Lankenau Heart Institute Trials

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Study compl

Morse, Michael A

COMPOSE, NCT04919226 / 2021-001086-20: Lutetium 177Lu-Edotreotide Versus Best Standard of Care in Well-differentiated Aggressive Grade-2 and Grade-3 GastroEnteroPancreatic NeuroEndocrine Tumors (GEP-NETs) -

Active, not recruiting

259

Europe, US, RoW

177Lu-Edotreotide (Peptide Receptor Radionuclide Therapy) PRRT, 177Lu-DOTATOC 177Lu-Edo, CAPTEM (Capecitabine and Temozolomide), Amino-Acid Solution, Arginine-Lysine Solution, Everolimus, FOLFOX (Folinic acid + Fluorouracil + Oxaliplatin)

ITM Solucin GmbH

Neuroendocrine Tumors

06/27

09/27

NCT03632941: A Study to Evaluate Concurrent VRP-HER2 Vaccination and Pembrolizumab for Patients With Breast Cancer

Active, not recruiting

VRP-HER2, AVX901, Pembrolizumab, Keytruda

Herbert Lyerly, Merck Sharp & Dohme LLC

Breast Cancer, HER2+ Breast Cancer

10/23

12/25

ACCRU-GI-2008, NCT05168163: Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Recruiting

122

Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, Tecentriq, Cabozantinib, Lenvatinib, E7080, ER-203492-00, Multi-Kinase Inhibitor E7080

Academic and Community Cancer Research United, National Cancer Institute (NCI), Genentech, Inc.

Locally Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IVA Hepatocellular Carcinoma AJCC v8, Stage IVB Hepatocellular Carcinoma AJCC v8, Unresectable Hepatocellular Carcinoma

12/24

12/26

ELU-FRÎ±-1, NCT05001282: A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)

Terminated

1/2

ELU001, FA-CDC

Elucida Oncology

Ovarian Cancer, Ovarian Neoplasms, Ovarian Carcinoma, Endometrial Cancer, Ovary Cancer, Ovary Neoplasm, Ovary Disease, Ovary Metastasis, Ovarian Diseases, Ovarian Cancer Stage, Ovarian Epithelial Cancer, Ovarian Adenocarcinoma, Ovarian Serous Adenocarcinoma, Ovarian Neoplasm Epithelial, Ovarian Cancer Recurrent, Endometrial Diseases, Endometrial Adenocarcinoma, Endometrial Carcinosarcoma, Endometrial Clear Cell Adenocarcinoma, Endometrioid Adenocarcinoma, Endometrial Neoplasms, Endometrial Cancer Recurrent, Endometrioid Tumor, Fallopian Tube Cancer, Peritoneal Cancer

06/24

KISIMA-01, NCT04046445: Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer

Active, not recruiting

Europe, US

ATP128, BI 754091, Ezabenlimab, VSV-GP128

Amal Therapeutics, Boehringer Ingelheim

Colorectal Cancer, MSS, Stage IV Colon Cancer, Stage IV Rectal Cancer, Metastatic Colorectal Cancer, Liver Metastasis Colon Cancer

05/25

08/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

Ramlawi, Basel

NCT03635424: Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Active, not recruiting

N/A

150

Medtronic TAVR Systems

Medtronic Cardiovascular

Bicuspid Aortic Valve

11/19

12/30

ReChord, NCT02803957: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Recruiting

N/A

585

NeoChord DS1000, Surgical Mitral Valve Repair

NeoChord

Mitral Valve Insufficiency

07/22

07/27

NCT06203054: CLIP-IT Post-Market Study

Active, not recruiting

N/A

150

Penditure™ Left Atrial Appendage (LAA) Exclusion System

Medtronic Cardiac Surgery

Left Atrial Appendage Exclusion

11/25

02/29

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT03546374: Medtronic Terminate AF Study

Recruiting

N/A

160

Surgical Ablation, Cardioblate and Cryoflex hand held devices

Medtronic Cardiac Surgery

Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation

10/24

12/26

NCT05295628: Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

Active, not recruiting

N/A

532

EMBLOK™ Embolic Protection System ("EMBLOK EPS"), SENTINEL™ Cerebral Protection System

Innovative Cardiovascular Solutions, Yale Cardiovascular Research Group

Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement

05/25

07/25

RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting

N/A

225

Medtronic TAV, Edwards TAV

Medtronic Cardiovascular

Aortic Stenosis

03/29

07/33

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

Sievert, Horst

SCOUT-II, NCT03225612: Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)

Recruiting

N/A

Europe

Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)

Mitralign, Inc., Genae, Regulatory and Clinical Research Institute Inc, CardioVascular Research Foundation, Korea

Chronic Symptomatic Functional Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Heart Valve Disease

06/18

11/22

NCT03666780: Lifetech LAmbre™ Left Atrial Appendage (LAA) Closure System Post-Market Clinical Follow-up Study

Completed

N/A

500

Europe, RoW

LAmbre Occluder

Lifetech Scientific (Shenzhen) Co., Ltd., IQVIA Biotech

Atrial Fibrillation

11/21

09/24

AcChord, NCT04190602: Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System

Recruiting

N/A

500

Europe

NeoChord Artificial Chordae Delivery System, Model DS1000, NeoChord DS1000, DS1000

NeoChord

Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse, Heart Valve Diseases

10/22

12/27

Omega, NCT04829929: Evaluation od Safety and Performance of the ™ LAA (Left Atrial Appendage) Occluder and ™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk

Recruiting

N/A

150

Europe

Omega™LAA Occluder implantation

Eclipse Medical Ltd., KCRI

Non-Valvular Atrial Fibrillation

05/23

11/23

CAPTURE2, NCT03892824: Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants

Active, not recruiting

N/A

100

Europe, RoW

Vine™ Embolic Protection System

Javelin Medical, Genae

Atrial Fibrillation, Stroke

10/24

10/27

PROOF, NCT04029233: The Trial - Prospective, Open-label, Multicenter, Non-randomized Investigation on Percutaneous Patent Foramen Ovale (PFO) Closure Using the Occlutech PFO Occluder to Prevent Recurrence of Stroke in Patients With Cryptogenic Stroke and High Risk PFO

Terminated

N/A

582

Europe, Canada

Occlutech PFO Occluder, Occlutech Figulla Flex II Occluder

Occlutech International AB

Stroke, PFO - Patent Foramen Ovale

04/24

CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

NCT02880631: BAROSTIM THERAPY™ In Resistant Hypertension

Recruiting

N/A

500

Europe

BAROSTIM NEO™ System

CVRx, Inc.

Hypertension

07/24

CALM-DIEM, NCT02827032: Controlling and Lowering Blood Pressure With the MobiusHD™

Recruiting

N/A

200

Europe

MobiusHD™

Vascular Dynamics, Inc.

Hypertension

12/24

06/26

VECTOR-HF, NCT03775161: V-LAP™ Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heaRt Failure

Active, not recruiting

N/A

Europe

V-LAP™ System, Echocardiography

Vectorious Medical Technologies Ltd., Horizon 2020 - European Commission

Heart Failure

12/26

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

HF-FIM, NCT04590001: Effect of the MobiusHD® in Patients With Heart Failure

Recruiting

N/A

Europe, Canada, RoW

MobiusHD

Vascular Dynamics, Inc.

Heart Failure With Reduced Ejection Fraction

12/25

06/26

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

LAAOS-4, NCT05963698: The Fourth Left Atrial Appendage Occlusion Study

Recruiting

N/A

4000

Europe, Canada, US

WATCHMAN device

Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation

Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism

09/29

12/29

Gray, William K

REGENERATE-PD, NCT06285643: A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease

Recruiting

Europe, US

AAV2-GDNF Gene therapy, Biological, Control Surgery

AskBio Inc, Bayer

Parkinson Disease

11/27

CT-AMT-130-02, NCT05243017 / 2020-001461-36: Safety and Efficacy of AMT-130 in European Adults with Early Manifest Huntington's Disease

Active, not recruiting

1/2

Europe

intra-striatal rAAV5-miHTT, AMT-130

UniQure Biopharma B.V., uniQure biopharma B.V.

Huntington Disease

03/29

10/29

TRANSCEND, NCT03241459: Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Completed

N/A

446

Europe, US, RoW

Surmodics SurVeil DCB, Medtronic IN.PACT Admiral DCB

SurModics, Inc.

Peripheral Arterial Disease, Peripheral Vascular Disease, Artery Disease, Peripheral, Femoropopliteal Artery Occlusion

09/20

09/24

ConformalEFS, NCT03616028: The CONFORMAL Early Feasibility Study

Active, not recruiting

N/A

left atrial appendage closure

Conformal Medical, Inc, Yale Cardiovascular Research Group

Non-valvular Atrial Fibrillation

05/22

06/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting

N/A

110

US, RoW

NEXUS Aortic Stent Graft System

Endospan Ltd.

Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer

07/25

10/29

NCT05653336: PerQseal® Clinical Study

Active, not recruiting

N/A

149

Europe, US

PerQseal® Closure Device System

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

12/24

06/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT04905017: Trisol System EFS Study

Recruiting

N/A

Transcatheter Tricuspid Valve Replacement

Trisol Medical

Tricuspid Regurgitation

01/25

07/27

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)

Recruiting

N/A

Europe, US

Trillium™

Innoventric LTD, Innoventric Inc.

Tricuspid Regurgitation, Tricuspid Regurgitation Functional

08/25

08/30

ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting

N/A

100

Europe, Canada, US

Edwards APTURE transcatheter shunt system, Sham procedure

Edwards Lifesciences

Heart Failure

01/26

08/30

NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting

N/A

Transcatheter Atrial Shunt System

Edwards Lifesciences

Heart Failure

12/23

11/28

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting

N/A

Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair

Edwards Lifesciences

Tricuspid Regurgitation

12/26

12/31

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

Goldman, Scott

SITRAL, NCT02830204: Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification () Study

Completed

N/A

Mitral Valve Replacement (MVR) with Sapien3, MVR

Baylor Research Institute, Edwards Lifesciences

Mitral Annular Calcification

01/23

11/23

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

Dhoble, Abhijeet

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT05295628: Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

Active, not recruiting

N/A

532

EMBLOK™ Embolic Protection System ("EMBLOK EPS"), SENTINEL™ Cerebral Protection System

Innovative Cardiovascular Solutions, Yale Cardiovascular Research Group

Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement

05/25

07/25

RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting

N/A

225

Medtronic TAV, Edwards TAV

Medtronic Cardiovascular

Aortic Stenosis

03/29

07/33

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

FROST-HF, NCT05136820: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study

Active, not recruiting

N/A

698

Atrial Flow Regulator, AFR, Sham Comparator

Occlutech International AB

Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)

02/26

02/29

Loyalka, Pranav

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting

N/A

100

Europe, Canada, US

Edwards APTURE transcatheter shunt system, Sham procedure

Edwards Lifesciences

Heart Failure

01/26

08/30

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

FROST-HF, NCT05136820: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study

Active, not recruiting

N/A

698

Atrial Flow Regulator, AFR, Sham Comparator

Occlutech International AB

Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)

02/26

02/29

PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Active, not recruiting

N/A

1252

Europe, Canada, US

Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump

Abiomed Inc.

Left Ventricular Dysfunction, Coronary Artery Disease

03/26

10/27

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Kar, Biswajit

TRICAV, NCT06137807: TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (-I)

Recruiting

N/A

TricValve® Transcatheter Bicaval Valve System, TricValve System

P+F Products + Features USA Inc., P+F Products + Features GmbH, Meditrial USA Inc.

Tricuspid Regurgitation, Tricuspid Valve Disease

11/25

09/29

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

Jordan, Jennifer H

NCT04502316: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Active, not recruiting

N/A

5000

Barostim™ System

CVRx, Inc.

Heart Failure

06/28

Chikowski, Ann Marie

NCT05163548: PerQseal®+ Early Feasibility Study

Completed

N/A

PerQseal Plus Device, Vascular Closure Device

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

07/22

NCT04905017: Trisol System EFS Study

Recruiting

N/A

Transcatheter Tricuspid Valve Replacement

Trisol Medical

Tricuspid Regurgitation

01/25

07/27

Coady, Paul

NCT05653336: PerQseal® Clinical Study

Active, not recruiting

N/A

149

Europe, US

PerQseal® Closure Device System

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

12/24

06/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Rodriguez, Roberto

NCT04557462 / 2020-002200-40: A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

Recruiting

540

Europe, Canada, Japan, US, RoW

LNP023, iptacopan

Novartis Pharmaceuticals, Novartis Pharma AG

Primary IgA Nephropathy

11/32

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Eads, Kristin

NCT05562934: An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.

Completed

191

Europe, Japan, US, RoW

XXB750 drug, Placebo

Novartis Pharmaceuticals

Resistant Hypertension

07/24

08/24

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

Al-Amoodi, Mohammed

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

Silva, Guilherme

PORTICO IDE, NCT02000115: Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial

Active, not recruiting

N/A

1242

US, RoW

Portico transcatheter aortic valve, Commercially available transcatheter aortic valve

Abbott Medical Devices

Aortic Valve Stenosis

10/19

12/26

CorCinch-PMVI, NCT03560167: Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation

Completed

N/A

AccuCinch® Ventricular Restoration System

Ancora Heart, Inc.

Heart Failure, Cardiomyopathy, Dilated

03/21

01/24

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting

N/A

636

PFO closure with GORE® CARDIOFORM Septal Occluder

W.L.Gore & Associates

Stroke, PFO - Patent Foramen Ovale

10/28

10/31

Rutherford, Cheryl

IMPRESS, NCT03531502: Initial Management of Patients Receiving a Single Shock

Terminated

N/A

Ventricular Tachycardia Ablation, Standard Medical Therapy, Non-Invasive Programmed Stimulation (NIPS)

Saint Luke's Health System, Medtronic

Ventricular Tachycardia

04/23

NCT05905835: Treatment of PAF With the Synaptic System

Active, not recruiting

N/A

128

Synaptic Cryoablation System

Synaptic Medical Corporation

Paroxysmal Atrial Fibrillation

11/25

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

08/25

10/25

ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation

Active, not recruiting

N/A

669

Europe, Canada, US

Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System

Boston Scientific Corporation

Persistent Atrial Fibrillation

03/25

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Morse, Michael A

Active, not recruiting

259

Europe, US, RoW

ITM Solucin GmbH

Neuroendocrine Tumors

06/27

09/27

NCT03632941: A Study to Evaluate Concurrent VRP-HER2 Vaccination and Pembrolizumab for Patients With Breast Cancer

Active, not recruiting

VRP-HER2, AVX901, Pembrolizumab, Keytruda

Herbert Lyerly, Merck Sharp & Dohme LLC

Breast Cancer, HER2+ Breast Cancer

10/23

12/25

ACCRU-GI-2008, NCT05168163: Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Recruiting

122

Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, Tecentriq, Cabozantinib, Lenvatinib, E7080, ER-203492-00, Multi-Kinase Inhibitor E7080

Academic and Community Cancer Research United, National Cancer Institute (NCI), Genentech, Inc.

12/24

12/26

ELU-FRÎ±-1, NCT05001282: A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)

Terminated

1/2

ELU001, FA-CDC

Elucida Oncology

06/24

KISIMA-01, NCT04046445: Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer

Active, not recruiting

Europe, US

ATP128, BI 754091, Ezabenlimab, VSV-GP128

Amal Therapeutics, Boehringer Ingelheim

Colorectal Cancer, MSS, Stage IV Colon Cancer, Stage IV Rectal Cancer, Metastatic Colorectal Cancer, Liver Metastasis Colon Cancer

05/25

08/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

Ramlawi, Basel

NCT03635424: Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Active, not recruiting

N/A

150

Medtronic TAVR Systems

Medtronic Cardiovascular

Bicuspid Aortic Valve

11/19

12/30

ReChord, NCT02803957: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Recruiting

N/A

585

NeoChord DS1000, Surgical Mitral Valve Repair

NeoChord

Mitral Valve Insufficiency

07/22

07/27

NCT06203054: CLIP-IT Post-Market Study

Active, not recruiting

N/A

150

Penditure™ Left Atrial Appendage (LAA) Exclusion System

Medtronic Cardiac Surgery

Left Atrial Appendage Exclusion

11/25

02/29

PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting

N/A

115

AMDS

Artivion Inc., Syneos Health

Acute Aortic Dissection

12/23

12/29

NCT03546374: Medtronic Terminate AF Study

Recruiting

N/A

160

Surgical Ablation, Cardioblate and Cryoflex hand held devices

Medtronic Cardiac Surgery

Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation

10/24

12/26

NCT05295628: Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

Active, not recruiting

N/A

532

EMBLOK™ Embolic Protection System ("EMBLOK EPS"), SENTINEL™ Cerebral Protection System

Innovative Cardiovascular Solutions, Yale Cardiovascular Research Group

Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement

05/25

07/25

RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting

N/A

225

Medtronic TAV, Edwards TAV

Medtronic Cardiovascular

Aortic Stenosis

03/29

07/33

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

Sievert, Horst

SCOUT-II, NCT03225612: Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)

Recruiting

N/A

Europe

Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)

Mitralign, Inc., Genae, Regulatory and Clinical Research Institute Inc, CardioVascular Research Foundation, Korea

Chronic Symptomatic Functional Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Heart Valve Disease

06/18

11/22

NCT03666780: Lifetech LAmbre™ Left Atrial Appendage (LAA) Closure System Post-Market Clinical Follow-up Study

Completed

N/A

500

Europe, RoW

LAmbre Occluder

Lifetech Scientific (Shenzhen) Co., Ltd., IQVIA Biotech

Atrial Fibrillation

11/21

09/24

AcChord, NCT04190602: Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System

Recruiting

N/A

500

Europe

NeoChord Artificial Chordae Delivery System, Model DS1000, NeoChord DS1000, DS1000

NeoChord

Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse, Heart Valve Diseases

10/22

12/27

Recruiting

N/A

150

Europe

Omega™LAA Occluder implantation

Eclipse Medical Ltd., KCRI

Non-Valvular Atrial Fibrillation

05/23

11/23

CAPTURE2, NCT03892824: Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants

Active, not recruiting

N/A

100

Europe, RoW

Vine™ Embolic Protection System

Javelin Medical, Genae

Atrial Fibrillation, Stroke

10/24

10/27

Terminated

N/A

582

Europe, Canada

Occlutech PFO Occluder, Occlutech Figulla Flex II Occluder

Occlutech International AB

Stroke, PFO - Patent Foramen Ovale

04/24

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

NCT02880631: BAROSTIM THERAPY™ In Resistant Hypertension

Recruiting

N/A

500

Europe

BAROSTIM NEO™ System

CVRx, Inc.

Hypertension

07/24

CALM-DIEM, NCT02827032: Controlling and Lowering Blood Pressure With the MobiusHD™

Recruiting

N/A

200

Europe

MobiusHD™

Vascular Dynamics, Inc.

Hypertension

12/24

06/26

VECTOR-HF, NCT03775161: V-LAP™ Left Atrium Monitoring systEm for Patients With Chronic sysTOlic & Diastolic Congestive heaRt Failure

Active, not recruiting

N/A

Europe

V-LAP™ System, Echocardiography

Vectorious Medical Technologies Ltd., Horizon 2020 - European Commission

Heart Failure

12/26

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

HF-FIM, NCT04590001: Effect of the MobiusHD® in Patients With Heart Failure

Recruiting

N/A

Europe, Canada, RoW

MobiusHD

Vascular Dynamics, Inc.

Heart Failure With Reduced Ejection Fraction

12/25

06/26

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

LAAOS-4, NCT05963698: The Fourth Left Atrial Appendage Occlusion Study

Recruiting

N/A

4000

Europe, Canada, US

WATCHMAN device

Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation

Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism

09/29

12/29

Gray, William K

REGENERATE-PD, NCT06285643: A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease

Recruiting

Europe, US

AAV2-GDNF Gene therapy, Biological, Control Surgery

AskBio Inc, Bayer

Parkinson Disease

11/27

CT-AMT-130-02, NCT05243017 / 2020-001461-36: Safety and Efficacy of AMT-130 in European Adults with Early Manifest Huntington's Disease

Active, not recruiting

1/2

Europe

intra-striatal rAAV5-miHTT, AMT-130

UniQure Biopharma B.V., uniQure biopharma B.V.

Huntington Disease

03/29

10/29

TRANSCEND, NCT03241459: Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Completed

N/A

446

Europe, US, RoW

Surmodics SurVeil DCB, Medtronic IN.PACT Admiral DCB

SurModics, Inc.

Peripheral Arterial Disease, Peripheral Vascular Disease, Artery Disease, Peripheral, Femoropopliteal Artery Occlusion

09/20

09/24

ConformalEFS, NCT03616028: The CONFORMAL Early Feasibility Study

Active, not recruiting

N/A

left atrial appendage closure

Conformal Medical, Inc, Yale Cardiovascular Research Group

Non-valvular Atrial Fibrillation

05/22

06/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting

N/A

110

US, RoW

NEXUS Aortic Stent Graft System

Endospan Ltd.

Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer

07/25

10/29

NCT05653336: PerQseal® Clinical Study

Active, not recruiting

N/A

149

Europe, US

PerQseal® Closure Device System

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

12/24

06/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT04905017: Trisol System EFS Study

Recruiting

N/A

Transcatheter Tricuspid Valve Replacement

Trisol Medical

Tricuspid Regurgitation

01/25

07/27

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)

Recruiting

N/A

Europe, US

Trillium™

Innoventric LTD, Innoventric Inc.

Tricuspid Regurgitation, Tricuspid Regurgitation Functional

08/25

08/30

ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting

N/A

100

Europe, Canada, US

Edwards APTURE transcatheter shunt system, Sham procedure

Edwards Lifesciences

Heart Failure

01/26

08/30

NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting

N/A

Transcatheter Atrial Shunt System

Edwards Lifesciences

Heart Failure

12/23

11/28

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting

N/A

Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair

Edwards Lifesciences

Tricuspid Regurgitation

12/26

12/31

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

Goldman, Scott

SITRAL, NCT02830204: Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification () Study

Completed

N/A

Mitral Valve Replacement (MVR) with Sapien3, MVR

Baylor Research Institute, Edwards Lifesciences

Mitral Annular Calcification

01/23

11/23

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

Dhoble, Abhijeet

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT05295628: Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR

Active, not recruiting

N/A

532

EMBLOK™ Embolic Protection System ("EMBLOK EPS"), SENTINEL™ Cerebral Protection System

Innovative Cardiovascular Solutions, Yale Cardiovascular Research Group

Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement

05/25

07/25

RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting

N/A

225

Medtronic TAV, Edwards TAV

Medtronic Cardiovascular

Aortic Stenosis

03/29

07/33

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

FROST-HF, NCT05136820: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study

Active, not recruiting

N/A

698

Atrial Flow Regulator, AFR, Sham Comparator

Occlutech International AB

Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)

02/26

02/29

Loyalka, Pranav

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Recruiting

N/A

400

Europe, US, RoW

AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy

Ancora Heart, Inc.

Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy

12/26

12/30

NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting

N/A

1070

Europe, US

Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure

12/25

12/29

ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting

N/A

100

Europe, Canada, US

Edwards APTURE transcatheter shunt system, Sham procedure

Edwards Lifesciences

Heart Failure

01/26

08/30

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting

N/A

450

Europe, Canada, US

Investigational PFO Closure Device, Standard of Care PFO Closure Device

Occlutech International AB

Stroke, Patent Foramen Ovale, PFO

11/25

10/26

FROST-HF, NCT05136820: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study

Active, not recruiting

N/A

698

Atrial Flow Regulator, AFR, Sham Comparator

Occlutech International AB

Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)

02/26

02/29

PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Active, not recruiting

N/A

1252

Europe, Canada, US

Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump

Abiomed Inc.

Left Ventricular Dysfunction, Coronary Artery Disease

03/26

10/27

NCT04198870: MitraClip REPAIR MR Study

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Kar, Biswajit

TRICAV, NCT06137807: TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (-I)

Recruiting

N/A

TricValve® Transcatheter Bicaval Valve System, TricValve System

P+F Products + Features USA Inc., P+F Products + Features GmbH, Meditrial USA Inc.

Tricuspid Regurgitation, Tricuspid Valve Disease

11/25

09/29

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

Jordan, Jennifer H

NCT04502316: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Active, not recruiting

N/A

5000

Barostim™ System

CVRx, Inc.

Heart Failure

06/28

Chikowski, Ann Marie

NCT05163548: PerQseal®+ Early Feasibility Study

Completed

N/A

PerQseal Plus Device, Vascular Closure Device

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

07/22

NCT04905017: Trisol System EFS Study

Recruiting

N/A

Transcatheter Tricuspid Valve Replacement

Trisol Medical

Tricuspid Regurgitation

01/25

07/27

Coady, Paul

NCT05653336: PerQseal® Clinical Study

Active, not recruiting

N/A

149

Europe, US

PerQseal® Closure Device System

Vivasure Medical Limited

Percutaneous Large Hole Vascular Closure

12/24

06/25

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Rodriguez, Roberto

NCT04557462 / 2020-002200-40: A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy

Recruiting

540

Europe, Canada, Japan, US, RoW

LNP023, iptacopan

Novartis Pharmaceuticals, Novartis Pharma AG

Primary IgA Nephropathy

11/32

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

Eads, Kristin

NCT05562934: An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.

Completed

191

Europe, Japan, US, RoW

XXB750 drug, Placebo

Novartis Pharmaceuticals

Resistant Hypertension

07/24

08/24

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

Al-Amoodi, Mohammed

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

Silva, Guilherme

PORTICO IDE, NCT02000115: Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial

Active, not recruiting

N/A

1242

US, RoW

Portico transcatheter aortic valve, Commercially available transcatheter aortic valve

Abbott Medical Devices

Aortic Valve Stenosis

10/19

12/26

CorCinch-PMVI, NCT03560167: Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation

Completed

N/A

AccuCinch® Ventricular Restoration System

Ancora Heart, Inc.

Heart Failure, Cardiomyopathy, Dilated

03/21

01/24

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

06/26

06/31

CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting

N/A

2650

Europe, Canada, Japan, US, RoW

Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC

Abbott Medical Devices

Atrial Fibrillation, Stroke, Bleeding

08/27

08/30

CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting

N/A

870

Canada, US

Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy

Edwards Lifesciences

Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease

12/27

12/31

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

05/27

09/36

Recruiting

N/A

636

PFO closure with GORE® CARDIOFORM Septal Occluder

W.L.Gore & Associates

Stroke, PFO - Patent Foramen Ovale

10/28

10/31

Rutherford, Cheryl

IMPRESS, NCT03531502: Initial Management of Patients Receiving a Single Shock

Terminated

N/A

Ventricular Tachycardia Ablation, Standard Medical Therapy, Non-Invasive Programmed Stimulation (NIPS)

Saint Luke's Health System, Medtronic

Ventricular Tachycardia

04/23

NCT05905835: Treatment of PAF With the Synaptic System

Active, not recruiting

N/A

128

Synaptic Cryoablation System

Synaptic Medical Corporation

Paroxysmal Atrial Fibrillation

11/25

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

08/25

10/25

ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation

Active, not recruiting

N/A

669

Europe, Canada, US

Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System

Boston Scientific Corporation

Persistent Atrial Fibrillation

03/25

NCT05147792: The CONFORM Pivotal Trial

Recruiting

N/A

1600

US, RoW

CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder

Conformal Medical, Inc

Atrial Fibrillation, Stroke

06/28

12/31

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