Toronto Western Hospital
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 300 Trials 
131 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Kim, Edward S
CIRCULATE-US, NCT05174169: Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Recruiting
2/3
1912
Canada, US
Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month, mFOLFIRINOX, mFOLFOX6 6 month, CAPOX 6 month
NRG Oncology, Natera, Inc., National Cancer Institute (NCI)
Stage III Colon Cancer
03/29
03/30
VIRAGE, NCT05673811: Study of Nab-Paclitaxel and Gemcitabine and Plus/minus VCN-01 in Patients with Metastatic Pancreatic Cancer

Active, not recruiting
2
96
Europe, US
Nab-paclitaxel, Gemcitabine, VCN-01
Theriva Biologics SL
Pancreatic Adenocarcinoma, Metastatic
04/25
04/25
AZUR-1, NCT05723562 / 2022-003289-18: A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer

Active, not recruiting
2
154
Europe, Canada, Japan, US, RoW
Dostarlimab, JEMPERLI, dostarlimab-gxly, TSR-042, GSK4057190A
GlaxoSmithKline, GlaxoSmithKline Research & Development Ltd
Neoplasms, Rectal
11/26
10/29
NCT03695250: BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancer

Terminated
1/2
8
US
IDO1 Inhibitor BMS-986205, BMS 986205, BMS-986205, BMS986205, IDO-1 Inhibitor BMS-986205, Indoleamine-pyrrole 2,3-Dioxygenase Inhibitor BMS-986205, ONO-7701, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo
Edward Kim, Bristol-Myers Squibb, National Cancer Institute (NCI)
Metastatic Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IVA Hepatocellular Carcinoma AJCC v8, Stage IVB Hepatocellular Carcinoma AJCC v8, Unresectable Hepatocellular Carcinoma
11/20
03/21
ARYA-1, NCT04502082: Study of ET140203 T Cells in Adults With Advanced Hepatocellular Carcinoma

Terminated
1/2
6
US
ET140203 autologous T cell product
Eureka Therapeutics Inc.
Hepatocellular Carcinoma, Liver Cancer, Liver Neoplasm, Metastatic Liver Cancer
06/23
06/23
NCT04050085: SD-101, Nivolumab, and Radiation Therapy in Treating Patients With Chemotherapy-Refractory Metastatic Pancreatic Cancer

Completed
1
6
US
Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo, Radiation Therapy, Cancer Radiotherapy, Irradiate, Irradiated, irradiation, Radiation, Radiotherapeutics, RADIOTHERAPY, RT, Therapy, Radiation, TLR9 Agonist SD-101, ISS-ODN SD-101, SD-101
University of California, Davis, National Cancer Institute (NCI), Bristol-Myers Squibb, Dynavax Technologies Corporation
Metastatic Pancreatic Adenocarcinoma, Refractory Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
12/21
05/22
Cheung, Angela M
NCT01896011: Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures

Completed
3
34
Canada
Teriparatide 20 mcg, Brand name Forteo, Placebo
University Health Network, Toronto, The Physicians' Services Incorporated Foundation, Eli Lilly and Company
Non Displaced Atypical Femoral Fractures
12/21
12/22
PRECIOSA, NCT03451292 / 2016-001789-28: Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites

Completed
3
410
Europe, Canada, US, RoW
Albutein 20% Injectable Solution, Standard medical treatment
Grifols Therapeutics LLC, Instituto Grifols, S.A.
Decompensated Cirrhosis and Ascites
05/24
05/24
NCT04950127 / 2021-000007-21: Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Active, not recruiting
3
238
Europe, Canada, Japan, US, RoW
Linerixibat, Placebo
GlaxoSmithKline
Pruritus
10/24
01/25
ESSOR, NCT05999435: Study of LAU-7b for the Treatment of Long COVID in Adults

Active, not recruiting
2/3
272
Canada
LAU-7b for 3 cycles, fenretinide, LAU-7b for 1 cycle, then placebo, Placebo for 3 cycles, sugar pill
Laurent Pharmaceuticals Inc.
Long COVID
08/24
10/24
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
NCT05231668: Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)

Terminated
1
16
Europe, Canada, US, RoW
SAR439459, Placebo
Sanofi
Osteogenesis Imperfecta
11/24
11/24
NCT01155245: Teriparatide (PTH) and Bone Strength in Postmenopausal Women

Active, not recruiting
N/A
60
Canada
Forteo
University Health Network, Toronto, Eli Lilly and Company
Osteoporosis
01/24
01/25
Shapiro, Colin M
SUVN-G3031, NCT04072380: A Study to Evaluate Safety, and Efficacy of (Samelisant) in Patients With Narcolepsy With and Without Cataplexy

Completed
2
190
Canada, US
SUVN-G3031, Samelisant, Placebo
Suven Life Sciences Limited
Narcolepsy
06/23
06/23
NCT06247878: Skiin-PSG Sleep Apnea

Recruiting
N/A
200
Canada
Skiin underwear chest band
Myant Medical Corp., Jodha Tishon Inc
Obstructive Sleep Apnea
10/24
02/25
Hudson, Chris
NCT05903651: Retinal Deep PhenotypingTM

Completed
N/A
813
Canada
Optina Diagnostics Inc.
Healthy
03/24
03/24
Chan, Vincent
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
Kennedy, Sidney H
NCT05711940: Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

Recruiting
3
568
Europe, Canada, US, RoW
Psilocybin, COMP360
COMPASS Pathways
Treatment Resistant Depression
03/25
05/25
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression

Completed
2
197
Canada, US
Liafensine, Placebo
Denovo Biopharma LLC
Treatment Resistant Depression
02/24
03/24
Menard, Cynthia
PATRON, NCT04557501: PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer

Active, not recruiting
3
800
Canada
PSMA PET/CT guided intensification of therapy, Control Arm
Centre hospitalier de l'Université de Montréal (CHUM), Canadian Cancer Society (CCS), Lantheus Medical Imaging, British Columbia Cancer Agency, London Health Sciences Centre, Princess Margaret Hospital, Canada, Tom Baker Cancer Centre, McMaster University, Institute of Health Economics, Canada, Queen's University
Prostate Cancer
01/29
01/29
Lozano, Andres
NCT02252380: ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders

Active, not recruiting
N/A
10
Canada
Transcranial ExAblate System, MRgFUS, Focused Ultrasound, FUS
InSightec
Movement Disorders, Essential Tremor, Holmes Tremor, Parkinson's Disease, Wilson's Disease, Huntington's Disease, Dystonia, Tardive Dyskinesia, Orofacial Dyskinesias
06/23
12/23
CAN-PRIME, NCT06700304: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices

Recruiting
N/A
6
Canada
N1 Implant, R1 Robot
Neuralink Corp, University Health Network, Toronto
Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis (ALS), Spinal Cord Injury (Quadraplegia), Spinal Cord Injury
11/27
11/30
Bril, Vera
NIMBLE, NCT05070858 / 2020-003272-41: A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis

Recruiting
3
235
Europe, Canada, Japan, US, RoW
Pozelimab + Cemdisiran, Cemdisiran, ALN-CC5, Placebo, Pozelimab, REGN3918
Regeneron Pharmaceuticals
Generalized Myasthenia Gravis
05/25
03/28
NEPTUNE-17, NCT05838755: A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain

Active, not recruiting
2
145
Europe, Canada, Japan, US, RoW
GSK3858279, Placebo
GlaxoSmithKline
Pain
10/24
01/25
Chan, Iris
WATER IV PCa, NCT06651632: WATER IV Prostate Cancer

Not yet recruiting
N/A
280
Europe, Canada, US, RoW
Aquablation Therapy, Radical Prostatectomy
PROCEPT BioRobotics
Localized Prostate Cancer
07/27
01/37
NCT04309695: The Zenflow Spring System Safety and Performance Study (ZEST CAN)

Recruiting
N/A
40
Canada
Zenflow Spring System
Zenflow, Inc.
Benign Prostatic Hyperplasia
12/25
01/26
Rajan, Dheeraj
AV PAS, NCT03506308: Post Approval Study Investigating Lutonix Drug Coated Balloon for Treatment of Dysfunctional Arteriovenous Fistulae

Recruiting
N/A
213
Canada, US
LUTONIX 035 Drug Coated Balloon PTA Catheter
C. R. Bard
Arteriovenous Fistula
09/25
03/30
WAVE, NCT04540302: The Merit WRAPSODY AV Access Efficacy Study

Active, not recruiting
N/A
357
Europe, Canada, US, RoW
Merit WRAPSODY Endovascular Stent Graft, PTA
Merit Medical Systems, Inc.
Venous Stenosis, Venous Occlusion
02/24
01/26
WRAP, NCT05062291: Merit SODY™ Endoprosthesis for Treatment of Stenosis or Occlusion

Recruiting
N/A
500
Europe, RoW
Merit WRAPSODY Endovascular Stent Graft
Merit Medical Systems, Inc.
Venous Stenosis, Venous Occlusion
12/25
07/27
Ferguson, Niall D
PROMIZING, NCT02447692: Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The Study

Completed
N/A
575
Europe, Canada, RoW
PSV ventilation strategy, PAV+ ventilation strategy
Lawson Health Research Institute, Canadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group
Critically Ill, Acute Respiratory Failure
07/24
07/24
Wong, David
NCT05372419: A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Color

Active, not recruiting
3
80
US
Lebrikizumab, LY3650150, DRM06
Eli Lilly and Company
Atopic Dermatitis
05/24
02/25
STARLIGHT, NCT06613698: A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 65 Years With Alcohol-related Liver Disease

Not yet recruiting
2
393
Europe, Canada, Japan, US, RoW
GSK4532990, Placebo
GlaxoSmithKline
Liver Diseases, Alcoholic
12/26
03/27
NCT03692897: An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection

Recruiting
N/A
5000
Canada, US
All approved therapies for the treatment of Chronic Hepatitis B (CHB)
Target PharmaSolutions, Inc.
Hepatitis B, Hepatitis, Liver Diseases
01/26
01/26
Lau, Johnny
NCT00552136: Canadian Orthopaedic Foot and Ankle Society Surgical Treatment of Ankle Arthritis Outcome Study

Active, not recruiting
N/A
250
Canada
Ankle Arthroplasty, Replacement, Ankle Arthrodesis, Fusion
Nova Scotia Health Authority, Canadian Orthopaedic Foot and Ankle Society, Johnson & Johnson
Ankle Arthritis
04/30
04/30
Andrade, Danielle
TrustTSC, NCT05323734 / 2021-003441-38: Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy

Completed
3
128
Europe, Canada, US, RoW
Ganaxalone, Placebo
Marinus Pharmaceuticals, Marinus Pharmaceuticals Inc., Marinus Pharmaceuticals, Inc.
Tuberous Sclerosis Complex
09/24
10/24
ARGUS, NCT04462770 / 2021-003425-30: A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

Recruiting
2
100
Europe, Canada, US, RoW
EPX-100 (clemizole HCl), Placebo
Epygenix, Harmony Biosciences, LLC
Dravet Syndrome
04/26
05/26
Laxton, Adrian W
NCT03622905: ADvance II Study: DBS-f in Patients With Mild Alzheimer's Disease

Completed
N/A
74
Europe, Canada, US
DBS-f On, DBS Off
Functional Neuromodulation Ltd
Alzheimer Disease
02/24
02/24
NCT05124912: REMASTer: REcurrent Brain Metastases After SRS Trial

Recruiting
N/A
261
US
Radiation Therapy, Steroid Therapy, Laser Interstitial Thermal Therapy
Monteris Medical
Brain Metastases, Radiation Necrosis, Recurrent Tumor, Recurrent Metastases
12/26
10/28
Brent, Michael
INSITE-DME, NCT05610319: Treat & Extend Versus Fixed Dosing with Faricimab for Management of Diabetic Macular Edema: a Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial

Active, not recruiting
4
446
Europe, Canada, US, RoW
Faricimab
McMaster University, Hoffmann-La Roche
Diabetic Macular Edema
12/26
12/26
Shah, Chirag
NCT05872269: A Study to Evaluate the Safety and Effectiveness of Saroglitazar 4 mg in Patients With NAFLD With Comorbidities

Recruiting
4
1500
RoW
Saroglitazar
Zydus Lifesciences Limited
NAFLD, Obesity, Type 2 Diabetes, Dyslipidemias, Metabolic Syndrome
01/25
06/25
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis

Active, not recruiting
N/A
270
Europe, US
RheOx Bronchial Rheoplasty, Sham Procedure
Gala Therapeutics, Inc.
Chronic Bronchitis
05/24
10/25
CASE5Y21, NCT05142358: A Prospective Study to Evaluate Continuous Positive Airway Pressure Devices to Reduce Pulmonary Dose

Recruiting
N/A
90
US
Continuous Positive Airway Pressure, CPAP, Deep inspiratory breath hold, DIBH, Free Breath, Without DIBH
Case Comprehensive Cancer Center, Varian Medical Systems
Lung Cancer, Left Sided Breast Cancer
06/25
12/25
PREDICT, NCT03448926: The Registry:

Recruiting
N/A
3000
US
Treatment Recommendation Surveys, 7-gene biosignature
PreludeDx, University of South Florida
DCIS
12/25
12/35
Lewis, Stephen
CADS, NCT04194138: Complex Adult Deformity Surgery

Recruiting
N/A
500
Canada, US
Index or spine revision surgery for complex adult spinal deformity
International Spine Study Group Foundation, Medtronic, Globus Medical Inc, SI-BONE, Inc.
Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
12/31
07/32
Chung, Frances
MAC-VITAL, NCT04976907: Peri-operative Mobile Application for Contactless Screening and Vital Signs Measurement

Not yet recruiting
N/A
200
Canada
Contactless vital sign information collection
Nuralogix Corporation, University Health Network, Toronto, Hamilton Health Sciences Corporation
Vital Signs
10/22
10/22
Wills, Anne-Marie A
LIGHTHOUSE, NCT05418673 / 2022-000747-77: A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale

Terminated
3
7
Europe, US
BIIB122, DNL151, BIIB122-Matching Placebo
Biogen, Denali Therapeutics Inc.
Parkinson Disease
07/23
07/23
ORION, NCT06122662: AMX0035 and Progressive Supranuclear Palsy

Active, not recruiting
2/3
110
Europe, US
AMX0035, Placebo
Amylyx Pharmaceuticals Inc.
Progressive Supranuclear Palsy, PSP, Neurodegenerative Diseases, Atypical Parkinsonism
04/26
11/29
PROSPER, NCT06355531: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)

Recruiting
2
220
Europe, US
FNP-223, Placebo
Ferrer Internacional S.A.
Progressive Supranuclear Palsy
11/26
11/26
LUMA, NCT05348785 / 2021-004849-20: A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80

Recruiting
2
640
Europe, Canada, Japan, US, RoW
BIIB122, DNL151, BIIB122-Matching Placebo
Biogen, Denali Therapeutics Inc.
Parkinson Disease
12/25
12/25
NCT05923866: A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy

Recruiting
2
80
US
ONO-2808, Placebo
Ono Pharmaceutical Co. Ltd
Multiple System Atrophy (MSA)
08/25
08/25
NCT05956834: A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes

Recruiting
N/A
60
US
PAMSys, LEGSys
Massachusetts General Hospital, Johns Hopkins University, BioSensics
PSP, CBD, Progressive Supranuclear Palsy, FTD, Corticobasal Degeneration, Frontotemporal Dementia, Frontotemporal Lobar Degeneration
12/25
12/26
Jackson, Timothy L
NCT06002906: The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.

Recruiting
4
300
Canada
Indocyanine green, SPY AGENT GREEN, Stryker 1688 AIM system
University Health Network, Toronto, Stryker Endoscopy
Ulcer, Gastric, Obesity, Morbid
12/24
12/26
NCT01191151: Web Based Orthopaedic Sports Medicine Registry

Terminated
N/A
12500
Europe, Canada, US, RoW
Arthrex, Inc.
Degenerative and Traumatic Pathology of the Knee, Degenerative and Traumatic Pathology of the Shoulder and Elbow, Degenerative and Traumatic Pathology of the Foot and Ankle, Degenerative and Traumatic Pathology of the Hand and Wrist, Degenerative and Traumatic Pathology of the Hip
07/23
07/23
NCT06467955: MagDI Canada Study

Recruiting
N/A
60
Canada
Magnet System, DI Biofragmentable
GT Metabolic Solutions, Inc.
Obesity, Type 2 Diabetes
03/26
05/26
QUANTUM, NCT05841862: Intravitreal Quantum Dots (QD) for Advanced Retinitis Pigmentosa (RP)

Not yet recruiting
N/A
20
NA
2C-QD, Sham 2C-QD
2C Tech Corp, ORA, Inc.
Retinitis Pigmentosa
03/25
03/25
Lam, Wai-Ching
INSITE-DME, NCT05610319: Treat & Extend Versus Fixed Dosing with Faricimab for Management of Diabetic Macular Edema: a Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial

Active, not recruiting
4
446
Europe, Canada, US, RoW
Faricimab
McMaster University, Hoffmann-La Roche
Diabetic Macular Edema
12/26
12/26
Cheng, Richard
MUSIC-HFrEF1, NCT04703842: Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

Recruiting
1/2
57
US
SRD-001, Placebo
Sardocor Corp., Covance
Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
12/25
12/28
ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting
N/A
100
Europe, Canada, US
Edwards APTURE transcatheter shunt system, Sham procedure
Edwards Lifesciences
Heart Failure
01/26
07/30
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Singh, Mandeep
POLARIS, NCT06435000: An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

Recruiting
N/A
75
Europe, US
Splice Bio
Stargardt, Stargardt's Disease, Stargardt Disease, STGD1
12/26
02/27
Shah, Hemant
RESOLUTION, NCT04417257: Study of LAU-7b for the Treatment of COVID-19 Disease in Adults

Completed
2/3
125
Canada, US
LAU-7b, fenretinide, Placebo oral capsule
Laurent Pharmaceuticals Inc.
COVID-19 Disease
02/24
05/24
Tartaglia, Carmela
COMPASS-ND, NCT03402919: Comprehensive Assessment of Neurodegeneration and Dementia

Recruiting
N/A
2300
Canada
McGill University, Canadian Institutes of Health Research (CIHR), Alzheimer Society of Canada, Sanofi, New Brunswick Health Research Foundation, Saskatchewan Health Research Foundation, Women's Brain Health Initiative, Michael Smith Foundation for Health Research, Alzheimer's Research UK, Alberta Prion Research Institute, Nova Scotia Health Research Foundation, Eli Lilly and Company, Canadian Nurses Foundation (CNF), Ontario Brain Institute, Consortium pour l'Identification precoce du Maladie Alzheimer du Quebec, Pfizer, Canadian Consortium on Neurodegeneration in Aging
Dementia
09/23
09/23
BEAM, NCT02524405: Brain-Eye Amyloid Memory Study

Recruiting
N/A
345
Canada
Pittsburgh Compound B [11C]-PIB
Sunnybrook Health Sciences Centre, Brain Canada, Weston Brain Institute, GE Healthcare, University Health Network, Toronto, Centre for Addiction and Mental Health, Baycrest, Unity Health Toronto, Kensington Eye Institute
Alzheimer's Disease, Mild Cognitive Impairment, Vascular Cognitive Impairment, Parkinson's Disease, Lewy Body Disease
03/25
03/25
PIOTIN, Michel
NCT04236856: CorPath® GRX Neuro Study

Completed
N/A
120
Europe, Canada, RoW
Robotic Endovascular Procedure, CorPath GRX System
Corindus Inc.
Intracranial Aneurysm, Subarachnoid Hemorrhage, Headache
04/22
10/22
FIRST, NCT04034810: Safety and Efficacy of Silk Vista and Silk Vista Baby Flow Diverter for Intracranial Aneurysm Treatment

Active, not recruiting
N/A
234
Europe, RoW
Intracranial aneurysm treated with Silk vista and silk vista baby
Balt Extrusion
Intracranial Aneurysm
03/23
11/27
IMPACT, NCT04572230: International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach

Active, not recruiting
N/A
405
Europe
Endovascular treatment of intracranial aneurysms using a flow-diverting stent
Stryker Neurovascular
Intracranial Aneurysm
09/24
09/25
SEALANT, NCT04999423: LVIS™ Evo™ and HydroCoil® Embolic System for Intracranial Aneurysm Treatment

Active, not recruiting
N/A
206
Europe
LVIS EVO and HydroCoil Embolic System
Microvention-Terumo, Inc.
Intracranial Aneurysm
03/25
12/26
Vaickus, Lou
NCT04679194: Study of Mana 312 (Multi Tumor-Associated Antigen T Cells) in Adults With AML/MDS After HSCT

Terminated
1
11
US
Mana 312
Mana Therapeutics
AML/MDS
03/23
03/23
NCT03364400: Phase 1 Study Evaluating VT1021 in Patients With Advanced Solid Tumors

Active, not recruiting
1
116
US
VT1021
Vigeo Therapeutics, Inc.
Solid Tumor
01/24
06/24
Skaro, Anton
NCT04512469: Study on the Efficacy of Prophylactic on Lay Mesh in Preventing Post-operative Hernia in Liver Transplant Patients

Not yet recruiting
N/A
100
NA
Low molecular weight mesh
Lawson Health Research Institute, Ethicon, Inc.
Incisional Hernia of Anterior Abdominal Wall
09/24
09/26
Budzik, Ronald
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device

Recruiting
N/A
180
US
WEB
Microvention-Terumo, Inc.
Wide Neck Bifurcation Intracranial Aneurysms
12/25
12/29
NCT05409989: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study

Recruiting
N/A
154
US
FRED™ X™, Flow Re-Direction Endoluminal Device X
Microvention-Terumo, Inc.
Intracranial Aneurysm
09/29
11/29
Fasano, Alfonso
NCT06325852: Directional Bilateral Thalamic Patterned Stimulation (Chronos)

Recruiting
N/A
15
Canada
DBS programing
Alfonso Fasano, Boston Scientific Corporation
Essential Tremor
04/26
01/27
NCT05363046: Noninterventional Study Evaluating Parkinson's Disease Diary Use

Active, not recruiting
N/A
194
Europe, Canada, US
BlueRock Therapeutics
Parkinson's Disease
10/25
10/26
Chahal, Jas
SECURE, NCT04537013: Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

Recruiting
N/A
234
Europe, Canada, US
Microfracture, Microfracture plus placement of Chondro-Gide® ACC
Geistlich Pharma AG, Telos Partners
Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
11/24
11/26
Tartaglia, Maria Carmela
ENVISION, NCT05310071 / 2022-001671-14: A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease

Terminated
3
1027
Europe, Canada, Japan, US, RoW
Aducanumab, BIIB037, Aducanumab-avwa, Aduhelm, Placebo
Biogen, Biogen Idec Research Limited
Alzheimer's Disease
08/24
08/24
PROGRESS-AD, NCT06079190: Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease

Recruiting
2
282
Europe, Canada, US, RoW
GSK4527226, Placebo
GlaxoSmithKline, Alector Inc.
Alzheimer's Disease
12/26
02/29
Okrainec, Allan
NCT06002906: The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.

Recruiting
4
300
Canada
Indocyanine green, SPY AGENT GREEN, Stryker 1688 AIM system
University Health Network, Toronto, Stryker Endoscopy
Ulcer, Gastric, Obesity, Morbid
12/24
12/26
NCT06467955: MagDI Canada Study

Recruiting
N/A
60
Canada
Magnet System, DI Biofragmentable
GT Metabolic Solutions, Inc.
Obesity, Type 2 Diabetes
03/26
05/26
Elterman, Dean S
NCT05186740: ProVee Urethral Expander System IDE Study (ProVIDE)

Active, not recruiting
N/A
225
Europe, Canada, US
ProVee Urethral Expander System, ProVee Expander, ProVee, Urethral Access Sheath
ProVerum Medical
Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms
03/24
12/28
NCT04309695: The Zenflow Spring System Safety and Performance Study (ZEST CAN)

Recruiting
N/A
40
Canada
Zenflow Spring System
Zenflow, Inc.
Benign Prostatic Hyperplasia
12/25
01/26
Rootman, David S
NCT05694247: Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness

Recruiting
N/A
40
Europe, Canada, RoW
CorNeat KPro
CorNeat Vision Ltd.
Corneal Disease, Corneal Opacity, Corneal Injuries
03/25
03/26
Ellenbogen, Aaron
NCT05357989 / 2022-001542-38: A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD

Completed
3
523
Europe, US
buntanetap/posiphen, Posiphen Tartrate, ANVS401, Placebo
Annovis Bio Inc., TFS Trial Form Support
Parkinson's Disease, Idiopathic
12/23
12/23
TEMPO-3, NCT04542499 / 2019-002951-40: Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations

Completed
3
507
Europe, US, RoW
Tavapadon, PF-06649751, CVL-751, Placebo
Cerevel Therapeutics, LLC
Parkinson Disease
01/24
02/24
TRAILBLAZER-ALZ 6, NCT05738486: A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease

Active, not recruiting
3
800
Europe, US
Donanemab, LY3002813, Placebo
Eli Lilly and Company
Alzheimer's Disease, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Neurodegenerative Diseases, Neurocognitive Disorders, Mental Disorders
05/24
05/25
TRAILRUNNER-ALZ 3, NCT06653153: A Study of Remternetug (LY3372993) in Early Alzheimer's Disease

Recruiting
3
1200
Europe, Canada, Japan, US, RoW
Remternetug, LY3372993, Placebo
Eli Lilly and Company
Alzheimer's Disease
04/29
10/30
NCT05686044: A Dose-ranging Study to Investigate Efficacy of Buntanetap in Mild to Moderate AD

Completed
2/3
320
US
Buntanetap/Posiphen, Posiphen Tartrate, Placebo
Annovis Bio Inc.
Alzheimer Disease
02/24
02/24
ORION, NCT06122662: AMX0035 and Progressive Supranuclear Palsy

Active, not recruiting
2/3
110
Europe, US
AMX0035, Placebo
Amylyx Pharmaceuticals Inc.
Progressive Supranuclear Palsy, PSP, Neurodegenerative Diseases, Atypical Parkinsonism
04/26
11/29
NCT04845178: Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults

Completed
2
797
NA
ABP-450, prabotulinumtoxinA, Placebo, 0.9% sodium chloride, saline
AEON Biopharma, Inc., PPD
Migraine
06/24
08/24
PROSPER, NCT06355531: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)

Recruiting
2
220
Europe, US
FNP-223, Placebo
Ferrer Internacional S.A.
Progressive Supranuclear Palsy
11/26
11/26
NCT06538116: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease

Recruiting
2
300
Japan, US
Mevidalen, LY3154207, Placebo
Eli Lilly and Company
Alzheimer Disease
12/25
01/26
NCT06006247: Early Parkinson's Disease Monotherapy With CVN424

Active, not recruiting
2
62
US
CVN424 150 mg, Placebo
Cerevance Beta, Inc.
Parkinson's Disease
10/24
02/25
NCT05526391 / 2022-000336-28: A Study of TAK-341 in Treatment of Multiple System Atrophy

Active, not recruiting
2
159
Europe, Japan, US
TAK-341, MEDI1341, Placebo
Takeda, AstraZeneca
Multiple System Atrophy
07/25
07/25
LUMA, NCT05348785 / 2021-004849-20: A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80

Recruiting
2
640
Europe, Canada, Japan, US, RoW
BIIB122, DNL151, BIIB122-Matching Placebo
Biogen, Denali Therapeutics Inc.
Parkinson Disease
12/25
12/25
NCT04680065: GDNF Gene Therapy for Multiple System Atrophy

Recruiting
1
9
US
AAV2-GDNF gene therapy, Sham (Placebo) Surgery
Brain Neurotherapy Bio, Inc.
Multiple System Atrophy
12/25
12/28
NCT05699460: Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy

Active, not recruiting
N/A
150
Europe, US
This is an observational study.
Asklepios Biopharmaceutical, Inc.
Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
08/25
10/25
Pereira, Vitor Mendes
NCT06165341: Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Recruiting
3
50
Europe, Canada, US
Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo
Takeda
Alpha1-Antitrypsin Deficiency
08/28
08/28
NCT05677971: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Recruiting
3
160
Europe, Canada, US, RoW
Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo, Sodium chloride
Takeda, Takeda Development Center Americas, Inc.
Alpha1-Antitrypsin Deficiency
03/27
03/29
 

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