| Goldstein, David |
ADIUVO-2, NCT03583710: Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence |
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| Recruiting | 3 | 240 | Europe, US | Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone''s Chloride, Peyrone''s Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP-16, VP-16-213, VP16, Mitotane, (o,p)-DDD, 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene, 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, 2, 4''-Dichlorodiphenyldichloroethane, CB 313, CB-313, Chloditan, Chlodithane, DDD, Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-, Khloditan, Lisodren, Lysodren, Mytotan, o,p'' - DDD, o,p''-DDD, Ortho,para-DDD, WR-13045, Quality-of-Life Assessment, Quality of Life Assessment | M.D. Anderson Cancer Center, National Cancer Institute (NCI), Assistance Publique - Hôpitaux de Paris | ENSAT Stage I Adrenal Cortex Carcinoma, ENSAT Stage II Adrenal Cortex Carcinoma, ENSAT Stage III Adrenal Cortex Carcinoma | 01/25 | 01/25 | | |
| Active, not recruiting | 3 | 450 | Europe, Japan, US, RoW | Regorafenib, Stivarga, Nivolumab, Opdivo, Docetaxel, Taxotere, Paclitaxel, Abraxane, Irinotecan, Camptosar, Trifluridine/Tipracil, Lonsurf | Australasian Gastro-Intestinal Trials Group, Bayer, Bristol-Myers Squibb, University of Sydney, Academic and Community Cancer Research United, Taiwanese Cooperative Oncology Group, Frankfurter Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, National Cancer Center Hospital East, Syneos Health | Gastro-Oesophageal Cancer | 06/25 | 06/26 | | |
NCT04624477: Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer |
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| Recruiting | N/A | 450 | Canada | | University Health Network, Toronto, University of British Columbia, University of Calgary, Lawson Health Research Institute, McMaster University, CHU de Quebec-Universite Laval, Dalhousie University, Canadian Cancer Society (CCS), Canadian Institutes of Health Research (CIHR), Centre hospitalier de l'Université de Montréal (CHUM) | Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid | 12/34 | 12/34 | | |
NCT03271892: Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer |
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| Active, not recruiting | N/A | 200 | Canada | | University Health Network, Toronto, Canadian Cancer Society (CCS), Ontario Ministry of Health and Long Term Care, Canadian Institutes of Health Research (CIHR) | Thyroid Cancer Stage I | 12/31 | 12/31 | | |
NCT03648905: Clinical Laboratory Evaluation of Chronic Autonomic Failure |
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| Active, not recruiting | N/A | 86 | US | 13N-Ammonia, 18F-DOPA, 11C-Methylreboxetine (11C-MRB), 18F-Dopamine | National Institute of Neurological Disorders and Stroke (NINDS) | Parkinson's Disease, Multiple System Atrophy, Autonomic Failure | 12/28 | 12/29 | | |
| Recruiting | N/A | 10000 | US | | Columbia University | Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation | 01/25 | 01/25 | | |
| Mulsant, Benoit H |
NCT06699719: Online Writing Intervention for Major Depressive Disorder |
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| Completed | N/A | 63 | Canada | Expressive writing, EW, online writing intervention | Centre for Addiction and Mental Health | Major Depression, Generalized Anxiety Disorder (GAD) | 06/22 | 06/22 | | |
| Active, not recruiting | N/A | 635 | Canada | Intervention: Mental Health Technician, Enhanced Usual Care | Centre for Addiction and Mental Health, CAMH Foundation, Capital Solution Design LLC | Depression, Anxiety, Alcohol Drinking | 01/21 | 12/24 | | |
PACt-MD, NCT02386670: Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression |
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| Active, not recruiting | N/A | 375 | Canada | tDCS + CR, transcranial Direct Current Stimulation (tDCS), Cognitive Remediation (CR), sham tDCS + sham CR | Centre for Addiction and Mental Health, Brain Canada, Applied Health Research Centre, Queen's University, Baycrest Centre for Geriatric Care, Unity Health Toronto, Sunnybrook Health Sciences Centre, University Health Network, Toronto | Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission | 12/22 | 12/24 | | |
StaN, NCT03672201: Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia |
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| Active, not recruiting | N/A | 187 | Canada | Non-Pharmacological Intervention, Behavioural Intervention, Pharmacological Intervention | Centre for Addiction and Mental Health, University of Calgary, Lawson Health Research Institute, Douglas Mental Health University Institute | Alzheimer's Disease, Alzheimer Dementia (AD), Aggression | 03/23 | 12/24 | | |
| Recruiting | N/A | 60 | Canada | Observation while participants receive treatment by their primary care provider | Centre for Addiction and Mental Health, The Physicians' Services Incorporated Foundation | Depression - Major Depressive Disorder, Depression Disorders | 08/25 | 12/25 | | |
Creyos-MD, NCT06780917: Validating the On-line Creyos Cognitive Assessment Platform in Older Adults with Major Depressive Disorder or Mild Cognitive Impairment |
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| Recruiting | N/A | 150 | Canada | | Centre for Addiction and Mental Health, Krembil Foundation | Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched | 01/29 | 01/29 | | |
| Wherrett, Diane |
| Recruiting | N/A | 75000 | Europe, Canada, US, RoW | | University of South Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), American Diabetes Association, National Institute of Allergy and Infectious Diseases (NIAID), National Center for Research Resources (NCRR) | Diabetes Mellitus, Type 1 | 07/25 | 07/25 | | |
| Fehlings, Michael |
| Recruiting | N/A | 960 | Europe, Canada, Japan, US, RoW | | AO Innovation Translation Center, AO Foundation, AO Spine | Metastatic Spine Tumor | 12/25 | 12/25 | | |
| Recruiting | N/A | 50 | Europe, Canada, US, RoW | Nonsurgical treatment, Surgical treatment | AO Foundation, AO Spine | Cervical Spinal Cord Injury | 05/26 | 08/27 | | |
| Recruiting | N/A | 1500 | Canada, US | No Treatment Given | Robert G. Grossman, MD, Christopher Reeve Paralysis Foundation, The Methodist Hospital Research Institute, The University of Texas Health Science Center, Houston, University of Virginia, University of Louisville, University of Toronto, University of Maryland, Baltimore, Walter Reed National Military Medical Center, Thomas Jefferson University, University of Miami, Brooke Army Medical Center, Louisiana State University Health Sciences Center in New Orleans, Vanderbilt University Medical Center, Medical College of Wisconsin, Duke University | Spinal Cord Injury | 07/25 | 07/28 | | |
| Waddell, Thomas |
SORT, NCT05183932: Surgery Versus Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 440 | Canada, US | | Washington University School of Medicine, National Cancer Institute (NCI) | Non Small Cell Lung Cancer, Non-small Cell Lung Cancer | 01/27 | 01/27 | | |
| Wolever, Thomas MS |
| Not yet recruiting | 4 | 12 | Canada | First Reference product, Second reference product, Third reference product, First Concept product, Second Concept product, Third Concept product, Fourth Concept product, Fifth Concept product, Sixth Concept product, Seventh Concept product | Nutricia Research, INQUIS Clinical Research | Glycemic Response | 04/25 | 04/25 | | |
NCT04507971: Effects of MET-3 and MET-5 on Gut Microbiome and Metabolic Function in Men and Women With Hypertriglyceridemia |
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| Recruiting | 1 | 20 | Canada | MET-3, MET-5 | NuBiyota | Obesity, Metabolically Benign | 12/21 | 12/21 | | |
| Active, not recruiting | N/A | 76 | Canada | muffin | St. Boniface Hospital, Agriculture and Agri-Food Canada | Above Optimal Plasma LDL Concentrations | 11/15 | 01/25 | | |
| Recruiting | N/A | 12 | Canada | First Reference product, Second Reference product, Third Reference product, First Concept product, Second Concept product, Third Concept product | Nutricia Research | Glycemic Response | 04/22 | 05/22 | | |
NCT06294938: Glycemic Index of Cacao Fruit Pulp in Healthy, Human Subjects |
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| Completed | N/A | 10 | Canada | Cacao fruit pulp, Dextrose | Mars Wrigley, INQUIS Clinical Research | Blood Sugar; High, Blood Sugar; Low | 01/23 | 05/23 | | |
NCT05870891: Equivalent Glycemic Load and Insulinemic Response Elicited by 7 Low Carbohydrate Products in Healthy Adults |
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| Completed | N/A | 25 | Canada | Food | General Mills, INQUIS Clinical Research | Healthy Nutrition | 10/23 | 10/23 | | |
| Completed | N/A | 20 | Canada | Commercial native starch without processing, Modified starch with extrusion processing | INQUIS Clinical Research, University of Saskatchewan | Glycemic Response | 11/23 | 11/23 | | |
NCT05556837: Effect of Extruded Cereals Enriched With β-glucan on Postprandial Plasma Glucose and Serum Insulin Responses |
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| Not yet recruiting | N/A | 42 | Canada | Control Cereal, OBG Cereal, BBG Cereal | Société des Produits Nestlé (SPN), INQUIS Clinical Research, Cereal Partners Worldwide | Healthy | 04/24 | 05/24 | | |
NCT05827198: Evaluating the Impact of Incremental Doses of a Sugar Replacer Blend on Gastrointestinal Tolerance in Candies |
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| Not yet recruiting | N/A | 60 | Canada | Low-sugar candies compared to regular sugar candies | Mondelēz International, Inc., INQUIS Clinical Research | Gastrointestinal Tolerance, Healthy Population | 12/23 | 01/24 | | |
| Completed | N/A | 12 | Canada | first reference product series 1, second reference product seies 1, third reference product series 1, first concept product series 1, second concept product series 1, third concept product series 1, 4th concept product seris 1, 5th concept product series 1, 6th concept product series 1, 1st reference product series 2, 2nd reference product series 2, 3rd reference product series 2, 1st concept product series 2, 2nd concept product series 2, 3rd concept product series 2, 4th concept product series 2, 5th concept product series 2, 6th concept product series 2 | Nutricia Research | Glycemic Response | 06/24 | 06/24 | | |
| Jenkins, David JA |
| Completed | N/A | 232 | Canada | Portfolio diet and structured exercise, Dietary Portfolio of cholesterol-lowering foods, Enhanced portfolio, Low Glycemic Index Portfolio, Portfolio Plus diet, Laval exercise program, structured exercise program, Portfolio diet, structured exercise, DASH-like diet and structured exercise, Modified DASH diet, high fibre diet, DASH-like diet, Portfolio diet and routine exercise, routine exercise, DASH-like diet and routine exercise | Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Laval University, University of Manitoba, University of British Columbia | Cardiovascular Diseases, Hypercholesterolemia, Type 2 Diabetes, Metabolic Syndrome | 06/23 | 06/23 | | |
NCT04861545: Meta-analyses of Soy Protein and Its Food Sources for Cholesterol Reduction |
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| Not yet recruiting | N/A | 1 | Canada | Soy, Isolated soy protein food sources, Non-Isolated soy protein food sources of soy protein | John Sievenpiper | Dyslipidemias, Cardiovascular Risk Factor, Dysglycemia | 05/22 | 05/22 | | |
NCT05191160: The Soy Treatment Evaluation for Metabolic Health (STEM) Trial |
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| Active, not recruiting | N/A | 186 | Canada | Soy Milk, Cow's Milk, Sugar Sweetened Beverages | University of Toronto, United Soybean Board | Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes, Healthy Obesity, Metabolically, Overweight, Obesity, Dysglycemia, Cardiovascular Diseases, Heart Disease Risk Factors, Hypertension, Dyslipidemias | 10/24 | 03/25 | | |
| Ostrowski, Mario |
NCT06731127: Vaccines in a Time of Dual Pandemic: COVID-19 Vaccine in People with HIV |
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| Completed | N/A | 75 | Canada | | University of Toronto | HIV Infections | 12/22 | 12/22 | | |
| Chan, Iris |
| Active, not recruiting | N/A | 5000 | Canada | Level of recreational water contact activities, Sand contact at beaches | Toronto Metropolitan University, University of Waterloo, University of Guelph, Health Canada, Public Health Agency of Canada (PHAC), Toronto Public Health, Vancouver Coastal Health, Government of Manitoba, Public Health Niagara Region, McMaster University, Halifax Regional Municipality | Water-Related Diseases, Gastrointestinal Diseases | 09/26 | 03/29 | | |
NCT04165408: Trial to Assess the Safety and Clinical Performance of Contino® in Preventing Urinary Incontinence |
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| Recruiting | N/A | 25 | Canada | Contino | CMX Research | Urinary Incontinence | 06/24 | 06/24 | | |
| Not yet recruiting | N/A | 280 | Europe, Canada, US, RoW | Aquablation Therapy, Radical Prostatectomy | PROCEPT BioRobotics | Localized Prostate Cancer | 07/27 | 01/37 | | |
NCT04309695: The Zenflow Spring System Safety and Performance Study (ZEST CAN) |
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| Recruiting | N/A | 40 | Canada | Zenflow Spring System | Zenflow, Inc. | Benign Prostatic Hyperplasia | 12/25 | 01/26 | | |
| O'Connor, Deborah L |
| Recruiting | N/A | 112 | Canada | Human donor milk, Donor milk, Formula, Cow's milk based formula | Mount Sinai Hospital, Canada, Mitacs | Small for Gestational Age at Delivery, Gestational Diabetes, type1diabetes, Type2diabetes | 11/24 | 03/25 | | |
NCT05308134: Individualized Fortification of Human Milk for Infants Born ≤ 1250 g (MaxiMoM-InForM) |
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| Recruiting | N/A | 615 | Canada | Standard fortification, Target fortification, BUN adjustable fortification | The Hospital for Sick Children | Very Low Birth Weight Infant | 07/26 | 07/26 | | |
| Wong, David |
NCT05372419: A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Color |
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| Active, not recruiting | 3 | 80 | US | Lebrikizumab, LY3650150, DRM06 | Eli Lilly and Company | Atopic Dermatitis | 05/24 | 02/25 | | |
STARLIGHT, NCT06613698: A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 65 Years With Alcohol-related Liver Disease |
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| Not yet recruiting | 2 | 393 | Europe, Canada, Japan, US, RoW | GSK4532990, Placebo | GlaxoSmithKline | Liver Diseases, Alcoholic | 12/26 | 03/27 | | |
NCT03692897: An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection |
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| Recruiting | N/A | 5000 | Canada, US | All approved therapies for the treatment of Chronic Hepatitis B (CHB) | Target PharmaSolutions, Inc. | Hepatitis B, Hepatitis, Liver Diseases | 01/26 | 01/26 | | |
| Metser, Ur |
NCT04644822: Safety and Efficacy of [18F]PSMA-1007 Injection in Suspected Persistent or Recurrent Prostate Cancer. |
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| Completed | 3 | 100 | Canada | [18F] PSMA-1007 Injection | Centre for Probe Development and Commercialization, McDougall Scientific Ltd. | Prostate Cancer Recurrent, Recurrent Prostate Cancer | 01/24 | 01/24 | | |
PET ABC, NCT02751710: Impact of 18F-FDG PET-CT Versus Conventional Staging in the Management of Patients Presenting With Clinical Stage III Breast Cancer |
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| Completed | N/A | 369 | Canada | Whole-body FDG PET-CT alone | Ontario Clinical Oncology Group (OCOG), Cancer Care Ontario | Stage III Breast Cancer (T0N2, T1N2, T2N2, T3N1, 2 or T4), Stage IIb Breast Cancer (T3N0) | 03/23 | 03/23 | | |
NCT03873870: 68Ga-DOTATATE PET for Management of Neuroendocrine Tumors |
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| Completed | N/A | 1916 | Canada | 68Ga -DOTATATE PET scans | University Health Network, Toronto | Neuroendocrine Tumors | 04/23 | 04/23 | | |
PET MUSE, NCT02462239: Impact of Positron Emission Tomography (PET) Imaging in Muscle-invasive Urothelial Carcinoma of the Bladder Staging |
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| Completed | N/A | 292 | Canada | Whole-body FDG PET-CT, PET-CT imaging | Ontario Clinical Oncology Group (OCOG), Cancer Care Ontario | Muscle-invasive Bladder Cancer | 03/24 | 11/24 | | |
NCT04804371: Dual Tracer (68Ga-DOTATATE and 18F-FDG) PET Imaging in G2 & G3 Gastroenteropancreatic Neuroendocrine Tumors |
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| Active, not recruiting | N/A | 40 | Canada | F18-FDG | University Health Network, Toronto, Canadian Neuroendocrine Tumour Society (CNETS) | Neuroendocrine Tumors | 02/25 | 02/25 | | |
NCT03718260: PSMA-PET Registry for Recurrent Prostate Cancer |
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| Recruiting | N/A | 3070 | Canada | [18F]-DCFPyL PET/ CT scan (PSMA PET) | Lawson Health Research Institute, Cancer Care Ontario, Centre for Probe Development and Commercialization | Recurrent Prostate Cancer | 03/24 | 12/25 | | |
| Recruiting | N/A | 160 | Canada | PET | University Health Network, Toronto | Cognitive Impairment | 12/26 | 12/26 | | |
| Anderson, Harvey G |
NCT03297931: Comparison of Pulse Chips and Commercial Snacks on Food Intake, Appetite and Blood Glucose in Healthy Young Adults |
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| Active, not recruiting | N/A | 26 | Canada | Corn Chips + Onion Dip, Yellow pea chip + hummus, Pinto bean chip + hummus, Pinto bean chip + onion dip, Yellow pea chip + onion dip, Corn chips + hummus | University of Toronto | Obesity, Diabetes | 12/21 | 05/22 | | |
NCT04399460: The Effects of Long-term Consumption of Full-fat Dairy Products on Satiety, Body Weight and Glycemic Control |
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| Active, not recruiting | N/A | 93 | Canada | Dairy-based commercially available food products, Restrictive Eating | University of Toronto, Mount Saint Vincent University | Overweight or Obesity, Body Weight | 09/23 | 09/23 | | |
NCT02658591: Effects of Faba Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control |
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| Active, not recruiting | N/A | 60 | Canada | Crackers/pasta with added faba bean protein concentrate, Crackers/pasta with added faba bean protein isolate, Crackers/pasta with added faba bean starch, Crackers/pasta with added faba bean flour, Crackers/pasta with no faba bean fraction | University of Toronto | Obesity, Diabetes | 12/23 | 05/24 | | |
| Grant, David |
NCT02478151: Using Ex-vivo Normothermic Machine Perfusion With the Organox Metra™ Device to Store Human Livers for Transplantation |
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| Enrolling by invitation | 1 | 40 | Canada | OrganOx Metra | University Health Network, Toronto | End-stage Liver Disease | 12/22 | 03/23 | | |
| Recruiting | N/A | 20 | US | GammaSense Stimulation device | University of Tennessee Medical Center | Alzheimer Disease | 12/25 | 06/26 | | |
| Not yet recruiting | N/A | 50 | NA | Sleeve gastrectomy | University Health Network, Toronto | Liver Transplantation, Obesity | 06/25 | 06/25 | | |
| Smith, Justin |
NCT01588054: Prospective Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity |
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| Completed | N/A | 100 | US | | International Spine Study Group Foundation, DePuy Spine | Cervical Deformity, Kyphosis, Scoliosis | 05/21 | 06/21 | | |
NCT04469816: AFRI Childhood Obesity Prevention Challenge Area |
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| Enrolling by invitation | N/A | 200 | US | Family Check-Up 4 Health, FCU4Health, Services as Usual | Arizona State University, Northwestern University | Clinical Trial | 03/22 | 04/22 | | |
WBCBHP, NCT04321876: Evaluation of a Collaborative Behavioral Health Program Implementation in Primary Care |
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| Active, not recruiting | N/A | 778 | US | Collaborative Behavioral Health Program | Northwestern University, Northwestern Medicine | Depression | 01/24 | 12/24 | | |
NCT06315218: Examining the Health Effects of iTHRIVE 365 Among Black Same Gender Loving Men |
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| Not yet recruiting | N/A | 350 | NA | iTHRIVE 365 HIV care intervention | Rutgers, The State University of New Jersey, Positive Impact Health Centers, George Washington University, Carnegie Mellon University, Emory University, Columbia University, Arizona State University, THRIVE Social Services Inc | Sexual and Gender Minorities, Social Stigma, Medication Adherence, Depressive Symptoms, Anxiety Symptoms | 04/28 | 04/28 | | |
| Not yet recruiting | N/A | 1200 | US | SMS/Text (CAMPI), Fidelity Monitoring System (Lyssn), Family Check-Up 4 Health (FCU4Health) | Arizona State University, Northwestern University, University of Oregon, University of Utah, National Heart, Lung, and Blood Institute (NHLBI) | Clinical Trial | 07/28 | 07/28 | | |
NCT06368245: Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions |
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| Not yet recruiting | N/A | 1244 | Europe, Canada, Japan, US, RoW | long-segment posterior TL instrumented fusion | AO Foundation, AO Spine | Spinal Fusion | 12/27 | 07/29 | | |
Symphony, NCT04912674: Evaluation of ™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity |
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| Recruiting | N/A | 100 | US | Symphony OCT System | International Spine Study Group Foundation, DePuy Synthes | Cervical Deformity | 07/27 | 07/27 | | |
| Recruiting | N/A | 500 | Canada, US | Index or spine revision surgery for complex adult spinal deformity | International Spine Study Group Foundation, Medtronic, Globus Medical Inc, SI-BONE, Inc. | Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance | 12/31 | 07/32 | | |
PCD 2, NCT04194996: Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0 |
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| Recruiting | N/A | 200 | US | Surgical intervention | International Spine Study Group Foundation, DePuy Synthes, Orthofix Inc. | Cervical Deformity | 12/32 | 07/33 | | |
NCT04888104: Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients |
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| Recruiting | N/A | 225 | US | Index or revision spine surgery for complex adult spinal deformity, VersaTie System | International Spine Study Group Foundation, NuVasive | Adult Spinal Deformity, Scoliosis, Kyphosis | 12/34 | 12/34 | | |
| Ward, Brian |
| Active, not recruiting | 2/3 | 30918 | Europe, Canada, US, RoW | Intramuscular injection, Intramuscular vaccine | Medicago | SARS-CoV-2 Infection | 08/21 | 04/22 | | |
NCT04662697: Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults (USA) |
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| Not yet recruiting | 2 | 918 | NA | Intramuscular injection, intramuscular accine | Medicago | SARS-CoV-2 Infection | 12/21 | 03/22 | | |
NCT04622592: Adjuvanted Seasonal Recombinant Quadrivalent Virus-Like Particles (QVLP) Influenza Vaccine in Adults 65 Years of Age and Older |
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| Completed | 1/2 | 209 | US | Instramuscular vaccine | Medicago | Influenza | 04/22 | 04/22 | | |
NCT06465420: A Study to Evaluate Safety and Immunogenicity of Haemophilus Influenzae Serotype a Vaccine |
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| Active, not recruiting | 1 | 30 | Canada | Haemophilus influenzae type a (Hia) glycoconjugate vaccine | InventVacc Biologicals Inc., Hia Consortium | Haemophilus Influenzae Meningitis, Invasive Haemophilus Influenzae Disease | 10/24 | 03/25 | | |
NCT06578650: A Prospective, Single-arm, Clinical Trial of Electrospun Fiber Matrix (Restrata) in the Treatment of Surgical Defects Secondary to Resection of Malignant Cutaneous Neoplasms |
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| Recruiting | N/A | 34 | US | Synthetic Electrospun Fiber Matrix | Acera Surgical, Inc. | Surgical Wound | 04/25 | 08/25 | | |
| Puri, Varun |
NCT04354064: Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors |
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| Recruiting | N/A | 100 | US | | Washington University School of Medicine, Roche Sequencing Solutions, The Foundation for Barnes-Jewish Hospital, National Center for Advancing Translational Sciences (NCATS), Radiological Society of North America, Skandalaris, The V Foundation for Cancer Research, National Institute of General Medical Sciences (NIGMS) | Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer, Genitourinary Cancer, Sarcoma, Breast Cancer, Colon Cancer, Gastrointestinal Cancer, Solid Tumor Cancer, Lung Cancer, Skin Cancer, Melanoma | 12/25 | 12/25 | | |
SORT, NCT05183932: Surgery Versus Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 440 | Canada, US | | Washington University School of Medicine, National Cancer Institute (NCI) | Non Small Cell Lung Cancer, Non-small Cell Lung Cancer | 01/27 | 01/27 | | |
NCT05513027: Augmented Whole-body Scanning Via Magnifying PET/CT (AWSM-PET/CT) Techniques Abilities to Improve Upon the Diagnostic Accuracy of the Standard-of-care (SOC) PET/CT for Malignant Lesion Detection |
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| Recruiting | N/A | 35 | US | Augmented Whole-body Scanning via Magnifying PET, AWSM-PET, PET/CT | Washington University School of Medicine, National Cancer Institute (NCI) | Cancer | 05/27 | 05/27 | | |
| Tam, Paul YW |
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease |
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| Recruiting | N/A | 3600 | Europe, Canada, RoW | Liberal phosphate target, Intensive phosphate target | The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago | Kidney Failure, Chronic, Hyperphosphatemia | 12/27 | 12/28 | | |
| Simpson, Robert |
NCT05997082: A Mindful Self-compassion Based Intervention for Specialist Rehabilitation Providers |
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| Completed | N/A | 26 | Canada | Mindfulness Self-Compassion Course | Sunnybrook Health Sciences Centre | Burnout, Professional, Compassion Fatigue, Secondary Traumatic Stress | 03/24 | 05/24 | | |
NCT06337903: Self-compassion for People with Multiple Sclerosis: an Exploratory Feasibility Study |
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| Not yet recruiting | N/A | 45 | Canada | Self-compassion intervention (the Mindful Self-Compassion course) | Robert Simpson | Multiple Sclerosis, Self-Compassion | 04/25 | 04/25 | | |
NCT06538597: Online Mindful Self-Compassion Training for Medical Students: an Exploratory Feasibility Study |
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| Not yet recruiting | N/A | 45 | Canada | Self-compassion intervention (Self-Compassion for Healthcare Communities course) | Robert Simpson | Self-Compassion | 08/25 | 08/25 | | |
| Anderson, G Harvey |
NCT05919667: Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes |
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| Completed | N/A | 16 | Canada | Dairy and plant-based dairy beverages and solids | University of Toronto | Obesity, Diabetes Mellitus, Type 2 | 02/22 | 03/23 | | |
NCT04399460: The Effects of Long-term Consumption of Full-fat Dairy Products on Satiety, Body Weight and Glycemic Control |
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| Active, not recruiting | N/A | 93 | Canada | Dairy-based commercially available food products, Restrictive Eating | University of Toronto, Mount Saint Vincent University | Overweight or Obesity, Body Weight | 09/23 | 09/23 | | |
NCT05610124: Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein |
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| Recruiting | N/A | 30 | Canada | Ad libitum full-fat French fries with beef meatballs, Ad libitum instant mashed potatoes with beef meatballs, Ad libitum macaroni pasta with beef meatballs, Ad libitum full-fat French fries with vegetarian substitute meatballs, Ad libitum instant mashed potatoes with vegetarian substitute meatballs, Ad libitum macaroni pasta with vegetarian substitute meatballs | University of Toronto, Alliance for Potato Research and Education | Glycemic Control, Satiety Response, Appetite Regulation, Diabetes, Obesity | 12/23 | 04/24 | | |
NCT05291351: Impact of Pea, Lentil and Oat Flour Particle Size on Glycemic Response in Healthy Adults |
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| Completed | N/A | 60 | Canada | Crackers made with whole, coarse, or fine pea and/or wheat flour, Crackers made with whole, coarse, or fine lentil and/or wheat flour, Porridge made with oat flour | University of Toronto, University of Saskatchewan, Saskatchewan Food Industry Development Center | Malnutrition; Diabetes, Malnutrition; Protein, Obesity | 12/23 | 12/23 | | |
PREVENT, NCT05303662: Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing an ERCP in Four Different Countries |
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| Recruiting | N/A | 1372 | Europe, US, RoW | Multidrug-Resistant Organisms (MDRO) testing through rectal and oral/nasal swabs, MDRO-testing duodenal aspirate, Microbiome through rectal swab, Microbiome testing duodenal aspirate | Marco J. Bruno, Boston Scientific Corporation | Drug Resistance, Multiple, Bacterial, Cholangiopancreatography, Endoscopic Retrograde | 09/24 | 10/24 | | |
| Feld, Jordan |
NCT04017338: Transplantation Using Hepatitis C Positive Donors, A Safety Trial |
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| Recruiting | 3 | 40 | Canada | Glecaprevir 300 MG / Pibrentasvir 120 MG Oral Tablet, Maviret, Ezetimibe 10Mg Oral Tablet, Ex Vivo Lung Perfusion, Normothermic EVLP | Jordan Feld, University Health Network, Toronto | Lung Transplant Infection, Heart Transplant Infection, Kidney Transplant Infection, Kidney Pancreas Infection, Hepatitis C | 12/20 | 12/24 | | |
NCT04967430: TOGETHER - Toronto: Trial to Evaluate the Effect of Peginterferon Lambda for the Treatment of COVID-19 |
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| Active, not recruiting | 3 | 763 | Canada | Peginterferon Lambda-1A, Placebo | University Health Network, Toronto | Sars-CoV2, Covid19 | 03/22 | 06/22 | | |
| Completed | 3 | 407 | Europe, Canada, US, RoW | Lonafarnib, EBP994, Sarasar, LNF, Ritonavir, Norvir, RTV, PEG IFN-alfa-2a, Pegasys, pegylated interferon-alfa, Placebo Lonafarnib, Placebo Ritonavir | Eiger BioPharmaceuticals | Hepatitis Delta Virus | 10/22 | 03/23 | | |
| Completed | 2 | 157 | Canada, RoW | Peginterferon Lambda-1A, placebo | University Health Network, Toronto, Michael Garron Hospital | Sars-CoV2, Covid-19 | 08/22 | 12/22 | | |
B-Fine, NCT04544956: A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B |
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| Completed | 2 | 12 | Europe, Canada, US | GSK3228836, Nucleos(t)ide therapy | GlaxoSmithKline | Hepatitis B | 11/23 | 11/23 | | |
NCT06216470: Vaccinal Effect of HBsAg Monoclonal Ab VIR-3434 in Chronic Hepatitis B Infection [VISION] |
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| Recruiting | 2 | 15 | Canada | VIR-3434 | University Health Network, Toronto | Hepatitis B, Chronic | 12/29 | 12/29 | | |
| Recruiting | 2 | 450 | Europe, Canada, Japan, US, RoW | Bepirovirsen, Placebo | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited | Hepatitis B | 02/29 | 02/29 | | |
| Active, not recruiting | N/A | 124 | Canada, US | Test and treat plus peer mentors, On-site treatment with peer support HCV treatment implementation strategy, Usual care, Standard of care referral HCV treatment implementation strategy | Johns Hopkins University, AbbVie | Hepatitis C Virus Infection, Response to Therapy of | 02/24 | 02/25 | | |
| Blumberger, Daniel M |
| Enrolling by invitation | 4 | 1500 | Canada, US | Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT) | Brigham and Women's Hospital, Johns Hopkins University, University of Pittsburgh, Baylor College of Medicine, University of Arizona, The Cleveland Clinic, Icahn School of Medicine at Mount Sinai, Washington University School of Medicine, The Center for Addiction and Mental Health (University of Toronto), The University of Texas Health Science Center, Houston | Acute Suicidal Depression (ASD) | 01/30 | 03/30 | | |
NCT04427137: Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic |
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| Completed | N/A | 29 | Canada | MagPro X100 Stimulator, B70 Fluid-Cooled Coil | Centre for Addiction and Mental Health | Bipolar Depression | 01/22 | 11/22 | | |
NCT04384965: Accelerated iTBS for Depressed Patients During the COVID-19 Pandemic |
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| Completed | N/A | 176 | Canada | MagPro X100 Stimulator, B70 Fluid-Cooled Coil | Centre for Addiction and Mental Health | Major Depressive Disorder | 05/22 | 11/22 | | |
NCT02998580: Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression |
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| Completed | N/A | 163 | Canada | LFR followed by HFL, cTBS followed by iTBS | Centre for Addiction and Mental Health, University Health Network, Toronto | Major Depression | 04/20 | 04/20 | | |
| Completed | N/A | 25 | Canada | Intranasal Ketamine (IN) | Centre for Addiction and Mental Health | Depression | 07/23 | 07/23 | | |
| Completed | N/A | 68 | Canada | active tDCS + mindfulness meditation, Soterix tDCS mini-Clinical Trials system (mini-CT) - active, sham tDCS + mindfulness meditation, Soterix tDCS mini-Clinical Trials system (mini-CT) - sham | Centre for Addiction and Mental Health, University Health Network, Toronto | Major Depressive Disorder | 08/20 | 08/20 | | |
NCT05097586: RCT of At-Home tDCS for Depression in Pregnancy |
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| Recruiting | N/A | 156 | Canada | active tDCS, workbook, sham tDCS | Women's College Hospital, Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre | Major Depression, Pregnancy, Postpartum Depression | 01/26 | 06/27 | | |
| Completed | N/A | 228 | Canada | Active iTBS, Sham iTBS | Centre for Addiction and Mental Health, University Health Network, Toronto, University of British Columbia | Major Depressive Disorder | 01/25 | 01/25 | | |
DEEPP, NCT05177146: Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression |
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| Recruiting | N/A | 30 | Canada | Intravenous Ketamine (IV) | Centre for Addiction and Mental Health | Bipolar Disorder (BD), Suicidality | 02/24 | 08/24 | | |
| Completed | N/A | 106 | Canada | Magnetic Seizure Therapy (MST), MST, RUL-UB ECT, Bitemporal ECT, ECT | Centre for Addiction and Mental Health, University of British Columbia, Ontario Shores Centre for Mental Health Sciences, Brain Canada | Depression, Bipolar Depression, Unipolar Depression, Treatment Resistant Depression | 10/24 | 10/24 | | |
| Completed | N/A | 76 | Canada | Magnetic Seizure Therapy (MST), MST, Electroconvulsive Therapy (ECT), ECT | Centre for Addiction and Mental Health, University of British Columbia, Ontario Shores Centre for Mental Health Sciences, Brain Canada | Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder | 03/24 | 08/24 | | |
| Completed | N/A | 219 | Canada, US | Magnetic Seizure Therapy, MST, Electroconvulsive Therapy, ECT | University of Texas Southwestern Medical Center, National Institute of Mental Health (NIMH), Centre for Addiction and Mental Health, University of California, San Diego | Depression, Unipolar Depression, Treatment Resistant Depression | 11/24 | 11/24 | | |
