL | Boston Scientific Corporation | Aortic Stenosis | 06/24 | 11/34 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 06/24 | 06/28 | | |
| Suga, Jennifer M |
SWOG S2302, NCT05633602: Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study |
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| Recruiting | 3 | 700 | US | Chemotherapy, Chemo, Chemotherapy (NOS), Chemotherapy, Cancer, General, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Ramucirumab, Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B, Cyramza, IMC-1121B, LY3009806 | SWOG Cancer Research Network, National Cancer Institute (NCI), Eli Lilly and Company, Merck Sharp & Dohme LLC | Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | 03/25 | 03/28 | | |
A011801, NCT04457596: T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial |
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| Recruiting | 3 | 1031 | Canada, US | Trastuzumab Emtansine, Placebo Administration, Tucatinib, Questionnaire Administration, Quality-of-Life Assessment | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Seagen Inc. | Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Synchronous Bilateral Breast Carcinoma | 01/28 | 05/35 | | |
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TAPUR, NCT02693535: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer |
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| Recruiting | 2 | 3791 | US | Palbociclib, Ibrance, Sunitinib, Sutent, Temsirolimus, Torisel, Trastuzumab and Pertuzumab, Herceptin and Perjeta, Vemurafenib and Cobimetinib, Zelboraf and Cotellic, Regorafenib, Stivarga, Olaparib, Lynparza, Pembrolizumab, Keytruda, Nivolumab and Ipilimumab, Opdivo and Yervoy, Abemaciclib, Verzenio, Talazoparib, Talzenna, Atezolizumab and PHESGO, Tecentriq and PHESGO, Atezolizumab and Talazoparib, Tecentriq and Talzenna, Entrectinib, Rozlytrek, Larotrectinib, Vitrakvi, Tucatinib plus Trastuzumab Subcutaneous (SC), Tukysa and Herceptin Hylecta, Futibatinib, Lytgobi | American Society of Clinical Oncology, AstraZeneca, Bayer, Bristol-Myers Squibb, Eli Lilly and Company, Genentech, Inc., Merck Sharp & Dohme LLC, Pfizer, Boehringer Ingelheim, Seagen Inc., Taiho Oncology, Inc. | Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors | 12/24 | 12/25 | | |
| Recruiting | 1/2 | 875 | Europe, Canada, Japan, US, RoW | LOXO-292, Selpercatinib, LY3527723 | Loxo Oncology, Inc., Eli Lilly and Company | Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor | 02/25 | 02/26 | | |
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NCT03906331: Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation |
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| Available | N/A | | Europe, Japan, US, RoW | Selpercatinib, LOXO-292, LY3527723 | Loxo Oncology, Inc., Eli Lilly and Company | Non Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Breast Cancer, Pancreatic Cancer, Papillary Thyroid Cancer, Other Solid Tumors With Evidence of Activating RET Alteration | | | | |
| Tiano, Joseph |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Recruiting | N/A | 400 | Europe, US | Arctic Front™ Cardiac Cryoablation Catheter System | Medtronic Cardiac Rhythm and Heart Failure | Persistent Atrial Fibrillation | 08/27 | 08/27 | | |
| Recruiting | N/A | 200 | US | Arctic Front™ Cardiac Cryoablation Catheter | Medtronic Cardiac Rhythm and Heart Failure | Paroxysmal Atrial Fibrillation | 01/28 | 01/28 | | |
| Brodt, Chad |
RESOLVE-AF, NCT05883631: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy. |
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| Recruiting | N/A | 400 | Europe, US, RoW | EGF-Mapping and EGF-Guided Ablation of AF Sources, EGF-Mapping of AF Sources (no ablation) | Ablacon, Inc. | Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrial Fibrillation Paroxysmal, Arrhythmia, Arrhythmias, Cardiac, Atrial Flutter, Atrial Fibrillation, Paroxysmal or Persistent, Atrial Arrhythmia, Atrial Tachycardia | 03/25 | 03/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Contact, Site Public |
| Completed | 4 | 50 | RoW | ADVATE | Baxalta now part of Shire, Takeda Development Center Americas, Inc. | Hemophilia A | 02/23 | 02/23 | | |
SWITCH, NCT04718779: A Study of Enzyme Replacement Therapy (VPRIV) in People With Type 1 Gaucher Disease Who Were Previously Treated With Substrate Reduction Therapy |
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| Completed | 4 | 4 | US | Digital Engagement Application (GD App), No Intervention | Takeda | Gaucher Disease | 02/23 | 02/23 | | |
| Active, not recruiting | 4 | 200 | US | CDPATH™, PROSPECT, Blood Draw | Takeda | Crohn's Disease | 08/23 | 06/26 | | |
| Recruiting | 4 | 80 | RoW | Leuprorelin Acetate Depot 3M, Leuprolide acetate Depot 3M | Takeda, Takeda | Central Precocious Puberty | 05/25 | 05/25 | | |
| Recruiting | 4 | 5 | RoW | Elaprase, Idursulfase | Takeda | Hunter Syndrome | 08/24 | 09/24 | | |
NCT05442554: A Study of Brentuximab Vedotin Treatment in Chinese Adults With CD30-Positive Cutaneous T-Cell Lymphoma |
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| Active, not recruiting | 4 | 10 | RoW | Brentuximab vedotin, SGN-35 | Takeda | T-Cell Lymphoma | 09/24 | 09/24 | | |
NCT05067868: A Study of Replagal in Children and Adults With Fabry Disease in India |
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| Active, not recruiting | 4 | 5 | RoW | Replagal | Shire | Fabry Disease | 10/26 | 11/26 | | |
| Active, not recruiting | 4 | 288 | Europe, US | Guanfacine hydrochloride (TAK-503), Intuniv, SPD503, Atomoxetine hydrochloride, Placebo | Shire, Takeda Development Center Americas, Inc. | Attention Deficit Hyperactivity Disorder | 06/27 | 06/27 | | |
ASPIRE, NCT04118088: A Study of Darvadstrocel in Adults With Crohn's Disease and Complex Perianal Fistula |
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| Active, not recruiting | 4 | 50 | Europe, RoW | Darvadstrocel, Alofisel, Cx601 | Takeda, Takeda Development Center Americas, Inc. | Crohn's Disease, Complex Perianal Fistula | 03/26 | 03/26 | | |
NCT05494593: A Study of ELAPRASE in Treatment-naïve Participants With Hunter Syndrome (Mucopolysaccharidosis [MPS] II) |
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| Recruiting | 4 | 5 | US | ELAPRASE, Idursulfase, Rituximab, Methotrexate, Intravenous Immunoglobulin (IVIG) | Takeda, Takeda Development Center Americas, Inc. | Mucopolysaccharidosis (MPS), Hunter Syndrome | 06/27 | 06/27 | | |
NCT06045754: A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease |
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| Recruiting | 4 | 150 | Canada, US | Vedolizumab, Entyvio, Adalimumab, Humira, Ustekinumab, Stelara | Takeda | Crohn's Disease | 06/27 | 06/27 | | |
