Atrium Health
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 98 Trials 
947 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Monk, Bradley
CALLA, NCT03830866 / 2018-002872-42: Study of Durvalumab With Chemoradiotherapy for Women With Locally Advanced Cervical Cancer

Hourglass Jan 2022 - Dec 2023 : Submission in Japan for cervical cancer based on CALLA trial
Hourglass Jan 2022 - Dec 2023 : Regulatory submission in EU for cervical cancer based on CALLA trial
Checkmark Presentation of data from CALLA trial for advanced cervical cancer at IGCS 2022
Sep 2022 - Sep 2022: Presentation of data from CALLA trial for advanced cervical cancer at IGCS 2022
Checkmark From CALLA trial for advanced cervical cancer
More
Completed
3
770
Europe, Japan, US, RoW
Durvalumab, Cisplatin, Carboplatin, external beam radiation therapy (EBRT) + brachytherapy
AstraZeneca
Locally Advanced Cervical Cancer
01/22
07/23
UP-NEXT, NCT05329545: Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer

Terminated
3
20
Canada, US, RoW
Upifitimab rilsodotin, XMT-1536 Antibody Drug Conjugate, Placebo
Mersana Therapeutics, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT)
High Grade Serous Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
09/23
09/23
EPIK-O, NCT04729387 / 2019-004682-40: Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected

Active, not recruiting
3
358
Europe, Canada, US, RoW
Alpelisib, BYL719, Olaparib, Paclitaxel, Pegylated liposomal doxorubicin (PLD)
Novartis Pharmaceuticals
Ovarian Cancer
04/23
06/25
ATHENA, NCT03522246 / 2017-004557-17: A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

Checkmark From monotherapy portion of P3 ATHENA trial for 1L ovarian cancer maintenance setting at IGCS 2022
Sep 2022 - Sep 2022: From monotherapy portion of P3 ATHENA trial for 1L ovarian cancer maintenance setting at IGCS 2022
Checkmark Submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
Sep 2022 - Sep 2022: Submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
Checkmark Type II variation submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
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Active, not recruiting
3
1097
Europe, Canada, Japan, US, RoW
Rucaparib, Rubraca, CO-338, Nivolumab, Opdivo, BMS-936558, Placebo Oral Tablet, Placebo IV Infusion
pharmaand GmbH, Bristol-Myers Squibb, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT), Foundation Medicine
Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed, FIGO Stage III-IV, Partial Response, Complete Response
05/24
12/30
ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer
Recruiting
3
220
Europe, Canada, US, RoW
Selinexor, KPT-330, Matching Placebo for selinexor
Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group
Endometrial Cancer
01/25
01/28
RAMP 301, NCT06072781: A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Recruiting
3
270
Europe, Canada, US, RoW
avutometinib, avutometinib (VS-6766), Defactinib, defactinib (VS-6063), Pegylated liposomal doxorubicin, Caelyx, Doxil, Lipodox, Paclitaxel, Nov-Onxol, Onxol, Navaplus, Taxol, Letrozole, Femara, Anastrozole, Arimidex
Verastem, Inc., GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Australia New Zealand Gynaecological Oncology Group, Korean Gynecologic Oncology Group
Low Grade Serous Ovarian Cancer
10/28
02/31
TETON, NCT04814108: A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma

Recruiting
2
76
Canada, US, RoW
ZN-c3, azenosertib, KP-2638
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Uterine Serous Carcinoma
11/24
05/25
PROFECTA-II, NCT04374630: Study with Afuresertib and Paclitaxel in Platinum Resistant Ovarian

Completed
2
150
US, RoW
Paclitaxel, Afuresertib, LAE002
Laekna Limited
Platinum-resistant Ovarian Cancer
07/23
06/24
NCT04998669: Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma

Recruiting
2
100
US
Loncastuximab tesirine, ADCT-402, Rituximab, Rituxan
Juan P. Alderuccio, MD, ADC Therapeutics S.A.
Follicular Lymphoma
08/27
08/30
ENGOT-ov60, NCT04625270 / 2020-004264-26: A Study of Avutometinib (VS-6766) V. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer with and Without a KRAS Mutation

Active, not recruiting
2
225
Europe, Canada, US
avutometinib (VS-6766), avutometinib (VS-6766) and defactinib, avutometinib (VS-6766) and VS-6063
Verastem, Inc., European Network of Gynaecological Oncological Trial Groups (ENGOT), GOG Foundation
Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
11/24
12/26
DENALI, NCT05128825: A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
2
170
Europe, US, RoW
azenosertib, ZN-c3
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
12/26
06/27
PRESERVE-004, NCT05446298: ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer

Active, not recruiting
2
58
US
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody made by OncoC4, Inc., Pembrolizumab, MK3475, Keytruda
OncoC4, Inc., Merck Sharp & Dohme LLC, GOG Foundation
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
06/25
06/26
ACR-368-201, NCT05548296: A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

Recruiting
1/2
390
US
ACR-368, prexasertib, Gemcitabine, OncoSignature
Acrivon Therapeutics, GOG Foundation
Platinum-resistant Ovarian Cancer, Endometrial Adenocarcinoma, Urothelial Carcinoma
07/26
12/27
Brennan, Michael T
NCT06233591: Evaluating LP-10 in Subjects With OLP

Recruiting
2
24
US
LP-10 (Liposomal Tacrolimus)
Lipella Pharmaceuticals, Inc.
Oral Lichen Planus
09/25
03/26
AQUAX2, NCT05926765: A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

Recruiting
2
120
Europe, Canada, US
AAV2-hAQP1 Concentration 1, AAV2-hAQP1 Concentration 2, Placebo
MeiraGTx, LLC
Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
07/25
07/25
ORARAD II, NCT05325970: Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
350
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Diseases, Osteoradionecrosis
06/25
06/25
ORARAD, NCT02057510: Observational Study of Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
575
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Disease, Xerostomia, Osteoradionecrosis
06/25
06/25
Iannitti, David A
DHF-01-SFT-194, NCT05385952: GATT-Patch Versus TachoSil in Liver Surgery

Completed
N/A
131
Europe, US
GATT-Patch, TachoSil
GATT Technologies BV, Syneos Health
Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases
05/24
05/24
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
NCT05900037: GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery

Recruiting
N/A
50
US
GATT-Patch, SURGICEL® Original, Surgicel Absorbable Hemostat
GATT Technologies BV
Intraoperative Bleeding, Liver Diseases, Gallbladder Diseases, Hemorrhage, Surgical
04/25
09/25
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Schwartz, Matthew W
FUEL-2, NCT05918211: Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

Recruiting
3
436
US, RoW
Udenafil, Placebo
Mezzion Pharma Co. Ltd
Single Ventricle Heart Disease
10/25
10/25
NCT05077774: Harmony TPV Post-Approval Study

Recruiting
N/A
150
Canada, US
Harmony TPV System, Model Numbers: HARMONY-22, HARMONY-25, and HARMONY-DCS
Medtronic Cardiovascular
Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
10/25
03/35
COMPASS, NCT05268094: Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The Trial)

Recruiting
N/A
300
Canada, US
Ductal Arterial Stent, Medtronic Resolute Onyx, Boston Scientific Promus Elite/Premier, Boston Scientific Synergy, Cordis Elunir, Abbott Xience, Systemic-to-Pulmonary Artery Shunt
Carelon Research, Pediatric Heart Network
Congenital Heart Disease in Children
09/26
04/27
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Osunkwo, Ifeyinwa
SPARTAN, NCT03938454: A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism

Completed
2
36
US
Crizanlizumab, SEG101
Novartis Pharmaceuticals
Priapism
03/23
11/23
Lodhia, Nilesh
VERDICT, NCT04259138 / 2019-002485-12: Determination of the Optimal Treatment Target in Ulcerative Colitis

Active, not recruiting
4
672
Europe, Canada, US, RoW
Treatment Algorithm A, vedolizumab, Treatment Algorithm B, Treatment Algorithm C
Alimentiv Inc., Takeda Development Center Americas, Inc.
Colitis, Ulcerative
03/26
03/26
Murphy, Erin S
NCT06368817: A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Recruiting
2
240
Canada, US, RoW
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D radiotherapy, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Three dimensional external beam radiation therapy (procedure), Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Intensity-Modulated Radiation Therapy, IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Lumbar Puncture, LP, Spinal Tap, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Questionnaire Administration, Surgical Procedure, Operation, Surgery, Surgery Type, Surgery, NOS, Surgical, Surgical Intervention, Surgical Interventions, Surgical Procedures, Type of Surgery
Children's Oncology Group
Basal Ganglia Germinoma, Central Nervous System Germinoma, Diabetes Insipidus, Pineal Region Germinoma, Suprasellar Germinoma, Thalamic Germinoma
11/33
11/33
NCT01891318: Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

Recruiting
1/2
36
US
radiosurgery, radiation surgery, therapeutic conventional surgery, quality-of-life assessment, quality of life assessment
Case Comprehensive Cancer Center
Tumors Metastatic to Brain
06/25
06/25
KQB198-102, NCT06645886: A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

Recruiting
1
122
Europe, US
KQB198, Dasatinib
Kumquat Biosciences Inc.
Hematologic Malignancies, Adult
08/27
02/28
NCT06090409: Encouraging a Plant Based Diet in an Underserved Urban Population

Recruiting
N/A
300
US
Implementing free/subsidized agricultural produce to encourage a plant-based diet.
University of Louisville, Oatly Group AB
Food Neophobia, Food Preferences, Dietary Habits
12/24
12/24
NCT05409976: The GORE® VIAFORT Vascular Stent IVC Study

Active, not recruiting
N/A
112
Europe, US, RoW
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
05/26
05/30
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study

Recruiting
N/A
165
US
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
03/26
03/31
Mehta, Rohit
NCT01424592: In-Hospital Portable Sleep Monitoring for the Evaluation of Obstructive Sleep Apnea (OSA)

Active, not recruiting
N/A
140
US
Testing with a portable sleep apnea monitor ., Alice PDx portable sleep testing system (Philips Respironics, Murraysville, PA)
John H. Stroger Hospital
Obstructive Sleep Apnea
06/22
12/24
RECTIFY, NCT05471973: CIED Infection Quality Initiative Demonstration Project

Recruiting
N/A
200
US
Multidisciplinary Team, Outreach Visits, Multifaceted Intervention, Measurement and Feedback
Duke University, Duke Clinical Research Institute, Philips Healthcare
Infections
12/25
12/25
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Recruiting
N/A
620
US
OPTIMIZER Smart System
Impulse Dynamics
Heart Failure
03/26
03/26
Magge, Sheela N
DISCOVERY, NCT06525259: of Risk Factors for Type 2 Diabetes in Youth

Recruiting
N/A
3600
US
George Washington University
Diabetes Mellitus Type 2, Childhood-Onset
01/28
01/28
Runyon, Michael
NCT04361123: Atrium COVID-19 Syndromic and Serologic Surveillance

Enrolling by invitation
N/A
450000
US
daily syndromic surveillance, monthly serologic IgM/G test
Michael Runyon, MD
Coronavirus, COVID
12/21
12/21
Taylor, Stephanie
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy

Terminated
4
6
US
Placebo, Rifaximin, XIFAXAN® Tablets
Bausch Health Americas, Inc.
Hepatic Encephalopathy
02/16
02/16
EAGLE-1, NCT04010539 / 2018-001780-23: A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea

Completed
3
628
Europe, US, RoW
Gepotidacin, Ceftriaxone, Azithromycin
GlaxoSmithKline, BARDA
Gonorrhea
10/23
10/23
NCT05790239: MDMA-Assisted Therapy for Veterans with Moderate to Severe Post Traumatic Stress Disorder

Recruiting
2
40
US
3,4-methylenedioxymethamphetamine, MDMA, d-amphetamine, Therapy
Stephen Robert Marder
Post Traumatic Stress Disorder
03/26
03/26
ENCOMPASS, NCT04495946: Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship

Completed
N/A
4018
US
Sepsis Transition and Recovery (STAR) program, Usual care
Wake Forest University Health Sciences, National Institute of Nursing Research (NINR)
Sepsis
04/24
04/24
NCT05097521: Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health

Completed
N/A
3726
US
Practitioner-delivered CIH therapies (acupuncture, therapeutic massage, chiropractic care) as received in VHA and community practice settings, Self-care CIH therapies (yoga, Tai Chi/Qigong , meditation) as received in VHA and community practice settings, Combination of practitioner-delivered and self-care CIH therapies (described above) as received in VHA and community practice settings
VA Office of Research and Development, Veterans Health Administration Office of Patient Centered Care & Cultural Transformation
Chronic Musculoskeletal Pain
09/23
09/23
Roses, Robert
EA2197, NCT04559139: Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer

Recruiting
2/3
186
US
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone''s Chloride, Peyrone''s Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, FF 10832, FF-10832, FF10832, Gemcitabine HCI, Gemzar, LY-188011, LY188011, Lymphadenectomy, excision of the lymph node, Lymph Node Dissection, lymph node excision, Partial Hepatectomy, partial excision of liver, subtotal hepatectomy
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8, Stage IIB Gallbladder Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8, Stage IIIA Gallbladder Cancer AJCC v8, Stage IIIB Gallbladder Cancer AJCC v8
06/29
06/29
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Farber, Alik
NCT03903692: A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

Terminated
N/A
62
US
Marine polysaccharide dressing, Carboxymethylcellulose dressing
Medline Industries
Venous Leg Ulcer
12/22
12/22
NCT04927702: Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)

Terminated
N/A
47
US
Synthetic Hybrid-Scale Fiber Matrix, Restrata, Standard of Care, Living Cellular Skin Substitute, Apligraf
Acera Surgical, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
07/24
08/24
NCT05313165: PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

Recruiting
N/A
100
US
LimFlow Stent Graft System
LimFlow, Inc.
Critical Limb Ischemia, Chronic Limb-Threatening Ischemia, Peripheral Arterial Disease
05/27
05/27
Ujiki, Michael
FLOWS, NCT06454916: Functional Lumen Opening With Self-Forming Magnetic Anastomosis

Active, not recruiting
N/A
70
US
Small Bowel Anastomosis with Flexagon SFM Device with OTOLoc
GI Windows, Inc.
Small Bowel Anastomosis
06/25
08/25
ENF 18-06, NCT04718168: GORE® ENFORM Biomaterial Product Study

Recruiting
N/A
245
US
Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal)
W.L.Gore & Associates
Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
09/26
09/26
NCT04578340: Long Term Outcomes Following Hernia Repair With Mesh

Recruiting
N/A
4700
US
NorthShore University HealthSystem, Medtronic
Abdominal Hernia
10/25
10/26
RETHINK REFLUX, NCT04253392: Registry

Active, not recruiting
N/A
500
Europe, US, RoW
LINX Reflux Management System, LINX
Ethicon Endo-Surgery
Gastroesophageal Reflux
07/32
07/32
Myers, Erinn
LOVE, NCT04680897: Trial: Limits On Vaginal Intercourse After Mid-urEthral Sling

Completed
N/A
155
US
Early restriction release, Standard restriction recommendation
Wake Forest University Health Sciences
Patient Satisfaction, Female Sexual Dysfunction
09/24
09/24
Arko, Frank
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms

Approved for marketing
N/A
US
GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aneurysm
 
 
ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease

Active, not recruiting
N/A
344
US
Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting
Silk Road Medical
Carotid Artery Diseases
09/25
09/25
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

Active, not recruiting
N/A
102
Europe, US
GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aortic Aneurysm
01/23
09/26
SOCRATES, NCT04503395: ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR:

Recruiting
N/A
204
Europe, US
ESAR treatment: Endograft + Heli-FX Endoanchor, FEVAR treatment : Fenestrated endograft
FCRE (Foundation for Cardiovascular Research and Education), Medtronic
Aortic Aneurysm, Abdominal
06/26
06/28
IMPROVE-AD, NCT06087029: IMPRoving Outcomes in Vascular DisEase- Aortic Dissection

Recruiting
N/A
1100
US
TEVAR, Guideline directed medical therapy and surveillance of dissection
Duke University, The University of Texas Health Science Center, Houston, State University of New York - Downstate Medical Center, Oregon Health and Science University, National Heart, Lung, and Blood Institute (NHLBI)
Type B Aortic Dissection
06/30
06/30
Gersin, Keith
NCT04544865: Study of ECHELON ENDOPATH(TM) Staple Line Reinforcement

Completed
N/A
240
US
Staple Line Reinforcement
Ethicon Endo-Surgery
Gastric Procedures, Lung Resection Procedures
10/22
02/23
NCT04763421: A Prospective, Single-Arm Multi-Center Study of the ENSEAL X1 Curved Jaw Tissue Sealer in Select Procedures

Completed
N/A
145
Europe, US
ENSEAL X1 Curved Jaw
Ethicon Endo-Surgery
Upper GI; Lower GI; Gynecological
08/23
09/23
AUDACITY, NCT05368259: The Study (AllUrion Device in Adults With Clinical ObesITY)

Active, not recruiting
N/A
1000
US
AGBS, Allurion Gastric Balloon System (AGBS)
Allurion Technologies
Obesity
11/24
03/25
Kennelly, Michael
CELLEBRATE, NCT03104517 / 2016-002635-15: Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence

Active, not recruiting
3
96
Europe, US
AMDC-USR (iltamiocel), Placebo
Cook MyoSite
Stress Urinary Incontinence
09/26
09/27
AHEAD CARE, NCT05353400: At Home Early vs. Delayed Catheter Removal Following Failed Postoperative Voiding Trial: a Randomized Trial

Terminated
N/A
9
US
Early urinary catheter removal, Catheter Removal on POD 1, Urinary catheter removal on POD 3
Wake Forest University Health Sciences
Urinary Retention Postoperative
04/23
04/23
NCT03083366: Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury

Terminated
N/A
4
US
PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN), Sacral neuromodulation
University of Utah, Rancho Research Institute, Inc.
Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
04/23
04/23
TITAN 2, NCT05226286: Evaluation of Implantable Tibial Neuromodulation Pivotal Study

Active, not recruiting
N/A
188
US
Medtronic Implantable Tibial Neuromodulation (TNM) System
MedtronicNeuro
Overactive Bladder
10/23
04/25
NCT06918067: Comparison of Urinary Flow Study

Not yet recruiting
N/A
17
US
Coloplast Micro Zone Luja Female Catheter, Coloplast SpeediCath Female Catheter
Wake Forest University Health Sciences
Urinary Retention
12/26
12/26
Kelly, Daniel F
NCT05643534: Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

Recruiting
3
180
US
Tenapanor 50 MG, Tenapanor 25 mg bid, Placebo
Ardelyx
Irritable Bowel Syndrome With Constipation (IBS-C)
12/25
12/25
Rinaldi, Michael J
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04820764: EFS of the CardioMech MVRS

Recruiting
N/A
25
US
CardioMech MVRS
CardioMech AS
Mitral Regurgitation
12/25
12/30
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
NCT05809596: HEAL-LAA Clinical Trial

Active, not recruiting
N/A
949
US
WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure
Boston Scientific Corporation
Atrial Fibrillation, Bleeding, Stroke
07/24
08/25
SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting
N/A
1857
US
WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device
Boston Scientific Corporation
Atrial Fibrillation, Stroke, Bleeding
07/26
01/27
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
Heniford, Todd
NCT04450628: Esophagogastric Junction Distensibility During Hiatal Hernia Repair

Recruiting
N/A
50
US
Surgeon unblinded, EndoFLIP 1.0 System EF-100
Wake Forest University Health Sciences, Medtronic
Esophagogastric Junction Distensibility, Hiatal Hernia
07/25
08/25
SDR, NCT06237855: Investigating the Feasibility and Outcomes of Patient Self-Drain Removal After Ventral Hernia Repair

Recruiting
N/A
100
US
Self-drain removal
Wake Forest University Health Sciences
Ventral Hernia
12/25
01/26
ENF 18-06, NCT04718168: GORE® ENFORM Biomaterial Product Study

Recruiting
N/A
245
US
Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal)
W.L.Gore & Associates
Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
09/26
09/26
NCT05572021: A Comparison of the Outcomes in Fortiva and Strattice Mesh

Recruiting
N/A
200
US
Propspective VHR with Fortiva, RetroSpective VHR with Strattice
Wake Forest University Health Sciences
Ventral Hernia
02/26
02/26
NCT05994248: Randomized Controlled Trial (RCT) Umbilical Hernia Repair (UHR) Absorbable vs Non-absorbable Synthetic Mesh

Withdrawn
N/A
420
US
Enform Mesh, Marlex
Wake Forest University Health Sciences
Umbilical Hernia
06/29
06/29
Skipper, Eric
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04464785: CentriMag Failure-to-Wean Post Approval Study

Completed
N/A
32
US
CentriMag Circulatory Support System
Abbott Medical Devices
Heart Failure
10/24
10/24
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
OHP-II, NCT05915299: US National OCS Heart Perfusion (OHP) Registry

Recruiting
N/A
100000
US
OCS Heart
TransMedics
Heart Transplant
08/29
08/33
Sommer, Robert
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Martinie, John B
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
NCT04171440: Observation of Perioperative Outcomes of Robotic Pancreaticoduodenectomy

Active, not recruiting
N/A
81
US
robotic pancreaticoduodenectomy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreaticoduodenectomy
12/24
06/25
Baker, Erin H
LIFE, NCT06206356: Lumbar Injectrode Feasibility Evaluation

Completed
1
10
US
PNS Injectrode F1, Injectrode
Neuronoff, Inc, Ohio Pain Clinic
Chronic Pain, Lower Back Pain Chronic
03/24
03/24
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
Usadi, Rebecca
NatPro, NCT04551807: Natural Versus Programmed Frozen Embryo Transfer

Active, not recruiting
3
788
US
Modified natural cycle, Programmed cycle
JHSPH Center for Clinical Trials
Pregnancy Related, Pre-Eclampsia
04/25
08/25
Jungheim, Emily
PREGnant, NCT06375811: Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis_temp

Recruiting
3
288
US
Elagolix 200 MG, Orlissa, Placebo or SOC IVF
Yale University, University of Colorado, Denver, Northwestern University, University of North Carolina, Duke University, Johns Hopkins University
Infertility, Endometriosis
06/26
09/26
NCT04173169: Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis

Active, not recruiting
3
103
US
Elagolix 200 MG, Orlissa, Placebo or SOC IVF
Yale University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Colorado, Denver, Northwestern University, University of North Carolina
Infertility, Endometriosis
05/25
05/25
NatPro, NCT04551807: Natural Versus Programmed Frozen Embryo Transfer

Active, not recruiting
3
788
US
Modified natural cycle, Programmed cycle
JHSPH Center for Clinical Trials
Pregnancy Related, Pre-Eclampsia
04/25
08/25
GPRPL, NCT05444283: Genomic Predictors of Recurrent Pregnancy Loss

Recruiting
N/A
1000
US
Yale University, Johns Hopkins University, University of Texas at Austin, Penn State University, Northwestern University, The University of Texas Health Science Center at San Antonio, Wayne State University, Columbia University, University of Colorado, Denver, University of Oklahoma, University of Chicago, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recurrent Pregnancy Loss
12/26
12/26
PROMISE, NCT05358483: PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health

Recruiting
N/A
1000
US
Northwestern University
Infertility, Female
12/46
12/46
Moorman, Claude T
NCT04440189: Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

Active, not recruiting
3
114
US
GID SVF-2 Device System
GID BIO, Inc.
Osteoarthritis, Knee
12/24
06/25
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Monk, Bradley
CALLA, NCT03830866 / 2018-002872-42: Study of Durvalumab With Chemoradiotherapy for Women With Locally Advanced Cervical Cancer

Hourglass Jan 2022 - Dec 2023 : Submission in Japan for cervical cancer based on CALLA trial
Hourglass Jan 2022 - Dec 2023 : Regulatory submission in EU for cervical cancer based on CALLA trial
Checkmark Presentation of data from CALLA trial for advanced cervical cancer at IGCS 2022
Sep 2022 - Sep 2022: Presentation of data from CALLA trial for advanced cervical cancer at IGCS 2022
Checkmark From CALLA trial for advanced cervical cancer
More
Completed
3
770
Europe, Japan, US, RoW
Durvalumab, Cisplatin, Carboplatin, external beam radiation therapy (EBRT) + brachytherapy
AstraZeneca
Locally Advanced Cervical Cancer
01/22
07/23
UP-NEXT, NCT05329545: Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer

Terminated
3
20
Canada, US, RoW
Upifitimab rilsodotin, XMT-1536 Antibody Drug Conjugate, Placebo
Mersana Therapeutics, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT)
High Grade Serous Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
09/23
09/23
EPIK-O, NCT04729387 / 2019-004682-40: Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected

Active, not recruiting
3
358
Europe, Canada, US, RoW
Alpelisib, BYL719, Olaparib, Paclitaxel, Pegylated liposomal doxorubicin (PLD)
Novartis Pharmaceuticals
Ovarian Cancer
04/23
06/25
ATHENA, NCT03522246 / 2017-004557-17: A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

Checkmark From monotherapy portion of P3 ATHENA trial for 1L ovarian cancer maintenance setting at IGCS 2022
Sep 2022 - Sep 2022: From monotherapy portion of P3 ATHENA trial for 1L ovarian cancer maintenance setting at IGCS 2022
Checkmark Submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
Sep 2022 - Sep 2022: Submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
Checkmark Type II variation submitted for 1L maintenance treatment of adv ovarian cancer regardless of biomarker status who have responded to 1L chemo
More
Active, not recruiting
3
1097
Europe, Canada, Japan, US, RoW
Rucaparib, Rubraca, CO-338, Nivolumab, Opdivo, BMS-936558, Placebo Oral Tablet, Placebo IV Infusion
pharmaand GmbH, Bristol-Myers Squibb, Gynecologic Oncology Group, European Network of Gynaecological Oncological Trial Groups (ENGOT), Foundation Medicine
Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed, FIGO Stage III-IV, Partial Response, Complete Response
05/24
12/30
ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer
Recruiting
3
220
Europe, Canada, US, RoW
Selinexor, KPT-330, Matching Placebo for selinexor
Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group
Endometrial Cancer
01/25
01/28
RAMP 301, NCT06072781: A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Recruiting
3
270
Europe, Canada, US, RoW
avutometinib, avutometinib (VS-6766), Defactinib, defactinib (VS-6063), Pegylated liposomal doxorubicin, Caelyx, Doxil, Lipodox, Paclitaxel, Nov-Onxol, Onxol, Navaplus, Taxol, Letrozole, Femara, Anastrozole, Arimidex
Verastem, Inc., GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Australia New Zealand Gynaecological Oncology Group, Korean Gynecologic Oncology Group
Low Grade Serous Ovarian Cancer
10/28
02/31
TETON, NCT04814108: A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma

Recruiting
2
76
Canada, US, RoW
ZN-c3, azenosertib, KP-2638
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Uterine Serous Carcinoma
11/24
05/25
PROFECTA-II, NCT04374630: Study with Afuresertib and Paclitaxel in Platinum Resistant Ovarian

Completed
2
150
US, RoW
Paclitaxel, Afuresertib, LAE002
Laekna Limited
Platinum-resistant Ovarian Cancer
07/23
06/24
NCT04998669: Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma

Recruiting
2
100
US
Loncastuximab tesirine, ADCT-402, Rituximab, Rituxan
Juan P. Alderuccio, MD, ADC Therapeutics S.A.
Follicular Lymphoma
08/27
08/30
ENGOT-ov60, NCT04625270 / 2020-004264-26: A Study of Avutometinib (VS-6766) V. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer with and Without a KRAS Mutation

Active, not recruiting
2
225
Europe, Canada, US
avutometinib (VS-6766), avutometinib (VS-6766) and defactinib, avutometinib (VS-6766) and VS-6063
Verastem, Inc., European Network of Gynaecological Oncological Trial Groups (ENGOT), GOG Foundation
Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
11/24
12/26
DENALI, NCT05128825: A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Recruiting
2
170
Europe, US, RoW
azenosertib, ZN-c3
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
12/26
06/27
PRESERVE-004, NCT05446298: ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer

Active, not recruiting
2
58
US
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody made by OncoC4, Inc., Pembrolizumab, MK3475, Keytruda
OncoC4, Inc., Merck Sharp & Dohme LLC, GOG Foundation
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
06/25
06/26
ACR-368-201, NCT05548296: A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

Recruiting
1/2
390
US
ACR-368, prexasertib, Gemcitabine, OncoSignature
Acrivon Therapeutics, GOG Foundation
Platinum-resistant Ovarian Cancer, Endometrial Adenocarcinoma, Urothelial Carcinoma
07/26
12/27
Brennan, Michael T
NCT06233591: Evaluating LP-10 in Subjects With OLP

Recruiting
2
24
US
LP-10 (Liposomal Tacrolimus)
Lipella Pharmaceuticals, Inc.
Oral Lichen Planus
09/25
03/26
AQUAX2, NCT05926765: A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

Recruiting
2
120
Europe, Canada, US
AAV2-hAQP1 Concentration 1, AAV2-hAQP1 Concentration 2, Placebo
MeiraGTx, LLC
Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
07/25
07/25
ORARAD II, NCT05325970: Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
350
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Diseases, Osteoradionecrosis
06/25
06/25
ORARAD, NCT02057510: Observational Study of Dental Outcomes in Head and Neck Cancer Patients

Active, not recruiting
N/A
575
US
Wake Forest University Health Sciences, National Institute of Dental and Craniofacial Research (NIDCR), University of Minnesota, UConn Health, University of Pennsylvania, Brigham and Women's Hospital, NYU Langone Health, University of North Carolina
Head and Neck Cancer, Dental Disease, Xerostomia, Osteoradionecrosis
06/25
06/25
Iannitti, David A
DHF-01-SFT-194, NCT05385952: GATT-Patch Versus TachoSil in Liver Surgery

Completed
N/A
131
Europe, US
GATT-Patch, TachoSil
GATT Technologies BV, Syneos Health
Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases
05/24
05/24
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
NCT05900037: GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery

Recruiting
N/A
50
US
GATT-Patch, SURGICEL® Original, Surgicel Absorbable Hemostat
GATT Technologies BV
Intraoperative Bleeding, Liver Diseases, Gallbladder Diseases, Hemorrhage, Surgical
04/25
09/25
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Schwartz, Matthew W
FUEL-2, NCT05918211: Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

Recruiting
3
436
US, RoW
Udenafil, Placebo
Mezzion Pharma Co. Ltd
Single Ventricle Heart Disease
10/25
10/25
NCT05077774: Harmony TPV Post-Approval Study

Recruiting
N/A
150
Canada, US
Harmony TPV System, Model Numbers: HARMONY-22, HARMONY-25, and HARMONY-DCS
Medtronic Cardiovascular
Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
10/25
03/35
COMPASS, NCT05268094: Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The Trial)

Recruiting
N/A
300
Canada, US
Ductal Arterial Stent, Medtronic Resolute Onyx, Boston Scientific Promus Elite/Premier, Boston Scientific Synergy, Cordis Elunir, Abbott Xience, Systemic-to-Pulmonary Artery Shunt
Carelon Research, Pediatric Heart Network
Congenital Heart Disease in Children
09/26
04/27
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Osunkwo, Ifeyinwa
SPARTAN, NCT03938454: A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism

Completed
2
36
US
Crizanlizumab, SEG101
Novartis Pharmaceuticals
Priapism
03/23
11/23
Lodhia, Nilesh
VERDICT, NCT04259138 / 2019-002485-12: Determination of the Optimal Treatment Target in Ulcerative Colitis

Active, not recruiting
4
672
Europe, Canada, US, RoW
Treatment Algorithm A, vedolizumab, Treatment Algorithm B, Treatment Algorithm C
Alimentiv Inc., Takeda Development Center Americas, Inc.
Colitis, Ulcerative
03/26
03/26
Murphy, Erin S
NCT06368817: A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

Recruiting
2
240
Canada, US, RoW
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D radiotherapy, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Three dimensional external beam radiation therapy (procedure), Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Intensity-Modulated Radiation Therapy, IMRT, Intensity modulated radiation therapy (procedure), Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Lumbar Puncture, LP, Spinal Tap, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Questionnaire Administration, Surgical Procedure, Operation, Surgery, Surgery Type, Surgery, NOS, Surgical, Surgical Intervention, Surgical Interventions, Surgical Procedures, Type of Surgery
Children's Oncology Group
Basal Ganglia Germinoma, Central Nervous System Germinoma, Diabetes Insipidus, Pineal Region Germinoma, Suprasellar Germinoma, Thalamic Germinoma
11/33
11/33
NCT01891318: Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

Recruiting
1/2
36
US
radiosurgery, radiation surgery, therapeutic conventional surgery, quality-of-life assessment, quality of life assessment
Case Comprehensive Cancer Center
Tumors Metastatic to Brain
06/25
06/25
KQB198-102, NCT06645886: A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies

Recruiting
1
122
Europe, US
KQB198, Dasatinib
Kumquat Biosciences Inc.
Hematologic Malignancies, Adult
08/27
02/28
NCT06090409: Encouraging a Plant Based Diet in an Underserved Urban Population

Recruiting
N/A
300
US
Implementing free/subsidized agricultural produce to encourage a plant-based diet.
University of Louisville, Oatly Group AB
Food Neophobia, Food Preferences, Dietary Habits
12/24
12/24
NCT05409976: The GORE® VIAFORT Vascular Stent IVC Study

Active, not recruiting
N/A
112
Europe, US, RoW
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
05/26
05/30
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study

Recruiting
N/A
165
US
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
03/26
03/31
Mehta, Rohit
NCT01424592: In-Hospital Portable Sleep Monitoring for the Evaluation of Obstructive Sleep Apnea (OSA)

Active, not recruiting
N/A
140
US
Testing with a portable sleep apnea monitor ., Alice PDx portable sleep testing system (Philips Respironics, Murraysville, PA)
John H. Stroger Hospital
Obstructive Sleep Apnea
06/22
12/24
RECTIFY, NCT05471973: CIED Infection Quality Initiative Demonstration Project

Recruiting
N/A
200
US
Multidisciplinary Team, Outreach Visits, Multifaceted Intervention, Measurement and Feedback
Duke University, Duke Clinical Research Institute, Philips Healthcare
Infections
12/25
12/25
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Recruiting
N/A
620
US
OPTIMIZER Smart System
Impulse Dynamics
Heart Failure
03/26
03/26
Magge, Sheela N
DISCOVERY, NCT06525259: of Risk Factors for Type 2 Diabetes in Youth

Recruiting
N/A
3600
US
George Washington University
Diabetes Mellitus Type 2, Childhood-Onset
01/28
01/28
Runyon, Michael
NCT04361123: Atrium COVID-19 Syndromic and Serologic Surveillance

Enrolling by invitation
N/A
450000
US
daily syndromic surveillance, monthly serologic IgM/G test
Michael Runyon, MD
Coronavirus, COVID
12/21
12/21
Taylor, Stephanie
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy

Terminated
4
6
US
Placebo, Rifaximin, XIFAXAN® Tablets
Bausch Health Americas, Inc.
Hepatic Encephalopathy
02/16
02/16
EAGLE-1, NCT04010539 / 2018-001780-23: A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea

Completed
3
628
Europe, US, RoW
Gepotidacin, Ceftriaxone, Azithromycin
GlaxoSmithKline, BARDA
Gonorrhea
10/23
10/23
NCT05790239: MDMA-Assisted Therapy for Veterans with Moderate to Severe Post Traumatic Stress Disorder

Recruiting
2
40
US
3,4-methylenedioxymethamphetamine, MDMA, d-amphetamine, Therapy
Stephen Robert Marder
Post Traumatic Stress Disorder
03/26
03/26
ENCOMPASS, NCT04495946: Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship

Completed
N/A
4018
US
Sepsis Transition and Recovery (STAR) program, Usual care
Wake Forest University Health Sciences, National Institute of Nursing Research (NINR)
Sepsis
04/24
04/24
NCT05097521: Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health

Completed
N/A
3726
US
Practitioner-delivered CIH therapies (acupuncture, therapeutic massage, chiropractic care) as received in VHA and community practice settings, Self-care CIH therapies (yoga, Tai Chi/Qigong , meditation) as received in VHA and community practice settings, Combination of practitioner-delivered and self-care CIH therapies (described above) as received in VHA and community practice settings
VA Office of Research and Development, Veterans Health Administration Office of Patient Centered Care & Cultural Transformation
Chronic Musculoskeletal Pain
09/23
09/23
Roses, Robert
EA2197, NCT04559139: Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer

Recruiting
2/3
186
US
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone''s Chloride, Peyrone''s Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, FF 10832, FF-10832, FF10832, Gemcitabine HCI, Gemzar, LY-188011, LY188011, Lymphadenectomy, excision of the lymph node, Lymph Node Dissection, lymph node excision, Partial Hepatectomy, partial excision of liver, subtotal hepatectomy
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8, Stage IIB Gallbladder Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8, Stage IIIA Gallbladder Cancer AJCC v8, Stage IIIB Gallbladder Cancer AJCC v8
06/29
06/29
PREVENT, NCT03911700: Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

Recruiting
N/A
477
Europe, US
Phasix™ Mesh
C. R. Bard
Open Midline Laparotomy
12/29
12/31
Farber, Alik
NCT03903692: A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

Terminated
N/A
62
US
Marine polysaccharide dressing, Carboxymethylcellulose dressing
Medline Industries
Venous Leg Ulcer
12/22
12/22
NCT04927702: Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)

Terminated
N/A
47
US
Synthetic Hybrid-Scale Fiber Matrix, Restrata, Standard of Care, Living Cellular Skin Substitute, Apligraf
Acera Surgical, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
07/24
08/24
NCT05313165: PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

Recruiting
N/A
100
US
LimFlow Stent Graft System
LimFlow, Inc.
Critical Limb Ischemia, Chronic Limb-Threatening Ischemia, Peripheral Arterial Disease
05/27
05/27
Ujiki, Michael
FLOWS, NCT06454916: Functional Lumen Opening With Self-Forming Magnetic Anastomosis

Active, not recruiting
N/A
70
US
Small Bowel Anastomosis with Flexagon SFM Device with OTOLoc
GI Windows, Inc.
Small Bowel Anastomosis
06/25
08/25
ENF 18-06, NCT04718168: GORE® ENFORM Biomaterial Product Study

Recruiting
N/A
245
US
Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal)
W.L.Gore & Associates
Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
09/26
09/26
NCT04578340: Long Term Outcomes Following Hernia Repair With Mesh

Recruiting
N/A
4700
US
NorthShore University HealthSystem, Medtronic
Abdominal Hernia
10/25
10/26
RETHINK REFLUX, NCT04253392: Registry

Active, not recruiting
N/A
500
Europe, US, RoW
LINX Reflux Management System, LINX
Ethicon Endo-Surgery
Gastroesophageal Reflux
07/32
07/32
Myers, Erinn
LOVE, NCT04680897: Trial: Limits On Vaginal Intercourse After Mid-urEthral Sling

Completed
N/A
155
US
Early restriction release, Standard restriction recommendation
Wake Forest University Health Sciences
Patient Satisfaction, Female Sexual Dysfunction
09/24
09/24
Arko, Frank
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms

Approved for marketing
N/A
US
GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aneurysm
 
 
ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease

Active, not recruiting
N/A
344
US
Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting
Silk Road Medical
Carotid Artery Diseases
09/25
09/25
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

Active, not recruiting
N/A
102
Europe, US
GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aortic Aneurysm
01/23
09/26
SOCRATES, NCT04503395: ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR:

Recruiting
N/A
204
Europe, US
ESAR treatment: Endograft + Heli-FX Endoanchor, FEVAR treatment : Fenestrated endograft
FCRE (Foundation for Cardiovascular Research and Education), Medtronic
Aortic Aneurysm, Abdominal
06/26
06/28
IMPROVE-AD, NCT06087029: IMPRoving Outcomes in Vascular DisEase- Aortic Dissection

Recruiting
N/A
1100
US
TEVAR, Guideline directed medical therapy and surveillance of dissection
Duke University, The University of Texas Health Science Center, Houston, State University of New York - Downstate Medical Center, Oregon Health and Science University, National Heart, Lung, and Blood Institute (NHLBI)
Type B Aortic Dissection
06/30
06/30
Gersin, Keith
NCT04544865: Study of ECHELON ENDOPATH(TM) Staple Line Reinforcement

Completed
N/A
240
US
Staple Line Reinforcement
Ethicon Endo-Surgery
Gastric Procedures, Lung Resection Procedures
10/22
02/23
NCT04763421: A Prospective, Single-Arm Multi-Center Study of the ENSEAL X1 Curved Jaw Tissue Sealer in Select Procedures

Completed
N/A
145
Europe, US
ENSEAL X1 Curved Jaw
Ethicon Endo-Surgery
Upper GI; Lower GI; Gynecological
08/23
09/23
AUDACITY, NCT05368259: The Study (AllUrion Device in Adults With Clinical ObesITY)

Active, not recruiting
N/A
1000
US
AGBS, Allurion Gastric Balloon System (AGBS)
Allurion Technologies
Obesity
11/24
03/25
Kennelly, Michael
CELLEBRATE, NCT03104517 / 2016-002635-15: Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence

Active, not recruiting
3
96
Europe, US
AMDC-USR (iltamiocel), Placebo
Cook MyoSite
Stress Urinary Incontinence
09/26
09/27
AHEAD CARE, NCT05353400: At Home Early vs. Delayed Catheter Removal Following Failed Postoperative Voiding Trial: a Randomized Trial

Terminated
N/A
9
US
Early urinary catheter removal, Catheter Removal on POD 1, Urinary catheter removal on POD 3
Wake Forest University Health Sciences
Urinary Retention Postoperative
04/23
04/23
NCT03083366: Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury

Terminated
N/A
4
US
PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN), Sacral neuromodulation
University of Utah, Rancho Research Institute, Inc.
Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
04/23
04/23
TITAN 2, NCT05226286: Evaluation of Implantable Tibial Neuromodulation Pivotal Study

Active, not recruiting
N/A
188
US
Medtronic Implantable Tibial Neuromodulation (TNM) System
MedtronicNeuro
Overactive Bladder
10/23
04/25
NCT06918067: Comparison of Urinary Flow Study

Not yet recruiting
N/A
17
US
Coloplast Micro Zone Luja Female Catheter, Coloplast SpeediCath Female Catheter
Wake Forest University Health Sciences
Urinary Retention
12/26
12/26
Kelly, Daniel F
NCT05643534: Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

Recruiting
3
180
US
Tenapanor 50 MG, Tenapanor 25 mg bid, Placebo
Ardelyx
Irritable Bowel Syndrome With Constipation (IBS-C)
12/25
12/25
Rinaldi, Michael J
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04820764: EFS of the CardioMech MVRS

Recruiting
N/A
25
US
CardioMech MVRS
CardioMech AS
Mitral Regurgitation
12/25
12/30
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
NCT05809596: HEAL-LAA Clinical Trial

Active, not recruiting
N/A
949
US
WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure
Boston Scientific Corporation
Atrial Fibrillation, Bleeding, Stroke
07/24
08/25
SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting
N/A
1857
US
WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device
Boston Scientific Corporation
Atrial Fibrillation, Stroke, Bleeding
07/26
01/27
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
Heniford, Todd
NCT04450628: Esophagogastric Junction Distensibility During Hiatal Hernia Repair

Recruiting
N/A
50
US
Surgeon unblinded, EndoFLIP 1.0 System EF-100
Wake Forest University Health Sciences, Medtronic
Esophagogastric Junction Distensibility, Hiatal Hernia
07/25
08/25
SDR, NCT06237855: Investigating the Feasibility and Outcomes of Patient Self-Drain Removal After Ventral Hernia Repair

Recruiting
N/A
100
US
Self-drain removal
Wake Forest University Health Sciences
Ventral Hernia
12/25
01/26
ENF 18-06, NCT04718168: GORE® ENFORM Biomaterial Product Study

Recruiting
N/A
245
US
Gore ENFORM Biomaterial (Preperitoneal), Gore ENFORM Biomaterial (Intraperitoneal)
W.L.Gore & Associates
Hernia, Ventral, Hernia, Hiatal, Hernia, Diaphragmatic, Incisional Hernia
09/26
09/26
NCT05572021: A Comparison of the Outcomes in Fortiva and Strattice Mesh

Recruiting
N/A
200
US
Propspective VHR with Fortiva, RetroSpective VHR with Strattice
Wake Forest University Health Sciences
Ventral Hernia
02/26
02/26
NCT05994248: Randomized Controlled Trial (RCT) Umbilical Hernia Repair (UHR) Absorbable vs Non-absorbable Synthetic Mesh

Withdrawn
N/A
420
US
Enform Mesh, Marlex
Wake Forest University Health Sciences
Umbilical Hernia
06/29
06/29
Skipper, Eric
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04464785: CentriMag Failure-to-Wean Post Approval Study

Completed
N/A
32
US
CentriMag Circulatory Support System
Abbott Medical Devices
Heart Failure
10/24
10/24
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
OHP-II, NCT05915299: US National OCS Heart Perfusion (OHP) Registry

Recruiting
N/A
100000
US
OCS Heart
TransMedics
Heart Transplant
08/29
08/33
Sommer, Robert
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Martinie, John B
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
NCT04171440: Observation of Perioperative Outcomes of Robotic Pancreaticoduodenectomy

Active, not recruiting
N/A
81
US
robotic pancreaticoduodenectomy
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreaticoduodenectomy
12/24
06/25
Baker, Erin H
LIFE, NCT06206356: Lumbar Injectrode Feasibility Evaluation

Completed
1
10
US
PNS Injectrode F1, Injectrode
Neuronoff, Inc, Ohio Pain Clinic
Chronic Pain, Lower Back Pain Chronic
03/24
03/24
MWA, NCT05471596: Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics

Completed
N/A
60
US
NeuWave Microwave Ablation System
Wake Forest University Health Sciences, Johnson & Johnson
Liver Diseases
11/23
11/23
Usadi, Rebecca
NatPro, NCT04551807: Natural Versus Programmed Frozen Embryo Transfer

Active, not recruiting
3
788
US
Modified natural cycle, Programmed cycle
JHSPH Center for Clinical Trials
Pregnancy Related, Pre-Eclampsia
04/25
08/25
Jungheim, Emily
PREGnant, NCT06375811: Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis_temp

Recruiting
3
288
US
Elagolix 200 MG, Orlissa, Placebo or SOC IVF
Yale University, University of Colorado, Denver, Northwestern University, University of North Carolina, Duke University, Johns Hopkins University
Infertility, Endometriosis
06/26
09/26
NCT04173169: Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis

Active, not recruiting
3
103
US
Elagolix 200 MG, Orlissa, Placebo or SOC IVF
Yale University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Colorado, Denver, Northwestern University, University of North Carolina
Infertility, Endometriosis
05/25
05/25
NatPro, NCT04551807: Natural Versus Programmed Frozen Embryo Transfer

Active, not recruiting
3
788
US
Modified natural cycle, Programmed cycle
JHSPH Center for Clinical Trials
Pregnancy Related, Pre-Eclampsia
04/25
08/25
GPRPL, NCT05444283: Genomic Predictors of Recurrent Pregnancy Loss

Recruiting
N/A
1000
US
Yale University, Johns Hopkins University, University of Texas at Austin, Penn State University, Northwestern University, The University of Texas Health Science Center at San Antonio, Wayne State University, Columbia University, University of Colorado, Denver, University of Oklahoma, University of Chicago, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recurrent Pregnancy Loss
12/26
12/26
PROMISE, NCT05358483: PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health

Recruiting
N/A
1000
US
Northwestern University
Infertility, Female
12/46
12/46
Moorman, Claude T
NCT04440189: Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

Active, not recruiting
3
114
US
GID SVF-2 Device System
GID BIO, Inc.
Osteoarthritis, Knee
12/24
06/25
 

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