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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Sims, John R
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy	Recruiting	N/A	620	US	OPTIMIZER Smart System	Impulse Dynamics	Heart Failure	03/26	03/26
Navetta, Frank
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN	Recruiting	N/A	1400	Europe, US, RoW	Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus	11/26	11/29
Thornton, Kevin
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN	Recruiting	N/A	1400	Europe, US, RoW	Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus	11/26	11/29
Torres, Raul
NAVIGATE, NCT04365868 / 2019-001983-31: Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis	Active, not recruiting	2b	357	Europe, Canada, US, RoW	belapectin, GR-MD-02, galactoarabino rhamnogalacturonate, Placebo	Galectin Therapeutics Inc., Galectin Therapeutics Inc	Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis	12/24	12/24
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure	Active, not recruiting	N/A	826	US	Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention	Medtronic Cardiac Rhythm and Heart Failure	Heart Failure NYHA Class II, Heart Failure NYHA Class III	05/25	05/25